Abstract:
PURPOSE OF REVIEW:Chronic consumption of fructose and fructose-containing sugars leads to dyslipidemia. Apolipoprotein (apo) CIII is strongly associated with elevated levels of triglycerides and cardiovascular disease risk. We reviewed the effects of fructose consumption on apoCIII levels and the role of apoCIII in fructose-induced dyslipidemia. RECENT FINDINGS:Consumption of fructose increases circulating apoCIII levels compared with glucose. The more marked effects of fructose compared with glucose on apoCIII concentrations may involve the failure of fructose consumption to stimulate insulin secretion. The increase in apoCIII levels after fructose consumption correlates with increased postprandial serum triglyceride. Further, RNA interference of apoCIII prevents fructose-induced dyslipidemia in nonhuman primates. Increases in postprandial apoCIII after fructose, but not glucose consumption, are positively associated with elevated triglycerides in large triglyceride-rich lipoproteins and increased small dense LDL levels. SUMMARY:ApoCIII might be causal in the lipid dysregulation observed after consumption of fructose and fructose-containing sugars. Decreased consumption of fructose and fructose-containing sugars could be an effective strategy for reducing circulating apoCIII and subsequently lowering triglyceride levels.
journal_name
Curr Opin Lipidoljournal_title
Current opinion in lipidologyauthors
Hieronimus B,Stanhope KLdoi
10.1097/MOL.0000000000000653subject
Has Abstractpub_date
2020-02-01 00:00:00pages
20-26issue
1eissn
0957-9672issn
1473-6535journal_volume
31pub_type
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journal_title:Current opinion in lipidology
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journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
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更新日期:2001-10-01 00:00:00
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journal_title:Current opinion in lipidology
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更新日期:2011-12-01 00:00:00
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