Lipid lowering in diabetes mellitus.


PURPOSE OF REVIEW:The purpose of this review is to present recent information on lipid lowering in diabetes mellitus. New information from randomized clinical trials will be discussed together with implications for clinical practice. Residual risk persists despite statin therapy and additional approaches, particularly in relation to increasing HDL cholesterol will be discussed. RECENT FINDINGS:Recent RCTS have shown evidence of benefit and safety of more intensive LDL cholesterol lowering in patients with diabetes and established cardiovascular disease supporting guidelines for a more intensive LDL goal of therapy. A recent meta-analysis has confirmed benefit on major coronary events and ischaemic stroke in many diabetic patient subgroups, including those with type 1 disease.Despite statin treatment, cardiovascular disease residual risk remains high. After LDL the next lipoprotein goal is to increase HDL. Although there has been disappointment with the first cholesterol ester transfer protein inhibitor, there is encouraging evidence that increasing HDL with the peroxisome proliferator activator receptor (PPAR) gamma agonist, pioglitazone and nicotinic acid derivatives may contribute beyond statin therapy. SUMMARY:In summary the benefits of statin therapy in diabetes has been confirmed and extended such that the overwhelming majority of diabetic patients should be considered for this therapy. Increasing HDL might provide additional benefit that may further reduce cardiovascular disease risk.


Curr Opin Lipidol


Betteridge DJ




Has Abstract


2008-12-01 00:00:00














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    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Fleming I

    更新日期:2011-10-01 00:00:00

  • Hypobetalipoproteinemia and abetalipoproteinemia: liver disease and cardiovascular disease.

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  • The menopause and lipid metabolism: strategies for cardiovascular disease prevention.

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    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Soma MR,Baetta R,Crosignani P

    更新日期:1997-08-01 00:00:00

  • Recent advances in liver-directed gene therapy: implications for the treatment of dyslipidemia.

    abstract::Somatic gene therapy for the treatment of dyslipidemia is an area of active investigation. A substantial body of data indicates that the transfer of various lipid-lowering genes to the liver is an effective method of restoring normal plasma lipids in animal models of dyslipidemia. Most studies have used adenoviral vec...

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    authors: Oka K,Davis AR,Chan L

    更新日期:2000-04-01 00:00:00

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    abstract:PURPOSE OF REVIEW:Proprotein convertase subtilisin kexin type 9 (PCSK9) acts as an endogenous natural inhibitor of the LDL receptor pathway, by targeting the receptor to lysosomes for degradation. Beside the liver, PCSK9 is also expressed at significant levels in other tissues, where its function remains unclear. The c...

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    authors: Cariou B,Si-Tayeb K,Le May C

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    authors: Marsch E,Sluimer JC,Daemen MJ

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    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Jessup W,Kritharides L

    更新日期:2000-10-01 00:00:00

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    authors: Egom EE,Mamas MA,Soran H

    更新日期:2013-08-01 00:00:00

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    authors: Gisterå A,Ketelhuth DFJ

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


    authors: Pham M,Oka RK,Giacomini JC

    更新日期:2005-12-01 00:00:00

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    journal_title:Current opinion in lipidology

    pub_type: 杂志文章


    authors: Langsted A,Nordestgaard BG

    更新日期:2020-06-01 00:00:00