Abstract：
PURPOSE OF REVIEW:Fibrates continue to be a viable treatment option for mixed atherogenic dyslipidemia, and recent reports from clinical studies have shed new light on the therapeutic utility of fibrates for the prevention of microvascular and macrovascular disease, especially in combination with statins. RECENT FINDINGS:Data from randomized placebo-controlled trials have shown that fibrates reduce nonfatal coronary events but do not confer any benefit on mortality or other adverse cardiovascular outcomes. The ACCORD Lipid trial studied the additive effect of fenofibrate therapy along with low-dose simvastatin therapy in 5,518 patients with type 2 diabetes mellitus, and found that fenofibrate did not affect any of the adverse cardiovascular outcomes, either individually or as part of a composite outcome, after 4.7 years of follow-up. An a priori subgroup analysis showed a significant benefit from fenofibrate-simvastatin combination therapy over simvastatin alone in participants with moderate hypertriglyceridemia and low HDL-cholesterol on major cardiovascular events, consistent with post-hoc analyses of previous fibrate trials. The ACCORD-Eye study adds to the sparse clinical data on the effect of fenofibrate on diabetic retinopathy, and showed that fenofibrate may be used to reduce the risk of progression of diabetic retinopathy even in patients with established disease. The combination of statin and fibrate was well tolerated. SUMMARY:Fibrate therapy does not reduce mortality but may reduce nonfatal coronary events in patients at risk for cardiovascular disease, including those with type 2 diabetes. The ACCORD Lipid study shows that the combination of low-dose simvastatin and fenofibrate is well tolerated, and is potentially cardioprotective in patients with atherogenic 'mixed' dyslipidemia.
journal_name
Curr Opin Lipidoljournal_title
Current opinion in lipidologyauthors
Saha SA,Arora RRdoi
10.1097/MOL.0b013e32834701c3subject
Has Abstractpub_date
2011-08-01 00:00:00pages
270-6issue
4eissn
0957-9672issn
1473-6535journal_volume
22pub_type
杂志文章,评审abstract：:Expression profiling and genomic DNA sequence comparisons are increasingly being applied to the identification and analysis of the genes that are involved in lipid metabolism. Not only has genome-wide expression profiling aided in the identification of novel genes that are involved in important processes in lipid meta...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-200204000-00009
更新日期：2002-04-01 00:00:00
abstract：:The cytokines interleukin-1 and tumor necrosis factor contribute to the pathogenesis of inflammatory diseases and, potentially, to atherogenesis. The synthesis of these cytokines in humans can be suppressed by oral intake of n-3 polyunsaturated fatty acids. This mechanism may contribute to the beneficial effect of lon...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-199602000-00011
更新日期：1996-02-01 00:00:00
abstract：PURPOSE OF REVIEW:Nonalcoholic fatty liver (NAFL) and especially its inflammatory variant nonalcoholic steatohepatitis (NASH) have become a major challenge to healthcare systems worldwide because of the increasing prevalence of its major risk factors obesity and type 2 diabetes, which are closely linked to overeating, ...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e32834c7cfc
更新日期：2011-12-01 00:00:00
abstract：:The Scandinavian Simvastatin Survival Study showed that a 35% decrease in LDL-cholesterol was accompanied by a 42% reduction in coronary mortality. Even if the period of time is longer than 1 year for the divergence of survival curves in the simvastatin and placebo groups there are reasons to believe that the benefici...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-199512000-00007
更新日期：1995-12-01 00:00:00
abstract：PURPOSE OF REVIEW:This review will summarize recent evidence demonstrating that biologically active phospholipid oxidation products modulate inflammatory reactions. RECENT FINDINGS:Structural identification of new biologically active oxidized phospholipids and the finding that they can also be formed at inflammatory s...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-200310000-00002
更新日期：2003-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Capsaicin and its nonpungent analog (capsinoids) are known to be food ingredients that increase energy expenditure and decrease body fat. This article reviews the role of brown adipose tissue (BAT) for the thermogenic effect of these compounds in humans and proposes the possibility of some other antio...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e32835a4f40
更新日期：2013-02-01 00:00:00
abstract：PURPOSE OF REVIEW:Randomized clinical trials provide strong evidence that pharmacological elevation of HDL-cholesterol (HDL-C) fails to reduce cardiovascular disease (CVD) risk in statin-treated humans. It is thus critical to identify new metrics that capture HDL's cardioprotective effects. RECENT FINDINGS:We review r...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000209
更新日期：2015-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Statins are the most prescribed medications worldwide with a proven ability to reduce major cardiovascular events. Recent data have revealed that statin therapy is associated with an increased risk for developing diabetes. We discuss the relevant data including newly published results, which demonstra...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e32834b4994
更新日期：2011-12-01 00:00:00
abstract：PURPOSE OF REVIEW:The effects of hormone-replacement therapy on cardiovascular risk factors are examined. In an attempt to explain the results of recent randomized controlled trials in which no benefit of hormone-replacement therapy for postmenopausal women has been observed, RECENT FINDINGS:Changes in lipoproteins in...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/01.mol.0000137231.84772.80
更新日期：2004-08-01 00:00:00
abstract：PURPOSE OF REVIEW:We review stable isotope tracer studies of apolipoprotein B-100 (apoB) kinetics concerning genetic polymorphisms and mutations that affect human lipoprotein metabolism. RECENT FINDINGS:In obese men, the allelic combination of the apoB signal peptide, SP24, and cholesteryl ester transfer protein, CETP...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e3283378e5a
更新日期：2010-04-01 00:00:00
abstract：:Niemann-Pick type C (NPC) is an autosomal recessive lysosomal storage disease. Fibroblasts from individuals with Niemann-Pick type C exhibit defective intracellular cholesterol transport. Linkage analysis has led to the recent cloning of the NPC1 gene on human chromosome 18, which is the major disease locus. Analysis ...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-199804000-00009
更新日期：1998-04-01 00:00:00
abstract：PURPOSE OF REVIEW:To describe the prevalence and population-specific genetic heterogeneity of familial hypercholesterolemia in South Africa. RECENT FINDINGS:This review highlights the paucity of data on familial hypercholesterolemia in South Africa, and the urgent need to uncover the mutation profiles in lipid-associa...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000488
更新日期：2018-04-01 00:00:00
abstract：PURPOSE OF REVIEW:Accumulating evidence has provided new insights regarding potentially effective therapeutic options targeting modulation of HDL metabolism, resulting in the prevention of cardiovascular diseases. The gut microbiota has now been convincingly linked to host health, but its impact on host lipid metabolis...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000472
更新日期：2018-02-01 00:00:00
abstract：PURPOSE OF REVIEW:Low HDL cholesterol and hypertriglyceridemia as well as lowering of LDL cholesterol with statins increase the risk of T2DM. We discuss the recent findings on the effects of lipoproteins and cholesterol on the function and survival of pancreatic β-cells as well as on obesity and insulin sensitivity of ...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e3283412279
更新日期：2011-02-01 00:00:00
abstract：PURPOSE OF REVIEW:Hypertriglyceridemia occurs mainly because of metabolic disorders secondary to diabetes, alcohol intake, and/or overweight. Genetic factors have also been clearly identified in most severe cases. Triglycerides are generally considered as 'bystanders' for cardiovascular diseases. However, biological an...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000622
更新日期：2019-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Nutrition recommendations emphasize that not only dietary fat quantity but also fat quality plays a role in the prevention of type 2 diabetes (T2D). The aim of this review is to summarize the evidence for dietary fat and risk of T2D, to highlight recent findings and point out future research direction...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000567
更新日期：2019-02-01 00:00:00
abstract：:The inverse relationship between HDL and apolipoprotein A-I concentrations and the risk for premature atherosclerosis is well established, but the mechanism whereby apolipoprotein A-I offers protection is still somewhat elusive. Recent studies suggest that a specific subpopulation within the lipoprotein (AI) subclass ...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-199410000-00007
更新日期：1994-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Fat accumulation in the liver is strongly associated with metabolic dysfunction. Regular exercise improves many cardiometabolic risks factors; however, its effect on intrahepatic triglyceride (IHTG) content remains elusive. This article summarizes available data regarding the effects of exercise on IH...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e32833ea912
更新日期：2010-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Lowering LDL cholesterol (LDL-C) reduces vascular risk. Current guidelines recommend initiating statin therapy in patients with a yearly coronary heart disease risk of around 1.5-2%, and most clinicians prescribe standard statin regimens (e.g. 40 mg simvastatin daily). However, there is some uncertain...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e3283556c1b
更新日期：2012-08-01 00:00:00
abstract：PURPOSE OF REVIEW:The science and policy of functional foods are a matter of global concern and this review provides up-to-date information about the Japanese 'food for specified health use' policy based on functional food science. RECENT FINDINGS:A great many studies on nonnutritive but physiologically functional foo...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e3282f3f505
更新日期：2008-02-01 00:00:00
abstract：PURPOSE OF REVIEW:The article reviews the challenges facing cardiovascular disease (CVD) guidelines committees. RECENT FINDINGS:Clinical trials in high-risk populations have shown additional CVD event reduction with ezetimibe and proprotein convertase subtilisin-kexin-9 inhibitors. These trials recruit middle-aged sec...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000453
更新日期：2017-12-01 00:00:00
abstract：:Recent epidemiological data have reaffirmed that elevated plasma triglyceride and low HDL-cholesterol levels are important risk factors for atherosclerotic vascular disease. The rationale for the clinical use of fibric acid derivatives, which are designed to correct this metabolic nexus, is now on firmer ground. The m...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-199912000-00011
更新日期：1999-12-01 00:00:00
abstract：:A site-specific cytidine deamination (cytidine to uridine) in nuclear apolipoprotein B messenger RNA creates a translational stop codon that produces apolipoprotein B48. This process is mediated by an enzyme composed of distinct subunits, including apolipoprotein B messenger RNA editing enzyme catalytic polypeptide-1 ...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-199504000-00002
更新日期：1995-04-01 00:00:00
abstract：PURPOSE OF REVIEW:Endocannabinoids are defined as endogenous agonists of cannabinoid receptors, that is, of the two G-protein-coupled receptors for the Cannabis psychoactive principle Delta-tetra-hydrocannabinol. Two such endogenous mediators have been most thoroughly studied so far: anandamide and 2-arachidonoylglycer...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e32803dbdec
更新日期：2007-04-01 00:00:00
abstract：:Familial combined hyperlipidaemia is the most common inherited hyperlipidaemia and is found in up to 10% of patients with premature myocardial infarction. The genetic and metabolic bases of the disorder have not yet been defined. This review discusses the important advances in the past year in our understanding of the...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-199806000-00002
更新日期：1998-06-01 00:00:00
abstract：PURPOSE OF REVIEW:The systematic analysis of the major candidate genes in autosomal dominant hypercholesterolemia (ADH) and the use of next-generation sequencing (NGS) technology have made possible the discovery of several rare gene variants whose pathogenic effect in most cases remains poorly defined. RECENT FINDINGS...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000414
更新日期：2017-06-01 00:00:00
abstract：:The ability of the apolipoprotein E-deficient mouse to develop spontaneous atherosclerosis, which resembles the human process, is an excellent model in which to assess the impact of dietary factors. This review discusses the role of several nutrients in the development of atherosclerosis and the mechanisms through whi...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-200002000-00004
更新日期：2000-02-01 00:00:00
abstract：:In many individuals, LDL-cholesterol levels rise following increased consumption of dietary cholesterol or saturated and trans-monounsaturated fatty acids. In others, a reduction of cholesterogenesis fully compensates for these effects. In responding individuals, much of the increase in LDL-cholesterol observed may re...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-199702000-00009
更新日期：1997-02-01 00:00:00
abstract：PURPOSE OF REVIEW:Cardiovascular risk scoring is incorporated in guidelines and recommended for targeting preventive treatment. Evidence is required on the most appropriate method, its accuracy in a given population, and its effectiveness in favourably influencing clinical behaviour and health outcomes. RECENT FINDING...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/01.mol.0000236362.56216.44
更新日期：2006-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Despite their pathophysiological importance, the molecular mechanisms and enzymatic components of lipid mobilization from intracellular storage compartments are insufficiently understood. The aim of this review is to evaluate the role of hormone-sensitive lipase in this process. RECENT FINDINGS:Hormo...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-200306000-00009
更新日期：2003-06-01 00:00:00
