Lipid lowering in diabetes mellitus.

abstract：PURPOSE OF REVIEW:Lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease (CVD) and calcific aortic valve stenosis. We review recent studies that highlight Lp(a) in CVD and calcific aortic valve stenosis and propose pathways to clinical registration of Lp(a)-lowering agents. RECENT FINDINGS:Over the last fe...

journal_title：Current opinion in lipidology

authors： Hung MY,Tsimikas S

更新日期：2014-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Inflammation has been widely acknowledged to contribute throughout all stages of atherogenesis. However, these recent advances in our understanding have not been translated into clinical practice in which the mainstay of treatment is still lipid-targeted therapy. This review provides an overview of pr...

journal_title：Current opinion in lipidology

authors： van der Valk FM,van Wijk DF,Stroes ES

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Angiogenesis and inflammation are important features in atherosclerotic plaque destabilization. The transcription factors hypoxia-inducible factor-1alpha and Notch are key regulators of angiogenesis. In addition, hypoxia-inducible factor-1alpha has been linked to regulation of inflammatory processes a...

journal_title：Current opinion in lipidology

authors： Ruas JL,Lendahl U,Poellinger L

更新日期：2007-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an overview of newly described mechanisms by which peroxisome proliferator-activated receptors (PPARs) (α, γ, and δ) regulate several factors associated with cardiovascular risk. RECENT FINDINGS:PPAR agonists have known effects on plasma lipoprotein levels, inflammation, and insu...

journal_title：Current opinion in lipidology

authors： Millar JS

更新日期：2013-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the role of the microRNA-30c (miR-30c) in lipid metabolism and adipogenesis, to address consequences associated with reduced expression in cancer and cardiac function, and to speculate benefits of overexpressing miR-30c in the treatment of hyperlipidemia, atherosclerosis, and cancer. REC...

journal_title：Current opinion in lipidology

authors： Irani S,Hussain MM

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past two decades serious efforts has been invested in the search for genes that predispose to common obesity, but progress has been slow and success limited. Genome-wide association, however, has revived optimism. Here we review recent advances in the field of obesity genetics and discuss the...

journal_title：Current opinion in lipidology

authors： Li S,Loos RJ

更新日期：2008-04-01 00:00:00

abstract：:Apolipoprotein E has key functions in lipoprotein metabolism, and polymorphisms in the apolipoprotein E gene are associated with distinct lipoprotein patterns. The possibility of gene-nutrient interactions for apolipoprotein E has been addressed in many studies. Although results have generally been mixed, the indicati...

journal_title：Current opinion in lipidology

authors： Rubin J,Berglund L

更新日期：2002-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The 3-hydroxy-3-methylglutaryl-coenzyme-A reductase inhibitors, or statins, have been shown to reduce cardiovascular morbidity and mortality among a wide spectrum of patients with established atherosclerotic vascular disease. Mounting experimental and clinical evidence also suggest a potential benefit...

journal_title：Current opinion in lipidology

authors： Pham M,Oka RK,Giacomini JC

更新日期：2005-12-01 00:00:00

abstract：:The inhibiting effect of insulin on the mobilization of free fatty acids (FFA) from adipose tissue is halted in prevalent conditions with systemic insulin resistance. The nature and cause of this perturbation are unknown, but steroid hormones may be involved. The consequence is the creation or amplification of insulin...

journal_title：Current opinion in lipidology

authors： Björntorp P

更新日期：1994-06-01 00:00:00

abstract：:The recently revised guidelines for cholesterol management in Europe and the USA have focused attention on triglycerides and HDL cholesterol as risk factors for coronary heart disease. In the present review, I shall discuss therapeutic considerations in the treatment of patients with hypertriglyceridemia or low HDL ch...

journal_title：Current opinion in lipidology

authors： Larsen ML

更新日期：1994-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Hypertriglyceridemia occurs mainly because of metabolic disorders secondary to diabetes, alcohol intake, and/or overweight. Genetic factors have also been clearly identified in most severe cases. Triglycerides are generally considered as 'bystanders' for cardiovascular diseases. However, biological an...

journal_title：Current opinion in lipidology

authors： Huet F,Roubille C,Roubille F

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Dementia is a major cause of disability and institutionalization. Apart from age and apolipoprotein E (APOE) genotype, there are currently no established, clinically relevant, noninvasive markers of dementia. We conducted a literature search of recent observational epidemiological studies evaluating t...

journal_title：Current opinion in lipidology

authors： Koch M,Jensen MK

更新日期：2016-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Metabolomics is emerging as a powerful tool for studying metabolic processes and in recent years, the applications in the area of nutrition have risen rapidly. The present review gives an overview of the current applications in the field of nutrition and identifies areas in need of advancement. RECEN...

journal_title：Current opinion in lipidology

authors： Gibbons H,O'Gorman A,Brennan L

更新日期：2015-02-01 00:00:00

abstract：:Oxidatively damaged LDL may play a critical role in the pathogenesis of atherosclerotic vascular disease. Several pathways promote LDL oxidation in vitro but the physiologically relevant mechanisms have proven difficult to identify. Detection of stable compounds that result from specific reaction pathways has provided...

journal_title：Current opinion in lipidology

authors： Heinecke JW

更新日期：1997-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Fibrates continue to be a viable treatment option for mixed atherogenic dyslipidemia, and recent reports from clinical studies have shed new light on the therapeutic utility of fibrates for the prevention of microvascular and macrovascular disease, especially in combination with statins. RECENT FINDI...

journal_title：Current opinion in lipidology

authors： Saha SA,Arora RR

更新日期：2011-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will provide an update on the structure of GPIHBP1, a 28-kDa glycosylphosphatidylinositol-anchored glycoprotein, and its role in the lipolytic processing of triglyceride-rich lipoproteins. RECENT FINDINGS:Gpihbp1 knockout mice on a chow diet have milky plasma and plasma triglyceride level...

journal_title：Current opinion in lipidology

authors： Beigneux AP,Weinstein MM,Davies BS,Gin P,Bensadoun A,Fong LG,Young SG

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Randomized clinical trials provide strong evidence that pharmacological elevation of HDL-cholesterol (HDL-C) fails to reduce cardiovascular disease (CVD) risk in statin-treated humans. It is thus critical to identify new metrics that capture HDL's cardioprotective effects. RECENT FINDINGS:We review r...

journal_title：Current opinion in lipidology

authors： Hutchins PM,Heinecke JW

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Dyslipidaemias are a major risk factor for cardiovascular disease (CVD); in particular, high levels of low-density lipoprotein cholesterol (LDL-C) have been associated to a higher cardiovascular risk. Reducing LDL-C levels decreases the risk of coronary heart disease (CHD), and the greater the LDL-C r...

journal_title：Current opinion in lipidology

authors： Pirillo A,Norata GD,Catapano AL

更新日期：2017-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Bile acid sequestrants (BAS) have been used for more than 50 years in the treatment of hypercholesterolemia. The last decade, bile acids are emerging as integrated regulators of metabolism via induction of various signal transduction pathways. Consequently, BAS treatment may exert unexpected side-effe...

journal_title：Current opinion in lipidology

authors： Out C,Groen AK,Brufau G

更新日期：2012-02-01 00:00:00

abstract：:The Scandinavian Simvastatin Survival Study showed that a 35% decrease in LDL-cholesterol was accompanied by a 42% reduction in coronary mortality. Even if the period of time is longer than 1 year for the divergence of survival curves in the simvastatin and placebo groups there are reasons to believe that the benefici...

journal_title：Current opinion in lipidology

authors： Olsson AG,Pedersen T,Bergdahl B

更新日期：1995-12-01 00:00:00

abstract：:The initial step of reverse cholesterol transport, the efflux of cell cholesterol into the extracellular fluid, has received much attention over the past year. Some studies have provided insights into the mechanism of cholesterol efflux and others have focused on the identity of the extracellular acceptors of cell cho...

journal_title：Current opinion in lipidology

authors： Barter PJ,Rye KA

更新日期：1996-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Current data suggest that proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors may affect many metabolic pathways beyond lowering LDL cholesterol. The aim of the present manuscript is to present these so-called pleiotropic effects of PCSK9 inhibitors. RECENT FINDINGS:PCSK9 may affect the ...

journal_title：Current opinion in lipidology

authors： Filippatos TD,Christopoulou EC,Elisaf MS

更新日期：2018-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Adipose tissue is an essential, highly dynamic and metabolically active tissue that vigorously communicates to support its primary function: the storage of lipids. It performs this function to secure energy supply and prevent lipotoxicity. Adipose tissue is essential for maintaining a healthy glucose ...

journal_title：Current opinion in lipidology

authors： Keijer J,van Schothorst EM

更新日期：2008-02-01 00:00:00

abstract：:HDL protects LDL from oxidative damage known to contribute to the onset and progression of atherosclerosis. This antioxidant protection by HDL is mediated by intrinsic hydrolytic enzyme systems, by accelerated selective uptake of lipid peroxides from HDL and by antioxidant molecules. Oxidative damage suffered by HDL a...

journal_title：Current opinion in lipidology

authors： Banka CL

更新日期：1996-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Routine measurement of echolucency of atherosclerotic plaques, in addition to degree of stenosis, may change clinical practice in the future. Within the context of previous knowledge in this field, we therefore review recent developments in detection and histological characterization of echolucent rup...

journal_title：Current opinion in lipidology

authors： Nordestgaard BG,Grønholdt ML,Sillesen H

更新日期：2003-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review covers recent developments in microarray studies in the field of atherogenesis research. RECENT FINDINGS:During the past year microarrays have been applied to the analysis of pathogenic mechanisms of several atherosclerosis risk factors, including ageing, hypertension, obesity, and cytome...

journal_title：Current opinion in lipidology

authors： Tuomisto TT,Ylä-Herttuala S

更新日期：2005-04-01 00:00:00

abstract：:Niemann-Pick type C (NPC) is an autosomal recessive lysosomal storage disease. Fibroblasts from individuals with Niemann-Pick type C exhibit defective intracellular cholesterol transport. Linkage analysis has led to the recent cloning of the NPC1 gene on human chromosome 18, which is the major disease locus. Analysis ...

journal_title：Current opinion in lipidology

authors： Liscum L,Klansek JJ

更新日期：1998-04-01 00:00:00

abstract：:Apolipoprotein A-I-containing lipoproteins represent a heterogeneous group of lipoparticles. Recent studies suggest that a specific subpopulation within the lipoprotein (AI) subclass may be more effective than other lipoproteins in promoting cholesterol efflux from cells and in the different steps of reverse cholester...

journal_title：Current opinion in lipidology

authors： Leroy A,Dallongeville J,Fruchart JC

更新日期：1995-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Fat accumulation in the liver is strongly associated with metabolic dysfunction. Regular exercise improves many cardiometabolic risks factors; however, its effect on intrahepatic triglyceride (IHTG) content remains elusive. This article summarizes available data regarding the effects of exercise on IH...

journal_title：Current opinion in lipidology

authors： Magkos F

更新日期：2010-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease; we highlight the most recent research initiatives that have sought to define Lp(a)-dependent pathogenicity as well as pharmacologic approaches to lowering Lp(a). RECENT FINDINGS:Recent large-scale meta-analyses have confirmed elevate...

journal_title：Current opinion in lipidology

authors： Dubé JB,Boffa MB,Hegele RA,Koschinsky ML

更新日期：2012-04-01 00:00:00