Long-term follow-up of lipid-lowering trials.

abstract：PURPOSE OF REVIEW:The aim of this review is to present the latest findings on the role of the circadian clock in the control of metabolism, and the therapeutic potential of chronotherapy to regulate energy homeostasis in humans. RECENT FINDINGS:We summarized the recent advances related to circadian clock regulation of...

journal_title：Current opinion in lipidology

authors： Dollet L,Pendergrast LA,Zierath JR

更新日期：2021-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Dysregulated lipoprotein metabolism leads to increased plasma concentrations of atherogenic lipoproteins. We highlight the findings from recent studies of the effect of lipid-regulating therapies on apolipoprotein metabolism in humans employing endogenous labelling with stable isotopically labelled is...

journal_title：Current opinion in lipidology

authors： Chan DC,Barrett PH,Watts GF

更新日期：2016-12-01 00:00:00

abstract：:PURPOSE OF REVIEW This review discusses recent progress in the role of ATP-binding cassette proteins ABCG5 and G8 in dietary sterol absorption, excretion and pathogenesis of cardiovascular disease. RECENT FINDINGS Identification of the genetic defect(s) underlying sitosterolemia has led to a renewed interest in the me...

journal_title：Current opinion in lipidology

authors： Klett EL,Patel S

更新日期：2003-08-01 00:00:00

abstract：:Recent epidemiological data have reaffirmed that elevated plasma triglyceride and low HDL-cholesterol levels are important risk factors for atherosclerotic vascular disease. The rationale for the clinical use of fibric acid derivatives, which are designed to correct this metabolic nexus, is now on firmer ground. The m...

journal_title：Current opinion in lipidology

authors： Watts GF,Dimmitt SB

更新日期：1999-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Inflammation has been widely acknowledged to contribute throughout all stages of atherogenesis. However, these recent advances in our understanding have not been translated into clinical practice in which the mainstay of treatment is still lipid-targeted therapy. This review provides an overview of pr...

journal_title：Current opinion in lipidology

authors： van der Valk FM,van Wijk DF,Stroes ES

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Several mutations in the apolipoprotein (apo) B, proprotein convertase subtilisin kexin 9 (PCSK9) and microsomal triglyceride transfer protein genes result in low or absent levels of apoB and LDL cholesterol (LDL-C) in plasma which cause familial hypobetalipoproteinemia (FHBL) and abetalipoproteinemia...

journal_title：Current opinion in lipidology

authors： Welty FK

更新日期：2020-04-01 00:00:00

abstract：:Rather than a link in a causal chain leading to hypertension, insulin resistance and resultant hyperinsulinemia may be 'spokes on a wheel', with central or visceral obesity as the postulated hub of the wheel. Hypertension, hypertriglyceridemia and high density lipoprotein cholesterol are depicted as other spokes. Newl...

journal_title：Current opinion in lipidology

authors： Hopkins PN,Hunt SC,Wu LL,Williams GH,Williams RR

更新日期：1996-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the prevalence and population-specific genetic heterogeneity of familial hypercholesterolemia in South Africa. RECENT FINDINGS:This review highlights the paucity of data on familial hypercholesterolemia in South Africa, and the urgent need to uncover the mutation profiles in lipid-associa...

journal_title：Current opinion in lipidology

authors： Smyth N,Ramsay M,Raal FJ

更新日期：2018-04-01 00:00:00

abstract：:The Scandinavian Simvastatin Survival Study showed that a 35% decrease in LDL-cholesterol was accompanied by a 42% reduction in coronary mortality. Even if the period of time is longer than 1 year for the divergence of survival curves in the simvastatin and placebo groups there are reasons to believe that the benefici...

journal_title：Current opinion in lipidology

authors： Olsson AG,Pedersen T,Bergdahl B

更新日期：1995-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Unregulated uptake of oxidized LDL by macrophages to form foam cells is the hallmark for atherosclerosis. The paraoxonase (PON) family of enzymes plays a critical role in attenuating atherosclerotic lesion formation by hydrolyzing lipid peroxides (LOOHs) and preventing the oxidation of LDL particles a...

journal_title：Current opinion in lipidology

authors： White CR,Anantharamaiah GM

更新日期：2017-10-01 00:00:00

abstract：:The microsomal triglyceride transfer protein is necessary for the assembly and secretion of lipoproteins containing apolipoprotein B. During the past year, significant progress has been made towards understanding the role of microsomal triglyceride transfer protein in lipoprotein assembly at both a cellular and molecu...

journal_title：Current opinion in lipidology

authors： Gordon DA

更新日期：1997-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Fibrates continue to be a viable treatment option for mixed atherogenic dyslipidemia, and recent reports from clinical studies have shed new light on the therapeutic utility of fibrates for the prevention of microvascular and macrovascular disease, especially in combination with statins. RECENT FINDI...

journal_title：Current opinion in lipidology

authors： Saha SA,Arora RR

更新日期：2011-08-01 00:00:00

abstract：:The metabolism of chylomicrons and their remnants is a highly facilitated route to distribute energy from the diet for storage in adipose tissue or immediate use in the muscles. It has been proposed that chylomicron remnants are atherogenic, and a delayed clearance of chylomicron remnants seems to be associated with c...

journal_title：Current opinion in lipidology

authors： Karpe F,Hamsten A

更新日期：1995-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Fat accumulation in the liver is strongly associated with metabolic dysfunction. Regular exercise improves many cardiometabolic risks factors; however, its effect on intrahepatic triglyceride (IHTG) content remains elusive. This article summarizes available data regarding the effects of exercise on IH...

journal_title：Current opinion in lipidology

authors： Magkos F

更新日期：2010-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The current review considers what we have learnt from the clinical outcome trials with the cetrapibs; the inhibitors of cholesteryl ester transfer protein that increase HDL cholesterol levels; torcetrapib, dalcetrapib, evacetrapib and anacetrapib. RECENT FINDINGS:Although an off-target increase in bl...

journal_title：Current opinion in lipidology

authors： Doggrell SA

更新日期：2018-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Sortilin, encoded SORT1 gene at chromosome 1p13.3, is a multiligand receptor that traffics protein from the Golgi to the endosomes, secretory vesicles, and the cell surface. Genome-wide association studies (GWAS) revealed an association between sortilin and reduced plasma LDL-cholesterol (LDL-C) as we...

journal_title：Current opinion in lipidology

authors： Conlon DM

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights the recent key advances in our understanding of the role of phospholipid transfer protein in lipid and lipoprotein metabolism. RECENT FINDINGS:The overexpression of human phospholipid transfer protein in mice is associated with an increase in atherosclerosis. This is consistent...

journal_title：Current opinion in lipidology

authors： Albers JJ,Cheung MC

更新日期：2004-06-01 00:00:00

abstract：PURPOSE OF REVIEW:As the incidence of obesity and the metabolic syndrome has increased, research has focused on the importance of the endocannabinoid system in the brain and peripheral tissues. Rimonabant, an inverse agonist of the CB1 receptor is being used therapeutically. This review presents recent advances in endo...

journal_title：Current opinion in lipidology

authors： Jesudason D,Wittert G

更新日期：2008-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Homozygous familial hypercholesterolemia (HoFH) is a rare disorder associated with early atherosclerotic disease due to impairment of the LDL receptor (LDLR) pathway. Because of their molecular defect, current treatment options have limited success in bringing HoFH patient to LDL-C target and morbidit...

journal_title：Current opinion in lipidology

authors： Bajaj A,Cuchel M

更新日期：2020-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The interest for the human HDL system was recently revived by the identification of the ABCA1 as a critical component in the formation and maintenance of plasma HDL levels. The present review focuses on recent progress in our understanding of the basic mechanisms underlying HDL biogenesis pathways. R...

journal_title：Current opinion in lipidology

authors： Krimbou L,Marcil M,Genest J

更新日期：2006-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Capsaicin and its nonpungent analog (capsinoids) are known to be food ingredients that increase energy expenditure and decrease body fat. This article reviews the role of brown adipose tissue (BAT) for the thermogenic effect of these compounds in humans and proposes the possibility of some other antio...

journal_title：Current opinion in lipidology

authors： Saito M,Yoneshiro T

更新日期：2013-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an update on recent mechanistic and clinical trial data related to the actions and efficacy of niacin. RECENT FINDINGS:Recent mechanistic studies have provided novel insights regarding the mechanism of action of niacin. Studies of the purported niacin receptor, GPR109A, indicate that niaci...

journal_title：Current opinion in lipidology

authors： Ginsberg HN,Reyes-Soffer G

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Fatty acid transport proteins are a family of proteins involved in fatty acid uptake and activation. This review summarizes recent progress in elucidating the function of fatty acid transport proteins. RECENT FINDINGS:Recent experiments clearly establish FATP1 as a regulated fatty acid transporter in...

journal_title：Current opinion in lipidology

authors： Gimeno RE

更新日期：2007-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will provide an update on the structure of GPIHBP1, a 28-kDa glycosylphosphatidylinositol-anchored glycoprotein, and its role in the lipolytic processing of triglyceride-rich lipoproteins. RECENT FINDINGS:Gpihbp1 knockout mice on a chow diet have milky plasma and plasma triglyceride level...

journal_title：Current opinion in lipidology

authors： Beigneux AP,Weinstein MM,Davies BS,Gin P,Bensadoun A,Fong LG,Young SG

更新日期：2009-06-01 00:00:00

abstract：:Coronary heart disease is the leading cause of death in the developed world. Current surgical and pharmacological interventions are essentially palliative and interest in preventive strategies, particularly through nutrition and avoidance of tobacco has increased in recent years. Basic scientific, clinical and epidemi...

journal_title：Current opinion in lipidology

authors： Graham IM,O'Callaghan P

更新日期：2000-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Oxidized LDL (oxLDL) contributes to many atherogenic steps in the vascular wall, but the significance of oxLDL in circulating blood remains unclear. Recent progress in procedures for measuring both human and murine oxLDL has provided growing evidence of the importance of circulating oxLDL. RECENT FIN...

journal_title：Current opinion in lipidology

authors： Ishigaki Y,Oka Y,Katagiri H

更新日期：2009-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Statins are the most prescribed medications worldwide with a proven ability to reduce major cardiovascular events. Recent data have revealed that statin therapy is associated with an increased risk for developing diabetes. We discuss the relevant data including newly published results, which demonstra...

journal_title：Current opinion in lipidology

authors： Preiss D,Sattar N

更新日期：2011-12-01 00:00:00

abstract：:The ability of the apolipoprotein E-deficient mouse to develop spontaneous atherosclerosis, which resembles the human process, is an excellent model in which to assess the impact of dietary factors. This review discusses the role of several nutrients in the development of atherosclerosis and the mechanisms through whi...

journal_title：Current opinion in lipidology

authors： Osada J,Joven J,Maeda N

更新日期：2000-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review addresses how, in atherosclerosis or systemic inflammation, HDL can lose its usual atheroprotective characteristics and even paradoxically assume proinflammatory properties. RECENT FINDINGS:Specific chemical and structural changes within HDL particles can impede reverse cholesterol transp...

journal_title：Current opinion in lipidology

authors： Ansell BJ,Fonarow GC,Fogelman AM

更新日期：2007-08-01 00:00:00

abstract：:The VLDL receptor (VLDLR) is a member of the LDL receptor family. The VLDLR was hypothesized to mediate fatty acid entry into peripheral tissues, on the basis of its expression in tissues that are active in fatty acid metabolism and its capacity to bind apolipoprotein-E-rich VLDL in vitro. This hypothesis initially pr...

journal_title：Current opinion in lipidology

authors： Tacken PJ,Hofker MH,Havekes LM,van Dijk KW

更新日期：2001-06-01 00:00:00