Abstract：
PURPOSE OF REVIEW:Lowering LDL cholesterol (LDL-C) reduces vascular risk. Current guidelines recommend initiating statin therapy in patients with a yearly coronary heart disease risk of around 1.5-2%, and most clinicians prescribe standard statin regimens (e.g. 40 mg simvastatin daily). However, there is some uncertainty about whether patients at somewhat lower vascular risk should receive lipid-lowering therapy and also how intensive statin treatment should be. RECENT FINDINGS:Lowering LDL-C by around 1 mmol/l reduces vascular mortality and major morbidity by about one-fifth, and more recent randomized trials comparing intensive versus standard statin regimens confirm that a further LDL-C reduction of 0.5 mmol/l results in an additional 15% reduction in the risk of a major vascular event. Furthermore, statin therapy significantly reduces vascular mortality and morbidity in patients with less than 1% annual risk of a major vascular event. In general, statins are safe and well tolerated, but 80 mg simvastatin is associated with an unacceptably high risk of statin-induced myopathy. SUMMARY:Lipid-lowering therapy with statins is cost-effective for a wider range of patients than currently recommended. Intensive statin therapy is associated with larger reductions in vascular risk, and lower LDL-C targets (particularly for higher-risk individuals) should help reduce vascular mortality and major vascular morbidity substantially.
journal_name
Curr Opin Lipidoljournal_title
Current opinion in lipidologyauthors
Bulbulia R,Armitage Jdoi
10.1097/MOL.0b013e3283556c1bsubject
Has Abstractpub_date
2012-08-01 00:00:00pages
265-70issue
4eissn
0957-9672issn
1473-6535journal_volume
23pub_type
杂志文章,评审abstract：PURPOSE OF REVIEW:This review will provide an update on the structure of GPIHBP1, a 28-kDa glycosylphosphatidylinositol-anchored glycoprotein, and its role in the lipolytic processing of triglyceride-rich lipoproteins. RECENT FINDINGS:Gpihbp1 knockout mice on a chow diet have milky plasma and plasma triglyceride level...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e32832ac026
更新日期：2009-06-01 00:00:00
abstract：PURPOSE OF REVIEW:To summarize the therapeutic strategies to inhibit PCSK9 and to describe the main results obtained in phase I and II trials with monoclonal antibodies targeting PCSK9. RECENT FINDINGS:Among the various approaches for PCSK9 inhibition, human data are only available for inhibition of PCSK9 binding to L...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e3283613a3d
更新日期：2013-06-01 00:00:00
abstract：:Niemann-Pick type C (NPC) is an autosomal recessive lysosomal storage disease. Fibroblasts from individuals with Niemann-Pick type C exhibit defective intracellular cholesterol transport. Linkage analysis has led to the recent cloning of the NPC1 gene on human chromosome 18, which is the major disease locus. Analysis ...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-199804000-00009
更新日期：1998-04-01 00:00:00
abstract：PURPOSE OF REVIEW:We will discuss the diverse roles of lipoprotein receptors that contribute to the maintenance and integrity of the vascular wall. RECENT FINDINGS:Lipoprotein receptors function not only as transporters for cholesterol and other lipids. They also act as sensors and signal transducers through which the...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-200404000-00010
更新日期：2004-04-01 00:00:00
abstract：PURPOSE OF REVIEW:We review stable isotope tracer studies of apolipoprotein B-100 (apoB) kinetics concerning genetic polymorphisms and mutations that affect human lipoprotein metabolism. RECENT FINDINGS:In obese men, the allelic combination of the apoB signal peptide, SP24, and cholesteryl ester transfer protein, CETP...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e3283378e5a
更新日期：2010-04-01 00:00:00
abstract：PURPOSE OF REVIEW:Although the role for microRNAs (miRNAs) in regulating multiple physiological processes including apoptosis, cell differentiation, and cancer is well established, the importance of these tiny RNAs in regulating lipid metabolism has only recently been uncovered. This review summarizes the evidence for ...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e3283428d9d
更新日期：2011-04-01 00:00:00
abstract：PURPOSE OF REVIEW:Lipoprotein metabolism and the role of apolipoprotein E in the pathogenesis of dysbetalipoproteinemia. RECENT FINDINGS:Remnant lipoproteins, modulated by lifestyle and genetic factors, are atherogenic. Dysbetalipoproteinemia could be viewed as a monogenic disorder of remnant metabolism. SUMMARY:Elev...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000192
更新日期：2015-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Hypertriglyceridemia occurs mainly because of metabolic disorders secondary to diabetes, alcohol intake, and/or overweight. Genetic factors have also been clearly identified in most severe cases. Triglycerides are generally considered as 'bystanders' for cardiovascular diseases. However, biological an...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000622
更新日期：2019-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Nonalcoholic fatty liver (NAFL) and especially its inflammatory variant nonalcoholic steatohepatitis (NASH) have become a major challenge to healthcare systems worldwide because of the increasing prevalence of its major risk factors obesity and type 2 diabetes, which are closely linked to overeating, ...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e32834c7cfc
更新日期：2011-12-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose is to evaluate recent findings concerning dietary fats and the risk of coronary heart disease. Monounsaturated fatty acids are often regarded as healthy, and many have recommended their consumption instead of saturated fatty acids and polyunsaturated fatty acids. Support for the benefits o...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-200302000-00008
更新日期：2003-02-01 00:00:00
abstract：PURPOSE OF REVIEW:It is well accepted that LDLs and its modified form oxidized-LDL (ox-LDL) play a major role in the development of atherosclerosis and foam cell formation. Whereas the majority of these cells have been demonstrated to be derived from macrophages, smooth muscle cells (SMCs) give rise to a significant nu...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000113
更新日期：2014-10-01 00:00:00
abstract：PURPOSE OF REVIEW:The metabolic syndrome has become a leading health concern in developed countries. In the search for strategies to combat this growing problem, stearoyl-CoA desaturase 1 (SCD1) inhibition has been proposed as an attractive therapeutic strategy. However, recent studies warn of potentially harmful conse...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e32833854ac
更新日期：2010-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Accumulating evidence has provided new insights regarding potentially effective therapeutic options targeting modulation of HDL metabolism, resulting in the prevention of cardiovascular diseases. The gut microbiota has now been convincingly linked to host health, but its impact on host lipid metabolis...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000472
更新日期：2018-02-01 00:00:00
abstract：PURPOSE OF REVIEW:Capsaicin and its nonpungent analog (capsinoids) are known to be food ingredients that increase energy expenditure and decrease body fat. This article reviews the role of brown adipose tissue (BAT) for the thermogenic effect of these compounds in humans and proposes the possibility of some other antio...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e32835a4f40
更新日期：2013-02-01 00:00:00
abstract：:Recent primary prevention trials demonstrated that cardiovascular morbidity and mortality benefits are not accompanied by adverse effects on overall mortality and morbidity in cohorts representing plasma cholesterol concentrations observed in the bulk of coronary artery disease. During the past year, further analyses ...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-199812000-00006
更新日期：1998-12-01 00:00:00
abstract：:Apolipoprotein A-I-containing lipoproteins represent a heterogeneous group of lipoparticles. Recent studies suggest that a specific subpopulation within the lipoprotein (AI) subclass may be more effective than other lipoproteins in promoting cholesterol efflux from cells and in the different steps of reverse cholester...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-199510000-00007
更新日期：1995-10-01 00:00:00
abstract：PURPOSE OF REVIEW:The aim of this study was to briefly summarize the contribution of the PREDIMED (PREvención con DIeta MEDiterránea) trial on cardiovascular evidence and examine in depth its groundbreaking trajectory.PREDIMED was conducted during 2003-2010 and represented the largest primary prevention trial ever test...
journal_title：Current opinion in lipidology
pub_type： 杂志文章
doi：10.1097/MOL.0000000000000731
更新日期：2021-02-01 00:00:00
abstract：PURPOSE OF REVIEW:To discuss crucial cues (chemokines, adhesion molecules and pharmacological means) that guide and control the context-specific mobilization, recruitment and fate of circulating progenitor cells in arterial repair and plaque stability. RECENT FINDINGS:The mobilization and recruitment of bone marrow de...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e32830dfe33
更新日期：2008-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Metabolomics is emerging as a powerful tool for studying metabolic processes and in recent years, the applications in the area of nutrition have risen rapidly. The present review gives an overview of the current applications in the field of nutrition and identifies areas in need of advancement. RECEN...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000140
更新日期：2015-02-01 00:00:00
abstract：:A site-specific cytidine deamination (cytidine to uridine) in nuclear apolipoprotein B messenger RNA creates a translational stop codon that produces apolipoprotein B48. This process is mediated by an enzyme composed of distinct subunits, including apolipoprotein B messenger RNA editing enzyme catalytic polypeptide-1 ...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-199504000-00002
更新日期：1995-04-01 00:00:00
abstract：:Oxidatively damaged LDL may play a critical role in the pathogenesis of atherosclerotic vascular disease. Several pathways promote LDL oxidation in vitro but the physiologically relevant mechanisms have proven difficult to identify. Detection of stable compounds that result from specific reaction pathways has provided...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-199710000-00005
更新日期：1997-10-01 00:00:00
abstract：PURPOSE OF REVIEW:This review examines recent evidence proposing that lipids and lipoproteins can act as nuclear factors regulating chromatin structure. These novel data broaden our understanding of the mechanisms by which lipoproteins can affect basic biological phenomena such as transcription, genome stability, and c...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/01.mol.0000180165.70077.ee
更新日期：2005-10-01 00:00:00
abstract：PURPOSE OF REVIEW:As our understanding of cardiovascular disease has advanced over the past decades, multiple novel treatment strategies have been developed with the hope of reducing the global morbidity and mortality associated with this condition. Large-scale trials to test such novel therapies using clinical end poi...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000350
更新日期：2016-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Brown adipose tissue (BAT) is an emerging target to combat cardiometabolic disorders as it can take up substantial amounts of glucose and lipids from the circulation for heat production. This review focuses on new concepts in BAT physiology and discusses the need for new techniques to determine BAT ac...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000296
更新日期：2016-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Fatty acid transport proteins are a family of proteins involved in fatty acid uptake and activation. This review summarizes recent progress in elucidating the function of fatty acid transport proteins. RECENT FINDINGS:Recent experiments clearly establish FATP1 as a regulated fatty acid transporter in...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e3281338558
更新日期：2007-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Atherogenic dyslipidaemia, characterized by high plasma triglycerides (a surrogate for triglyceride-rich remnant lipoproteins) and low high-density lipoprotein cholesterol (HDL-C), is prevalent in patients with type 2 diabetes mellitus (T2DM) and contributes to a high modifiable residual cardiovascula...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000640
更新日期：2019-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Because human genetic studies and large clinical trials have demonstrated that HDL-cholesterol levels are not causally related to cardiovascular disease risk, attention has shifted toward the functional properties of HDL. Infusion of HDL mimetics containing apolipoprotein A-I remains a potential strat...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000349
更新日期：2016-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Several members of the fibroblast growth factor (FGF) family have been identified as key regulators of energy metabolism in rodents and nonhuman primates. Translational studies show that their metabolic actions are largely conserved in humans, which led to the development of various FGF-based drugs, i...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000599
更新日期：2019-06-01 00:00:00
abstract：:The cytokines interleukin-1 and tumor necrosis factor contribute to the pathogenesis of inflammatory diseases and, potentially, to atherogenesis. The synthesis of these cytokines in humans can be suppressed by oral intake of n-3 polyunsaturated fatty acids. This mechanism may contribute to the beneficial effect of lon...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-199602000-00011
更新日期：1996-02-01 00:00:00
abstract：PURPOSE OF REVIEW:To provide an update on clinical trials of gene therapy for atherosclerotic cardiovascular disease published since 1 August 2001 and summarize the general advantages and potential problems of gene transfer in these disorders. RECENT FINDINGS:There are two major areas in which gene therapy has entered...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-200212000-00009
更新日期：2002-12-01 00:00:00
