abstract：Objective:In order to further study the changes of cerebral functional connectivity in patients with toothache (TA), this study used the resting-state functional magnetic resonance imaging (rs-fMRI) technique and degree centrality (DC) analysis method. Methods:Eighteen TA patients (8 males, 10 females) and 18 healthy ...

journal_title：Disease markers

authors： Wu SN,Zhang MY,Shu HY,Liang RB,Ge QM,Pan YC,Zhang LJ,Li QY,Shao Y

更新日期：2020-12-28 00:00:00

abstract：Purpose:Liver metastasis is the final stage of cancer progression and is associated with poor prognosis. Although numerous indicators have been identified as having prognostic value for lung cancer and liver metastasis, liver metastases are still not diagnosed by imaging in many patients. To provide a more accurate met...

journal_title：Disease markers

authors： Wang CF,Peng SJ,Liu RQ,Yu YJ,Ge QM,Liang RB,Li QY,Li B,Shao Y

更新日期：2020-12-09 00:00:00

abstract：Objective:A growing body of emerging evidence indicates that metabolic processes play a pivotal role in the biological processes underlying acute myocardial infarction (AMI). The aim of the current study was to identify featured metabolism-related genes in patients with AMI using a support vector machine (SVM) and to f...

journal_title：Disease markers

authors： Xie H,Zha E,Zhang Y

更新日期：2020-11-28 00:00:00

abstract：Purpose:To investigate the expression profiles of long noncoding RNAs (lncRNAs) in patients with atrial fibrillation (AF). Methods:The peripheral blood monocytes of a total of 20 patients with AF and 20 healthy subjects were collected for gene chip technology to detect differentially expressed lncRNAs from 2017.01 to ...

journal_title：Disease markers

authors： Ruan ZB,Wang F,Gongben BD,Chen GC,Zhu L

更新日期：2020-11-22 00:00:00

abstract：Objective:Long noncoding RNAs (lncRNAs) have been strongly associated with various types of cancer. The present study aimed at exploring the diagnostic and prognostic value of lncRNA Zinc finger protein 667-antisense RNA 1 (ZNF667-AS1) in glioma patients. Patients and Methods. The expressions of ZNF667-AS1 were detecte...

journal_title：Disease markers

authors： Yuan Q,Gao C,Lai XD,Chen LY,Lai TB

更新日期：2020-11-16 00:00:00

abstract：Background:The C-reactive protein (CRP)/albumin ratio is a useful index used to represent patient inflammation and nutritional status. Elderly patients are at the highest risk for acute kidney injury (AKI). We clarified the impact of the preoperative CRP/albumin ratio on AKI and evaluated the impact of postoperative AK...

journal_title：Disease markers

authors： Yu J,Park JY,Ha S,Hwang JH,Kim YK

更新日期：2020-10-27 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2017/1202710.]. ...

journal_title：Disease markers

authors： Jiang T,Yang C,Ma L,Wu Z,Ye L,Ma X,Li H,Fan J,Yang Y

更新日期：2020-10-14 00:00:00

abstract：Background:Obstructive sleep apnea (OSA) was highly prevalent in patients with type 2 diabetes (T2D). Cathepsin S (CTSS), a cysteine protease, is involved in the inflammatory activity in T2D and hypoxia conditions. The aim of the study was to evaluate whether CTSS could be involved in the inflammatory reaction of OSA i...

journal_title：Disease markers

authors： Wen W,Sun H,Yang Y,Jia Y,Fang F,Qin Y,Zhang M,Wei Y

更新日期：2020-09-25 00:00:00

abstract：Background:The pathogenesis of thoracic aortopathy is complex, and much evidence suggests the influence of genetic factors. Some genes with polymorphisms are widely considered critical factors in the initiation and development of aortic aneurysm. The aim of our study was to analyze the association of genetic polymorphi...

journal_title：Disease markers

authors： Gorący I,Grudniewicz S,Safranow K,Ciechanowicz A,Jakubiszyn P,Gorący A,Brykczyński M

更新日期：2020-09-24 00:00:00

abstract：:Vitamin D plays a role in central nervous system (CNS) development. Recent literature focused on vitamin D status in children and adolescents with autism spectrum disorder (ASD), but with inconsistent results. Our case-control study is aimed at evaluating serum 25-hydroxyl-vitamin D (25(OH)D) concentration in children...

journal_title：Disease markers

authors： Petruzzelli MG,Marzulli L,Margari F,De Giacomo A,Gabellone A,Giannico OV,Margari L

更新日期：2020-09-18 00:00:00

abstract：Background:Few previous studies have comprehensively explored the level of DNA methylation and gene expression in ccRCC. The purpose of this study was to identify the key clear cell renal cell carcinoma- (ccRCC-) related DNA methylation-driven genes (MDG) and to build a prognostic model based on the level of DNA methyl...

journal_title：Disease markers

authors： Hu M,Xie J,Hou H,Liu M,Wang J

更新日期：2020-07-11 00:00:00

abstract：:Kinesin family member 20A (KIF20A) has been recently reported to be upregulated and associated with increased invasiveness and metastasis in several malignancies. However, the role of KIF20A in colorectal cancer (CRC) is still unclear. This study is aimed at investigating the potential roles of KIF20A in the developme...

journal_title：Disease markers

authors： Zhang Q,Di J,Ji Z,Mi A,Li Q,Du X,Wang A,Wang A,Qin C

更新日期：2020-07-08 00:00:00

abstract：Materials and Methods:Relative expression of lncRNAs CARMN, LUCAT1, SMILR, and MALAT1 was tested in clinical aortic tissue and blood plasma samples from TAA and non-TAA patients using the qRT-PCR method. The Mann-Whitney U test was used to compare ΔCt values between the study groups. ROC curve analysis was performed to...

journal_title：Disease markers

authors： Patamsytė V,Žukovas G,Gečys D,Žaliaduonytė D,Jakuška P,Benetis R,Lesauskaitė V

更新日期：2020-06-17 00:00:00

abstract：:The prevalence of heart failure (HF) due to cardiac remodelling after acute myocardial infarction (AMI) does not decrease regardless of implementation of new technologies supporting opening culprit coronary artery and solving of ischemia-relating stenosis with primary percutaneous coronary intervention (PCI). Numerous...

journal_title：Disease markers

authors： Berezin AE,Berezin AA

更新日期：2020-06-12 00:00:00

abstract：:PD1/PDL1 inhibitors have been adopted for the treatment of advanced non-small-cell lung cancer, and PDL1 expression has been investigated as a predictive biomarker for PD1/PDL1 inhibitor therapy. However, PDL1 lacks diagnostic accuracy in differentiating patients who are likely or unlikely to benefit. So, it is urgent...

journal_title：Disease markers

authors： Wu Y,Lin L,Liu X

更新日期：2020-06-09 00:00:00

abstract：Background:Breast cancer is the commonest malignancy in women worldwide. It is estimated to affect approximately 1.5 million women annually and responsible for the greatest number of cancer-related mortalities among women. In 2018, breast cancer mortalities stood at 627,000 women representing approximately 15% of all c...

journal_title：Disease markers

authors： Arko-Boham B,Owusu BA,Aryee NA,Blay RM,Owusu EDA,Tagoe EA,Adams AR,Gyasi RK,Adu-Aryee NA,Mahmood S

更新日期：2020-05-24 00:00:00

abstract：Methods:We collected 732 samples from Liaoning Province, China, and three polymorphisms in long noncoding RNA H19 were genotyped using the KASP platform. Results:Our data showed that H19 rs2735971 and rs3024270 variant genotypes were associated with a decreased risk of CAD (rs2735971, P = 0.003, odds ratio (OR) = 0.61...

journal_title：Disease markers

authors： Hu WN,Ding HX,Xu Q,Zhang XY,Yang DT,Jin YZ

更新日期：2020-05-10 00:00:00

abstract：Background:Obese women with gestational diabetes mellitus (GDM) have a higher risk of adverse outcomes than women with obesity or GDM alone. Our study is aimed at investigating the discriminatory power of circulatory Wnt1-inducible signaling pathway protein-1 (WISP1), a novel adipocytokine, on the copresence of prepreg...

journal_title：Disease markers

authors： Liu L,Hu J,Yang L,Wang N,Liu Y,Wei X,Gao M,Wang Y,Ma Y,Wen D

更新日期：2020-04-14 00:00:00

abstract：Aim:Increasing evidence indicates that hepatic subcapsular flow (HSF) can serve as a noninvasive ultrasonographic marker for the early diagnosis of biliary atresia (BA). However, results regarding its diagnostic accuracy are inconsistent and inconclusive. We conducted this meta-analysis with an aim to systematically ev...

journal_title：Disease markers

authors： Sun C,Wu B,Pan J,Chen L,Zhi W,Tang R,Zhao D,Guo W,Wang J,Huang S

更新日期：2020-03-01 00:00:00

abstract：:Background and Objective. The main purpose of this study was to develop a simple automatic diagnostic classification scheme for chemotherapy-induced peripheral neuropathy. Methods:This was a prospective cohort study that enrolled patients with colorectal or gynecologic cancer post chemotherapy for more than 1 year. T...

journal_title：Disease markers

authors： Huang HW,Wu PY,Su PF,Li CI,Yeh YM,Lin PC,Hsu KF,Shen MR,Chang JY,Lin CK

更新日期：2020-01-25 00:00:00

abstract：Objectives:To explore the impact of volume change in the fractionated tracking of stereotactic radiotherapy on the results of synchronous, respiratory tracking algorithm using CyberKnife. Methods:A total of 38 lung tumor patients receiving stereotactic radiotherapy at our center from March 2018 to October 2019 were co...

journal_title：Disease markers

authors： Li GQ,Wang Y,Qiu MJ,Yang J,Peng ZJ,Zhang S,Fang X,Yang SL

更新日期：2020-01-11 00:00:00

abstract：Backgrounds:Both pretreatment serum CRP (C-reactive protein) level and ALB (albumin) level have been found to be predictive of survival for multiple malignancies including sarcoma. Since both of the GPS (Glasgow prognostic score) and CAR (C-reactive protein to albumin ratio) are based on the combination of CRP and ALB,...

journal_title：Disease markers

authors： Fang E,Wang X,Feng J,Zhao X

更新日期：2020-01-07 00:00:00

abstract：:To identify the novel, noninvasive biomarkers to assess the outcome and prognosis of breast cancer (BC), patients with high sensitivity and specificity are greatly desired. Herein, the miRNA expression profile and matched clinical features of BC patients were extracted from The Cancer Genome Atlas (TCGA) database. The...

journal_title：Disease markers

authors： Tang J,Ma W,Zeng Q,Tan J,Cao K,Luo L

更新日期：2019-12-30 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases. Obesity is the most common and well-established risk factor for NAFLD, but there are large interindividual differences in the relationship between weight status and the development of NAFLD. Beta-3-adrenergic receptor (ADRB3)...

journal_title：Disease markers

authors： Sakamoto Y,Oniki K,Kumagae N,Morita K,Otake K,Ogata Y,Saruwatari J

更新日期：2019-12-17 00:00:00

abstract：Background:We have previously shown that the deficiency of the gut enzyme intestinal alkaline phosphatase (IAP) is associated with type 2 diabetes mellitus (T2DM) in humans, and mice deficient in IAP develop the metabolic syndrome, a precipitant of T2DM and ischemic heart disease (IHD). We hypothesized that IAP deficie...

journal_title：Disease markers

authors： Malo J,Alam MJ,Shahnaz M,Kaliannan K,Chandra G,Aziz T,Sarker T,Bala M,Paul R,Saha CK,Karmakar PK,Malo MS

更新日期：2019-12-13 00:00:00

abstract：:The eukaryotic initiation factor 3 (eIF3) is the largest and most complex translation initiation factor in mammalian cells. It consists of 13 subunits and among which several were implicated to have significant prognostic effects on multiple human cancer entities. To examine the expression profiles of eIF3 subunits an...

journal_title：Disease markers

authors： Wang D,Jia Y,Zheng W,Li C,Cui W

更新日期：2019-12-07 00:00:00

abstract：:Renal cell carcinoma (RCC) is one of the most common genitourinary cancers worldwide. Previous evidence shows that long noncoding RNA (LncRNA) APOC1P1 plays an important role in cancer development. However, the role of LncRNA APOC1P1 in ccRCC remains to be explored. LncRNA APOC1P1 expression in 283 ccRCC tissues and 3...

journal_title：Disease markers

authors： Sun C,Zhou Z,Shi H,Li F,Zhang G

更新日期：2019-12-01 00:00:00

abstract：Background:Lactate has been widely used as a risk indicator of outcomes in critically ill patients due to its ready measurement and good predictive ability. However, the interconnections between lactate metabolism and glucose metabolism have not been sufficiently explored, yet. In this study, we aimed to investigate wh...

journal_title：Disease markers

authors： Chen X,Bi J,Zhang J,Du Z,Ren Y,Wei S,Ren F,Wu Z,Lv Y,Wu R

更新日期：2019-11-26 00:00:00

abstract：Purpose:To determine the frequency of the genotype of signal transducer and activator of transcription protein 3 (STAT3) rs744166, sirtuin (SIRT1) rs12778366, fibroblast growth factor (FGFR2) rs2981582, and advanced glycosylation end product-specific receptor (RAGE) rs1800625 gene polymorphisms in patients with larynge...

journal_title：Disease markers

authors： Uloza V,Tamauskaite T,Vilkeviciute A,Pasvenskaite A,Liutkevicius V,Liutkeviciene R

更新日期：2019-11-12 00:00:00

abstract：:INHBA-encoded inhibin β A is a member of the transforming growth factor-β (TGF-β) superfamily. INHBA has been reported to be implicated in the progression of multiple types of cancer including ovarian cancer (OC). However, the mechanisms by which INHBA affects OC progression are not well-characterized. The aim of our ...

journal_title：Disease markers

authors： Li X,Yang Z,Xu S,Wang Z,Jin P,Yang X,Zhang Z,Wang Y,Wei X,Fang T,Gao Q

更新日期：2019-11-11 00:00:00

abstract：Objective:Several serum markers were reported to reflect the severity of pulmonary alveolar proteinosis (PAP). The aim of this study is to investigate a reliable and facile marker to access and monitor the clinical course of PAP in a large cohort. Methods:PAP patients from January 2010 to June 2018 were enrolled. Hosp...

journal_title：Disease markers

authors： Shi S,Chen L,Qiu X,Zhao Q,Xiao Y,Yan X

更新日期：2019-11-11 00:00:00

abstract：:Cyclin-dependent kinase regulatory subunit 2 (CKS2) is a member of the cell cycle-dependent protein kinase subunit family, which is implicated as an oncogene in various malignancies. However, the clinical significance, oncogenic functions, and related mechanisms of CKS2 in hepatocellular carcinoma (HCC) remain largely...

journal_title：Disease markers

authors： Zhang J,Song Q,Liu J,Lu L,Xu Y,Zheng W

更新日期：2019-10-22 00:00:00

abstract：:Pancreatic adenocarcinoma (PDAC) still represents a devastating disease associated with a very limited survival. Novel biomarkers allowing an early diagnosis as well as an optimal selection of suitable treatment options for individual patients are urgently needed to improve the dismal outcome of PDAC patients. Recentl...

journal_title：Disease markers

authors： Loosen SH,Luedde M,Lurje G,Spehlmann M,Paffenholz P,Ulmer TF,Tacke F,Vucur M,Trautwein C,Neumann UP,Luedde T,Roderburg C

更新日期：2019-10-20 00:00:00

abstract：Aim:To evaluate the diagnosis value of serum human epididymis protein 4 (HE4), cancer antigen 125 (CA125), the Risk of Ovarian Malignancy Algorithm (ROMA), and Copenhagen Index (CPH-I) at early stages for differentiating borderline ovarian tumors from epithelial ovarian cancer. Methods:We recruited 144 borderline ovar...

journal_title：Disease markers

authors： Wang Z,Tao X,Ying C

更新日期：2019-10-13 00:00:00

abstract：Purpose:To investigate the association of galectin-3 (Gal-3) and soluble ST2 (sST2) and their follow-up changes with the development of heart failure (HF) and echocardiographic parameters of HF (ejection fraction, atrial and ventricular size, left ventricular hypertrophy, e', and E/e') in patients with ST-segment eleva...

journal_title：Disease markers

authors： Tymińska A,Kapłon-Cieślicka A,Ozierański K,Budnik M,Wancerz A,Sypień P,Peller M,Balsam P,Opolski G,Filipiak KJ

更新日期：2019-10-10 00:00:00

abstract：Background:The role of the NFKB1 gene rs28362491 polymorphism and NFKBIA gene rs2233406 polymorphism in the development of head and neck cancer (HNC) remains controversial. This meta-analysis was performed to assess the relationship between the gene polymorphisms and HNC quantitatively. Methods:PubMed, Embase, Web of ...

journal_title：Disease markers

authors： Li L,Zhang ZT

更新日期：2019-09-12 00:00:00

abstract：Background:The ratio of early mitral inflow velocity to the global diastolic strain rate (E/E'sr) and global longitudinal systolic strain (GLS) of the left ventricle (LV) are emerging indices of diastolic and systolic functions, respectively, for the LV. Their prognostic significance in the prediction of mortality and ...

journal_title：Disease markers

authors： Huang JC,Su HM,Wu PY,Lee JJ,Lee WH,Chen SC,Chiu YW,Hsu YL,Chang JM,Chen HC

更新日期：2019-09-05 00:00:00

abstract：:Colorectal cancer is one of the most common cancers in the world. Due to its still undetermined pathogenesis, we are searching for signaling pathways that are important in the development of colorectal cancer. In this article, we present results of study on the role of ADAM proteins in colorectal cancer. The study inc...

journal_title：Disease markers

authors： Walkiewicz K,Strzelczyk J,Waniczek D,Biernacki K,Muc-Wierzgoń M,Copija A,Nowakowska-Zajdel E

更新日期：2019-09-02 00:00:00

abstract：:There is a known relationship between serum alanine aminotransferase (ALT) and obesity in humans, but the mechanism(s) are not clarified. This study investigated the associations between serum ALT and body composition in an overweight and obese population. The results are based on data from a previous randomized contr...

journal_title：Disease markers

authors： Bekkelund SI,Jorde R

更新日期：2019-08-26 00:00:00

abstract：Background:Epithelial ovarian cancer (EOC) is highly lethal worldwide. Factors involved in the inflammation and hormone-associated signaling pathway play vital roles in EOC carcinogenesis. The transforming growth factor-β- (TGF-β-) activated kinase 1 (MAP3K7) binding protein 2 (TAB2), mediating convergence of inflammat...

journal_title：Disease markers

authors： Huang X,Shen C,Zhang Y,Li Q,Li K,Wang Y,Song Y,Su M,Zhou B,Wang W

更新日期：2019-08-14 00:00:00