Abstract:
PURPOSE OF REVIEW:Although the role for microRNAs (miRNAs) in regulating multiple physiological processes including apoptosis, cell differentiation, and cancer is well established, the importance of these tiny RNAs in regulating lipid metabolism has only recently been uncovered. This review summarizes the evidence for a critical role of miRNAs in regulating lipid metabolism. RECENT FINDINGS:Lipid metabolism is tightly regulated at the cellular level. In addition to classic transcriptional regulation of cholesterol metabolism (e.g. by SREBP and LXR), members of a class of noncoding RNAs termed miRNAs have now been identified to be potent post-transcriptional regulators of lipid metabolism genes involved in cholesterol homeostasis and fatty acid oxidation. Several reports have recently shown that miR-33 regulates cholesterol efflux and HDL biogenesis by downregulating the expression of the ABC transporters, ABCA1 and ABCG1. In addition, miR-33 also inhibits the translation of several transcripts encoding proteins involved in fatty acid β-oxidation including CPT1a, CROT, and HADHB, thereby reducing fatty acid degradation. Other miRNAs including miR-122, miR-370, miR-335, and miR-378/378*, miR-27 and miR-125a-5p have been implicated in regulating cholesterol homeostasis, fatty acid metabolism and lipogenesis. SUMMARY:Recent advances in the understanding of the regulation of lipid metabolism indicate that miRNAs play major roles in regulating cholesterol and fatty acid metabolism. These new findings may open new avenues for the treatment of dyslipidemias.
journal_name
Curr Opin Lipidoljournal_title
Current opinion in lipidologyauthors
Fernández-Hernando C,Suárez Y,Rayner KJ,Moore KJdoi
10.1097/MOL.0b013e3283428d9dsubject
Has Abstractpub_date
2011-04-01 00:00:00pages
86-92issue
2eissn
0957-9672issn
1473-6535journal_volume
22pub_type
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journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
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journal_title:Current opinion in lipidology
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journal_title:Current opinion in lipidology
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journal_title:Current opinion in lipidology
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journal_title:Current opinion in lipidology
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journal_title:Current opinion in lipidology
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更新日期:2015-10-01 00:00:00
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journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/MOL.0b013e32834f0ef3
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journal_title:Current opinion in lipidology
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journal_title:Current opinion in lipidology
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journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
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更新日期:2018-08-01 00:00:00
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journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
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更新日期:2005-10-01 00:00:00
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journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/MOL.0000000000000391
更新日期:2017-04-01 00:00:00
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journal_title:Current opinion in lipidology
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journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/MOL.0b013e32834b4994
更新日期:2011-12-01 00:00:00
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journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/MOL.0000000000000622
更新日期:2019-08-01 00:00:00
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journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/00041433-200304000-00003
更新日期:2003-04-01 00:00:00
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journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/00041433-199910000-00002
更新日期:1999-10-01 00:00:00
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journal_title:Current opinion in lipidology
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更新日期:2001-02-01 00:00:00
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journal_title:Current opinion in lipidology
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更新日期:2013-06-01 00:00:00
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journal_title:Current opinion in lipidology
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journal_title:Current opinion in lipidology
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更新日期:2007-04-01 00:00:00
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journal_title:Current opinion in lipidology
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更新日期:1995-06-01 00:00:00
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journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
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更新日期:2014-08-01 00:00:00
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journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
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更新日期:2003-10-01 00:00:00
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journal_title:Current opinion in lipidology
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更新日期:2015-04-01 00:00:00
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journal_title:Current opinion in lipidology
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更新日期:2013-08-01 00:00:00
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journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
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更新日期:2011-02-01 00:00:00
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journal_title:Current opinion in lipidology
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更新日期:2010-04-01 00:00:00