GPIHBP1 and lipolysis: an update.

abstract：PURPOSE OF REVIEW:Unregulated uptake of oxidized LDL by macrophages to form foam cells is the hallmark for atherosclerosis. The paraoxonase (PON) family of enzymes plays a critical role in attenuating atherosclerotic lesion formation by hydrolyzing lipid peroxides (LOOHs) and preventing the oxidation of LDL particles a...

journal_title：Current opinion in lipidology

authors： White CR,Anantharamaiah GM

更新日期：2017-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Mesenchymal stem cells (or multipotent stromal cells) are emerging as a potent cell type for cardiac cell therapy. This review describes the potential of cardiac mesenchymal stem cell therapy, but also highlights some recently discovered less favorable mesenchymal stem cell characteristics. RECENT FI...

journal_title：Current opinion in lipidology

authors： Atsma DE,Fibbe WE,Rabelink TJ

更新日期：2007-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Nutrition recommendations emphasize that not only dietary fat quantity but also fat quality plays a role in the prevention of type 2 diabetes (T2D). The aim of this review is to summarize the evidence for dietary fat and risk of T2D, to highlight recent findings and point out future research direction...

journal_title：Current opinion in lipidology

authors： Schlesinger S,Schwingshackl L,Neuenschwander M

更新日期：2019-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the role of the microRNA-30c (miR-30c) in lipid metabolism and adipogenesis, to address consequences associated with reduced expression in cancer and cardiac function, and to speculate benefits of overexpressing miR-30c in the treatment of hyperlipidemia, atherosclerosis, and cancer. REC...

journal_title：Current opinion in lipidology

authors： Irani S,Hussain MM

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Genetic LCAT deficiency is a rare metabolic disorder characterized by low-plasma HDL cholesterol levels. Clinical manifestations of the disease include corneal opacification, anemia, and renal disease, which represents the major cause of morbidity and mortality in carriers. RECENT FINDINGS:Biochemica...

journal_title：Current opinion in lipidology

authors： Pavanello C,Calabresi L

更新日期：2020-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Remnant lipoproteins that persist in the bloodstream after each meal have become increasingly important contributors to atherosclerotic vascular disease, owing to the spread of overnutrition, underexertion, obesity, insulin resistance, and type 2 diabetes. Here, we review recent work that clarified lo...

journal_title：Current opinion in lipidology

authors： Williams KJ,Chen K

更新日期：2010-06-01 00:00:00

abstract：:HDL protects LDL from oxidative damage known to contribute to the onset and progression of atherosclerosis. This antioxidant protection by HDL is mediated by intrinsic hydrolytic enzyme systems, by accelerated selective uptake of lipid peroxides from HDL and by antioxidant molecules. Oxidative damage suffered by HDL a...

journal_title：Current opinion in lipidology

authors： Banka CL

更新日期：1996-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Peroxisome proliferator-activated receptors alpha, beta/delta and gamma are members of the nuclear receptor superfamily. They mediate the effects of fatty acids and their derivatives at the transcriptional level, and are considered to be lipid sensors that participate in the regulation of energy homeo...

journal_title：Current opinion in lipidology

authors： Michalik L,Desvergne B,Wahli W

更新日期：2003-04-01 00:00:00

abstract：:The development of atherosclerosis in animal models and the incidence of coronary heart disease in postmenopausal women are markedly reduced by estrogen treatment. Estrogen have acute beneficial effects on vascular reactivity and longer-term effects on critical steps in the pathogenesis of atherosclerosis. Phytoestrog...

journal_title：Current opinion in lipidology

authors： St Clair RW

更新日期：1998-10-01 00:00:00

abstract：PURPOSE OF REVIEW:In recent years, many of the concerns surrounding the glycemic index have been addressed by methodological studies and clinical trials comparing diets carefully matched for other nutrients. These findings are reviewed together with new observational evidence for the role of the dietary glycemic index ...

journal_title：Current opinion in lipidology

authors： Brand-Miller J,Buyken AE

更新日期：2012-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Dysregulated lipoprotein metabolism leads to increased plasma concentrations of atherogenic lipoproteins. We highlight the findings from recent studies of the effect of lipid-regulating therapies on apolipoprotein metabolism in humans employing endogenous labelling with stable isotopically labelled is...

journal_title：Current opinion in lipidology

authors： Chan DC,Barrett PH,Watts GF

更新日期：2016-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Hypoxia triggers various cellular processes, both in physiological and pathological conditions, and has recently also been implicated in atherosclerosis. This review summarizes the recent evidence for the presence and the role of hypoxia in atherosclerosis. Additionally, it will elucidate on hypoxic s...

journal_title：Current opinion in lipidology

authors： Marsch E,Sluimer JC,Daemen MJ

更新日期：2013-10-01 00:00:00

abstract：:The plasminogen and coagulation systems have been extensively characterized at the biochemical level. Recent gene targeting and gene transfer studies have provided novel insights into their role in the formation of blood vessels and in the pathogenesis of blood vessel disorders including thrombosis, restenosis and ath...

journal_title：Current opinion in lipidology

authors： Carmeliet P,Collen D

更新日期：1997-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic consumption of fructose and fructose-containing sugars leads to dyslipidemia. Apolipoprotein (apo) CIII is strongly associated with elevated levels of triglycerides and cardiovascular disease risk. We reviewed the effects of fructose consumption on apoCIII levels and the role of apoCIII in fru...

journal_title：Current opinion in lipidology

authors： Hieronimus B,Stanhope KL

更新日期：2020-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To review how leveraging familial hypercholesterolemia registries can impact molecular genetic research and precision medicine. RECENT FINDINGS:Familial hypercholesterolemia is both much more common and more phenotypically heterogeneous than previously thought with some evidence for significant genot...

journal_title：Current opinion in lipidology

authors： Kindt I,Mata P,Knowles JW

更新日期：2017-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease (CVD) and calcific aortic valve stenosis. We review recent studies that highlight Lp(a) in CVD and calcific aortic valve stenosis and propose pathways to clinical registration of Lp(a)-lowering agents. RECENT FINDINGS:Over the last fe...

journal_title：Current opinion in lipidology

authors： Hung MY,Tsimikas S

更新日期：2014-12-01 00:00:00

abstract：:Recent epidemiological data have reaffirmed that elevated plasma triglyceride and low HDL-cholesterol levels are important risk factors for atherosclerotic vascular disease. The rationale for the clinical use of fibric acid derivatives, which are designed to correct this metabolic nexus, is now on firmer ground. The m...

journal_title：Current opinion in lipidology

authors： Watts GF,Dimmitt SB

更新日期：1999-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Substantial risk of ASCVD events persists despite intensive statin therapy and other agents to lower LDL-C. The optimal way to address other elements of dyslipidemia, such as triglyceride-rich particles (TRL) and when to treat has remained unclear. RECENT FINDINGS:Several lines of evidence indicate t...

journal_title：Current opinion in lipidology

authors： Ganda OP

更新日期：2020-08-01 00:00:00

abstract：:The microsomal triglyceride transfer protein is necessary for the assembly and secretion of lipoproteins containing apolipoprotein B. During the past year, significant progress has been made towards understanding the role of microsomal triglyceride transfer protein in lipoprotein assembly at both a cellular and molecu...

journal_title：Current opinion in lipidology

authors： Gordon DA

更新日期：1997-06-01 00:00:00

abstract：PURPOSE OF REVIEW:It is well recognized that adipose tissue in obesity is characterized by macrophage accumulation and local inflammation. This review summarizes current evidence regarding dietary cholesterol on adipose tissue macrophage accrual, systemic inflammation and its potential link to atherosclerosis. RECENT ...

journal_title：Current opinion in lipidology

authors： Subramanian S,Chait A

更新日期：2009-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Bile acid sequestrants (BAS) have been used for more than 50 years in the treatment of hypercholesterolemia. The last decade, bile acids are emerging as integrated regulators of metabolism via induction of various signal transduction pathways. Consequently, BAS treatment may exert unexpected side-effe...

journal_title：Current opinion in lipidology

authors： Out C,Groen AK,Brufau G

更新日期：2012-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review addresses a syndrome of dyslipidemia and lipodystrophy that has emerged in HIV-infected patients receiving highly active antiretroviral therapy (HAART). The term 'HIV/HAART associated dyslipidemic lipodystrophy (HADL)' describes this syndrome. Although HAART increases patient survival rate...

journal_title：Current opinion in lipidology

authors： Balasubramanyam A,Sekhar RV,Jahoor F,Jones PH,Pownall HJ

更新日期：2004-02-01 00:00:00

abstract：:The most likely cholesterol-raising factors in unfiltered coffee are kahweol and cafestol. Different brewing methods alter the concentrations of these diterpenes and have caused discrepant results in studies from different parts of the world. The effect of tea on the risk of coronary heart disease is much less clear b...

journal_title：Current opinion in lipidology

authors： Thelle DS

更新日期：1995-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The antioxidant activity of high-density lipoprotein is largely due to the paraoxonase 1 located on it. Experiments with transgenic paraoxonase 1 knock-out mice indicate the potential for this enzyme to protect against atherogenesis. This effect of high-density lipoprotein in decreasing low-density li...

journal_title：Current opinion in lipidology

authors： Mackness B,Durrington PN,Mackness MI

更新日期：2002-08-01 00:00:00

abstract：PURPOSE OF REVIEW:In the last 2 years, significant advances in the understanding of HDL particle structure and the associations between particle structure, function, and atherosclerosis have been made. We will review and provide clinical and epidemiological context to these recent advances. RECENT FINDINGS:Several rec...

journal_title：Current opinion in lipidology

authors： Wilkins JT,Seckler HS

更新日期：2019-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this study was to briefly summarize the contribution of the PREDIMED (PREvención con DIeta MEDiterránea) trial on cardiovascular evidence and examine in depth its groundbreaking trajectory.PREDIMED was conducted during 2003-2010 and represented the largest primary prevention trial ever test...

journal_title：Current opinion in lipidology

authors： Fernández-Lázaro CI,Ruiz-Canela M,Martínez-González MÁ

更新日期：2021-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an update on recent mechanistic and clinical trial data related to the actions and efficacy of niacin. RECENT FINDINGS:Recent mechanistic studies have provided novel insights regarding the mechanism of action of niacin. Studies of the purported niacin receptor, GPR109A, indicate that niaci...

journal_title：Current opinion in lipidology

authors： Ginsberg HN,Reyes-Soffer G

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Low HDL cholesterol and hypertriglyceridemia as well as lowering of LDL cholesterol with statins increase the risk of T2DM. We discuss the recent findings on the effects of lipoproteins and cholesterol on the function and survival of pancreatic β-cells as well as on obesity and insulin sensitivity of ...

journal_title：Current opinion in lipidology

authors： von Eckardstein A,Sibler RA

更新日期：2011-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on proof-of-principle experiments providing validation of new targets for the development of RNA interference-based therapeutics for dyslipidemia. RECENT FINDINGS:Over the past few years, RNA interference has become an accepted approach to manipulate gene expression in mammalian s...

journal_title：Current opinion in lipidology

authors： Rondinone CM

更新日期：2008-06-01 00:00:00

abstract：:Common variants at the apolipoprotein B gene locus are associated with hyperlipidaemia, but conflicting data have been presented in the literature concerning the size of the effects and which polymorphisms give the best signal in the different groups of individuals studied. In this review, we will present a critique o...

journal_title：Current opinion in lipidology

authors： Humphries SE,Talmud PJ

更新日期：1995-08-01 00:00:00