Hyperlipidaemia and cardiovascular disease: do fibrates have a role?


PURPOSE OF REVIEW:Fibrates continue to be a viable treatment option for mixed atherogenic dyslipidemia, and recent reports from clinical studies have shed new light on the therapeutic utility of fibrates for the prevention of microvascular and macrovascular disease, especially in combination with statins. RECENT FINDINGS:Data from randomized placebo-controlled trials have shown that fibrates reduce nonfatal coronary events but do not confer any benefit on mortality or other adverse cardiovascular outcomes. The ACCORD Lipid trial studied the additive effect of fenofibrate therapy along with low-dose simvastatin therapy in 5,518 patients with type 2 diabetes mellitus, and found that fenofibrate did not affect any of the adverse cardiovascular outcomes, either individually or as part of a composite outcome, after 4.7 years of follow-up. An a priori subgroup analysis showed a significant benefit from fenofibrate-simvastatin combination therapy over simvastatin alone in participants with moderate hypertriglyceridemia and low HDL-cholesterol on major cardiovascular events, consistent with post-hoc analyses of previous fibrate trials. The ACCORD-Eye study adds to the sparse clinical data on the effect of fenofibrate on diabetic retinopathy, and showed that fenofibrate may be used to reduce the risk of progression of diabetic retinopathy even in patients with established disease. The combination of statin and fibrate was well tolerated. SUMMARY:Fibrate therapy does not reduce mortality but may reduce nonfatal coronary events in patients at risk for cardiovascular disease, including those with type 2 diabetes. The ACCORD Lipid study shows that the combination of low-dose simvastatin and fenofibrate is well tolerated, and is potentially cardioprotective in patients with atherogenic 'mixed' dyslipidemia.


Curr Opin Lipidol


Saha SA,Arora RR




Has Abstract


2011-08-01 00:00:00












  • Clinical trials of gene therapy for atherosclerotic cardiovascular disease.

    abstract:PURPOSE OF REVIEW:To provide an update on clinical trials of gene therapy for atherosclerotic cardiovascular disease published since 1 August 2001 and summarize the general advantages and potential problems of gene transfer in these disorders. RECENT FINDINGS:There are two major areas in which gene therapy has entered...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Freedman SB

    更新日期:2002-12-01 00:00:00

  • Role of microRNA-30c in lipid metabolism, adipogenesis, cardiac remodeling and cancer.

    abstract:PURPOSE OF REVIEW:To summarize the role of the microRNA-30c (miR-30c) in lipid metabolism and adipogenesis, to address consequences associated with reduced expression in cancer and cardiac function, and to speculate benefits of overexpressing miR-30c in the treatment of hyperlipidemia, atherosclerosis, and cancer. REC...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Irani S,Hussain MM

    更新日期:2015-04-01 00:00:00

  • Lipoprotein(a): is it more, less or equal to LDL as a causal factor for cardiovascular disease and mortality?

    abstract:PURPOSE OF REVIEW:To summarize the recent studies directly comparing LDL and lipoprotein(a) as causal factors for cardiovascular disease and mortality. RECENT FINDINGS:In approximately 100,000 individuals from the Copenhagen General Population Study for risk of myocardial infarction, in observational analyses per 39 m...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章


    authors: Langsted A,Nordestgaard BG

    更新日期:2020-06-01 00:00:00

  • The paradox of dysfunctional high-density lipoprotein.

    abstract:PURPOSE OF REVIEW:This review addresses how, in atherosclerosis or systemic inflammation, HDL can lose its usual atheroprotective characteristics and even paradoxically assume proinflammatory properties. RECENT FINDINGS:Specific chemical and structural changes within HDL particles can impede reverse cholesterol transp...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Ansell BJ,Fonarow GC,Fogelman AM

    更新日期:2007-08-01 00:00:00

  • Update on cardiometabolic health effects of ω-3 fatty acids.

    abstract:PURPOSE OF REVIEW:The fish fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may promote cardiometabolic health. This review summarizes the results of recent meta-analyses of prospective studies on cardiovascular diseases, diabetes type 2 and markers of atherosclerosis and thrombosis. RECENT FINDI...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Kromhout D,de Goede J

    更新日期:2014-02-01 00:00:00

  • LDL cholesterol targets--how low to go?

    abstract:PURPOSE OF REVIEW:Lowering LDL cholesterol (LDL-C) reduces vascular risk. Current guidelines recommend initiating statin therapy in patients with a yearly coronary heart disease risk of around 1.5-2%, and most clinicians prescribe standard statin regimens (e.g. 40 mg simvastatin daily). However, there is some uncertain...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Bulbulia R,Armitage J

    更新日期:2012-08-01 00:00:00

  • Echolucent rupture-prone plaques.

    abstract:PURPOSE OF REVIEW:Routine measurement of echolucency of atherosclerotic plaques, in addition to degree of stenosis, may change clinical practice in the future. Within the context of previous knowledge in this field, we therefore review recent developments in detection and histological characterization of echolucent rup...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Nordestgaard BG,Grønholdt ML,Sillesen H

    更新日期:2003-10-01 00:00:00

  • Muscle lipid metabolism in the metabolic syndrome.

    abstract:PURPOSE OF REVIEW:The metabolic syndrome has been emphasized as affecting an important subset of individuals at high risk for cardiovascular disease leading the National Cholesterol Educational Program Adult Treatment Panel III in highlighting awareness of insulin-resistance syndrome. Insulin resistance is thought to b...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Perseghin G

    更新日期:2005-08-01 00:00:00

  • When to lower triglycerides?

    abstract:PURPOSE OF REVIEW:Substantial risk of ASCVD events persists despite intensive statin therapy and other agents to lower LDL-C. The optimal way to address other elements of dyslipidemia, such as triglyceride-rich particles (TRL) and when to treat has remained unclear. RECENT FINDINGS:Several lines of evidence indicate t...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章


    authors: Ganda OP

    更新日期:2020-08-01 00:00:00

  • The value of apolipoprotein E knockout mice for studying the effects of dietary fat and cholesterol on atherogenesis.

    abstract::The ability of the apolipoprotein E-deficient mouse to develop spontaneous atherosclerosis, which resembles the human process, is an excellent model in which to assess the impact of dietary factors. This review discusses the role of several nutrients in the development of atherosclerosis and the mechanisms through whi...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Osada J,Joven J,Maeda N

    更新日期:2000-02-01 00:00:00

  • Response of low density lipoprotein cholesterol levels to dietary change: contributions of different mechanisms.

    abstract::In many individuals, LDL-cholesterol levels rise following increased consumption of dietary cholesterol or saturated and trans-monounsaturated fatty acids. In others, a reduction of cholesterogenesis fully compensates for these effects. In responding individuals, much of the increase in LDL-cholesterol observed may re...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Fielding CJ

    更新日期:1997-02-01 00:00:00

  • Pleiotropic effects of proprotein convertase subtilisin/kexin type 9 inhibitors?

    abstract:PURPOSE OF REVIEW:Current data suggest that proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors may affect many metabolic pathways beyond lowering LDL cholesterol. The aim of the present manuscript is to present these so-called pleiotropic effects of PCSK9 inhibitors. RECENT FINDINGS:PCSK9 may affect the ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Filippatos TD,Christopoulou EC,Elisaf MS

    更新日期:2018-08-01 00:00:00

  • Expression profiling and comparative sequence derived insights into lipid metabolism.

    abstract::Expression profiling and genomic DNA sequence comparisons are increasingly being applied to the identification and analysis of the genes that are involved in lipid metabolism. Not only has genome-wide expression profiling aided in the identification of novel genes that are involved in important processes in lipid meta...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Callow MJ,Rubin EM

    更新日期:2002-04-01 00:00:00

  • Molecular genetics of the fibrinolytic and coagulation systems in haemostasis, thrombogenesis, restenosis and atherosclerosis.

    abstract::The plasminogen and coagulation systems have been extensively characterized at the biochemical level. Recent gene targeting and gene transfer studies have provided novel insights into their role in the formation of blood vessels and in the pathogenesis of blood vessel disorders including thrombosis, restenosis and ath...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Carmeliet P,Collen D

    更新日期:1997-04-01 00:00:00

  • Recent explanatory trials of the mode of action of drug therapies on lipoprotein metabolism.

    abstract:PURPOSE OF REVIEW:Dysregulated lipoprotein metabolism leads to increased plasma concentrations of atherogenic lipoproteins. We highlight the findings from recent studies of the effect of lipid-regulating therapies on apolipoprotein metabolism in humans employing endogenous labelling with stable isotopically labelled is...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Chan DC,Barrett PH,Watts GF

    更新日期:2016-12-01 00:00:00

  • Bile acid sequestrants: more than simple resins.

    abstract:PURPOSE OF REVIEW:Bile acid sequestrants (BAS) have been used for more than 50 years in the treatment of hypercholesterolemia. The last decade, bile acids are emerging as integrated regulators of metabolism via induction of various signal transduction pathways. Consequently, BAS treatment may exert unexpected side-effe...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Out C,Groen AK,Brufau G

    更新日期:2012-02-01 00:00:00

  • Deep dive to the secrets of the PREDIMED trial.

    abstract:PURPOSE OF REVIEW:The aim of this study was to briefly summarize the contribution of the PREDIMED (PREvención con DIeta MEDiterránea) trial on cardiovascular evidence and examine in depth its groundbreaking trajectory.PREDIMED was conducted during 2003-2010 and represented the largest primary prevention trial ever test...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章


    authors: Fernández-Lázaro CI,Ruiz-Canela M,Martínez-González MÁ

    更新日期:2021-02-01 00:00:00

  • High-density lipoprotein subclasses.

    abstract::This review describes recent advances that have been made in the separation of HDL subfractions by physicochemical and immunological methods and the relationship between the particles obtained by the different procedures. The metabolic interconversions that occur as a result of cholesteryl ester transfer protein (CETP...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Skinner ER

    更新日期:1994-06-01 00:00:00

  • Novel anti-inflammatory strategies in atherosclerosis.

    abstract:PURPOSE OF REVIEW:Inflammation has been widely acknowledged to contribute throughout all stages of atherogenesis. However, these recent advances in our understanding have not been translated into clinical practice in which the mainstay of treatment is still lipid-targeted therapy. This review provides an overview of pr...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: van der Valk FM,van Wijk DF,Stroes ES

    更新日期:2012-12-01 00:00:00

  • Niemann-Pick disease type C.

    abstract::Niemann-Pick type C (NPC) is an autosomal recessive lysosomal storage disease. Fibroblasts from individuals with Niemann-Pick type C exhibit defective intracellular cholesterol transport. Linkage analysis has led to the recent cloning of the NPC1 gene on human chromosome 18, which is the major disease locus. Analysis ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Liscum L,Klansek JJ

    更新日期:1998-04-01 00:00:00

  • Statin therapy in heart failure.

    abstract:PURPOSE OF REVIEW:The 3-hydroxy-3-methylglutaryl-coenzyme-A reductase inhibitors, or statins, have been shown to reduce cardiovascular morbidity and mortality among a wide spectrum of patients with established atherosclerotic vascular disease. Mounting experimental and clinical evidence also suggest a potential benefit...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Pham M,Oka RK,Giacomini JC

    更新日期:2005-12-01 00:00:00

  • Conjugated linoleic acid: effects on plasma lipids and cardiovascular function.

    abstract::Conjugated linoleic acid is a collective name for mixtures of several positional and geometric conjugated dienoic isomers of linoleic acid, which have been shown to impact favorably on several biological processes, particularly carcinogenesis. Recent studies have clearly established that the c9, t11 and t10, c12 isome...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Khosla P,Fungwe TV

    更新日期:2001-02-01 00:00:00

  • Cardiovascular risk factors in inflammatory arthritis.

    abstract:PURPOSE OF REVIEW:To assess factors that promote atherogenesis and cardiovascular disease (CVD) in rheumatoid arthritis (RA). Also, to determine how control of inflammation with conventional and biological antirheumatic drugs affects cardiovascular risk. RECENT FINDINGS:An excess risk of CVD occurs early in the RA dis...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Mirjafari H,Al-Husain A,Bruce IN

    更新日期:2011-08-01 00:00:00

  • Folate and coronary heart disease.

    abstract::Low folate intake is an important determinant of elevated blood levels of homocysteine. Because elevated homocysteine has been shown to be a possible graded risk factor for CHD, sufficient folate intake may be important in the prevention of CHD. The magnitude of the association between folate and CHD is consistent wit...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Verhoef P,Stampfer MJ,Rimm EB

    更新日期:1998-02-01 00:00:00

  • Stearoyl-coenzyme A desaturase 1 inhibition and the metabolic syndrome: considerations for future drug discovery.

    abstract:PURPOSE OF REVIEW:The metabolic syndrome has become a leading health concern in developed countries. In the search for strategies to combat this growing problem, stearoyl-CoA desaturase 1 (SCD1) inhibition has been proposed as an attractive therapeutic strategy. However, recent studies warn of potentially harmful conse...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Brown JM,Rudel LL

    更新日期:2010-06-01 00:00:00

  • Follow-up on primary prevention trials.

    abstract::Recent primary prevention trials demonstrated that cardiovascular morbidity and mortality benefits are not accompanied by adverse effects on overall mortality and morbidity in cohorts representing plasma cholesterol concentrations observed in the bulk of coronary artery disease. During the past year, further analyses ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Marais AD

    更新日期:1998-12-01 00:00:00

  • Dietary monounsaturated versus polyunsaturated fatty acids: which is really better for protection from coronary heart disease?

    abstract:PURPOSE OF REVIEW:The purpose is to evaluate recent findings concerning dietary fats and the risk of coronary heart disease. Monounsaturated fatty acids are often regarded as healthy, and many have recommended their consumption instead of saturated fatty acids and polyunsaturated fatty acids. Support for the benefits o...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Lada AT,Rudel LL

    更新日期:2003-02-01 00:00:00

  • Letting lipids go: hormone-sensitive lipase.

    abstract:PURPOSE OF REVIEW:Despite their pathophysiological importance, the molecular mechanisms and enzymatic components of lipid mobilization from intracellular storage compartments are insufficiently understood. The aim of this review is to evaluate the role of hormone-sensitive lipase in this process. RECENT FINDINGS:Hormo...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Haemmerle G,Zimmermann R,Zechner R

    更新日期:2003-06-01 00:00:00

  • Hyperlipidaemia associated with genetic variation in the apolipoprotein B gene.

    abstract::Common variants at the apolipoprotein B gene locus are associated with hyperlipidaemia, but conflicting data have been presented in the literature concerning the size of the effects and which polymorphisms give the best signal in the different groups of individuals studied. In this review, we will present a critique o...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Humphries SE,Talmud PJ

    更新日期:1995-08-01 00:00:00

  • Metabolism of innate immune cells: impact on atherosclerosis.

    abstract:PURPOSE OF REVIEW:It is increasingly recognized that profound metabolic changes occur in activated myeloid cells, which shape their inflammatory phenotype and cellular functions. The purpose of this review is to summarize the accumulating evidence that major metabolic adaptations occur in monocytes and macrophages in t...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Riksen NP,Stienstra R

    更新日期:2018-10-01 00:00:00