Response of low density lipoprotein cholesterol levels to dietary change: contributions of different mechanisms.


:In many individuals, LDL-cholesterol levels rise following increased consumption of dietary cholesterol or saturated and trans-monounsaturated fatty acids. In others, a reduction of cholesterogenesis fully compensates for these effects. In responding individuals, much of the increase in LDL-cholesterol observed may result directly from an increase in plasma cholesteryl ester transfer protein activity whose effect is not mediated by hepatic LDL receptors.


Curr Opin Lipidol


Fielding CJ




Has Abstract


1997-02-01 00:00:00












  • Recent explanatory trials of the mode of action of drug therapies on lipoprotein metabolism.

    abstract:PURPOSE OF REVIEW:Dysregulated lipoprotein metabolism leads to increased plasma concentrations of atherogenic lipoproteins. We highlight the findings from recent studies of the effect of lipid-regulating therapies on apolipoprotein metabolism in humans employing endogenous labelling with stable isotopically labelled is...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Chan DC,Barrett PH,Watts GF

    更新日期:2016-12-01 00:00:00

  • Gut microbiota as a regulator of energy homeostasis and ectopic fat deposition: mechanisms and implications for metabolic disorders.

    abstract:PURPOSE OF REVIEW:To examine the role of gut microbiota in the regulation of host energy homeostasis and its role in the pathogenesis of obesity, diabetes and nonalcoholic fatty liver disease (NAFLD). RECENT FINDINGS:Experimental models highlight several mechanisms connecting gut microbiota to host energy metabolism: ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Musso G,Gambino R,Cassader M

    更新日期:2010-02-01 00:00:00

  • Population specific genetic heterogeneity of familial hypercholesterolemia in South Africa.

    abstract:PURPOSE OF REVIEW:To describe the prevalence and population-specific genetic heterogeneity of familial hypercholesterolemia in South Africa. RECENT FINDINGS:This review highlights the paucity of data on familial hypercholesterolemia in South Africa, and the urgent need to uncover the mutation profiles in lipid-associa...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Smyth N,Ramsay M,Raal FJ

    更新日期:2018-04-01 00:00:00

  • Postprandial lipoprotein metabolism and atherosclerosis.

    abstract::The metabolism of chylomicrons and their remnants is a highly facilitated route to distribute energy from the diet for storage in adipose tissue or immediate use in the muscles. It has been proposed that chylomicron remnants are atherogenic, and a delayed clearance of chylomicron remnants seems to be associated with c...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Karpe F,Hamsten A

    更新日期:1995-06-01 00:00:00

  • Follow-up on primary prevention trials.

    abstract::Recent primary prevention trials demonstrated that cardiovascular morbidity and mortality benefits are not accompanied by adverse effects on overall mortality and morbidity in cohorts representing plasma cholesterol concentrations observed in the bulk of coronary artery disease. During the past year, further analyses ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Marais AD

    更新日期:1998-12-01 00:00:00

  • Progress in the genetics of common obesity: size matters.

    abstract:PURPOSE OF REVIEW:Over the past two decades serious efforts has been invested in the search for genes that predispose to common obesity, but progress has been slow and success limited. Genome-wide association, however, has revived optimism. Here we review recent advances in the field of obesity genetics and discuss the...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Li S,Loos RJ

    更新日期:2008-04-01 00:00:00

  • Novel benefits of peroxisome proliferator-activated receptors on cardiovascular risk.

    abstract:PURPOSE OF REVIEW:This review provides an overview of newly described mechanisms by which peroxisome proliferator-activated receptors (PPARs) (α, γ, and δ) regulate several factors associated with cardiovascular risk. RECENT FINDINGS:PPAR agonists have known effects on plasma lipoprotein levels, inflammation, and insu...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Millar JS

    更新日期:2013-06-01 00:00:00

  • Resident intimal dendritic cells and the initiation of atherosclerosis.

    abstract:PURPOSE OF REVIEW:To highlight the fact that regional differences in the normal arterial intima are critical to atherosclerotic lesion formation driven by systemic risk factors. RECENT FINDINGS:At arterial curvatures, bifurcations and branches unique hemodynamics influence endothelial cell signaling and gene expressio...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Cybulsky MI,Jongstra-Bilen J

    更新日期:2010-10-01 00:00:00

  • Inherited lipodystrophies and hypertriglyceridemia.

    abstract:PURPOSE OF REVIEW:Inherited lipodystrophies are rare autosomal recessive and dominant disorders characterized by selective, but variable, loss of adipose tissue. Marked hypertriglyceridemia is a common feature of these disorders and highlights the role of adipose tissue in lipid homeostasis. In the last decade, advance...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Simha V,Garg A

    更新日期:2009-08-01 00:00:00

  • Molecular genetics of the Smith-Lemli-Opitz syndrome and postsqualene sterol metabolism.

    abstract::The Smith-Lemli-Opitz syndrome is a disorder of morphogenesis resulting from an enzymatic defect in the last step of cholesterol metabolism (reduction of 7-dehydrocholesterol). Analysis of the defective gene and identification of mutations therein have paved the way for the study of the molecular genetics of the disor...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Fitzky BU,Glossmann H,Utermann G,Moebius FF

    更新日期:1999-04-01 00:00:00

  • Lipid-driven immunometabolic responses in atherosclerosis.

    abstract:PURPOSE OF REVIEW:Atherosclerosis is a chronic inflammatory disease in which subendothelial infiltration of lipoproteins leads to inflamed lesions in arteries. Despite improvements in secondary prevention, most cardiovascular events cannot be avoided with current therapies. This review focuses on novel mechanistic insi...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Gisterå A,Ketelhuth DFJ

    更新日期:2018-10-01 00:00:00

  • The role of registries and genetic databases in familial hypercholesterolemia.

    abstract:PURPOSE OF REVIEW:To review how leveraging familial hypercholesterolemia registries can impact molecular genetic research and precision medicine. RECENT FINDINGS:Familial hypercholesterolemia is both much more common and more phenotypically heterogeneous than previously thought with some evidence for significant genot...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Kindt I,Mata P,Knowles JW

    更新日期:2017-04-01 00:00:00

  • Phenotypes, genotypes and response to statin therapy.

    abstract:PURPOSE OF REVIEW:Response to statin treatment can vary widely from person to person as a result of inherited traits (genotype) and acquired characteristics such as obesity (phenotype). The aim of this review is to describe what is known about factors that determine a patient's response, and to offer a mechanism to exp...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Caslake MJ,Packard CJ

    更新日期:2004-08-01 00:00:00

  • Defects of lipoprotein metabolism in familial combined hyperlipidaemia.

    abstract::Familial combined hyperlipidaemia is the most common inherited hyperlipidaemia and is found in up to 10% of patients with premature myocardial infarction. The genetic and metabolic bases of the disorder have not yet been defined. This review discusses the important advances in the past year in our understanding of the...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: de Graaf J,Stalenhoef AF

    更新日期:1998-06-01 00:00:00

  • Exercise and fat accumulation in the human liver.

    abstract:PURPOSE OF REVIEW:Fat accumulation in the liver is strongly associated with metabolic dysfunction. Regular exercise improves many cardiometabolic risks factors; however, its effect on intrahepatic triglyceride (IHTG) content remains elusive. This article summarizes available data regarding the effects of exercise on IH...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Magkos F

    更新日期:2010-12-01 00:00:00

  • Nonalcoholic steatohepatitis: the therapeutic challenge of a global epidemic.

    abstract:PURPOSE OF REVIEW:Nonalcoholic fatty liver (NAFL) and especially its inflammatory variant nonalcoholic steatohepatitis (NASH) have become a major challenge to healthcare systems worldwide because of the increasing prevalence of its major risk factors obesity and type 2 diabetes, which are closely linked to overeating, ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Schattenberg JM,Schuppan D

    更新日期:2011-12-01 00:00:00

  • The effect of dietary cholesterol on macrophage accumulation in adipose tissue: implications for systemic inflammation and atherosclerosis.

    abstract:PURPOSE OF REVIEW:It is well recognized that adipose tissue in obesity is characterized by macrophage accumulation and local inflammation. This review summarizes current evidence regarding dietary cholesterol on adipose tissue macrophage accrual, systemic inflammation and its potential link to atherosclerosis. RECENT ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Subramanian S,Chait A

    更新日期:2009-02-01 00:00:00

  • The molecular basis of abetalipoproteinemia.

    abstract::Abetalipoproteinemia is a recessive genetic disease in humans characterized by the virtual absence of apolipoprotein (apo)B and apoB-containing lipoproteins in plasma. Microsomal triglyceride transfer protein (MTP), a resident lipid transfer protein within the endoplasmic reticulum of hepatocytes and enterocytes, has ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Gregg RE,Wetterau JR

    更新日期:1994-04-01 00:00:00

  • ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins.

    abstract::Lipid-poor apolipoproteins remove cellular cholesterol and phospholipids by an active transport pathway controlled by an ATP binding cassette transporter called ABCA1 (formerly ABC1). Mutations in ABCA1 cause Tangier disease, a severe HDL deficiency syndrome characterized by a rapid turnover of plasma apolipoprotein A...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Oram JF,Vaughan AM

    更新日期:2000-06-01 00:00:00

  • Estrogens, lipoproteins, and cardiovascular risk factors: an update following the randomized placebo-controlled trials of hormone-replacement therapy.

    abstract:PURPOSE OF REVIEW:The effects of hormone-replacement therapy on cardiovascular risk factors are examined. In an attempt to explain the results of recent randomized controlled trials in which no benefit of hormone-replacement therapy for postmenopausal women has been observed, RECENT FINDINGS:Changes in lipoproteins in...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Seed M,Knopp RH

    更新日期:2004-08-01 00:00:00

  • Circulating oxidized LDL: a biomarker and a pathogenic factor.

    abstract:PURPOSE OF REVIEW:Oxidized LDL (oxLDL) contributes to many atherogenic steps in the vascular wall, but the significance of oxLDL in circulating blood remains unclear. Recent progress in procedures for measuring both human and murine oxLDL has provided growing evidence of the importance of circulating oxLDL. RECENT FIN...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Ishigaki Y,Oka Y,Katagiri H

    更新日期:2009-10-01 00:00:00

  • Nutrition, nonalcoholic fatty liver disease and the microbiome: recent progress in the field.

    abstract:PURPOSE OF REVIEW:Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and it has overlapping pathogenesis with diabetes and cardiovascular disease. Reviewed here are recent advances in understanding the contribution of diet and selected nutrients to NAFLD. RECENT FINDINGS:To und...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Vos MB

    更新日期:2014-02-01 00:00:00

  • The role of apolipoprotein A-I-containing lipoproteins in atherosclerosis.

    abstract::The inverse relationship between HDL and apolipoprotein A-I concentrations and the risk for premature atherosclerosis is well established, but the mechanism whereby apolipoprotein A-I offers protection is still somewhat elusive. Recent studies suggest that a specific subpopulation within the lipoprotein (AI) subclass ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Forte TM,McCall MR

    更新日期:1994-10-01 00:00:00

  • Oxidized phospholipids as modulators of inflammation in atherosclerosis.

    abstract:PURPOSE OF REVIEW:This review will summarize recent evidence demonstrating that biologically active phospholipid oxidation products modulate inflammatory reactions. RECENT FINDINGS:Structural identification of new biologically active oxidized phospholipids and the finding that they can also be formed at inflammatory s...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Leitinger N

    更新日期:2003-10-01 00:00:00

  • Phenotype vs. genotype in severe familial hypercholesterolemia: what matters most for the clinician?

    abstract:PURPOSE OF REVIEW:Familial hypercholesterolemia is associated with a high lifetime risk of atherosclerotic cardiovascular disease (ASCVD). However, this risk is variable. This review evaluates recent evidence related to ASCVD risk stratification in familial hypercholesterolemia considering aspects of phenotype and geno...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Santos RD

    更新日期:2017-04-01 00:00:00

  • Lowering LDL-cholesterol through diet: potential role in the statin era.

    abstract:PURPOSE OF REVIEW:A healthy diet should be rich in vegetables and fruits, whole-grain, high-fiber foods, and fish and should contain a small amount of saturated and trans fats. In addition to these recommendations, some food ingredients such as plant sterol/stanol soy protein and isoflavones may help reduce cholesterol...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Bruckert E,Rosenbaum D

    更新日期:2011-02-01 00:00:00

  • What have we learnt from the clinical outcomes trials with the cetrapibs?

    abstract:PURPOSE OF REVIEW:The current review considers what we have learnt from the clinical outcome trials with the cetrapibs; the inhibitors of cholesteryl ester transfer protein that increase HDL cholesterol levels; torcetrapib, dalcetrapib, evacetrapib and anacetrapib. RECENT FINDINGS:Although an off-target increase in bl...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Doggrell SA

    更新日期:2018-08-01 00:00:00

  • Folate and coronary heart disease.

    abstract::Low folate intake is an important determinant of elevated blood levels of homocysteine. Because elevated homocysteine has been shown to be a possible graded risk factor for CHD, sufficient folate intake may be important in the prevention of CHD. The magnitude of the association between folate and CHD is consistent wit...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Verhoef P,Stampfer MJ,Rimm EB

    更新日期:1998-02-01 00:00:00

  • Hyperlipidaemia and cardiovascular disease: do fibrates have a role?

    abstract:PURPOSE OF REVIEW:Fibrates continue to be a viable treatment option for mixed atherogenic dyslipidemia, and recent reports from clinical studies have shed new light on the therapeutic utility of fibrates for the prevention of microvascular and macrovascular disease, especially in combination with statins. RECENT FINDI...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Saha SA,Arora RR

    更新日期:2011-08-01 00:00:00

  • Role of microRNA-30c in lipid metabolism, adipogenesis, cardiac remodeling and cancer.

    abstract:PURPOSE OF REVIEW:To summarize the role of the microRNA-30c (miR-30c) in lipid metabolism and adipogenesis, to address consequences associated with reduced expression in cancer and cardiac function, and to speculate benefits of overexpressing miR-30c in the treatment of hyperlipidemia, atherosclerosis, and cancer. REC...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Irani S,Hussain MM

    更新日期:2015-04-01 00:00:00