Hypobetalipoproteinemia and abetalipoproteinemia: liver disease and cardiovascular disease.

abstract：PURPOSE OF REVIEW:The metabolic syndrome has become a leading health concern in developed countries. In the search for strategies to combat this growing problem, stearoyl-CoA desaturase 1 (SCD1) inhibition has been proposed as an attractive therapeutic strategy. However, recent studies warn of potentially harmful conse...

journal_title：Current opinion in lipidology

authors： Brown JM,Rudel LL

更新日期：2010-06-01 00:00:00

abstract：:The most likely cholesterol-raising factors in unfiltered coffee are kahweol and cafestol. Different brewing methods alter the concentrations of these diterpenes and have caused discrepant results in studies from different parts of the world. The effect of tea on the risk of coronary heart disease is much less clear b...

journal_title：Current opinion in lipidology

authors： Thelle DS

更新日期：1995-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Cardiovascular risk scoring is incorporated in guidelines and recommended for targeting preventive treatment. Evidence is required on the most appropriate method, its accuracy in a given population, and its effectiveness in favourably influencing clinical behaviour and health outcomes. RECENT FINDING...

journal_title：Current opinion in lipidology

authors： Beswick A,Brindle P

更新日期：2006-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an update on clinical trials of gene therapy for atherosclerotic cardiovascular disease published since 1 August 2001 and summarize the general advantages and potential problems of gene transfer in these disorders. RECENT FINDINGS:There are two major areas in which gene therapy has entered...

journal_title：Current opinion in lipidology

authors： Freedman SB

更新日期：2002-12-01 00:00:00

abstract：:Common variants at the apolipoprotein B gene locus are associated with hyperlipidaemia, but conflicting data have been presented in the literature concerning the size of the effects and which polymorphisms give the best signal in the different groups of individuals studied. In this review, we will present a critique o...

journal_title：Current opinion in lipidology

authors： Humphries SE,Talmud PJ

更新日期：1995-08-01 00:00:00

abstract：:Basic research has provided strong evidence that oxidation of LDL plays an important role in the pathogenesis of atherosclerosis. Several mechanisms have been identified which can lead to LDL oxidation in vivo. Clinical and epidemiological studies have provided circumstantial evidence that oxidized LDL, as measured by...

journal_title：Current opinion in lipidology

authors： Ylä-Herttuala S

更新日期：1998-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights recent advances in eicosanoid biology, especially linked to the cytochrome P450 (CYP)/soluble epoxide hydrolase (sEH) axis in vascular biology and disease. RECENT FINDINGS:Since the first reports that CYP-derived metabolites of arachidonic acid can elicit vascular smooth muscle...

journal_title：Current opinion in lipidology

authors： Fleming I

更新日期：2011-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Accumulating evidence has provided new insights regarding potentially effective therapeutic options targeting modulation of HDL metabolism, resulting in the prevention of cardiovascular diseases. The gut microbiota has now been convincingly linked to host health, but its impact on host lipid metabolis...

journal_title：Current opinion in lipidology

authors： Nakaya K,Ikewaki K

更新日期：2018-02-01 00:00:00

abstract：:The ability of the apolipoprotein E-deficient mouse to develop spontaneous atherosclerosis, which resembles the human process, is an excellent model in which to assess the impact of dietary factors. This review discusses the role of several nutrients in the development of atherosclerosis and the mechanisms through whi...

journal_title：Current opinion in lipidology

authors： Osada J,Joven J,Maeda N

更新日期：2000-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines recent evidence proposing that lipids and lipoproteins can act as nuclear factors regulating chromatin structure. These novel data broaden our understanding of the mechanisms by which lipoproteins can affect basic biological phenomena such as transcription, genome stability, and c...

journal_title：Current opinion in lipidology

authors： Zaina S,Døssing KB,Lindholm MW,Lund G

更新日期：2005-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The 3-hydroxy-3-methylglutaryl-coenzyme-A reductase inhibitors, or statins, have been shown to reduce cardiovascular morbidity and mortality among a wide spectrum of patients with established atherosclerotic vascular disease. Mounting experimental and clinical evidence also suggest a potential benefit...

journal_title：Current opinion in lipidology

authors： Pham M,Oka RK,Giacomini JC

更新日期：2005-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Lowering LDL cholesterol (LDL-C) reduces vascular risk. Current guidelines recommend initiating statin therapy in patients with a yearly coronary heart disease risk of around 1.5-2%, and most clinicians prescribe standard statin regimens (e.g. 40 mg simvastatin daily). However, there is some uncertain...

journal_title：Current opinion in lipidology

authors： Bulbulia R,Armitage J

更新日期：2012-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The review presents recent developments in the identification of specialized proresolving mediators (SPMs) of inflammation following supplementation with n-3 fatty acids in humans. RECENT FINDINGS:A number of reports have measured SPMs in human plasma after n-3 fatty acid supplementation. Although st...

journal_title：Current opinion in lipidology

authors： Barden AE,Mas E,Mori TA

更新日期：2016-02-01 00:00:00

abstract：:In many individuals, LDL-cholesterol levels rise following increased consumption of dietary cholesterol or saturated and trans-monounsaturated fatty acids. In others, a reduction of cholesterogenesis fully compensates for these effects. In responding individuals, much of the increase in LDL-cholesterol observed may re...

journal_title：Current opinion in lipidology

authors： Fielding CJ

更新日期：1997-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review is to present the latest findings on the role of the circadian clock in the control of metabolism, and the therapeutic potential of chronotherapy to regulate energy homeostasis in humans. RECENT FINDINGS:We summarized the recent advances related to circadian clock regulation of...

journal_title：Current opinion in lipidology

authors： Dollet L,Pendergrast LA,Zierath JR

更新日期：2021-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Unregulated uptake of oxidized LDL by macrophages to form foam cells is the hallmark for atherosclerosis. The paraoxonase (PON) family of enzymes plays a critical role in attenuating atherosclerotic lesion formation by hydrolyzing lipid peroxides (LOOHs) and preventing the oxidation of LDL particles a...

journal_title：Current opinion in lipidology

authors： White CR,Anantharamaiah GM

更新日期：2017-10-01 00:00:00

abstract：PURPOSE OF REVIEW:It is increasingly recognized that profound metabolic changes occur in activated myeloid cells, which shape their inflammatory phenotype and cellular functions. The purpose of this review is to summarize the accumulating evidence that major metabolic adaptations occur in monocytes and macrophages in t...

journal_title：Current opinion in lipidology

authors： Riksen NP,Stienstra R

更新日期：2018-10-01 00:00:00

abstract：:PURPOSE OF REVIEW This review discusses recent progress in the role of ATP-binding cassette proteins ABCG5 and G8 in dietary sterol absorption, excretion and pathogenesis of cardiovascular disease. RECENT FINDINGS Identification of the genetic defect(s) underlying sitosterolemia has led to a renewed interest in the me...

journal_title：Current opinion in lipidology

authors： Klett EL,Patel S

更新日期：2003-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Atherosclerosis is a chronic inflammatory disease in which subendothelial infiltration of lipoproteins leads to inflamed lesions in arteries. Despite improvements in secondary prevention, most cardiovascular events cannot be avoided with current therapies. This review focuses on novel mechanistic insi...

journal_title：Current opinion in lipidology

authors： Gisterå A,Ketelhuth DFJ

更新日期：2018-10-01 00:00:00

abstract：:The recent discovery of a second estrogen receptor subtype, estrogen receptor-beta, may significantly advance our understanding of tissue specific effects of estrogenic compounds, both natural and synthetic. Although specific effects mediated by estrogen receptor beta in vivo remain to be elucidated, hypothetically th...

journal_title：Current opinion in lipidology

authors： Cassidy A

更新日期：1999-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Nonalcoholic fatty liver (NAFL) and especially its inflammatory variant nonalcoholic steatohepatitis (NASH) have become a major challenge to healthcare systems worldwide because of the increasing prevalence of its major risk factors obesity and type 2 diabetes, which are closely linked to overeating, ...

journal_title：Current opinion in lipidology

authors： Schattenberg JM,Schuppan D

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides a concise update of the involvement of endothelial adhesion molecules in atherogenesis, an overview of current advances in the development of adhesion molecule blocking agents, as well as an insight into the potential of these molecules in cardiovascular therapy. RECENT FINDINGS:...

journal_title：Current opinion in lipidology

authors： Lutters BC,Leeuwenburgh MA,Appeldoorn CC,Molenaar TJ,Van Berkel TJ,Biessen EA

更新日期：2004-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Because human genetic studies and large clinical trials have demonstrated that HDL-cholesterol levels are not causally related to cardiovascular disease risk, attention has shifted toward the functional properties of HDL. Infusion of HDL mimetics containing apolipoprotein A-I remains a potential strat...

journal_title：Current opinion in lipidology

authors： Zheng KH,Stroes ES

更新日期：2016-12-01 00:00:00

abstract：:Rather than a link in a causal chain leading to hypertension, insulin resistance and resultant hyperinsulinemia may be 'spokes on a wheel', with central or visceral obesity as the postulated hub of the wheel. Hypertension, hypertriglyceridemia and high density lipoprotein cholesterol are depicted as other spokes. Newl...

journal_title：Current opinion in lipidology

authors： Hopkins PN,Hunt SC,Wu LL,Williams GH,Williams RR

更新日期：1996-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The interest for the human HDL system was recently revived by the identification of the ABCA1 as a critical component in the formation and maintenance of plasma HDL levels. The present review focuses on recent progress in our understanding of the basic mechanisms underlying HDL biogenesis pathways. R...

journal_title：Current opinion in lipidology

authors： Krimbou L,Marcil M,Genest J

更新日期：2006-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The endoplasmic reticulum (ER) maintains cellular metabolic homeostasis by coordinating protein synthesis, secretion activities, lipid biosynthesis and calcium (Ca²⁺) storage. In this review, we will discuss how altered ER homeostasis contributes to dysregulation of hepatic lipid metabolism and contri...

journal_title：Current opinion in lipidology

authors： Wang S,Kaufman RJ

更新日期：2014-04-01 00:00:00

abstract：:The microsomal triglyceride transfer protein is necessary for the assembly and secretion of lipoproteins containing apolipoprotein B. During the past year, significant progress has been made towards understanding the role of microsomal triglyceride transfer protein in lipoprotein assembly at both a cellular and molecu...

journal_title：Current opinion in lipidology

authors： Gordon DA

更新日期：1997-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and it has overlapping pathogenesis with diabetes and cardiovascular disease. Reviewed here are recent advances in understanding the contribution of diet and selected nutrients to NAFLD. RECENT FINDINGS:To und...

journal_title：Current opinion in lipidology

authors： Vos MB

更新日期：2014-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Dietary and blood carotenoids, including alpha-carotene, beta-carotene, lycopene, lutein/zeaxanthin, and beta-cryptoxanthin, have been examined in a number of epidemiological studies in recent years for the risk of cardiovascular disease. This review assimilated the existing and recent literature on c...

journal_title：Current opinion in lipidology

authors： Sesso HD

更新日期：2006-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Familial hypercholesterolaemia is a hereditary disorder of lipoprotein metabolism which causes a lifelong increase in LDL-C levels resulting in premature coronary heart disease. The present review looks at some of the recent literature on how molecular methods can be used to assist in the definitive d...

journal_title：Current opinion in lipidology

authors： Graham CA,Latten MJ,Hart PJ

更新日期：2017-08-01 00:00:00