Microbiota and HDL metabolism.

abstract：PURPOSE OF REVIEW:Statins are the most prescribed medications worldwide with a proven ability to reduce major cardiovascular events. Recent data have revealed that statin therapy is associated with an increased risk for developing diabetes. We discuss the relevant data including newly published results, which demonstra...

journal_title：Current opinion in lipidology

authors： Preiss D,Sattar N

更新日期：2011-12-01 00:00:00

abstract：:The initial step of reverse cholesterol transport, the efflux of cell cholesterol into the extracellular fluid, has received much attention over the past year. Some studies have provided insights into the mechanism of cholesterol efflux and others have focused on the identity of the extracellular acceptors of cell cho...

journal_title：Current opinion in lipidology

authors： Barter PJ,Rye KA

更新日期：1996-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides a concise update of the involvement of endothelial adhesion molecules in atherogenesis, an overview of current advances in the development of adhesion molecule blocking agents, as well as an insight into the potential of these molecules in cardiovascular therapy. RECENT FINDINGS:...

journal_title：Current opinion in lipidology

authors： Lutters BC,Leeuwenburgh MA,Appeldoorn CC,Molenaar TJ,Van Berkel TJ,Biessen EA

更新日期：2004-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To assess factors that promote atherogenesis and cardiovascular disease (CVD) in rheumatoid arthritis (RA). Also, to determine how control of inflammation with conventional and biological antirheumatic drugs affects cardiovascular risk. RECENT FINDINGS:An excess risk of CVD occurs early in the RA dis...

journal_title：Current opinion in lipidology

authors： Mirjafari H,Al-Husain A,Bruce IN

更新日期：2011-08-01 00:00:00

abstract：:Most of the LDL receptor family members recognize apolipoprotein E. The structures of the VLDL receptor, and recently identified apolipoprotein E receptor 2, closely resemble the LDL receptor. Recent studies have demonstrated that the VLDL receptor is responsible for the reproduction of premammalian species by mediati...

journal_title：Current opinion in lipidology

authors： Yamamoto T,Bujo H

更新日期：1996-10-01 00:00:00

abstract：:The ability of the apolipoprotein E-deficient mouse to develop spontaneous atherosclerosis, which resembles the human process, is an excellent model in which to assess the impact of dietary factors. This review discusses the role of several nutrients in the development of atherosclerosis and the mechanisms through whi...

journal_title：Current opinion in lipidology

authors： Osada J,Joven J,Maeda N

更新日期：2000-02-01 00:00:00

abstract：PURPOSE OF REVIEW:As the incidence of obesity and the metabolic syndrome has increased, research has focused on the importance of the endocannabinoid system in the brain and peripheral tissues. Rimonabant, an inverse agonist of the CB1 receptor is being used therapeutically. This review presents recent advances in endo...

journal_title：Current opinion in lipidology

authors： Jesudason D,Wittert G

更新日期：2008-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and it has overlapping pathogenesis with diabetes and cardiovascular disease. Reviewed here are recent advances in understanding the contribution of diet and selected nutrients to NAFLD. RECENT FINDINGS:To und...

journal_title：Current opinion in lipidology

authors： Vos MB

更新日期：2014-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The current review considers what we have learnt from the clinical outcome trials with the cetrapibs; the inhibitors of cholesteryl ester transfer protein that increase HDL cholesterol levels; torcetrapib, dalcetrapib, evacetrapib and anacetrapib. RECENT FINDINGS:Although an off-target increase in bl...

journal_title：Current opinion in lipidology

authors： Doggrell SA

更新日期：2018-08-01 00:00:00

abstract：:The most likely cholesterol-raising factors in unfiltered coffee are kahweol and cafestol. Different brewing methods alter the concentrations of these diterpenes and have caused discrepant results in studies from different parts of the world. The effect of tea on the risk of coronary heart disease is much less clear b...

journal_title：Current opinion in lipidology

authors： Thelle DS

更新日期：1995-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Nutrition recommendations emphasize that not only dietary fat quantity but also fat quality plays a role in the prevention of type 2 diabetes (T2D). The aim of this review is to summarize the evidence for dietary fat and risk of T2D, to highlight recent findings and point out future research direction...

journal_title：Current opinion in lipidology

authors： Schlesinger S,Schwingshackl L,Neuenschwander M

更新日期：2019-02-01 00:00:00

abstract：:Expression profiling and genomic DNA sequence comparisons are increasingly being applied to the identification and analysis of the genes that are involved in lipid metabolism. Not only has genome-wide expression profiling aided in the identification of novel genes that are involved in important processes in lipid meta...

journal_title：Current opinion in lipidology

authors： Callow MJ,Rubin EM

更新日期：2002-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The metabolic syndrome has been emphasized as affecting an important subset of individuals at high risk for cardiovascular disease leading the National Cholesterol Educational Program Adult Treatment Panel III in highlighting awareness of insulin-resistance syndrome. Insulin resistance is thought to b...

journal_title：Current opinion in lipidology

authors： Perseghin G

更新日期：2005-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Dietary and blood carotenoids, including alpha-carotene, beta-carotene, lycopene, lutein/zeaxanthin, and beta-cryptoxanthin, have been examined in a number of epidemiological studies in recent years for the risk of cardiovascular disease. This review assimilated the existing and recent literature on c...

journal_title：Current opinion in lipidology

authors： Sesso HD

更新日期：2006-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Inflammation has been widely acknowledged to contribute throughout all stages of atherogenesis. However, these recent advances in our understanding have not been translated into clinical practice in which the mainstay of treatment is still lipid-targeted therapy. This review provides an overview of pr...

journal_title：Current opinion in lipidology

authors： van der Valk FM,van Wijk DF,Stroes ES

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:HDLs possess several physiological activities that may explain their antiatherosclerotic properties. Among them, the most relevant is the ability of HDL to promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion. RECENT FINDINGS:The ability of HDL to promote choles...

journal_title：Current opinion in lipidology

authors： Norata GD,Pirillo A,Catapano AL

更新日期：2011-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The 3-hydroxy-3-methylglutaryl-coenzyme-A reductase inhibitors, or statins, have been shown to reduce cardiovascular morbidity and mortality among a wide spectrum of patients with established atherosclerotic vascular disease. Mounting experimental and clinical evidence also suggest a potential benefit...

journal_title：Current opinion in lipidology

authors： Pham M,Oka RK,Giacomini JC

更新日期：2005-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Lowering LDL cholesterol (LDL-C) reduces vascular risk. Current guidelines recommend initiating statin therapy in patients with a yearly coronary heart disease risk of around 1.5-2%, and most clinicians prescribe standard statin regimens (e.g. 40 mg simvastatin daily). However, there is some uncertain...

journal_title：Current opinion in lipidology

authors： Bulbulia R,Armitage J

更新日期：2012-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Fatty acid transport proteins are a family of proteins involved in fatty acid uptake and activation. This review summarizes recent progress in elucidating the function of fatty acid transport proteins. RECENT FINDINGS:Recent experiments clearly establish FATP1 as a regulated fatty acid transporter in...

journal_title：Current opinion in lipidology

authors： Gimeno RE

更新日期：2007-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to present recent information on lipid lowering in diabetes mellitus. New information from randomized clinical trials will be discussed together with implications for clinical practice. Residual risk persists despite statin therapy and additional approaches, particularly ...

journal_title：Current opinion in lipidology

authors： Betteridge DJ

更新日期：2008-12-01 00:00:00

abstract：:The protective effect of HDL against the development of atherosclerosis appears to be multifaceted involving a number of mechanisms. One of the major mechanisms is, however, the ability of HDL to decrease, directly or indirectly, the lipid peroxidation of LDL. The hydrolysis of lipid peroxides by PON1 makes a major co...

journal_title：Current opinion in lipidology

authors： Mackness MI,Durrington PN,Mackness B

更新日期：2000-08-01 00:00:00

abstract：:Atherosclerotic cardiovascular disease is the most common complication of diabetes. Recent guidelines in the USA have underlined the importance of treating lipid abnormalities in people with diabetes in order to reduce the risk of this complication. Should lifestyle approaches not be sufficient drugs will need to be a...

journal_title：Current opinion in lipidology

authors： Steiner G

更新日期：2001-12-01 00:00:00

abstract：:The cytokines interleukin-1 and tumor necrosis factor contribute to the pathogenesis of inflammatory diseases and, potentially, to atherogenesis. The synthesis of these cytokines in humans can be suppressed by oral intake of n-3 polyunsaturated fatty acids. This mechanism may contribute to the beneficial effect of lon...

journal_title：Current opinion in lipidology

authors： Endres S,von Schacky C

更新日期：1996-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Metabolomics is emerging as a powerful tool for studying metabolic processes and in recent years, the applications in the area of nutrition have risen rapidly. The present review gives an overview of the current applications in the field of nutrition and identifies areas in need of advancement. RECEN...

journal_title：Current opinion in lipidology

authors： Gibbons H,O'Gorman A,Brennan L

更新日期：2015-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Mesenchymal stem cells (or multipotent stromal cells) are emerging as a potent cell type for cardiac cell therapy. This review describes the potential of cardiac mesenchymal stem cell therapy, but also highlights some recently discovered less favorable mesenchymal stem cell characteristics. RECENT FI...

journal_title：Current opinion in lipidology

authors： Atsma DE,Fibbe WE,Rabelink TJ

更新日期：2007-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past two decades serious efforts has been invested in the search for genes that predispose to common obesity, but progress has been slow and success limited. Genome-wide association, however, has revived optimism. Here we review recent advances in the field of obesity genetics and discuss the...

journal_title：Current opinion in lipidology

authors： Li S,Loos RJ

更新日期：2008-04-01 00:00:00

abstract：:Antithrombotic therapy has assumed a central role in the therapy of the acute coronary syndromes and chronic coronary artery disease. The theoretical rationale for antithrombotic therapy, and the established and evolving roles of antiplatelet agents and anticoagulants in coronary disease are reviewed. Emphasis is focu...

journal_title：Current opinion in lipidology

authors： Di Salvo TG,Fuster V

更新日期：1994-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The goal of this review is to provide an update on the most recent and relevant findings in the area of genotype-phenotype associations as well as the relationships between genetic factors and cardiovascular disease risk markers and events. In addition, emphasis will be placed on the methodological pr...

journal_title：Current opinion in lipidology

authors： Visvikis-Siest S,Marteau JB

更新日期：2006-04-01 00:00:00

abstract：:The microsomal triglyceride transfer protein is necessary for the assembly and secretion of lipoproteins containing apolipoprotein B. During the past year, significant progress has been made towards understanding the role of microsomal triglyceride transfer protein in lipoprotein assembly at both a cellular and molecu...

journal_title：Current opinion in lipidology

authors： Gordon DA

更新日期：1997-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine the role of gut microbiota in the regulation of host energy homeostasis and its role in the pathogenesis of obesity, diabetes and nonalcoholic fatty liver disease (NAFLD). RECENT FINDINGS:Experimental models highlight several mechanisms connecting gut microbiota to host energy metabolism: ...

journal_title：Current opinion in lipidology

authors： Musso G,Gambino R,Cassader M

更新日期：2010-02-01 00:00:00