Metabolism of oxidized LDL by macrophages.


:Oxidation products of lipids and proteins are found in atherosclerotic plaque and in macrophage foam cells. Macrophages avidly endocytose in-vitro oxidized LDL and accumulate sterols. What is the evidence that such a process is involved in in-vivo foam cell formation? The present review surveys current knowledge on the metabolism of oxidized LDL by macrophages, and the types, amounts and location of oxidation products that accumulate in these cells. Comparable studies of lesion lipoproteins and foam cells indicate that limited extracellular lipoprotein oxidation, perhaps followed by more extensive intracellular oxidation subsequent to uptake by macrophages, is a more likely scenario in vivo.


Curr Opin Lipidol


Jessup W,Kritharides L




Has Abstract


2000-10-01 00:00:00












  • Update on cardiometabolic health effects of ω-3 fatty acids.

    abstract:PURPOSE OF REVIEW:The fish fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may promote cardiometabolic health. This review summarizes the results of recent meta-analyses of prospective studies on cardiovascular diseases, diabetes type 2 and markers of atherosclerosis and thrombosis. RECENT FINDI...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Kromhout D,de Goede J

    更新日期:2014-02-01 00:00:00

  • Strategies for the use of nonstatin therapies.

    abstract:PURPOSE OF REVIEW:Dyslipidaemias are a major risk factor for cardiovascular disease (CVD); in particular, high levels of low-density lipoprotein cholesterol (LDL-C) have been associated to a higher cardiovascular risk. Reducing LDL-C levels decreases the risk of coronary heart disease (CHD), and the greater the LDL-C r...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Pirillo A,Norata GD,Catapano AL

    更新日期:2017-12-01 00:00:00

  • Peroxisome proliferator-activated receptors in endothelial cell biology.

    abstract::New insights into the endothelium as a dynamic, interactive organ have generated increased interest in endothelial cell transcriptional regulation. Peroxisomal proliferator-activated receptors (PPARs), as ligand-activated nuclear receptors expressed in endothelial cells, represent one important pathway that likely inf...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Plutzky J

    更新日期:2001-10-01 00:00:00

  • Echolucent rupture-prone plaques.

    abstract:PURPOSE OF REVIEW:Routine measurement of echolucency of atherosclerotic plaques, in addition to degree of stenosis, may change clinical practice in the future. Within the context of previous knowledge in this field, we therefore review recent developments in detection and histological characterization of echolucent rup...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Nordestgaard BG,Grønholdt ML,Sillesen H

    更新日期:2003-10-01 00:00:00

  • High-density lipoprotein subclasses.

    abstract::This review describes recent advances that have been made in the separation of HDL subfractions by physicochemical and immunological methods and the relationship between the particles obtained by the different procedures. The metabolic interconversions that occur as a result of cholesteryl ester transfer protein (CETP...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Skinner ER

    更新日期:1994-06-01 00:00:00

  • Genetic variants predisposing to cardiovascular disease.

    abstract:PURPOSE OF REVIEW:The goal of this review is to provide an update on the most recent and relevant findings in the area of genotype-phenotype associations as well as the relationships between genetic factors and cardiovascular disease risk markers and events. In addition, emphasis will be placed on the methodological pr...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Visvikis-Siest S,Marteau JB

    更新日期:2006-04-01 00:00:00

  • Potential tissue selectivity of dietary phytoestrogens and estrogens.

    abstract::The recent discovery of a second estrogen receptor subtype, estrogen receptor-beta, may significantly advance our understanding of tissue specific effects of estrogenic compounds, both natural and synthetic. Although specific effects mediated by estrogen receptor beta in vivo remain to be elucidated, hypothetically th...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Cassidy A

    更新日期:1999-02-01 00:00:00

  • HDL-cholesterol and apolipoproteins in relation to dementia.

    abstract:PURPOSE OF REVIEW:Dementia is a major cause of disability and institutionalization. Apart from age and apolipoprotein E (APOE) genotype, there are currently no established, clinically relevant, noninvasive markers of dementia. We conducted a literature search of recent observational epidemiological studies evaluating t...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Koch M,Jensen MK

    更新日期:2016-02-01 00:00:00

  • Apolipoprotein E and diets: a case of gene-nutrient interaction?

    abstract::Apolipoprotein E has key functions in lipoprotein metabolism, and polymorphisms in the apolipoprotein E gene are associated with distinct lipoprotein patterns. The possibility of gene-nutrient interactions for apolipoprotein E has been addressed in many studies. Although results have generally been mixed, the indicati...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Rubin J,Berglund L

    更新日期:2002-02-01 00:00:00

  • Coffee, tea and coronary heart disease.

    abstract::The most likely cholesterol-raising factors in unfiltered coffee are kahweol and cafestol. Different brewing methods alter the concentrations of these diterpenes and have caused discrepant results in studies from different parts of the world. The effect of tea on the risk of coronary heart disease is much less clear b...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Thelle DS

    更新日期:1995-02-01 00:00:00

  • Apolipoprotein A-I-containing lipoproteins and atherosclerosis.

    abstract::Apolipoprotein A-I-containing lipoproteins represent a heterogeneous group of lipoparticles. Recent studies suggest that a specific subpopulation within the lipoprotein (AI) subclass may be more effective than other lipoproteins in promoting cholesterol efflux from cells and in the different steps of reverse cholester...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Leroy A,Dallongeville J,Fruchart JC

    更新日期:1995-10-01 00:00:00

  • How does protein misfolding in the endoplasmic reticulum affect lipid metabolism in the liver?

    abstract:PURPOSE OF REVIEW:The endoplasmic reticulum (ER) maintains cellular metabolic homeostasis by coordinating protein synthesis, secretion activities, lipid biosynthesis and calcium (Ca²⁺) storage. In this review, we will discuss how altered ER homeostasis contributes to dysregulation of hepatic lipid metabolism and contri...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Wang S,Kaufman RJ

    更新日期:2014-04-01 00:00:00

  • Statin therapy in heart failure.

    abstract:PURPOSE OF REVIEW:The 3-hydroxy-3-methylglutaryl-coenzyme-A reductase inhibitors, or statins, have been shown to reduce cardiovascular morbidity and mortality among a wide spectrum of patients with established atherosclerotic vascular disease. Mounting experimental and clinical evidence also suggest a potential benefit...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Pham M,Oka RK,Giacomini JC

    更新日期:2005-12-01 00:00:00

  • The role of folic acid in the prevention of cardiovascular disease.

    abstract::Coronary heart disease is the leading cause of death in the developed world. Current surgical and pharmacological interventions are essentially palliative and interest in preventive strategies, particularly through nutrition and avoidance of tobacco has increased in recent years. Basic scientific, clinical and epidemi...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Graham IM,O'Callaghan P

    更新日期:2000-12-01 00:00:00

  • Resident intimal dendritic cells and the initiation of atherosclerosis.

    abstract:PURPOSE OF REVIEW:To highlight the fact that regional differences in the normal arterial intima are critical to atherosclerotic lesion formation driven by systemic risk factors. RECENT FINDINGS:At arterial curvatures, bifurcations and branches unique hemodynamics influence endothelial cell signaling and gene expressio...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Cybulsky MI,Jongstra-Bilen J

    更新日期:2010-10-01 00:00:00

  • Hyperlipidaemia and cardiovascular disease: do fibrates have a role?

    abstract:PURPOSE OF REVIEW:Fibrates continue to be a viable treatment option for mixed atherogenic dyslipidemia, and recent reports from clinical studies have shed new light on the therapeutic utility of fibrates for the prevention of microvascular and macrovascular disease, especially in combination with statins. RECENT FINDI...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Saha SA,Arora RR

    更新日期:2011-08-01 00:00:00

  • Long-term follow-up of lipid-lowering trials.

    abstract:PURPOSE OF REVIEW:Most LDL-lowering trials are limited in duration while the disease process occurs over decades. It is informative, therefore, to evaluate the long-term effects of treatment by undertaking extended observation beyond the formal double-blind phase of intervention studies. The current review brings toget...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Packard CJ,Ford I

    更新日期:2015-12-01 00:00:00

  • Emerging roles for phospholipid transfer protein in lipid and lipoprotein metabolism.

    abstract:PURPOSE OF REVIEW:This review highlights the recent key advances in our understanding of the role of phospholipid transfer protein in lipid and lipoprotein metabolism. RECENT FINDINGS:The overexpression of human phospholipid transfer protein in mice is associated with an increase in atherosclerosis. This is consistent...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Albers JJ,Cheung MC

    更新日期:2004-06-01 00:00:00

  • Close encounters with apolipoprotein E receptors.

    abstract::Most of the LDL receptor family members recognize apolipoprotein E. The structures of the VLDL receptor, and recently identified apolipoprotein E receptor 2, closely resemble the LDL receptor. Recent studies have demonstrated that the VLDL receptor is responsible for the reproduction of premammalian species by mediati...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Yamamoto T,Bujo H

    更新日期:1996-10-01 00:00:00

  • Recent advances in elucidating the role of the microsomal triglyceride transfer protein in apolipoprotein B lipoprotein assembly.

    abstract::The microsomal triglyceride transfer protein is necessary for the assembly and secretion of lipoproteins containing apolipoprotein B. During the past year, significant progress has been made towards understanding the role of microsomal triglyceride transfer protein in lipoprotein assembly at both a cellular and molecu...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Gordon DA

    更新日期:1997-06-01 00:00:00

  • Defects of lipoprotein metabolism in familial combined hyperlipidaemia.

    abstract::Familial combined hyperlipidaemia is the most common inherited hyperlipidaemia and is found in up to 10% of patients with premature myocardial infarction. The genetic and metabolic bases of the disorder have not yet been defined. This review discusses the important advances in the past year in our understanding of the...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: de Graaf J,Stalenhoef AF

    更新日期:1998-06-01 00:00:00

  • Electronegative low-density lipoprotein.

    abstract:PURPOSE OF REVIEW:The occurrence in blood of an electronegatively charged LDL was described in 1988. During the 1990s reports studying electronegative LDL (LDL(-)) were scant and its atherogenic role controversial. Nevertheless, recent reports have provided new evidence on a putative atherogenic role of LDL(-). This re...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Sánchez-Quesada JL,Benítez S,Ordóñez-Llanos J

    更新日期:2004-06-01 00:00:00

  • The paraoxonase gene family and coronary heart disease.

    abstract:PURPOSE OF REVIEW:The antioxidant activity of high-density lipoprotein is largely due to the paraoxonase 1 located on it. Experiments with transgenic paraoxonase 1 knock-out mice indicate the potential for this enzyme to protect against atherogenesis. This effect of high-density lipoprotein in decreasing low-density li...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Mackness B,Durrington PN,Mackness MI

    更新日期:2002-08-01 00:00:00

  • The challenges of proprotein convertase subtilisin-kexin-9 inhibitors for lipid guidelines and models of care.

    abstract:PURPOSE OF REVIEW:The article reviews the challenges facing cardiovascular disease (CVD) guidelines committees. RECENT FINDINGS:Clinical trials in high-risk populations have shown additional CVD event reduction with ezetimibe and proprotein convertase subtilisin-kexin-9 inhibitors. These trials recruit middle-aged sec...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Wierzbicki AS

    更新日期:2017-12-01 00:00:00

  • Metabolic effects of thia fatty acids.

    abstract::Thia substituted fatty acids are saturated fatty acids which are modified by insertion of a sulfur atom at specific positions in the carbon backbone. During the last few years pleiotropic effects of the 3-thia fatty acid tetradecylthioacetic acid have been revealed. The biological responses to tetradecylthioacetic aci...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Berge RK,Skorve J,Tronstad KJ,Berge K,Gudbrandsen OA,Grav H

    更新日期:2002-06-01 00:00:00

  • The use of fibrates and of statins in preventing atherosclerosis in diabetes.

    abstract::Atherosclerotic cardiovascular disease is the most common complication of diabetes. Recent guidelines in the USA have underlined the importance of treating lipid abnormalities in people with diabetes in order to reduce the risk of this complication. Should lifestyle approaches not be sufficient drugs will need to be a...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Steiner G

    更新日期:2001-12-01 00:00:00

  • Chromatin modification by lipids and lipoprotein components: an initiating event in atherogenesis?

    abstract:PURPOSE OF REVIEW:This review examines recent evidence proposing that lipids and lipoproteins can act as nuclear factors regulating chromatin structure. These novel data broaden our understanding of the mechanisms by which lipoproteins can affect basic biological phenomena such as transcription, genome stability, and c...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Zaina S,Døssing KB,Lindholm MW,Lund G

    更新日期:2005-10-01 00:00:00

  • Vaccine strategies for lowering LDL by immunization against proprotein convertase subtilisin/kexin type 9.

    abstract:PURPOSE OF REVIEW:mAbs targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) have the potential to become groundbreaking therapies for the treatment of hypercholesterolemia. However, one major drawback of mAb-based therapy for a chronic condition like dyslipidemia is its relatively high cost. This review summ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Chackerian B,Remaley A

    更新日期:2016-08-01 00:00:00

  • Risk scoring in the assessment of cardiovascular risk.

    abstract:PURPOSE OF REVIEW:Cardiovascular risk scoring is incorporated in guidelines and recommended for targeting preventive treatment. Evidence is required on the most appropriate method, its accuracy in a given population, and its effectiveness in favourably influencing clinical behaviour and health outcomes. RECENT FINDING...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Beswick A,Brindle P

    更新日期:2006-08-01 00:00:00

  • Folate and coronary heart disease.

    abstract::Low folate intake is an important determinant of elevated blood levels of homocysteine. Because elevated homocysteine has been shown to be a possible graded risk factor for CHD, sufficient folate intake may be important in the prevention of CHD. The magnitude of the association between folate and CHD is consistent wit...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Verhoef P,Stampfer MJ,Rimm EB

    更新日期:1998-02-01 00:00:00