Epigenetics of paraoxonases.

abstract：PURPOSE OF REVIEW:Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and it has overlapping pathogenesis with diabetes and cardiovascular disease. Reviewed here are recent advances in understanding the contribution of diet and selected nutrients to NAFLD. RECENT FINDINGS:To und...

journal_title：Current opinion in lipidology

authors： Vos MB

更新日期：2014-02-01 00:00:00

abstract：:Apolipoprotein E has key functions in lipoprotein metabolism, and polymorphisms in the apolipoprotein E gene are associated with distinct lipoprotein patterns. The possibility of gene-nutrient interactions for apolipoprotein E has been addressed in many studies. Although results have generally been mixed, the indicati...

journal_title：Current opinion in lipidology

authors： Rubin J,Berglund L

更新日期：2002-02-01 00:00:00

abstract：:Antithrombotic therapy has assumed a central role in the therapy of the acute coronary syndromes and chronic coronary artery disease. The theoretical rationale for antithrombotic therapy, and the established and evolving roles of antiplatelet agents and anticoagulants in coronary disease are reviewed. Emphasis is focu...

journal_title：Current opinion in lipidology

authors： Di Salvo TG,Fuster V

更新日期：1994-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Several members of the fibroblast growth factor (FGF) family have been identified as key regulators of energy metabolism in rodents and nonhuman primates. Translational studies show that their metabolic actions are largely conserved in humans, which led to the development of various FGF-based drugs, i...

journal_title：Current opinion in lipidology

authors： Struik D,Dommerholt MB,Jonker JW

更新日期：2019-06-01 00:00:00

abstract：:The microsomal triglyceride transfer protein is necessary for the assembly and secretion of lipoproteins containing apolipoprotein B. During the past year, significant progress has been made towards understanding the role of microsomal triglyceride transfer protein in lipoprotein assembly at both a cellular and molecu...

journal_title：Current opinion in lipidology

authors： Gordon DA

更新日期：1997-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine the role of gut microbiota in the regulation of host energy homeostasis and its role in the pathogenesis of obesity, diabetes and nonalcoholic fatty liver disease (NAFLD). RECENT FINDINGS:Experimental models highlight several mechanisms connecting gut microbiota to host energy metabolism: ...

journal_title：Current opinion in lipidology

authors： Musso G,Gambino R,Cassader M

更新日期：2010-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Substantial risk of ASCVD events persists despite intensive statin therapy and other agents to lower LDL-C. The optimal way to address other elements of dyslipidemia, such as triglyceride-rich particles (TRL) and when to treat has remained unclear. RECENT FINDINGS:Several lines of evidence indicate t...

journal_title：Current opinion in lipidology

authors： Ganda OP

更新日期：2020-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Control of vascular smooth muscle cell (VSMC) phenotype is essential in the development and maintenance of a healthy vasculature. Acquisition of a synthetic, proproliferative phenotype by VSMCs following vascular insult is central to neointimal formation and the development of vascular pathology. Micr...

journal_title：Current opinion in lipidology

authors： Robinson HC,Baker AH

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Peroxisome proliferator-activated receptors alpha, beta/delta and gamma are members of the nuclear receptor superfamily. They mediate the effects of fatty acids and their derivatives at the transcriptional level, and are considered to be lipid sensors that participate in the regulation of energy homeo...

journal_title：Current opinion in lipidology

authors： Michalik L,Desvergne B,Wahli W

更新日期：2003-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To review how leveraging familial hypercholesterolemia registries can impact molecular genetic research and precision medicine. RECENT FINDINGS:Familial hypercholesterolemia is both much more common and more phenotypically heterogeneous than previously thought with some evidence for significant genot...

journal_title：Current opinion in lipidology

authors： Kindt I,Mata P,Knowles JW

更新日期：2017-04-01 00:00:00

abstract：:Abetalipoproteinemia is a recessive genetic disease in humans characterized by the virtual absence of apolipoprotein (apo)B and apoB-containing lipoproteins in plasma. Microsomal triglyceride transfer protein (MTP), a resident lipid transfer protein within the endoplasmic reticulum of hepatocytes and enterocytes, has ...

journal_title：Current opinion in lipidology

authors： Gregg RE,Wetterau JR

更新日期：1994-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The goal of this review is to provide an update on the most recent and relevant findings in the area of genotype-phenotype associations as well as the relationships between genetic factors and cardiovascular disease risk markers and events. In addition, emphasis will be placed on the methodological pr...

journal_title：Current opinion in lipidology

authors： Visvikis-Siest S,Marteau JB

更新日期：2006-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Current data suggest that proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors may affect many metabolic pathways beyond lowering LDL cholesterol. The aim of the present manuscript is to present these so-called pleiotropic effects of PCSK9 inhibitors. RECENT FINDINGS:PCSK9 may affect the ...

journal_title：Current opinion in lipidology

authors： Filippatos TD,Christopoulou EC,Elisaf MS

更新日期：2018-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to present recent information on lipid lowering in diabetes mellitus. New information from randomized clinical trials will be discussed together with implications for clinical practice. Residual risk persists despite statin therapy and additional approaches, particularly ...

journal_title：Current opinion in lipidology

authors： Betteridge DJ

更新日期：2008-12-01 00:00:00

abstract：:Atherosclerotic macrovascular disease is the leading cause of both morbidity and mortality in non-insulin dependent diabetes mellitus. Endothelial dysfunction is a key, early and potentially reversible event in pathogenesis of atherosclerosis. Its occurrence in non-insulin dependent diabetes mellitus is well supported...

journal_title：Current opinion in lipidology

authors： Evans M,Khan N,Rees A

更新日期：1999-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Sortilin, encoded SORT1 gene at chromosome 1p13.3, is a multiligand receptor that traffics protein from the Golgi to the endosomes, secretory vesicles, and the cell surface. Genome-wide association studies (GWAS) revealed an association between sortilin and reduced plasma LDL-cholesterol (LDL-C) as we...

journal_title：Current opinion in lipidology

authors： Conlon DM

更新日期：2019-06-01 00:00:00

abstract：:PURPOSE OF REVIEW This review discusses recent progress in the role of ATP-binding cassette proteins ABCG5 and G8 in dietary sterol absorption, excretion and pathogenesis of cardiovascular disease. RECENT FINDINGS Identification of the genetic defect(s) underlying sitosterolemia has led to a renewed interest in the me...

journal_title：Current opinion in lipidology

authors： Klett EL,Patel S

更新日期：2003-08-01 00:00:00

abstract：:Thia substituted fatty acids are saturated fatty acids which are modified by insertion of a sulfur atom at specific positions in the carbon backbone. During the last few years pleiotropic effects of the 3-thia fatty acid tetradecylthioacetic acid have been revealed. The biological responses to tetradecylthioacetic aci...

journal_title：Current opinion in lipidology

authors： Berge RK,Skorve J,Tronstad KJ,Berge K,Gudbrandsen OA,Grav H

更新日期：2002-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Familial hypercholesterolaemia is a hereditary disorder of lipoprotein metabolism which causes a lifelong increase in LDL-C levels resulting in premature coronary heart disease. The present review looks at some of the recent literature on how molecular methods can be used to assist in the definitive d...

journal_title：Current opinion in lipidology

authors： Graham CA,Latten MJ,Hart PJ

更新日期：2017-08-01 00:00:00

abstract：:The Scandinavian Simvastatin Survival Study showed that a 35% decrease in LDL-cholesterol was accompanied by a 42% reduction in coronary mortality. Even if the period of time is longer than 1 year for the divergence of survival curves in the simvastatin and placebo groups there are reasons to believe that the benefici...

journal_title：Current opinion in lipidology

authors： Olsson AG,Pedersen T,Bergdahl B

更新日期：1995-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The endoplasmic reticulum (ER) maintains cellular metabolic homeostasis by coordinating protein synthesis, secretion activities, lipid biosynthesis and calcium (Ca²⁺) storage. In this review, we will discuss how altered ER homeostasis contributes to dysregulation of hepatic lipid metabolism and contri...

journal_title：Current opinion in lipidology

authors： Wang S,Kaufman RJ

更新日期：2014-04-01 00:00:00

abstract：:Coronary heart disease is the leading cause of death in the developed world. Current surgical and pharmacological interventions are essentially palliative and interest in preventive strategies, particularly through nutrition and avoidance of tobacco has increased in recent years. Basic scientific, clinical and epidemi...

journal_title：Current opinion in lipidology

authors： Graham IM,O'Callaghan P

更新日期：2000-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Because human genetic studies and large clinical trials have demonstrated that HDL-cholesterol levels are not causally related to cardiovascular disease risk, attention has shifted toward the functional properties of HDL. Infusion of HDL mimetics containing apolipoprotein A-I remains a potential strat...

journal_title：Current opinion in lipidology

authors： Zheng KH,Stroes ES

更新日期：2016-12-01 00:00:00

abstract：:Low folate intake is an important determinant of elevated blood levels of homocysteine. Because elevated homocysteine has been shown to be a possible graded risk factor for CHD, sufficient folate intake may be important in the prevention of CHD. The magnitude of the association between folate and CHD is consistent wit...

journal_title：Current opinion in lipidology

authors： Verhoef P,Stampfer MJ,Rimm EB

更新日期：1998-02-01 00:00:00

abstract：PURPOSE OF REVIEW:As the incidence of obesity and the metabolic syndrome has increased, research has focused on the importance of the endocannabinoid system in the brain and peripheral tissues. Rimonabant, an inverse agonist of the CB1 receptor is being used therapeutically. This review presents recent advances in endo...

journal_title：Current opinion in lipidology

authors： Jesudason D,Wittert G

更新日期：2008-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The cell death-inducing DFF45-like effector (CIDE) family proteins, comprising three members, Cidea, Cideb, and Fsp27 (Cidec), have emerged as important regulators for various aspects of metabolism. This review summarizes our current understanding about the physiological roles of CIDE proteins, their ...

journal_title：Current opinion in lipidology

authors： Gong J,Sun Z,Li P

更新日期：2009-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Accumulating evidence has provided new insights regarding potentially effective therapeutic options targeting modulation of HDL metabolism, resulting in the prevention of cardiovascular diseases. The gut microbiota has now been convincingly linked to host health, but its impact on host lipid metabolis...

journal_title：Current opinion in lipidology

authors： Nakaya K,Ikewaki K

更新日期：2018-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides a concise update of the involvement of endothelial adhesion molecules in atherogenesis, an overview of current advances in the development of adhesion molecule blocking agents, as well as an insight into the potential of these molecules in cardiovascular therapy. RECENT FINDINGS:...

journal_title：Current opinion in lipidology

authors： Lutters BC,Leeuwenburgh MA,Appeldoorn CC,Molenaar TJ,Van Berkel TJ,Biessen EA

更新日期：2004-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights recent advances in eicosanoid biology, especially linked to the cytochrome P450 (CYP)/soluble epoxide hydrolase (sEH) axis in vascular biology and disease. RECENT FINDINGS:Since the first reports that CYP-derived metabolites of arachidonic acid can elicit vascular smooth muscle...

journal_title：Current opinion in lipidology

authors： Fleming I

更新日期：2011-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The number of deaths associated with cardiovascular disease remains high, despite great advances in treating the associated high levels of cholesterol. The main underlying pathology of cardiovascular disease is atherosclerosis, which is recognized as a chronic autoimmune-like inflammatory disease. Hen...

journal_title：Current opinion in lipidology

authors： Douna H,Kuiper J

更新日期：2016-10-01 00:00:00