Abstract：
PURPOSE OF REVIEW:To provide an update on clinical trials of gene therapy for atherosclerotic cardiovascular disease published since 1 August 2001 and summarize the general advantages and potential problems of gene transfer in these disorders. RECENT FINDINGS:There are two major areas in which gene therapy has entered clinical trials. The first is angiogenesis for coronary and peripheral arterial disease. Two relatively small placebo-controlled trials for coronary disease were reported, one using intramyocardial plasmid VEGF-2 gene, the other using intracoronary adenoviral FGF-4 gene. The VEGF-2 study in no-option patients showed reduced angina, and significant improvement in perfusion and function, whereas the FGF-4 study in less severely affected patients showed promising results in some subsets. In peripheral artery disease two phase 1 studies of adenoviral NV1FGF and VEGF showed some objective improvement in pain, ulcer size and ankle:brachial index in one study and endothelial function in the other. Both adenoviral and plasmid VEGF gene transfer at angioplasty increased vascularity in a phase 2 double-blind study. The other major area is the prevention of graft disease and restenosis using antisense oligodeoxynucleotides. E2F decoy led to a significant reduction in venous graft complications after ex-vivo transfection at the time of coronary bypass surgery, whereas the c-Myc oligodeoxynucleotide was ineffective in preventing in-stent coronary restenosis. SUMMARY:There are more reviews of gene therapy for atherosclerosis in the literature than publications with original data or trials, but in the past year the imbalance is being redressed, with some promising results from controlled studies.
journal_name
Curr Opin Lipidoljournal_title
Current opinion in lipidologyauthors
Freedman SBdoi
10.1097/00041433-200212000-00009subject
Has Abstractpub_date
2002-12-01 00:00:00pages
653-61issue
6eissn
0957-9672issn
1473-6535journal_volume
13pub_type
杂志文章,评审abstract：PURPOSE OF REVIEW:Bile acid sequestrants (BAS) have been used for more than 50 years in the treatment of hypercholesterolemia. The last decade, bile acids are emerging as integrated regulators of metabolism via induction of various signal transduction pathways. Consequently, BAS treatment may exert unexpected side-effe...
journal_title：Current opinion in lipidology
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doi：10.1097/MOL.0b013e32834f0ef3
更新日期：2012-02-01 00:00:00
abstract：PURPOSE OF REVIEW:As our understanding of cardiovascular disease has advanced over the past decades, multiple novel treatment strategies have been developed with the hope of reducing the global morbidity and mortality associated with this condition. Large-scale trials to test such novel therapies using clinical end poi...
journal_title：Current opinion in lipidology
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更新日期：2016-12-01 00:00:00
abstract：PURPOSE OF REVIEW:It is well recognized that adipose tissue in obesity is characterized by macrophage accumulation and local inflammation. This review summarizes current evidence regarding dietary cholesterol on adipose tissue macrophage accrual, systemic inflammation and its potential link to atherosclerosis. RECENT ...
journal_title：Current opinion in lipidology
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doi：10.1097/mol.0b013e32831bef8b
更新日期：2009-02-01 00:00:00
abstract：PURPOSE OF REVIEW:Response to statin treatment can vary widely from person to person as a result of inherited traits (genotype) and acquired characteristics such as obesity (phenotype). The aim of this review is to describe what is known about factors that determine a patient's response, and to offer a mechanism to exp...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/01.mol.0000137225.46654.4d
更新日期：2004-08-01 00:00:00
abstract：PURPOSE OF REVIEW:The article reviews the challenges facing cardiovascular disease (CVD) guidelines committees. RECENT FINDINGS:Clinical trials in high-risk populations have shown additional CVD event reduction with ezetimibe and proprotein convertase subtilisin-kexin-9 inhibitors. These trials recruit middle-aged sec...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000453
更新日期：2017-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Adipose tissue is an essential, highly dynamic and metabolically active tissue that vigorously communicates to support its primary function: the storage of lipids. It performs this function to secure energy supply and prevent lipotoxicity. Adipose tissue is essential for maintaining a healthy glucose ...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e3282f39f95
更新日期：2008-02-01 00:00:00
abstract：PURPOSE OF REVIEW:To provide an update on recent mechanistic and clinical trial data related to the actions and efficacy of niacin. RECENT FINDINGS:Recent mechanistic studies have provided novel insights regarding the mechanism of action of niacin. Studies of the purported niacin receptor, GPR109A, indicate that niaci...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000017
更新日期：2013-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Recent findings suggesting that cannabinoid receptors are potential targets for the treatment of atherosclerosis are reviewed. RECENT FINDINGS:Cannabinoids, such as Delta9-tetrahydrocannabinol, the major psychoactive compound of marijuana, their synthetic analogs and endogenous cannabinoid ligands, p...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/01.mol.0000245257.17764.b2
更新日期：2006-10-01 00:00:00
abstract：PURPOSE OF REVIEW:The nine members of the proprotein convertase family play major physiological roles during development and in the adult, and their dysregulation leads to various diseases. The primary objective of this article is to review recent findings on the clinical importance of some of these convertases concent...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000484
更新日期：2018-04-01 00:00:00
abstract：PURPOSE OF REVIEW:Over the past two decades serious efforts has been invested in the search for genes that predispose to common obesity, but progress has been slow and success limited. Genome-wide association, however, has revived optimism. Here we review recent advances in the field of obesity genetics and discuss the...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e3282f6a7f3
更新日期：2008-04-01 00:00:00
abstract：PURPOSE OF REVIEW:The new risk-based guidelines on blood cholesterol treatment from the American College of Cardiology and the American Heart Association reflect the now widespread international agreement that lipid-lowering treatment decisions should be based primarily on individuals' predicted cardiovascular disease ...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000089
更新日期：2014-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Atherosclerosis is a chronic inflammatory disease in which subendothelial infiltration of lipoproteins leads to inflamed lesions in arteries. Despite improvements in secondary prevention, most cardiovascular events cannot be avoided with current therapies. This review focuses on novel mechanistic insi...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000540
更新日期：2018-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Epidemiological and clinical studies link low levels of HDL cholesterol (HDL-C) with increased risk of atherosclerotic cardiovascular disease (CVD). However, genetic polymorphisms linked to HDL-C do not associate consistently with CVD risk, and randomized clinical studies of drugs that elevate HDL-C v...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000446
更新日期：2017-10-01 00:00:00
abstract：PURPOSE OF REVIEW:The aim of this study was to briefly summarize the contribution of the PREDIMED (PREvención con DIeta MEDiterránea) trial on cardiovascular evidence and examine in depth its groundbreaking trajectory.PREDIMED was conducted during 2003-2010 and represented the largest primary prevention trial ever test...
journal_title：Current opinion in lipidology
pub_type： 杂志文章
doi：10.1097/MOL.0000000000000731
更新日期：2021-02-01 00:00:00
abstract：PURPOSE OF REVIEW:The absolute level of HDL cholesterol (HDL-C) may not be the only criterion contributing to their antiatherothrombotic effects. This review focuses on evidence in support of the concept that HDL-bound sphingosine-1-phosphate (S1P) plays a role in different HDL atheroprotective properties and may repre...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e328361f822
更新日期：2013-08-01 00:00:00
abstract：PURPOSE OF REVIEW:The discovery of Niemann-Pick C1-like 1 (NPC1L1) and ezetimibe, a drug that lowers intestinal cholesterol absorption, has contributed to the recognition of the intestine as an important organ in whole-body cholesterol homeostasis. Unfortunately, the majority of the studies on NPC1L1 have been conducte...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e3283468c28
更新日期：2011-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease; we highlight the most recent research initiatives that have sought to define Lp(a)-dependent pathogenicity as well as pharmacologic approaches to lowering Lp(a). RECENT FINDINGS:Recent large-scale meta-analyses have confirmed elevate...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e32835111d8
更新日期：2012-04-01 00:00:00
abstract：PURPOSE OF REVIEW:As the incidence of obesity and the metabolic syndrome has increased, research has focused on the importance of the endocannabinoid system in the brain and peripheral tissues. Rimonabant, an inverse agonist of the CB1 receptor is being used therapeutically. This review presents recent advances in endo...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e328304b62b
更新日期：2008-08-01 00:00:00
abstract：PURPOSE OF REVIEW:The aim of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study was to provide valuable information on the ability of fibrates to reduce cardiovascular risk in type 2 diabetes. The purpose of this review is to analyse results from FIELD and to see whether they may lead to modify t...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/01.mol.0000252612.21602.e3
更新日期：2006-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Inflammation has been widely acknowledged to contribute throughout all stages of atherogenesis. However, these recent advances in our understanding have not been translated into clinical practice in which the mainstay of treatment is still lipid-targeted therapy. This review provides an overview of pr...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e3283587543
更新日期：2012-12-01 00:00:00
abstract：:The microsomal triglyceride transfer protein is necessary for the assembly and secretion of lipoproteins containing apolipoprotein B. During the past year, significant progress has been made towards understanding the role of microsomal triglyceride transfer protein in lipoprotein assembly at both a cellular and molecu...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-199706000-00002
更新日期：1997-06-01 00:00:00
abstract：PURPOSE OF REVIEW:To discuss crucial cues (chemokines, adhesion molecules and pharmacological means) that guide and control the context-specific mobilization, recruitment and fate of circulating progenitor cells in arterial repair and plaque stability. RECENT FINDINGS:The mobilization and recruitment of bone marrow de...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e32830dfe33
更新日期：2008-10-01 00:00:00
abstract：PURPOSE OF REVIEW:The endoplasmic reticulum (ER) maintains cellular metabolic homeostasis by coordinating protein synthesis, secretion activities, lipid biosynthesis and calcium (Ca²⁺) storage. In this review, we will discuss how altered ER homeostasis contributes to dysregulation of hepatic lipid metabolism and contri...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000056
更新日期：2014-04-01 00:00:00
abstract：PURPOSE OF REVIEW:This review will summarize recent evidence demonstrating that biologically active phospholipid oxidation products modulate inflammatory reactions. RECENT FINDINGS:Structural identification of new biologically active oxidized phospholipids and the finding that they can also be formed at inflammatory s...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-200310000-00002
更新日期：2003-10-01 00:00:00
abstract：:Somatic gene therapy for the treatment of dyslipidemia is an area of active investigation. A substantial body of data indicates that the transfer of various lipid-lowering genes to the liver is an effective method of restoring normal plasma lipids in animal models of dyslipidemia. Most studies have used adenoviral vec...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-200004000-00011
更新日期：2000-04-01 00:00:00
abstract：PURPOSE OF REVIEW:To examine the role of gut microbiota in the regulation of host energy homeostasis and its role in the pathogenesis of obesity, diabetes and nonalcoholic fatty liver disease (NAFLD). RECENT FINDINGS:Experimental models highlight several mechanisms connecting gut microbiota to host energy metabolism: ...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e3283347ebb
更新日期：2010-02-01 00:00:00
abstract：PURPOSE OF REVIEW:In the last 2 years, significant advances in the understanding of HDL particle structure and the associations between particle structure, function, and atherosclerosis have been made. We will review and provide clinical and epidemiological context to these recent advances. RECENT FINDINGS:Several rec...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0000000000000571
更新日期：2019-02-01 00:00:00
abstract：:The mechanism and regulation of the degradation of cholesterol into bile acids has attracted increased interest, in particular after the recent discovery that nuclear receptors (farnesoid X receptor and liver X receptor) are involved in the regulation of bile acid synthesis. Recently, it has also been shown that the b...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-200104000-00002
更新日期：2001-04-01 00:00:00
abstract：:The recently revised guidelines for cholesterol management in Europe and the USA have focused attention on triglycerides and HDL cholesterol as risk factors for coronary heart disease. In the present review, I shall discuss therapeutic considerations in the treatment of patients with hypertriglyceridemia or low HDL ch...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/00041433-199402000-00008
更新日期：1994-02-01 00:00:00
abstract：PURPOSE OF REVIEW:The cell death-inducing DFF45-like effector (CIDE) family proteins, comprising three members, Cidea, Cideb, and Fsp27 (Cidec), have emerged as important regulators for various aspects of metabolism. This review summarizes our current understanding about the physiological roles of CIDE proteins, their ...
journal_title：Current opinion in lipidology
pub_type： 杂志文章,评审
doi：10.1097/MOL.0b013e328328d0bb
更新日期：2009-04-01 00:00:00
