Abstract:
PURPOSE OF REVIEW:Control of vascular smooth muscle cell (VSMC) phenotype is essential in the development and maintenance of a healthy vasculature. Acquisition of a synthetic, proproliferative phenotype by VSMCs following vascular insult is central to neointimal formation and the development of vascular pathology. MicroRNAs (miRNAs) are relatively recently discovered negative regulators of gene expression and act at the post-transcriptional level. MiRNAs have the potential to control VSMC phenotype. In this review, we discuss the recent findings on how miRNAs influence VSMC biology and acute vascular pathology. RECENT FINDINGS:MiRNAs play an important role in the gene regulation by growth factors and downstream transcription factors involved in VSMC phenotypic control and deregulation. Recent studies have revealed miRNAs that are involved in VSMC regulation and further identified several target genes which are implicated in VSMC pathobiology, highlighting new disease mechanisms. Paracrine miRNA-regulated crosstalk between endothelial and VSMCs has also been demonstrated, revealing a novel mechanism through which vascular cells communicate in health and disease. SUMMARY:MiRNAs appear to play a major role in the capability of VSMCs to phenotypically switch from a contractile to a synthetic state. Altering miRNA expression levels can prevent and even reverse the acquisition of VSMC synthetic phenotype in vivo and reduce neointimal formation, thereby implicating miRNAs as exciting future therapeutic targets for vascular proliferative disease.
journal_name
Curr Opin Lipidoljournal_title
Current opinion in lipidologyauthors
Robinson HC,Baker AHdoi
10.1097/MOL.0b013e32835719a1subject
Has Abstractpub_date
2012-10-01 00:00:00pages
405-11issue
5eissn
0957-9672issn
1473-6535pii
00041433-201210000-00002journal_volume
23pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:HDLs possess several physiological activities that may explain their antiatherosclerotic properties. Among them, the most relevant is the ability of HDL to promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion. RECENT FINDINGS:The ability of HDL to promote choles...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/MOL.0b013e32834adac3
更新日期:2011-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Nutrition recommendations emphasize that not only dietary fat quantity but also fat quality plays a role in the prevention of type 2 diabetes (T2D). The aim of this review is to summarize the evidence for dietary fat and risk of T2D, to highlight recent findings and point out future research direction...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/MOL.0000000000000567
更新日期:2019-02-01 00:00:00
abstract::Further understanding of the causative link between plasma lipids and coronary heart disease will come from a deeper appreciation of the impact of lipoprotein heterogeneity on the processes of atherosclerosis and thrombosis. It is now widely appreciated that remnants of triglyceride-rich lipoproteins, IDL and specific...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/00041433-199906000-00006
更新日期:1999-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Familial hypercholesterolemia is associated with a high lifetime risk of atherosclerotic cardiovascular disease (ASCVD). However, this risk is variable. This review evaluates recent evidence related to ASCVD risk stratification in familial hypercholesterolemia considering aspects of phenotype and geno...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/MOL.0000000000000391
更新日期:2017-04-01 00:00:00
abstract::PURPOSE OF REVIEW This review discusses recent progress in the role of ATP-binding cassette proteins ABCG5 and G8 in dietary sterol absorption, excretion and pathogenesis of cardiovascular disease. RECENT FINDINGS Identification of the genetic defect(s) underlying sitosterolemia has led to a renewed interest in the me...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/01.mol.0000083763.66245.18
更新日期:2003-08-01 00:00:00
abstract:PURPOSE OF REVIEW:mAbs targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) have the potential to become groundbreaking therapies for the treatment of hypercholesterolemia. However, one major drawback of mAb-based therapy for a chronic condition like dyslipidemia is its relatively high cost. This review summ...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/MOL.0000000000000312
更新日期:2016-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Substantial risk of ASCVD events persists despite intensive statin therapy and other agents to lower LDL-C. The optimal way to address other elements of dyslipidemia, such as triglyceride-rich particles (TRL) and when to treat has remained unclear. RECENT FINDINGS:Several lines of evidence indicate t...
journal_title:Current opinion in lipidology
pub_type: 杂志文章
doi:10.1097/MOL.0000000000000694
更新日期:2020-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study was to provide valuable information on the ability of fibrates to reduce cardiovascular risk in type 2 diabetes. The purpose of this review is to analyse results from FIELD and to see whether they may lead to modify t...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/01.mol.0000252612.21602.e3
更新日期:2006-12-01 00:00:00
abstract::Rather than a link in a causal chain leading to hypertension, insulin resistance and resultant hyperinsulinemia may be 'spokes on a wheel', with central or visceral obesity as the postulated hub of the wheel. Hypertension, hypertriglyceridemia and high density lipoprotein cholesterol are depicted as other spokes. Newl...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/00041433-199608000-00011
更新日期:1996-08-01 00:00:00
abstract::Conjugated linoleic acid is a collective name for mixtures of several positional and geometric conjugated dienoic isomers of linoleic acid, which have been shown to impact favorably on several biological processes, particularly carcinogenesis. Recent studies have clearly established that the c9, t11 and t10, c12 isome...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/00041433-200102000-00006
更新日期:2001-02-01 00:00:00
abstract::The inverse relationship between HDL and apolipoprotein A-I concentrations and the risk for premature atherosclerosis is well established, but the mechanism whereby apolipoprotein A-I offers protection is still somewhat elusive. Recent studies suggest that a specific subpopulation within the lipoprotein (AI) subclass ...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/00041433-199410000-00007
更新日期:1994-10-01 00:00:00
abstract::The VLDL receptor (VLDLR) is a member of the LDL receptor family. The VLDLR was hypothesized to mediate fatty acid entry into peripheral tissues, on the basis of its expression in tissues that are active in fatty acid metabolism and its capacity to bind apolipoprotein-E-rich VLDL in vitro. This hypothesis initially pr...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/00041433-200106000-00006
更新日期:2001-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The cell death-inducing DFF45-like effector (CIDE) family proteins, comprising three members, Cidea, Cideb, and Fsp27 (Cidec), have emerged as important regulators for various aspects of metabolism. This review summarizes our current understanding about the physiological roles of CIDE proteins, their ...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/MOL.0b013e328328d0bb
更新日期:2009-04-01 00:00:00
abstract::Low folate intake is an important determinant of elevated blood levels of homocysteine. Because elevated homocysteine has been shown to be a possible graded risk factor for CHD, sufficient folate intake may be important in the prevention of CHD. The magnitude of the association between folate and CHD is consistent wit...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/00041433-199802000-00005
更新日期:1998-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Although the role for microRNAs (miRNAs) in regulating multiple physiological processes including apoptosis, cell differentiation, and cancer is well established, the importance of these tiny RNAs in regulating lipid metabolism has only recently been uncovered. This review summarizes the evidence for ...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/MOL.0b013e3283428d9d
更新日期:2011-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Dysregulated lipoprotein metabolism leads to increased plasma concentrations of atherogenic lipoproteins. We highlight the findings from recent studies of the effect of lipid-regulating therapies on apolipoprotein metabolism in humans employing endogenous labelling with stable isotopically labelled is...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/MOL.0000000000000348
更新日期:2016-12-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide an update on clinical trials of gene therapy for atherosclerotic cardiovascular disease published since 1 August 2001 and summarize the general advantages and potential problems of gene transfer in these disorders. RECENT FINDINGS:There are two major areas in which gene therapy has entered...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/00041433-200212000-00009
更新日期:2002-12-01 00:00:00
abstract::Antithrombotic therapy has assumed a central role in the therapy of the acute coronary syndromes and chronic coronary artery disease. The theoretical rationale for antithrombotic therapy, and the established and evolving roles of antiplatelet agents and anticoagulants in coronary disease are reviewed. Emphasis is focu...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/00041433-199408000-00007
更新日期:1994-08-01 00:00:00
abstract:PURPOSE OF REVIEW:This review will provide an update on the structure of GPIHBP1, a 28-kDa glycosylphosphatidylinositol-anchored glycoprotein, and its role in the lipolytic processing of triglyceride-rich lipoproteins. RECENT FINDINGS:Gpihbp1 knockout mice on a chow diet have milky plasma and plasma triglyceride level...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/MOL.0b013e32832ac026
更新日期:2009-06-01 00:00:00
abstract::Basic research has provided strong evidence that oxidation of LDL plays an important role in the pathogenesis of atherosclerosis. Several mechanisms have been identified which can lead to LDL oxidation in vivo. Clinical and epidemiological studies have provided circumstantial evidence that oxidized LDL, as measured by...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/00041433-199808000-00009
更新日期:1998-08-01 00:00:00
abstract::Oxidation products of lipids and proteins are found in atherosclerotic plaque and in macrophage foam cells. Macrophages avidly endocytose in-vitro oxidized LDL and accumulate sterols. What is the evidence that such a process is involved in in-vivo foam cell formation? The present review surveys current knowledge on th...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/00041433-200010000-00005
更新日期:2000-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Response to statin treatment can vary widely from person to person as a result of inherited traits (genotype) and acquired characteristics such as obesity (phenotype). The aim of this review is to describe what is known about factors that determine a patient's response, and to offer a mechanism to exp...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/01.mol.0000137225.46654.4d
更新日期:2004-08-01 00:00:00
abstract::The development of atherosclerosis in animal models and the incidence of coronary heart disease in postmenopausal women are markedly reduced by estrogen treatment. Estrogen have acute beneficial effects on vascular reactivity and longer-term effects on critical steps in the pathogenesis of atherosclerosis. Phytoestrog...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/00041433-199810000-00010
更新日期:1998-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Hepatic steatosis is a leading cause of adult and paediatric liver disease and is inextricably linked to obesity, insulin resistance and cardiovascular disease. Here we summarize our current understanding of the role of the patatin-like phospholipase domain-containing 3 gene (PNPLA3) in hepatic steato...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/mol.0b013e328338ca61
更新日期:2010-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Several mutations in the apolipoprotein (apo) B, proprotein convertase subtilisin kexin 9 (PCSK9) and microsomal triglyceride transfer protein genes result in low or absent levels of apoB and LDL cholesterol (LDL-C) in plasma which cause familial hypobetalipoproteinemia (FHBL) and abetalipoproteinemia...
journal_title:Current opinion in lipidology
pub_type: 杂志文章
doi:10.1097/MOL.0000000000000663
更新日期:2020-04-01 00:00:00
abstract::The present review summarizes recent advances in the transcriptional regulation of the human apolipoprotein genes, focusing mostly, but not exclusively, on in-vivo studies and signaling mechanisms that affect apolipoprotein gene transcription. An attempt is made to explain how interactions of transcription factors tha...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/00041433-200104000-00012
更新日期:2001-04-01 00:00:00
abstract:PURPOSE OF REVIEW:This review provides an overview of newly described mechanisms by which peroxisome proliferator-activated receptors (PPARs) (α, γ, and δ) regulate several factors associated with cardiovascular risk. RECENT FINDINGS:PPAR agonists have known effects on plasma lipoprotein levels, inflammation, and insu...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/MOL.0b013e3283613a7d
更新日期:2013-06-01 00:00:00
abstract::This review describes recent advances that have been made in the separation of HDL subfractions by physicochemical and immunological methods and the relationship between the particles obtained by the different procedures. The metabolic interconversions that occur as a result of cholesteryl ester transfer protein (CETP...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/00041433-199405030-00013
更新日期:1994-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Studies have shown the three-member paraoxonase (PON) multigene family to be involved in the development of a large variety of diseases with an inflammatory component. Environmental factors such as lifestyle-related factors differ widely between populations and it is important to consider that their i...
journal_title:Current opinion in lipidology
pub_type: 杂志文章
doi:10.1097/MOL.0000000000000687
更新日期:2020-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The science and policy of functional foods are a matter of global concern and this review provides up-to-date information about the Japanese 'food for specified health use' policy based on functional food science. RECENT FINDINGS:A great many studies on nonnutritive but physiologically functional foo...
journal_title:Current opinion in lipidology
pub_type: 杂志文章,评审
doi:10.1097/MOL.0b013e3282f3f505
更新日期:2008-02-01 00:00:00