Update on cardiometabolic health effects of ω-3 fatty acids.

abstract：PURPOSE OF REVIEW:Dementia is a major cause of disability and institutionalization. Apart from age and apolipoprotein E (APOE) genotype, there are currently no established, clinically relevant, noninvasive markers of dementia. We conducted a literature search of recent observational epidemiological studies evaluating t...

journal_title：Current opinion in lipidology

authors： Koch M,Jensen MK

更新日期：2016-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose is to evaluate recent findings concerning dietary fats and the risk of coronary heart disease. Monounsaturated fatty acids are often regarded as healthy, and many have recommended their consumption instead of saturated fatty acids and polyunsaturated fatty acids. Support for the benefits o...

journal_title：Current opinion in lipidology

authors： Lada AT,Rudel LL

更新日期：2003-02-01 00:00:00

abstract：PURPOSE OF REVIEW:We will discuss the diverse roles of lipoprotein receptors that contribute to the maintenance and integrity of the vascular wall. RECENT FINDINGS:Lipoprotein receptors function not only as transporters for cholesterol and other lipids. They also act as sensors and signal transducers through which the...

journal_title：Current opinion in lipidology

authors： Herz J,Hui DY

更新日期：2004-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The occurrence in blood of an electronegatively charged LDL was described in 1988. During the 1990s reports studying electronegative LDL (LDL(-)) were scant and its atherogenic role controversial. Nevertheless, recent reports have provided new evidence on a putative atherogenic role of LDL(-). This re...

journal_title：Current opinion in lipidology

authors： Sánchez-Quesada JL,Benítez S,Ordóñez-Llanos J

更新日期：2004-06-01 00:00:00

abstract：:Common variants at the apolipoprotein B gene locus are associated with hyperlipidaemia, but conflicting data have been presented in the literature concerning the size of the effects and which polymorphisms give the best signal in the different groups of individuals studied. In this review, we will present a critique o...

journal_title：Current opinion in lipidology

authors： Humphries SE,Talmud PJ

更新日期：1995-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will provide an update on the structure of GPIHBP1, a 28-kDa glycosylphosphatidylinositol-anchored glycoprotein, and its role in the lipolytic processing of triglyceride-rich lipoproteins. RECENT FINDINGS:Gpihbp1 knockout mice on a chow diet have milky plasma and plasma triglyceride level...

journal_title：Current opinion in lipidology

authors： Beigneux AP,Weinstein MM,Davies BS,Gin P,Bensadoun A,Fong LG,Young SG

更新日期：2009-06-01 00:00:00

abstract：:The initial step of reverse cholesterol transport, the efflux of cell cholesterol into the extracellular fluid, has received much attention over the past year. Some studies have provided insights into the mechanism of cholesterol efflux and others have focused on the identity of the extracellular acceptors of cell cho...

journal_title：Current opinion in lipidology

authors： Barter PJ,Rye KA

更新日期：1996-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine the role of gut microbiota in the regulation of host energy homeostasis and its role in the pathogenesis of obesity, diabetes and nonalcoholic fatty liver disease (NAFLD). RECENT FINDINGS:Experimental models highlight several mechanisms connecting gut microbiota to host energy metabolism: ...

journal_title：Current opinion in lipidology

authors： Musso G,Gambino R,Cassader M

更新日期：2010-02-01 00:00:00

abstract：:The cytokines interleukin-1 and tumor necrosis factor contribute to the pathogenesis of inflammatory diseases and, potentially, to atherogenesis. The synthesis of these cytokines in humans can be suppressed by oral intake of n-3 polyunsaturated fatty acids. This mechanism may contribute to the beneficial effect of lon...

journal_title：Current opinion in lipidology

authors： Endres S,von Schacky C

更新日期：1996-02-01 00:00:00

abstract：:The Smith-Lemli-Opitz syndrome is a disorder of morphogenesis resulting from an enzymatic defect in the last step of cholesterol metabolism (reduction of 7-dehydrocholesterol). Analysis of the defective gene and identification of mutations therein have paved the way for the study of the molecular genetics of the disor...

journal_title：Current opinion in lipidology

authors： Fitzky BU,Glossmann H,Utermann G,Moebius FF

更新日期：1999-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Although the role for microRNAs (miRNAs) in regulating multiple physiological processes including apoptosis, cell differentiation, and cancer is well established, the importance of these tiny RNAs in regulating lipid metabolism has only recently been uncovered. This review summarizes the evidence for ...

journal_title：Current opinion in lipidology

authors： Fernández-Hernando C,Suárez Y,Rayner KJ,Moore KJ

更新日期：2011-04-01 00:00:00

abstract：:Lipid-poor apolipoproteins remove cellular cholesterol and phospholipids by an active transport pathway controlled by an ATP binding cassette transporter called ABCA1 (formerly ABC1). Mutations in ABCA1 cause Tangier disease, a severe HDL deficiency syndrome characterized by a rapid turnover of plasma apolipoprotein A...

journal_title：Current opinion in lipidology

authors： Oram JF,Vaughan AM

更新日期：2000-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this study was to briefly summarize the contribution of the PREDIMED (PREvención con DIeta MEDiterránea) trial on cardiovascular evidence and examine in depth its groundbreaking trajectory.PREDIMED was conducted during 2003-2010 and represented the largest primary prevention trial ever test...

journal_title：Current opinion in lipidology

authors： Fernández-Lázaro CI,Ruiz-Canela M,Martínez-González MÁ

更新日期：2021-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Statins are the most prescribed medications worldwide with a proven ability to reduce major cardiovascular events. Recent data have revealed that statin therapy is associated with an increased risk for developing diabetes. We discuss the relevant data including newly published results, which demonstra...

journal_title：Current opinion in lipidology

authors： Preiss D,Sattar N

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The 3-hydroxy-3-methylglutaryl-coenzyme-A reductase inhibitors, or statins, have been shown to reduce cardiovascular morbidity and mortality among a wide spectrum of patients with established atherosclerotic vascular disease. Mounting experimental and clinical evidence also suggest a potential benefit...

journal_title：Current opinion in lipidology

authors： Pham M,Oka RK,Giacomini JC

更新日期：2005-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Response to statin treatment can vary widely from person to person as a result of inherited traits (genotype) and acquired characteristics such as obesity (phenotype). The aim of this review is to describe what is known about factors that determine a patient's response, and to offer a mechanism to exp...

journal_title：Current opinion in lipidology

authors： Caslake MJ,Packard CJ

更新日期：2004-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Routine measurement of echolucency of atherosclerotic plaques, in addition to degree of stenosis, may change clinical practice in the future. Within the context of previous knowledge in this field, we therefore review recent developments in detection and histological characterization of echolucent rup...

journal_title：Current opinion in lipidology

authors： Nordestgaard BG,Grønholdt ML,Sillesen H

更新日期：2003-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the recent studies on intensive glucose control and the risk of cardiovascular disease (CVD) in type 2 diabetes, to discuss potential reasons for discordant results among recent trials, and to comment on implications for clinical practice. RECENT FINDINGS:Three large randomized controlled t...

journal_title：Current opinion in lipidology

authors： Park L,Wexler D

更新日期：2010-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Accumulating evidence has provided new insights regarding potentially effective therapeutic options targeting modulation of HDL metabolism, resulting in the prevention of cardiovascular diseases. The gut microbiota has now been convincingly linked to host health, but its impact on host lipid metabolis...

journal_title：Current opinion in lipidology

authors： Nakaya K,Ikewaki K

更新日期：2018-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Epidemiological and clinical studies link low levels of HDL cholesterol (HDL-C) with increased risk of atherosclerotic cardiovascular disease (CVD). However, genetic polymorphisms linked to HDL-C do not associate consistently with CVD risk, and randomized clinical studies of drugs that elevate HDL-C v...

journal_title：Current opinion in lipidology

authors： Ronsein GE,Heinecke JW

更新日期：2017-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past two decades serious efforts has been invested in the search for genes that predispose to common obesity, but progress has been slow and success limited. Genome-wide association, however, has revived optimism. Here we review recent advances in the field of obesity genetics and discuss the...

journal_title：Current opinion in lipidology

authors： Li S,Loos RJ

更新日期：2008-04-01 00:00:00

abstract：:Apolipoprotein E has key functions in lipoprotein metabolism, and polymorphisms in the apolipoprotein E gene are associated with distinct lipoprotein patterns. The possibility of gene-nutrient interactions for apolipoprotein E has been addressed in many studies. Although results have generally been mixed, the indicati...

journal_title：Current opinion in lipidology

authors： Rubin J,Berglund L

更新日期：2002-02-01 00:00:00

abstract：:Oxidation products of lipids and proteins are found in atherosclerotic plaque and in macrophage foam cells. Macrophages avidly endocytose in-vitro oxidized LDL and accumulate sterols. What is the evidence that such a process is involved in in-vivo foam cell formation? The present review surveys current knowledge on th...

journal_title：Current opinion in lipidology

authors： Jessup W,Kritharides L

更新日期：2000-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on proof-of-principle experiments providing validation of new targets for the development of RNA interference-based therapeutics for dyslipidemia. RECENT FINDINGS:Over the past few years, RNA interference has become an accepted approach to manipulate gene expression in mammalian s...

journal_title：Current opinion in lipidology

authors： Rondinone CM

更新日期：2008-06-01 00:00:00

abstract：:The plasminogen and coagulation systems have been extensively characterized at the biochemical level. Recent gene targeting and gene transfer studies have provided novel insights into their role in the formation of blood vessels and in the pathogenesis of blood vessel disorders including thrombosis, restenosis and ath...

journal_title：Current opinion in lipidology

authors： Carmeliet P,Collen D

更新日期：1997-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Bile acid sequestrants (BAS) have been used for more than 50 years in the treatment of hypercholesterolemia. The last decade, bile acids are emerging as integrated regulators of metabolism via induction of various signal transduction pathways. Consequently, BAS treatment may exert unexpected side-effe...

journal_title：Current opinion in lipidology

authors： Out C,Groen AK,Brufau G

更新日期：2012-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The review presents recent developments in the identification of specialized proresolving mediators (SPMs) of inflammation following supplementation with n-3 fatty acids in humans. RECENT FINDINGS:A number of reports have measured SPMs in human plasma after n-3 fatty acid supplementation. Although st...

journal_title：Current opinion in lipidology

authors： Barden AE,Mas E,Mori TA

更新日期：2016-02-01 00:00:00

abstract：PURPOSE OF REVIEW:A healthy diet should be rich in vegetables and fruits, whole-grain, high-fiber foods, and fish and should contain a small amount of saturated and trans fats. In addition to these recommendations, some food ingredients such as plant sterol/stanol soy protein and isoflavones may help reduce cholesterol...

journal_title：Current opinion in lipidology

authors： Bruckert E,Rosenbaum D

更新日期：2011-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Oxidized LDL (oxLDL) contributes to many atherogenic steps in the vascular wall, but the significance of oxLDL in circulating blood remains unclear. Recent progress in procedures for measuring both human and murine oxLDL has provided growing evidence of the importance of circulating oxLDL. RECENT FIN...

journal_title：Current opinion in lipidology

authors： Ishigaki Y,Oka Y,Katagiri H

更新日期：2009-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent advances towards an understanding of the three-dimensional structures of the apolipoprotein components of HDL with a specific focus on high resolution models of apolipoprotein A-I. RECENT FINDINGS:Since the primary sequence was first reported, various models have been advanced for...

journal_title：Current opinion in lipidology

authors： Davidson WS,Silva RA

更新日期：2005-06-01 00:00:00