Apolipoprotein B messenger RNA editing: insights into the molecular regulation of post-transcriptional cytidine deamination.

abstract：:Based on evidence that hormone replacement therapy is cardioprotective, enthusiasm for universal hormone replacement therapy in postmenopausal women has grown Estrogens lower LDL, raise HDL, dilate arteries and reduce LDL oxidation potential. However, the benefits of hormone replacement therapy must be weighed against...

journal_title：Current opinion in lipidology

authors： Denke MA

更新日期：1996-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease; we highlight the most recent research initiatives that have sought to define Lp(a)-dependent pathogenicity as well as pharmacologic approaches to lowering Lp(a). RECENT FINDINGS:Recent large-scale meta-analyses have confirmed elevate...

journal_title：Current opinion in lipidology

authors： Dubé JB,Boffa MB,Hegele RA,Koschinsky ML

更新日期：2012-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Remnant lipoproteins that persist in the bloodstream after each meal have become increasingly important contributors to atherosclerotic vascular disease, owing to the spread of overnutrition, underexertion, obesity, insulin resistance, and type 2 diabetes. Here, we review recent work that clarified lo...

journal_title：Current opinion in lipidology

authors： Williams KJ,Chen K

更新日期：2010-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Brown adipose tissue (BAT) is an emerging target to combat cardiometabolic disorders as it can take up substantial amounts of glucose and lipids from the circulation for heat production. This review focuses on new concepts in BAT physiology and discusses the need for new techniques to determine BAT ac...

journal_title：Current opinion in lipidology

authors： Schilperoort M,Hoeke G,Kooijman S,Rensen PC

更新日期：2016-06-01 00:00:00

abstract：:Apolipoprotein A-I-containing lipoproteins represent a heterogeneous group of lipoparticles. Recent studies suggest that a specific subpopulation within the lipoprotein (AI) subclass may be more effective than other lipoproteins in promoting cholesterol efflux from cells and in the different steps of reverse cholester...

journal_title：Current opinion in lipidology

authors： Leroy A,Dallongeville J,Fruchart JC

更新日期：1995-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Atherogenic dyslipidaemia, characterized by high plasma triglycerides (a surrogate for triglyceride-rich remnant lipoproteins) and low high-density lipoprotein cholesterol (HDL-C), is prevalent in patients with type 2 diabetes mellitus (T2DM) and contributes to a high modifiable residual cardiovascula...

journal_title：Current opinion in lipidology

authors： Fruchart JC,Santos RD

更新日期：2019-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Studies have shown the three-member paraoxonase (PON) multigene family to be involved in the development of a large variety of diseases with an inflammatory component. Environmental factors such as lifestyle-related factors differ widely between populations and it is important to consider that their i...

journal_title：Current opinion in lipidology

authors： Mahrooz A,Mackness M

更新日期：2020-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review addresses how, in atherosclerosis or systemic inflammation, HDL can lose its usual atheroprotective characteristics and even paradoxically assume proinflammatory properties. RECENT FINDINGS:Specific chemical and structural changes within HDL particles can impede reverse cholesterol transp...

journal_title：Current opinion in lipidology

authors： Ansell BJ,Fonarow GC,Fogelman AM

更新日期：2007-08-01 00:00:00

abstract：:Most of the LDL receptor family members recognize apolipoprotein E. The structures of the VLDL receptor, and recently identified apolipoprotein E receptor 2, closely resemble the LDL receptor. Recent studies have demonstrated that the VLDL receptor is responsible for the reproduction of premammalian species by mediati...

journal_title：Current opinion in lipidology

authors： Yamamoto T,Bujo H

更新日期：1996-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite their pathophysiological importance, the molecular mechanisms and enzymatic components of lipid mobilization from intracellular storage compartments are insufficiently understood. The aim of this review is to evaluate the role of hormone-sensitive lipase in this process. RECENT FINDINGS:Hormo...

journal_title：Current opinion in lipidology

authors： Haemmerle G,Zimmermann R,Zechner R

更新日期：2003-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past two decades serious efforts has been invested in the search for genes that predispose to common obesity, but progress has been slow and success limited. Genome-wide association, however, has revived optimism. Here we review recent advances in the field of obesity genetics and discuss the...

journal_title：Current opinion in lipidology

authors： Li S,Loos RJ

更新日期：2008-04-01 00:00:00

abstract：:The cytokines interleukin-1 and tumor necrosis factor contribute to the pathogenesis of inflammatory diseases and, potentially, to atherogenesis. The synthesis of these cytokines in humans can be suppressed by oral intake of n-3 polyunsaturated fatty acids. This mechanism may contribute to the beneficial effect of lon...

journal_title：Current opinion in lipidology

authors： Endres S,von Schacky C

更新日期：1996-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Although the role for microRNAs (miRNAs) in regulating multiple physiological processes including apoptosis, cell differentiation, and cancer is well established, the importance of these tiny RNAs in regulating lipid metabolism has only recently been uncovered. This review summarizes the evidence for ...

journal_title：Current opinion in lipidology

authors： Fernández-Hernando C,Suárez Y,Rayner KJ,Moore KJ

更新日期：2011-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine the role of gut microbiota in the regulation of host energy homeostasis and its role in the pathogenesis of obesity, diabetes and nonalcoholic fatty liver disease (NAFLD). RECENT FINDINGS:Experimental models highlight several mechanisms connecting gut microbiota to host energy metabolism: ...

journal_title：Current opinion in lipidology

authors： Musso G,Gambino R,Cassader M

更新日期：2010-02-01 00:00:00

abstract：:The development of atherosclerosis in animal models and the incidence of coronary heart disease in postmenopausal women are markedly reduced by estrogen treatment. Estrogen have acute beneficial effects on vascular reactivity and longer-term effects on critical steps in the pathogenesis of atherosclerosis. Phytoestrog...

journal_title：Current opinion in lipidology

authors： St Clair RW

更新日期：1998-10-01 00:00:00

abstract：:Oxidation products of lipids and proteins are found in atherosclerotic plaque and in macrophage foam cells. Macrophages avidly endocytose in-vitro oxidized LDL and accumulate sterols. What is the evidence that such a process is involved in in-vivo foam cell formation? The present review surveys current knowledge on th...

journal_title：Current opinion in lipidology

authors： Jessup W,Kritharides L

更新日期：2000-10-01 00:00:00

abstract：:Thia substituted fatty acids are saturated fatty acids which are modified by insertion of a sulfur atom at specific positions in the carbon backbone. During the last few years pleiotropic effects of the 3-thia fatty acid tetradecylthioacetic acid have been revealed. The biological responses to tetradecylthioacetic aci...

journal_title：Current opinion in lipidology

authors： Berge RK,Skorve J,Tronstad KJ,Berge K,Gudbrandsen OA,Grav H

更新日期：2002-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Lowering LDL cholesterol (LDL-C) reduces vascular risk. Current guidelines recommend initiating statin therapy in patients with a yearly coronary heart disease risk of around 1.5-2%, and most clinicians prescribe standard statin regimens (e.g. 40 mg simvastatin daily). However, there is some uncertain...

journal_title：Current opinion in lipidology

authors： Bulbulia R,Armitage J

更新日期：2012-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Endocannabinoids are defined as endogenous agonists of cannabinoid receptors, that is, of the two G-protein-coupled receptors for the Cannabis psychoactive principle Delta-tetra-hydrocannabinol. Two such endogenous mediators have been most thoroughly studied so far: anandamide and 2-arachidonoylglycer...

journal_title：Current opinion in lipidology

authors： Di Marzo V,Petrosino S

更新日期：2007-04-01 00:00:00

abstract：:This review describes recent advances that have been made in the separation of HDL subfractions by physicochemical and immunological methods and the relationship between the particles obtained by the different procedures. The metabolic interconversions that occur as a result of cholesteryl ester transfer protein (CETP...

journal_title：Current opinion in lipidology

authors： Skinner ER

更新日期：1994-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent advances towards an understanding of the three-dimensional structures of the apolipoprotein components of HDL with a specific focus on high resolution models of apolipoprotein A-I. RECENT FINDINGS:Since the primary sequence was first reported, various models have been advanced for...

journal_title：Current opinion in lipidology

authors： Davidson WS,Silva RA

更新日期：2005-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The metabolic syndrome has been emphasized as affecting an important subset of individuals at high risk for cardiovascular disease leading the National Cholesterol Educational Program Adult Treatment Panel III in highlighting awareness of insulin-resistance syndrome. Insulin resistance is thought to b...

journal_title：Current opinion in lipidology

authors： Perseghin G

更新日期：2005-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Metabolomics is emerging as a powerful tool for studying metabolic processes and in recent years, the applications in the area of nutrition have risen rapidly. The present review gives an overview of the current applications in the field of nutrition and identifies areas in need of advancement. RECEN...

journal_title：Current opinion in lipidology

authors： Gibbons H,O'Gorman A,Brennan L

更新日期：2015-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Alterations in the gut microbiome composition or function are associated with risk factors for cardiometabolic diseases, including hypertension, hyperlipidemia and hyperglycemia. Based on recent evidence that also oral medications used to treat these conditions could alter the gut microbiome compositi...

journal_title：Current opinion in lipidology

authors： Balvers M,van den Born BH,Levin E,Nieuwdorp M

更新日期：2021-02-01 00:00:00

abstract：:The menopause and its biology are as yet still incompletely understood. Very little is known about biological and molecular changes in cardiovascular target tissues and organs after menopause. Experimental and clinical evidence indicate that prevention of cardiovascular disease by estrogens is aimed both at the correc...

journal_title：Current opinion in lipidology

authors： Soma MR,Baetta R,Crosignani P

更新日期：1997-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the role of the microRNA-30c (miR-30c) in lipid metabolism and adipogenesis, to address consequences associated with reduced expression in cancer and cardiac function, and to speculate benefits of overexpressing miR-30c in the treatment of hyperlipidemia, atherosclerosis, and cancer. REC...

journal_title：Current opinion in lipidology

authors： Irani S,Hussain MM

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Unregulated uptake of oxidized LDL by macrophages to form foam cells is the hallmark for atherosclerosis. The paraoxonase (PON) family of enzymes plays a critical role in attenuating atherosclerotic lesion formation by hydrolyzing lipid peroxides (LOOHs) and preventing the oxidation of LDL particles a...

journal_title：Current opinion in lipidology

authors： White CR,Anantharamaiah GM

更新日期：2017-10-01 00:00:00

abstract：:The microsomal triglyceride transfer protein is necessary for the assembly and secretion of lipoproteins containing apolipoprotein B. During the past year, significant progress has been made towards understanding the role of microsomal triglyceride transfer protein in lipoprotein assembly at both a cellular and molecu...

journal_title：Current opinion in lipidology

authors： Gordon DA

更新日期：1997-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The endoplasmic reticulum (ER) maintains cellular metabolic homeostasis by coordinating protein synthesis, secretion activities, lipid biosynthesis and calcium (Ca²⁺) storage. In this review, we will discuss how altered ER homeostasis contributes to dysregulation of hepatic lipid metabolism and contri...

journal_title：Current opinion in lipidology

authors： Wang S,Kaufman RJ

更新日期：2014-04-01 00:00:00

abstract：:The inhibiting effect of insulin on the mobilization of free fatty acids (FFA) from adipose tissue is halted in prevalent conditions with systemic insulin resistance. The nature and cause of this perturbation are unknown, but steroid hormones may be involved. The consequence is the creation or amplification of insulin...

journal_title：Current opinion in lipidology

authors： Björntorp P

更新日期：1994-06-01 00:00:00