New insights into the biogenesis of human high-density lipoproteins.


PURPOSE OF REVIEW:The interest for the human HDL system was recently revived by the identification of the ABCA1 as a critical component in the formation and maintenance of plasma HDL levels. The present review focuses on recent progress in our understanding of the basic mechanisms underlying HDL biogenesis pathways. RECENT FINDINGS:Several novel mechanisms governing ABCA1/apoA-I interactions have recently been identified: apolipoprotein A-I activates ABCA1 phosphorylation through the cAMP/protein kinase A-dependent pathway; the majority of ABCA1 exists as a tetramer in human living cell, supporting the concept that the homotetrameric ABCA1 complex constitutes the minimum functional unit for the formation of nascent HDL particles; apolipoprotein A-I has been shown to have a recycling retroendocytic pathway with uptake and resecretion of the lipidated nascent HDL particles by the cell, most likely through the ABCA1 transporter pathway; there is evidence that the speciation of nascent HDL into pre-beta and alpha-HDL is linked to specific cell lines, and occurs by both ABCA1-dependent and independent pathways. SUMMARY:The fundamental mechanisms underlying the biogenesis, speciation and maturation of HDL remain complex and not well understood. Understanding the mechanisms governing HDL genesis at the cellular level could provide novel insights into the human atheroprotective system in health and disease.


Curr Opin Lipidol


Krimbou L,Marcil M,Genest J




Has Abstract


2006-06-01 00:00:00














  • The role of folic acid in the prevention of cardiovascular disease.

    abstract::Coronary heart disease is the leading cause of death in the developed world. Current surgical and pharmacological interventions are essentially palliative and interest in preventive strategies, particularly through nutrition and avoidance of tobacco has increased in recent years. Basic scientific, clinical and epidemi...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Graham IM,O'Callaghan P

    更新日期:2000-12-01 00:00:00

  • HDL-cholesterol and apolipoproteins in relation to dementia.

    abstract:PURPOSE OF REVIEW:Dementia is a major cause of disability and institutionalization. Apart from age and apolipoprotein E (APOE) genotype, there are currently no established, clinically relevant, noninvasive markers of dementia. We conducted a literature search of recent observational epidemiological studies evaluating t...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


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    更新日期:2016-02-01 00:00:00

  • Hypertriglyceridemia and low HDL: therapeutic considerations.

    abstract::The recently revised guidelines for cholesterol management in Europe and the USA have focused attention on triglycerides and HDL cholesterol as risk factors for coronary heart disease. In the present review, I shall discuss therapeutic considerations in the treatment of patients with hypertriglyceridemia or low HDL ch...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Larsen ML

    更新日期:1994-02-01 00:00:00

  • Early initiation of statin treatment in children with familial hypercholesterolaemia.

    abstract:PURPOSE OF REVIEW:This article provides recent insights on the early onset of atherosclerosis in heterozygous familial hypercholesterolemia and reports on novel treatment options as well as on the consequences of long-term statin use in childhood. RECENT FINDINGS:Children with familial hypercholesterolemia have greate...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Braamskamp MJ,Hutten BA,Wiegman A

    更新日期:2015-06-01 00:00:00

  • HDL infusion for the management of atherosclerosis: current developments and new directions.

    abstract:PURPOSE OF REVIEW:Because human genetic studies and large clinical trials have demonstrated that HDL-cholesterol levels are not causally related to cardiovascular disease risk, attention has shifted toward the functional properties of HDL. Infusion of HDL mimetics containing apolipoprotein A-I remains a potential strat...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Zheng KH,Stroes ES

    更新日期:2016-12-01 00:00:00

  • Genetic defenses against noncholesterol sterols.

    abstract::PURPOSE OF REVIEW This review discusses recent progress in the role of ATP-binding cassette proteins ABCG5 and G8 in dietary sterol absorption, excretion and pathogenesis of cardiovascular disease. RECENT FINDINGS Identification of the genetic defect(s) underlying sitosterolemia has led to a renewed interest in the me...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Klett EL,Patel S

    更新日期:2003-08-01 00:00:00

  • The future of imaging in cardiovascular disease intervention trials: 2017 and beyond.

    abstract:PURPOSE OF REVIEW:As our understanding of cardiovascular disease has advanced over the past decades, multiple novel treatment strategies have been developed with the hope of reducing the global morbidity and mortality associated with this condition. Large-scale trials to test such novel therapies using clinical end poi...

    journal_title:Current opinion in lipidology

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    authors: Doris MK,Dweck MR,Fayad ZA

    更新日期:2016-12-01 00:00:00

  • Recent insights into factors affecting remnant lipoprotein uptake.

    abstract:PURPOSE OF REVIEW:Remnant lipoproteins that persist in the bloodstream after each meal have become increasingly important contributors to atherosclerotic vascular disease, owing to the spread of overnutrition, underexertion, obesity, insulin resistance, and type 2 diabetes. Here, we review recent work that clarified lo...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Williams KJ,Chen K

    更新日期:2010-06-01 00:00:00

  • Peroxisome proliferator-activated receptors beta/delta: emerging roles for a previously neglected third family member.

    abstract:PURPOSE OF REVIEW:Peroxisome proliferator-activated receptors alpha, beta/delta and gamma are members of the nuclear receptor superfamily. They mediate the effects of fatty acids and their derivatives at the transcriptional level, and are considered to be lipid sensors that participate in the regulation of energy homeo...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Michalik L,Desvergne B,Wahli W

    更新日期:2003-04-01 00:00:00

  • Fenofibrate therapy and cardiovascular protection in diabetes: recommendations after FIELD.

    abstract:PURPOSE OF REVIEW:The aim of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study was to provide valuable information on the ability of fibrates to reduce cardiovascular risk in type 2 diabetes. The purpose of this review is to analyse results from FIELD and to see whether they may lead to modify t...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Vergès B

    更新日期:2006-12-01 00:00:00

  • RNA interference to target lipid disorders.

    abstract:PURPOSE OF REVIEW:This review focuses on proof-of-principle experiments providing validation of new targets for the development of RNA interference-based therapeutics for dyslipidemia. RECENT FINDINGS:Over the past few years, RNA interference has become an accepted approach to manipulate gene expression in mammalian s...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Rondinone CM

    更新日期:2008-06-01 00:00:00

  • Trials of lipid-lowering therapy in secondary prevention of coronary heart disease.

    abstract::The Scandinavian Simvastatin Survival Study showed that a 35% decrease in LDL-cholesterol was accompanied by a 42% reduction in coronary mortality. Even if the period of time is longer than 1 year for the divergence of survival curves in the simvastatin and placebo groups there are reasons to believe that the benefici...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Olsson AG,Pedersen T,Bergdahl B

    更新日期:1995-12-01 00:00:00

  • Lipoprotein(a): more interesting than ever after 50 years.

    abstract:PURPOSE OF REVIEW:Lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease; we highlight the most recent research initiatives that have sought to define Lp(a)-dependent pathogenicity as well as pharmacologic approaches to lowering Lp(a). RECENT FINDINGS:Recent large-scale meta-analyses have confirmed elevate...

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    更新日期:2012-04-01 00:00:00

  • What is the ultimate test that lowering lipoprotein(a) is beneficial for cardiovascular disease and aortic stenosis?

    abstract:PURPOSE OF REVIEW:Lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease (CVD) and calcific aortic valve stenosis. We review recent studies that highlight Lp(a) in CVD and calcific aortic valve stenosis and propose pathways to clinical registration of Lp(a)-lowering agents. RECENT FINDINGS:Over the last fe...

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    pub_type: 杂志文章,评审


    authors: Hung MY,Tsimikas S

    更新日期:2014-12-01 00:00:00

  • Response of low density lipoprotein cholesterol levels to dietary change: contributions of different mechanisms.

    abstract::In many individuals, LDL-cholesterol levels rise following increased consumption of dietary cholesterol or saturated and trans-monounsaturated fatty acids. In others, a reduction of cholesterogenesis fully compensates for these effects. In responding individuals, much of the increase in LDL-cholesterol observed may re...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Fielding CJ

    更新日期:1997-02-01 00:00:00

  • Circulating oxidized LDL: a biomarker and a pathogenic factor.

    abstract:PURPOSE OF REVIEW:Oxidized LDL (oxLDL) contributes to many atherogenic steps in the vascular wall, but the significance of oxLDL in circulating blood remains unclear. Recent progress in procedures for measuring both human and murine oxLDL has provided growing evidence of the importance of circulating oxLDL. RECENT FIN...

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    pub_type: 杂志文章,评审


    authors: Ishigaki Y,Oka Y,Katagiri H

    更新日期:2009-10-01 00:00:00

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    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Gimeno RE

    更新日期:2007-06-01 00:00:00

  • Fibrates, dyslipoproteinaemia and cardiovascular disease.

    abstract::Recent epidemiological data have reaffirmed that elevated plasma triglyceride and low HDL-cholesterol levels are important risk factors for atherosclerotic vascular disease. The rationale for the clinical use of fibric acid derivatives, which are designed to correct this metabolic nexus, is now on firmer ground. The m...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Watts GF,Dimmitt SB

    更新日期:1999-12-01 00:00:00

  • Inherited lipodystrophies and hypertriglyceridemia.

    abstract:PURPOSE OF REVIEW:Inherited lipodystrophies are rare autosomal recessive and dominant disorders characterized by selective, but variable, loss of adipose tissue. Marked hypertriglyceridemia is a common feature of these disorders and highlights the role of adipose tissue in lipid homeostasis. In the last decade, advance...

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    pub_type: 杂志文章,评审


    authors: Simha V,Garg A

    更新日期:2009-08-01 00:00:00

  • HDLs, immunity, and atherosclerosis.

    abstract:PURPOSE OF REVIEW:HDLs possess several physiological activities that may explain their antiatherosclerotic properties. Among them, the most relevant is the ability of HDL to promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion. RECENT FINDINGS:The ability of HDL to promote choles...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Norata GD,Pirillo A,Catapano AL

    更新日期:2011-10-01 00:00:00

  • Living up to a name: the role of the VLDL receptor in lipid metabolism.

    abstract::The VLDL receptor (VLDLR) is a member of the LDL receptor family. The VLDLR was hypothesized to mediate fatty acid entry into peripheral tissues, on the basis of its expression in tissues that are active in fatty acid metabolism and its capacity to bind apolipoprotein-E-rich VLDL in vitro. This hypothesis initially pr...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Tacken PJ,Hofker MH,Havekes LM,van Dijk KW

    更新日期:2001-06-01 00:00:00

  • Apolipoprotein B messenger RNA editing: insights into the molecular regulation of post-transcriptional cytidine deamination.

    abstract::A site-specific cytidine deamination (cytidine to uridine) in nuclear apolipoprotein B messenger RNA creates a translational stop codon that produces apolipoprotein B48. This process is mediated by an enzyme composed of distinct subunits, including apolipoprotein B messenger RNA editing enzyme catalytic polypeptide-1 ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Davidson NO,Anant S,MacGinnitie AJ

    更新日期:1995-04-01 00:00:00

  • Role of PCSK9 beyond liver involvement.

    abstract:PURPOSE OF REVIEW:Proprotein convertase subtilisin kexin type 9 (PCSK9) acts as an endogenous natural inhibitor of the LDL receptor pathway, by targeting the receptor to lysosomes for degradation. Beside the liver, PCSK9 is also expressed at significant levels in other tissues, where its function remains unclear. The c...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Cariou B,Si-Tayeb K,Le May C

    更新日期:2015-06-01 00:00:00

  • Postprandial lipoprotein metabolism and atherosclerosis.

    abstract::The metabolism of chylomicrons and their remnants is a highly facilitated route to distribute energy from the diet for storage in adipose tissue or immediate use in the muscles. It has been proposed that chylomicron remnants are atherogenic, and a delayed clearance of chylomicron remnants seems to be associated with c...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Karpe F,Hamsten A

    更新日期:1995-06-01 00:00:00

  • Molecular genetics of the Smith-Lemli-Opitz syndrome and postsqualene sterol metabolism.

    abstract::The Smith-Lemli-Opitz syndrome is a disorder of morphogenesis resulting from an enzymatic defect in the last step of cholesterol metabolism (reduction of 7-dehydrocholesterol). Analysis of the defective gene and identification of mutations therein have paved the way for the study of the molecular genetics of the disor...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Fitzky BU,Glossmann H,Utermann G,Moebius FF

    更新日期:1999-04-01 00:00:00

  • The role of apolipoprotein A-I-containing lipoproteins in atherosclerosis.

    abstract::The inverse relationship between HDL and apolipoprotein A-I concentrations and the risk for premature atherosclerosis is well established, but the mechanism whereby apolipoprotein A-I offers protection is still somewhat elusive. Recent studies suggest that a specific subpopulation within the lipoprotein (AI) subclass ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Forte TM,McCall MR

    更新日期:1994-10-01 00:00:00

  • Lipid lowering in diabetes mellitus.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to present recent information on lipid lowering in diabetes mellitus. New information from randomized clinical trials will be discussed together with implications for clinical practice. Residual risk persists despite statin therapy and additional approaches, particularly ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Betteridge DJ

    更新日期:2008-12-01 00:00:00

  • MicroRNAs in lipid metabolism.

    abstract:PURPOSE OF REVIEW:Although the role for microRNAs (miRNAs) in regulating multiple physiological processes including apoptosis, cell differentiation, and cancer is well established, the importance of these tiny RNAs in regulating lipid metabolism has only recently been uncovered. This review summarizes the evidence for ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Fernández-Hernando C,Suárez Y,Rayner KJ,Moore KJ

    更新日期:2011-04-01 00:00:00

  • Update in diabetes and cardiovascular disease: synthesizing the evidence from recent trials of glycemic control to prevent cardiovascular disease.

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    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Park L,Wexler D

    更新日期:2010-02-01 00:00:00

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    abstract:PURPOSE OF REVIEW:Lowering LDL cholesterol (LDL-C) reduces vascular risk. Current guidelines recommend initiating statin therapy in patients with a yearly coronary heart disease risk of around 1.5-2%, and most clinicians prescribe standard statin regimens (e.g. 40 mg simvastatin daily). However, there is some uncertain...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Bulbulia R,Armitage J

    更新日期:2012-08-01 00:00:00