Resident intimal dendritic cells and the initiation of atherosclerosis.


PURPOSE OF REVIEW:To highlight the fact that regional differences in the normal arterial intima are critical to atherosclerotic lesion formation driven by systemic risk factors. RECENT FINDINGS:At arterial curvatures, bifurcations and branches unique hemodynamics influence endothelial cell signaling and gene expression patterns, which create a proinflammatory environment, with low-grade recruitment of monocytes and accumulation of cells with dendritic features in the intima. Upon induction of hypercholesterolemia, these resident intimal dendritic cells initiate atherosclerosis by rapidly engulfing lipid and becoming the first foam cells in nascent lesions. This step precedes endothelial cell activation and increased monocyte recruitment. SUMMARY:The unique features of the arterial intima at atherosclerosis-susceptible sites do not lead to disease under normal physiological conditions, but this intimal environment promotes the initiation of atherogenesis upon induction of systemic risk factors such as hypercholesterolemia.


Curr Opin Lipidol


Cybulsky MI,Jongstra-Bilen J




Has Abstract


2010-10-01 00:00:00












  • n-3 polyunsaturated fatty acids and human cytokine synthesis.

    abstract::The cytokines interleukin-1 and tumor necrosis factor contribute to the pathogenesis of inflammatory diseases and, potentially, to atherogenesis. The synthesis of these cytokines in humans can be suppressed by oral intake of n-3 polyunsaturated fatty acids. This mechanism may contribute to the beneficial effect of lon...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Endres S,von Schacky C

    更新日期:1996-02-01 00:00:00

  • Transintestinal cholesterol efflux.

    abstract:PURPOSE OF REVIEW:Regulation of cholesterol homeostasis is a complex interplay of a multitude of metabolic pathways situated in different organs. The liver plays a central role and has received most attention of the research community. In this review, we discuss recent progress in the understanding of the emerging role...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: van der Velde AE,Brufau G,Groen AK

    更新日期:2010-06-01 00:00:00

  • Postprandial lipoprotein metabolism and atherosclerosis.

    abstract::The metabolism of chylomicrons and their remnants is a highly facilitated route to distribute energy from the diet for storage in adipose tissue or immediate use in the muscles. It has been proposed that chylomicron remnants are atherogenic, and a delayed clearance of chylomicron remnants seems to be associated with c...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Karpe F,Hamsten A

    更新日期:1995-06-01 00:00:00

  • Stearoyl-coenzyme A desaturase 1 inhibition and the metabolic syndrome: considerations for future drug discovery.

    abstract:PURPOSE OF REVIEW:The metabolic syndrome has become a leading health concern in developed countries. In the search for strategies to combat this growing problem, stearoyl-CoA desaturase 1 (SCD1) inhibition has been proposed as an attractive therapeutic strategy. However, recent studies warn of potentially harmful conse...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Brown JM,Rudel LL

    更新日期:2010-06-01 00:00:00

  • How does protein misfolding in the endoplasmic reticulum affect lipid metabolism in the liver?

    abstract:PURPOSE OF REVIEW:The endoplasmic reticulum (ER) maintains cellular metabolic homeostasis by coordinating protein synthesis, secretion activities, lipid biosynthesis and calcium (Ca²⁺) storage. In this review, we will discuss how altered ER homeostasis contributes to dysregulation of hepatic lipid metabolism and contri...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Wang S,Kaufman RJ

    更新日期:2014-04-01 00:00:00

  • Recent insights into factors affecting remnant lipoprotein uptake.

    abstract:PURPOSE OF REVIEW:Remnant lipoproteins that persist in the bloodstream after each meal have become increasingly important contributors to atherosclerotic vascular disease, owing to the spread of overnutrition, underexertion, obesity, insulin resistance, and type 2 diabetes. Here, we review recent work that clarified lo...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Williams KJ,Chen K

    更新日期:2010-06-01 00:00:00

  • Role of PCSK9 beyond liver involvement.

    abstract:PURPOSE OF REVIEW:Proprotein convertase subtilisin kexin type 9 (PCSK9) acts as an endogenous natural inhibitor of the LDL receptor pathway, by targeting the receptor to lysosomes for degradation. Beside the liver, PCSK9 is also expressed at significant levels in other tissues, where its function remains unclear. The c...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Cariou B,Si-Tayeb K,Le May C

    更新日期:2015-06-01 00:00:00

  • Lipid-driven immunometabolic responses in atherosclerosis.

    abstract:PURPOSE OF REVIEW:Atherosclerosis is a chronic inflammatory disease in which subendothelial infiltration of lipoproteins leads to inflamed lesions in arteries. Despite improvements in secondary prevention, most cardiovascular events cannot be avoided with current therapies. This review focuses on novel mechanistic insi...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Gisterå A,Ketelhuth DFJ

    更新日期:2018-10-01 00:00:00

  • Genetic determinants of apolipoprotein B-100 kinetics.

    abstract:PURPOSE OF REVIEW:We review stable isotope tracer studies of apolipoprotein B-100 (apoB) kinetics concerning genetic polymorphisms and mutations that affect human lipoprotein metabolism. RECENT FINDINGS:In obese men, the allelic combination of the apoB signal peptide, SP24, and cholesteryl ester transfer protein, CETP...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Ng TW,Ooi EM,Watts GF,Chan DC,Barrett PH

    更新日期:2010-04-01 00:00:00

  • Potential tissue selectivity of dietary phytoestrogens and estrogens.

    abstract::The recent discovery of a second estrogen receptor subtype, estrogen receptor-beta, may significantly advance our understanding of tissue specific effects of estrogenic compounds, both natural and synthetic. Although specific effects mediated by estrogen receptor beta in vivo remain to be elucidated, hypothetically th...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Cassidy A

    更新日期:1999-02-01 00:00:00

  • Expression profiling and comparative sequence derived insights into lipid metabolism.

    abstract::Expression profiling and genomic DNA sequence comparisons are increasingly being applied to the identification and analysis of the genes that are involved in lipid metabolism. Not only has genome-wide expression profiling aided in the identification of novel genes that are involved in important processes in lipid meta...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Callow MJ,Rubin EM

    更新日期:2002-04-01 00:00:00

  • Cardiovascular risk factors in inflammatory arthritis.

    abstract:PURPOSE OF REVIEW:To assess factors that promote atherogenesis and cardiovascular disease (CVD) in rheumatoid arthritis (RA). Also, to determine how control of inflammation with conventional and biological antirheumatic drugs affects cardiovascular risk. RECENT FINDINGS:An excess risk of CVD occurs early in the RA dis...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Mirjafari H,Al-Husain A,Bruce IN

    更新日期:2011-08-01 00:00:00

  • The role of apolipoprotein A-I-containing lipoproteins in atherosclerosis.

    abstract::The inverse relationship between HDL and apolipoprotein A-I concentrations and the risk for premature atherosclerosis is well established, but the mechanism whereby apolipoprotein A-I offers protection is still somewhat elusive. Recent studies suggest that a specific subpopulation within the lipoprotein (AI) subclass ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Forte TM,McCall MR

    更新日期:1994-10-01 00:00:00

  • Homozygous familial hypercholesterolemia: what treatments are on the horizon?

    abstract:PURPOSE OF REVIEW:Homozygous familial hypercholesterolemia (HoFH) is a rare disorder associated with early atherosclerotic disease due to impairment of the LDL receptor (LDLR) pathway. Because of their molecular defect, current treatment options have limited success in bringing HoFH patient to LDL-C target and morbidit...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章


    authors: Bajaj A,Cuchel M

    更新日期:2020-06-01 00:00:00

  • The paraoxonase gene family and coronary heart disease.

    abstract:PURPOSE OF REVIEW:The antioxidant activity of high-density lipoprotein is largely due to the paraoxonase 1 located on it. Experiments with transgenic paraoxonase 1 knock-out mice indicate the potential for this enzyme to protect against atherogenesis. This effect of high-density lipoprotein in decreasing low-density li...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Mackness B,Durrington PN,Mackness MI

    更新日期:2002-08-01 00:00:00

  • MicroRNAs in lipid metabolism.

    abstract:PURPOSE OF REVIEW:Although the role for microRNAs (miRNAs) in regulating multiple physiological processes including apoptosis, cell differentiation, and cancer is well established, the importance of these tiny RNAs in regulating lipid metabolism has only recently been uncovered. This review summarizes the evidence for ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Fernández-Hernando C,Suárez Y,Rayner KJ,Moore KJ

    更新日期:2011-04-01 00:00:00

  • Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing 3 protein.

    abstract:PURPOSE OF REVIEW:Hepatic steatosis is a leading cause of adult and paediatric liver disease and is inextricably linked to obesity, insulin resistance and cardiovascular disease. Here we summarize our current understanding of the role of the patatin-like phospholipase domain-containing 3 gene (PNPLA3) in hepatic steato...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Romeo S,Huang-Doran I,Baroni MG,Kotronen A

    更新日期:2010-06-01 00:00:00

  • SPPARM alpha: the Lazarus effect.

    abstract:PURPOSE OF REVIEW:Atherogenic dyslipidaemia, characterized by high plasma triglycerides (a surrogate for triglyceride-rich remnant lipoproteins) and low high-density lipoprotein cholesterol (HDL-C), is prevalent in patients with type 2 diabetes mellitus (T2DM) and contributes to a high modifiable residual cardiovascula...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Fruchart JC,Santos RD

    更新日期:2019-12-01 00:00:00

  • Statins and the risk of new-onset diabetes: a review of recent evidence.

    abstract:PURPOSE OF REVIEW:Statins are the most prescribed medications worldwide with a proven ability to reduce major cardiovascular events. Recent data have revealed that statin therapy is associated with an increased risk for developing diabetes. We discuss the relevant data including newly published results, which demonstra...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Preiss D,Sattar N

    更新日期:2011-12-01 00:00:00

  • The ever-expanding saga of the proprotein convertases and their roles in body homeostasis: emphasis on novel proprotein convertase subtilisin kexin number 9 functions and regulation.

    abstract:PURPOSE OF REVIEW:The nine members of the proprotein convertase family play major physiological roles during development and in the adult, and their dysregulation leads to various diseases. The primary objective of this article is to review recent findings on the clinical importance of some of these convertases concent...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Seidah NG,Chrétien M,Mbikay M

    更新日期:2018-04-01 00:00:00

  • Cholesterol efflux capacity, macrophage reverse cholesterol transport and cardioprotective HDL.

    abstract:PURPOSE OF REVIEW:Randomized clinical trials provide strong evidence that pharmacological elevation of HDL-cholesterol (HDL-C) fails to reduce cardiovascular disease (CVD) risk in statin-treated humans. It is thus critical to identify new metrics that capture HDL's cardioprotective effects. RECENT FINDINGS:We review r...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Hutchins PM,Heinecke JW

    更新日期:2015-10-01 00:00:00

  • Genetic variants predisposing to cardiovascular disease.

    abstract:PURPOSE OF REVIEW:The goal of this review is to provide an update on the most recent and relevant findings in the area of genotype-phenotype associations as well as the relationships between genetic factors and cardiovascular disease risk markers and events. In addition, emphasis will be placed on the methodological pr...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Visvikis-Siest S,Marteau JB

    更新日期:2006-04-01 00:00:00

  • Cholesterol reduction and macrophage function: role of paraoxonases.

    abstract:PURPOSE OF REVIEW:Unregulated uptake of oxidized LDL by macrophages to form foam cells is the hallmark for atherosclerosis. The paraoxonase (PON) family of enzymes plays a critical role in attenuating atherosclerotic lesion formation by hydrolyzing lipid peroxides (LOOHs) and preventing the oxidation of LDL particles a...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: White CR,Anantharamaiah GM

    更新日期:2017-10-01 00:00:00

  • Muscle lipid metabolism in the metabolic syndrome.

    abstract:PURPOSE OF REVIEW:The metabolic syndrome has been emphasized as affecting an important subset of individuals at high risk for cardiovascular disease leading the National Cholesterol Educational Program Adult Treatment Panel III in highlighting awareness of insulin-resistance syndrome. Insulin resistance is thought to b...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Perseghin G

    更新日期:2005-08-01 00:00:00

  • Electronegative low-density lipoprotein.

    abstract:PURPOSE OF REVIEW:The occurrence in blood of an electronegatively charged LDL was described in 1988. During the 1990s reports studying electronegative LDL (LDL(-)) were scant and its atherogenic role controversial. Nevertheless, recent reports have provided new evidence on a putative atherogenic role of LDL(-). This re...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Sánchez-Quesada JL,Benítez S,Ordóñez-Llanos J

    更新日期:2004-06-01 00:00:00

  • How high-density lipoprotein protects against the effects of lipid peroxidation.

    abstract::The protective effect of HDL against the development of atherosclerosis appears to be multifaceted involving a number of mechanisms. One of the major mechanisms is, however, the ability of HDL to decrease, directly or indirectly, the lipid peroxidation of LDL. The hydrolysis of lipid peroxides by PON1 makes a major co...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Mackness MI,Durrington PN,Mackness B

    更新日期:2000-08-01 00:00:00

  • Is hypertriglyceridemia atherogenic?

    abstract:PURPOSE OF REVIEW:Hypertriglyceridemia occurs mainly because of metabolic disorders secondary to diabetes, alcohol intake, and/or overweight. Genetic factors have also been clearly identified in most severe cases. Triglycerides are generally considered as 'bystanders' for cardiovascular diseases. However, biological an...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Huet F,Roubille C,Roubille F

    更新日期:2019-08-01 00:00:00

  • Antithrombotic therapy in coronary artery disease.

    abstract::Antithrombotic therapy has assumed a central role in the therapy of the acute coronary syndromes and chronic coronary artery disease. The theoretical rationale for antithrombotic therapy, and the established and evolving roles of antiplatelet agents and anticoagulants in coronary disease are reviewed. Emphasis is focu...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Di Salvo TG,Fuster V

    更新日期:1994-08-01 00:00:00

  • HDL modification: recent developments and their relevance to atherosclerotic cardiovascular disease.

    abstract:PURPOSE OF REVIEW:In the last 2 years, significant advances in the understanding of HDL particle structure and the associations between particle structure, function, and atherosclerosis have been made. We will review and provide clinical and epidemiological context to these recent advances. RECENT FINDINGS:Several rec...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Wilkins JT,Seckler HS

    更新日期:2019-02-01 00:00:00

  • The menopause and lipid metabolism: strategies for cardiovascular disease prevention.

    abstract::The menopause and its biology are as yet still incompletely understood. Very little is known about biological and molecular changes in cardiovascular target tissues and organs after menopause. Experimental and clinical evidence indicate that prevention of cardiovascular disease by estrogens is aimed both at the correc...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Soma MR,Baetta R,Crosignani P

    更新日期:1997-08-01 00:00:00