Lipid lowering in diabetes mellitus.

abstract：PURPOSE OF REVIEW:To provide an update on clinical trials of gene therapy for atherosclerotic cardiovascular disease published since 1 August 2001 and summarize the general advantages and potential problems of gene transfer in these disorders. RECENT FINDINGS:There are two major areas in which gene therapy has entered...

journal_title：Current opinion in lipidology

authors： Freedman SB

更新日期：2002-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the therapeutic strategies to inhibit PCSK9 and to describe the main results obtained in phase I and II trials with monoclonal antibodies targeting PCSK9. RECENT FINDINGS:Among the various approaches for PCSK9 inhibition, human data are only available for inhibition of PCSK9 binding to L...

journal_title：Current opinion in lipidology

authors： Farnier M

更新日期：2013-06-01 00:00:00

abstract：:Lipid-poor apolipoproteins remove cellular cholesterol and phospholipids by an active transport pathway controlled by an ATP binding cassette transporter called ABCA1 (formerly ABC1). Mutations in ABCA1 cause Tangier disease, a severe HDL deficiency syndrome characterized by a rapid turnover of plasma apolipoprotein A...

journal_title：Current opinion in lipidology

authors： Oram JF,Vaughan AM

更新日期：2000-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides a concise update of the involvement of endothelial adhesion molecules in atherogenesis, an overview of current advances in the development of adhesion molecule blocking agents, as well as an insight into the potential of these molecules in cardiovascular therapy. RECENT FINDINGS:...

journal_title：Current opinion in lipidology

authors： Lutters BC,Leeuwenburgh MA,Appeldoorn CC,Molenaar TJ,Van Berkel TJ,Biessen EA

更新日期：2004-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an overview of newly described mechanisms by which peroxisome proliferator-activated receptors (PPARs) (α, γ, and δ) regulate several factors associated with cardiovascular risk. RECENT FINDINGS:PPAR agonists have known effects on plasma lipoprotein levels, inflammation, and insu...

journal_title：Current opinion in lipidology

authors： Millar JS

更新日期：2013-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The endoplasmic reticulum (ER) maintains cellular metabolic homeostasis by coordinating protein synthesis, secretion activities, lipid biosynthesis and calcium (Ca²⁺) storage. In this review, we will discuss how altered ER homeostasis contributes to dysregulation of hepatic lipid metabolism and contri...

journal_title：Current opinion in lipidology

authors： Wang S,Kaufman RJ

更新日期：2014-04-01 00:00:00

abstract：:Atherosclerotic cardiovascular disease is the most common complication of diabetes. Recent guidelines in the USA have underlined the importance of treating lipid abnormalities in people with diabetes in order to reduce the risk of this complication. Should lifestyle approaches not be sufficient drugs will need to be a...

journal_title：Current opinion in lipidology

authors： Steiner G

更新日期：2001-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To highlight the fact that regional differences in the normal arterial intima are critical to atherosclerotic lesion formation driven by systemic risk factors. RECENT FINDINGS:At arterial curvatures, bifurcations and branches unique hemodynamics influence endothelial cell signaling and gene expressio...

journal_title：Current opinion in lipidology

authors： Cybulsky MI,Jongstra-Bilen J

更新日期：2010-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Capsaicin and its nonpungent analog (capsinoids) are known to be food ingredients that increase energy expenditure and decrease body fat. This article reviews the role of brown adipose tissue (BAT) for the thermogenic effect of these compounds in humans and proposes the possibility of some other antio...

journal_title：Current opinion in lipidology

authors： Saito M,Yoneshiro T

更新日期：2013-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Substantial risk of ASCVD events persists despite intensive statin therapy and other agents to lower LDL-C. The optimal way to address other elements of dyslipidemia, such as triglyceride-rich particles (TRL) and when to treat has remained unclear. RECENT FINDINGS:Several lines of evidence indicate t...

journal_title：Current opinion in lipidology

authors： Ganda OP

更新日期：2020-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Inherited lipodystrophies are rare autosomal recessive and dominant disorders characterized by selective, but variable, loss of adipose tissue. Marked hypertriglyceridemia is a common feature of these disorders and highlights the role of adipose tissue in lipid homeostasis. In the last decade, advance...

journal_title：Current opinion in lipidology

authors： Simha V,Garg A

更新日期：2009-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Inflammation has been widely acknowledged to contribute throughout all stages of atherogenesis. However, these recent advances in our understanding have not been translated into clinical practice in which the mainstay of treatment is still lipid-targeted therapy. This review provides an overview of pr...

journal_title：Current opinion in lipidology

authors： van der Valk FM,van Wijk DF,Stroes ES

更新日期：2012-12-01 00:00:00

abstract：:The recent discovery of a second estrogen receptor subtype, estrogen receptor-beta, may significantly advance our understanding of tissue specific effects of estrogenic compounds, both natural and synthetic. Although specific effects mediated by estrogen receptor beta in vivo remain to be elucidated, hypothetically th...

journal_title：Current opinion in lipidology

authors： Cassidy A

更新日期：1999-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Peroxisome proliferator-activated receptors alpha, beta/delta and gamma are members of the nuclear receptor superfamily. They mediate the effects of fatty acids and their derivatives at the transcriptional level, and are considered to be lipid sensors that participate in the regulation of energy homeo...

journal_title：Current opinion in lipidology

authors： Michalik L,Desvergne B,Wahli W

更新日期：2003-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent findings suggesting that cannabinoid receptors are potential targets for the treatment of atherosclerosis are reviewed. RECENT FINDINGS:Cannabinoids, such as Delta9-tetrahydrocannabinol, the major psychoactive compound of marijuana, their synthetic analogs and endogenous cannabinoid ligands, p...

journal_title：Current opinion in lipidology

authors： Steffens S,Mach F

更新日期：2006-10-01 00:00:00

abstract：:In many individuals, LDL-cholesterol levels rise following increased consumption of dietary cholesterol or saturated and trans-monounsaturated fatty acids. In others, a reduction of cholesterogenesis fully compensates for these effects. In responding individuals, much of the increase in LDL-cholesterol observed may re...

journal_title：Current opinion in lipidology

authors： Fielding CJ

更新日期：1997-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Metabolomics is emerging as a powerful tool for studying metabolic processes and in recent years, the applications in the area of nutrition have risen rapidly. The present review gives an overview of the current applications in the field of nutrition and identifies areas in need of advancement. RECEN...

journal_title：Current opinion in lipidology

authors： Gibbons H,O'Gorman A,Brennan L

更新日期：2015-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past two decades serious efforts has been invested in the search for genes that predispose to common obesity, but progress has been slow and success limited. Genome-wide association, however, has revived optimism. Here we review recent advances in the field of obesity genetics and discuss the...

journal_title：Current opinion in lipidology

authors： Li S,Loos RJ

更新日期：2008-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Routine measurement of echolucency of atherosclerotic plaques, in addition to degree of stenosis, may change clinical practice in the future. Within the context of previous knowledge in this field, we therefore review recent developments in detection and histological characterization of echolucent rup...

journal_title：Current opinion in lipidology

authors： Nordestgaard BG,Grønholdt ML,Sillesen H

更新日期：2003-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Phospholipids are major constituents in the intestinal lumen after meal consumption. This article highlights current literature suggesting the contributory role of intestinal phospholipid metabolism toward cardiometabolic disease manifestation. RECENT FINDINGS:Group 1b phospholipase A2 (PLA2g1b) cata...

journal_title：Current opinion in lipidology

authors： Hui DY

更新日期：2016-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Fatty acid transport proteins are a family of proteins involved in fatty acid uptake and activation. This review summarizes recent progress in elucidating the function of fatty acid transport proteins. RECENT FINDINGS:Recent experiments clearly establish FATP1 as a regulated fatty acid transporter in...

journal_title：Current opinion in lipidology

authors： Gimeno RE

更新日期：2007-06-01 00:00:00

abstract：PURPOSE OF REVIEW:As our understanding of cardiovascular disease has advanced over the past decades, multiple novel treatment strategies have been developed with the hope of reducing the global morbidity and mortality associated with this condition. Large-scale trials to test such novel therapies using clinical end poi...

journal_title：Current opinion in lipidology

authors： Doris MK,Dweck MR,Fayad ZA

更新日期：2016-12-01 00:00:00

abstract：:Apolipoprotein A-I-containing lipoproteins represent a heterogeneous group of lipoparticles. Recent studies suggest that a specific subpopulation within the lipoprotein (AI) subclass may be more effective than other lipoproteins in promoting cholesterol efflux from cells and in the different steps of reverse cholester...

journal_title：Current opinion in lipidology

authors： Leroy A,Dallongeville J,Fruchart JC

更新日期：1995-10-01 00:00:00

abstract：:Niemann-Pick type C (NPC) is an autosomal recessive lysosomal storage disease. Fibroblasts from individuals with Niemann-Pick type C exhibit defective intracellular cholesterol transport. Linkage analysis has led to the recent cloning of the NPC1 gene on human chromosome 18, which is the major disease locus. Analysis ...

journal_title：Current opinion in lipidology

authors： Liscum L,Klansek JJ

更新日期：1998-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Alterations in the gut microbiome composition or function are associated with risk factors for cardiometabolic diseases, including hypertension, hyperlipidemia and hyperglycemia. Based on recent evidence that also oral medications used to treat these conditions could alter the gut microbiome compositi...

journal_title：Current opinion in lipidology

authors： Balvers M,van den Born BH,Levin E,Nieuwdorp M

更新日期：2021-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Dyslipidaemias are a major risk factor for cardiovascular disease (CVD); in particular, high levels of low-density lipoprotein cholesterol (LDL-C) have been associated to a higher cardiovascular risk. Reducing LDL-C levels decreases the risk of coronary heart disease (CHD), and the greater the LDL-C r...

journal_title：Current opinion in lipidology

authors： Pirillo A,Norata GD,Catapano AL

更新日期：2017-12-01 00:00:00

abstract：:Low folate intake is an important determinant of elevated blood levels of homocysteine. Because elevated homocysteine has been shown to be a possible graded risk factor for CHD, sufficient folate intake may be important in the prevention of CHD. The magnitude of the association between folate and CHD is consistent wit...

journal_title：Current opinion in lipidology

authors： Verhoef P,Stampfer MJ,Rimm EB

更新日期：1998-02-01 00:00:00

abstract：:Rather than a link in a causal chain leading to hypertension, insulin resistance and resultant hyperinsulinemia may be 'spokes on a wheel', with central or visceral obesity as the postulated hub of the wheel. Hypertension, hypertriglyceridemia and high density lipoprotein cholesterol are depicted as other spokes. Newl...

journal_title：Current opinion in lipidology

authors： Hopkins PN,Hunt SC,Wu LL,Williams GH,Williams RR

更新日期：1996-08-01 00:00:00

abstract：:The metabolism of chylomicrons and their remnants is a highly facilitated route to distribute energy from the diet for storage in adipose tissue or immediate use in the muscles. It has been proposed that chylomicron remnants are atherogenic, and a delayed clearance of chylomicron remnants seems to be associated with c...

journal_title：Current opinion in lipidology

authors： Karpe F,Hamsten A

更新日期：1995-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Nonalcoholic fatty liver (NAFL) and especially its inflammatory variant nonalcoholic steatohepatitis (NASH) have become a major challenge to healthcare systems worldwide because of the increasing prevalence of its major risk factors obesity and type 2 diabetes, which are closely linked to overeating, ...

journal_title：Current opinion in lipidology

authors： Schattenberg JM,Schuppan D

更新日期：2011-12-01 00:00:00