听力与言语-语言病理学

行为科学

医学伦理学

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  • Genetic heterogeneity and clonal evolution in acute myeloid leukemia.

    abstract:PURPOSE OF REVIEW:Clonal heterogeneity is a significant obstacle to successful treatment of patients with acute myeloid leukemia (AML). Here, we review new advances in the understanding of genetic heterogeneity in AML using single-cell DNA-sequencing technology. RECENT FINDINGS:New genomics and immunologic discovery t...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章

    doi:10.1097/MOH.0000000000000626

    authors: Romer-Seibert JS,Meyer SE

    更新日期:2021-01-01 00:00:00

  • New insights into IVIg mechanisms and alternatives in autoimmune and inflammatory diseases.

    abstract:PURPOSE OF REVIEW:Intravenous immunoglobulin (IVIg) is an effective treatment for an increasing number of autoimmune and inflammatory conditions. However, IVIg continues to be limited by problems of potential shortages and cost. A number of mechanisms have been described for IVIg, which have been captured in newly emer...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章

    doi:10.1097/MOH.0000000000000609

    authors: Norris PAA,Kaur G,Lazarus AH

    更新日期:2020-11-01 00:00:00

  • Current state of nonengrafting donor leukocyte infusion (focus on microtransplantation for acute myeloid leukemia).

    abstract:PURPOSE OF REVIEW:Microtransplantation (or micro-stem cell transplantation, MST) is one permutation of alloreactive immunotherapy increasingly studied in clinical trials. It is most commonly applied to patients with myeloid malignancies who are not suitable candidates for allogeneic hematopoietic cell transplantation. ...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000539

    authors: Krakow EF

    更新日期:2019-11-01 00:00:00

  • Neonatal and pediatric platelet transfusions: current concepts and controversies.

    abstract:PURPOSE OF REVIEW:In this review, we focus on three specific concepts related to platelet transfusion in the neonatal and pediatric population: choice of transfusion threshold; use of ABO-mismatched platelets; transfusion of pathogen-reduced or inactivated platelets. RECENT FINDINGS:Recent trials support the use of lo...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000542

    authors: Patel RM,Josephson C

    更新日期:2019-11-01 00:00:00

  • Recent advances in inherited platelet disorders.

    abstract:PURPOSE OF REVIEW:The increasing use of high throughput sequencing and genomic analysis has facilitated the discovery of new causes of inherited platelet disorders. Studies of these disorders and their respective mouse models have been central to understanding their biology, and also in revealing new aspects of platele...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000525

    authors: Pluthero FG,Kahr WHA

    更新日期:2019-09-01 00:00:00

  • Hematopoietic stem cells: self-renewal and expansion.

    abstract::: Hematopoietic stem cells (HSCs) are a unique population of cells with the remarkable ability to replenish themselves through self-renewal and to give rise to differentiated cell lineages. Though having been discovered more than 50 years ago, and having been widely used in bone marrow transplantation to treat blood d...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000506

    authors: Li Z,He XC,Li L

    更新日期:2019-07-01 00:00:00

  • Neutropenia in glycogen storage disease Ib: outcomes for patients treated with granulocyte colony-stimulating factor.

    abstract:PURPOSE OF REVIEW:Glycogen storage disease Ib (GSD Ib) is characterized by hepatomegaly, hypoglycemia, neutropenia, enterocolitis and recurrent bacterial infections. It is attributable to mutations in G6PT1, the gene for the glucose-6-phosphate transporter responsible for transport of glucose into the endoplasmic retic...

    journal_title:Current opinion in hematology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/MOH.0000000000000474

    authors: Dale DC,Bolyard AA,Marrero T,Kelley ML,Makaryan V,Tran E,Leung J,Boxer LA,Kishnani PS,Austin S,Wanner C,Ferrecchia IA,Khalaf D,Maze D,Kurtzberg J,Zeidler C,Welte K,Weinstein DA

    更新日期:2019-01-01 00:00:00

  • The clinical consequences of neutrophil priming.

    abstract:PURPOSE OF REVIEW:Neutrophils priming has been long studied in vitro. Recent studies describe it in vivo. In pathophysiological conditions, complex, heterogeneous characteristics of priming are described in the last few years. RECENT FINDINGS:Priming can occur systemically when insults such as sepsis or trauma result ...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000471

    authors: Vogt KL,Summers C,Condliffe AM

    更新日期:2019-01-01 00:00:00

  • Microtransplantation: clinical applications and mechanisms.

    abstract:PURPOSE OF REVIEW:Microtransplantation (MST) has been successfully used to manage patients with hematological malignancies, especially older patients with acute myeloid leukemia (AML). Recent clinical applications and mechanistic studies of MST are reviewed. RECENT FINDINGS:MST improves complete remission rates which ...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000470

    authors: Cai B,Guo M,Ai H

    更新日期:2018-11-01 00:00:00

  • Hemolysis and immune regulation.

    abstract:PURPOSE OF REVIEW:Hemolytic anemias caused by premature destruction of red blood cells occur in many disorders including hemoglobinopathies, autoimmune conditions, during infection or following reaction to drugs or transfusions. Recent studies which will be reviewed here have uncovered several novel mechanisms by which...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000423

    authors: Zhong H,Yazdanbakhsh K

    更新日期:2018-05-01 00:00:00

  • Endothelial cell biology of Endoglin in hereditary hemorrhagic telangiectasia.

    abstract:PURPOSE OF REVIEW:Mutations in the Endoglin (Eng) gene, an auxiliary receptor in the transforming growth factor beta (TGFβ)-superfamily signaling pathway, are responsible for the human vascular disorder hereditary hemorrhagic telangiectasia (HHT) type 1, characterized in part by blood vessel enlargement. A growing body...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000419

    authors: Sugden WW,Siekmann AF

    更新日期:2018-05-01 00:00:00

  • MicroRNAs in endothelial cell homeostasis and vascular disease.

    abstract:PURPOSE OF REVIEW:Since the first discovery of microRNAs (miRNAs) in 1993, the involvement of miRNAs in different aspects of vascular disease has emerged as an important research field. In this review, we summarize the fundamental roles of miRNAs in controlling endothelial cell functions and their implication with seve...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000424

    authors: Fernández-Hernando C,Suárez Y

    更新日期:2018-05-01 00:00:00

  • Immune therapies in acute myeloid leukemia: a focus on monoclonal antibodies and immune checkpoint inhibitors.

    abstract:PURPOSE OF REVIEW:This review discusses the rationale, efficacy, and toxicity of a variety of immune approaches being evaluated in the therapy of acute myeloid leukemia (AML) including naked and conjugated monoclonal antibodies, bispecific T-cell engager antibodies, and immune checkpoint blockade via antibodies targeti...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000401

    authors: Assi R,Kantarjian H,Ravandi F,Daver N

    更新日期:2018-03-01 00:00:00

  • Long non-coding RNAs in leukemia: biology and clinical impact.

    abstract:PURPOSE OF REVIEW:Over the last years, long non-coding RNAs (lncRNAs) have emerged as putative regulators of malignant hematopoietic development. Here, we review recent literature on the involvement of lncRNAs in leukemia, including their role in driving or sustaining disease and their potential impact on diagnosis, cl...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000354

    authors: Lammens T,Durinck K,Wallaert A,Speleman F,Van Vlierberghe P

    更新日期:2017-07-01 00:00:00

  • Regulation of the hematopoietic stem cell lifecycle by the endothelial niche.

    abstract:PURPOSE OF REVIEW:Hematopoietic stem cells (HSCs) predominantly reside either in direct contact or in close proximity to the vascular endothelium throughout their lifespan. From the moment of HSC embryonic specification from hemogenic endothelium, endothelial cells (ECs) act as a critical cellular-hub that regulates a ...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000350

    authors: Ramalingam P,Poulos MG,Butler JM

    更新日期:2017-07-01 00:00:00

  • Endothelial cell disease: emerging knowledge from cerebral cavernous malformations.

    abstract:PURPOSE OF REVIEW:Endothelial cells dysfunctions are crucial determinants of several human diseases. We review here the most recent reports on endothelial cell defects in cerebral cavernous malformations (CCMs), particularly focusing on adherens junctions. CCM is a vascular disease that affects specifically the venous ...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000338

    authors: Lampugnani MG,Malinverno M,Dejana E,Rudini N

    更新日期:2017-05-01 00:00:00

  • Matched sibling donor hematopoietic stem cell transplantation for thalassemia.

    abstract:PURPOSE OF REVIEW:Bone marrow transplantation is the only curative treatment for severe thalassemia. Since its successful first report in 1981, more than 4000 patients with this disease worldwide underwent bone marrow transplantation. The purpose of this review is to update the most recent reports of matched sibling do...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000286

    authors: Issaragrisil S,Kunacheewa C

    更新日期:2016-11-01 00:00:00

  • 'Waterloo': when normal blood cells meet leukemia.

    abstract:PURPOSE OF REVIEW:Mortality and morbidity associated with leukemia are largely due to frequently occurring cytopenias or the dysfunction of normal blood cells in patients. Our knowledge of how normal blood cells degenerate in response to leukemic cell infiltration has been quite limited. This review summarizes recent f...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000253

    authors: Cheng H,Cheng T

    更新日期:2016-07-01 00:00:00

  • Hematopoietic stem cell lineage specification.

    abstract:PURPOSE OF REVIEW:Hematopoietic stem cells (HSCs) possess two fundamental characteristics, the capacity for self-renewal and the sustained production of all blood cell lineages. The fine balance between HSC expansion and lineage specification is dynamically regulated by the interplay between external and internal stimu...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000260

    authors: Pouzolles M,Oburoglu L,Taylor N,Zimmermann VS

    更新日期:2016-07-01 00:00:00

  • Exosomes promote bone marrow angiogenesis in hematologic neoplasia: the role of hypoxia.

    abstract:PURPOSE OF REVIEW:To review the data on angiogenesis related to exosomes secreted by tumor cells in hematologic neoplasia and to elucidate the role of exosomes and exosomal miRNA in the bone marrow microenvironment, especially under hypoxic conditions. RECENT FINDINGS:Cross-talk between bone marrow tumor cells and sur...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000235

    authors: Ohyashiki JH,Umezu T,Ohyashiki K

    更新日期:2016-05-01 00:00:00

  • Is cure for chronic myeloid leukemia possible in the tyrosine kinase inhibitors era?

    abstract:PURPOSE OF REVIEW:The advent of tyrosine kinase inhibitors (TKI) has remarkably changed the treatment of chronic myeloid leukemia (CML). Patients treated in chronic phase can enjoy an expected survival similar to the general population. In the last few years we have found that some patients with an excellent therapeuti...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000224

    authors: Bansal A,Radich J

    更新日期:2016-03-01 00:00:00

  • Update on granulocyte transfusions: accumulation of promising data, but still lack of decisive evidence.

    abstract:PURPOSE OF REVIEW:Inconsistent results regarding the clinical efficacy of granulocyte transfusions for the treatment or prophylaxis of life-threatening infections in neutropenic patients have been attributed to insufficient number of transfused neutrophils. Since the introduction of granulocyte colony-stimulating facto...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000203

    authors: Yoshihara S,Ikemoto J,Fujimori Y

    更新日期:2016-01-01 00:00:00

  • Activated T cells armed with bispecific antibodies kill tumor targets.

    abstract:PURPOSE OF REVIEW:Adoptive T-cell therapy has become one of the most exciting fields of cancer therapy in the past few years. In this article, we describe a method which combines adoptive T-cell therapy with antibody therapy by arming T cells from cord blood, normal patients, and cancer patients with bispecific antibod...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000176

    authors: Bhutani D,Lum LG

    更新日期:2015-11-01 00:00:00

  • Massive transfusion: red blood cell to plasma and platelet unit ratios for resuscitation of massive hemorrhage.

    abstract:PURPOSE OF REVIEW:The aim of this short study is to review recently published data bearing on how to resuscitate massive uncontrolled hemorrhage. RECENT FINDINGS:New data inform our understanding of the mechanisms of the acute coagulopathy of trauma, the median time to death of trauma patients with uncontrolled hemorr...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000184

    authors: Murphy CH,Hess JR

    更新日期:2015-11-01 00:00:00

  • Role of the mammalian target of rapamycin pathway in lentiviral vector transduction of hematopoietic stem cells.

    abstract:PURPOSE OF REVIEW:A major goal in repopulating hematopoietic stem cell (HSC) gene therapies is achieving high-efficacy gene transfer, while maintaining robust HSC engraftment and differentiation in vivo. Recent studies have documented that rapamycin treatment of HSC during lentiviral vector transduction enhances gene t...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000150

    authors: Wang CX,Torbett BE

    更新日期:2015-07-01 00:00:00

  • Unexpected functions of nuclear factor-κB during germinal center B-cell development: implications for lymphomagenesis.

    abstract:PURPOSE OF REVIEW:B-cell tumors originating from the transformation of germinal center B cells frequently harbor genetic mutations, leading to constitutive activation of the nuclear factor-κB (NF-κB) signaling pathway. The present review highlights recent insights into the roles of separate NF-κB transcription factors ...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000160

    authors: Klein U,Heise N

    更新日期:2015-07-01 00:00:00

  • New insights into iron regulation and erythropoiesis.

    abstract:PURPOSE OF REVIEW:Iron homeostasis and erythropoiesis regulate each other to ensure optimal delivery of oxygen and iron to cells and tissues. Defining the mechanisms of this crosstalk is important for understanding the pathogenesis of common conditions associated with disordered iron metabolism and erythropoiesis. REC...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000132

    authors: Kim A,Nemeth E

    更新日期:2015-05-01 00:00:00

  • Neutrophilic dermatosis: disease mechanism and treatment.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to describe the physiopathological and therapeutic aspects of neutrophilic dermatosis, taking into account their most frequent associated conditions. RECENT FINDINGS:In autoinflammatory syndromes featuring neutrophilic dermatosis, the role of interleukin-1 and tumor necr...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000100

    authors: Maalouf D,Battistella M,Bouaziz JD

    更新日期:2015-01-01 00:00:00

  • Leukoreduction and blood-borne vCJD transmission risk.

    abstract:PURPOSE OF REVIEW:Risk assessments for transmission of variant Creutzfeldt-Jakob disease predicted that leukocyte reduction would be inefficient at preventing transmission of the disease by blood transfusion. Nevertheless, approximately 14 years ago, a significant proportion of European countries decided to implement l...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000101

    authors: Douet JY,Bujdoso R,Andréoletti O

    更新日期:2015-01-01 00:00:00

  • Recent advances in the antiphospholipid antibody syndrome.

    abstract:PURPOSE OF REVIEW:The antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by recurrent thrombosis and/or obstetrical morbidity in the presence of persistently positive antiphospholipid antibodies. Recent insights into the pathogenesis of APS have begun to elucidate pathophysiology and led to...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000067

    authors: Chaturvedi S,McCrae KR

    更新日期:2014-09-01 00:00:00

  • Zebrafish as a model system for the study of hemostasis and thrombosis.

    abstract:PURPOSE OF REVIEW:Although the zebrafish has been established as a research tool over the past two to three decades, in hematology it has primarily been used to investigate areas distinct from coagulation. The advantages of this vertebrate model include high fecundity, rapid and external development, and conservation o...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000075

    authors: Weyand AC,Shavit JA

    更新日期:2014-09-01 00:00:00

  • Beyond Philadelphia: 'Ph-like' B cell precursor acute lymphoblastic leukemias - diagnostic challenges and therapeutic promises.

    abstract:PURPOSE OF REVIEW:The presence of the Philadelphia chromosome causing the fusion between BCR to ABL1 in B cell precursor acute lymphoblastic leukemias (ALLs) was associated with a particularly bad prognosis, which has been markedly improved with the addition of imatinib to chemotherapy. Recent genomic studies have lead...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000050

    authors: Izraeli S

    更新日期:2014-07-01 00:00:00

  • Iron chelation: an update.

    abstract:PURPOSE OF REVIEW:This review provides an update on advances in the area of iron chelation therapy, including new indications and uses of currently available agents, and preliminary data on potential new agents in development. RECENT FINDINGS:Two new oral agents, deferasirox and deferiprone, have become available in t...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000031

    authors: Sheth S

    更新日期:2014-05-01 00:00:00

  • Defensins in innate immunity.

    abstract:PURPOSE OF REVIEW:Defensins are a major family of antimicrobial peptides expressed predominantly in neutrophils and epithelial cells, and play important roles in innate immune defense against infectious pathogens. Their biological functions in and beyond innate immunity, structure and activity relationships, mechanisms...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0000000000000005

    authors: Zhao L,Lu W

    更新日期:2014-01-01 00:00:00

  • Stem cell transplantation for primary immune deficiency.

    abstract:PURPOSE OF REVIEW:In this article, we summarize the recent advances in treating primary immune deficiency (PID) disorders by stem cell transplantation (SCT); we have focused on articles published in the past 2 years since the last major review of SCT for PID. RECENT FINDINGS:Analyses of the outcomes of SCT for PID by ...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0b013e328365a13b

    authors: Worth AJ,Booth C,Veys P

    更新日期:2013-11-01 00:00:00

  • Mechanisms of thrombosis in obesity.

    abstract:PURPOSE OF REVIEW:Obesity has become a worldwide epidemic that is driving increased morbidity and mortality from thrombotic disorders such as myocardial infarction, stroke, and venous thromboembolism. Effective prevention and treatment of thrombosis in obese patients is limited by an incomplete understanding of the und...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0b013e3283634443

    authors: Blokhin IO,Lentz SR

    更新日期:2013-09-01 00:00:00

  • Early T-cell precursor acute lymphoblastic leukaemia.

    abstract:PURPOSE OF REVIEW:Early T-cell precursor (ETP) leukaemias have been recently recognized as a form of T-cell acute lymphoblastic leukaemia (T-ALL) with a poor prognosis. The purpose of this review is to outline the most recent advances in the biology, genetics and prognostic significance of this aggressive disease. REC...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0b013e3283623c61

    authors: Haydu JE,Ferrando AA

    更新日期:2013-07-01 00:00:00

  • Role of sphingosine 1-phosphate in trafficking and mobilization of hematopoietic stem cells.

    abstract:PURPOSE OF REVIEW:The 'mobilization' of hematopoietic stem cells (HSCs) out of the bone marrow and into the peripheral blood is used clinically to obtain HSCs for transplantation. Although generally successful, mobilization protocols remain imperfect and the mechanisms involved are not fully understood. This review dis...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0b013e3283606090

    authors: Bendall LJ,Basnett J

    更新日期:2013-07-01 00:00:00

  • The metabolism of lymphomas.

    abstract:PURPOSE OF REVIEW:Cellular to animal to human studies are shedding light on metabolic pathways that contribute to sustaining lymphomagenesis. Old players with new metabolic tricks and new metabolic players come into the scene. The purpose of this review is to discuss the recent advances made in the field of lymphoma me...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0b013e3283623d16

    authors: Calvo-Vidal MN,Cerchietti L

    更新日期:2013-07-01 00:00:00

  • Fibroblast growth factor signaling promotes physiological bone remodeling and stem cell self-renewal.

    abstract:PURPOSE OF REVIEW:Fibroblast growth factor (FGF) signaling activates many bone marrow cell types, including various stem cells, osteoblasts, and osteoclasts. However, the role of FGF signaling in regulation of normal and leukemic stem cells is poorly understood. This review highlights the physiological roles of FGF sig...

    journal_title:Current opinion in hematology

    pub_type: 杂志文章,评审

    doi:10.1097/MOH.0b013e3283606162

    authors: Itkin T,Kaufmann KB,Gur-Cohen S,Ludin A,Lapidot T

    更新日期:2013-05-01 00:00:00

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