abstract：CONTEXT.—:Breast cancer biomarker assessment is critical in determining treatment and prognosis. In Tanzania, immunohistochemistry (IHC) is limited to surgical specimens and core biopsies. However, performing IHC on fine-needle aspiration biopsy cell blocks would offer numerous advantages. OBJECTIVE.—:To compare the p...

journal_title：Archives of pathology & laboratory medicine

authors： Kimambo AH,Vuhahula EA,Mwakigonja AR,Ljung BM,Zhang L,Van Loon K,Ng DL

更新日期：2020-10-14 00:00:00

abstract：CONTEXT.—:Pathologist interobserver discordance is significant in grading of prostate cancer, limiting reliability. Diagnostic reproducibility may be improved with digital images, but adoption faces workflow, cost, and quality challenges. A novel digital method using an alternative tissue processing approach and novel ...

journal_title：Archives of pathology & laboratory medicine

authors： Torres R,Olson E,Homer R,Martin DT,Levene MJ,Perincheri S,Sprenkle PC,Humphrey PA

更新日期：2020-09-29 00:00:00

abstract：CONTEXT.—:Studies on the adoption of voice recognition in health care have mostly focused on turnaround time and error rate, with less attention paid to the impact on the efficiency of the providers. OBJECTIVE.—:To study the impact of voice recognition on the efficiency of grossing biopsy specimens. DESIGN.—:Timestam...

journal_title：Archives of pathology & laboratory medicine

authors： Ye JJ,Tan MR,Shum CH

更新日期：2020-09-22 00:00:00

abstract：CONTEXT.—:The diagnostic distinction of pulmonary neuroendocrine (NE) tumors from non-small cell lung carcinomas (NSCLCs) is clinically relevant for prognostication and treatment. Diagnosis is based on morphology and immunohistochemical staining. OBJECTIVE.—:To determine the diagnostic value of insulinoma-associated p...

journal_title：Archives of pathology & laboratory medicine

authors： Staaf J,Tran L,Söderlund L,Nodin B,Jirström K,Vidarsdottir H,Planck M,Mattsson JSM,Botling J,Micke P,Brunnström H

更新日期：2020-09-01 00:00:00

abstract：CONTEXT.—:Treatment of chronic viral hepatitis C (HCV) infection with direct-acting antiviral agents (DAAs) results in cure, or sustained viral response (SVR), in more than 90% of patients. However, there are subsets of patients who have persistent liver inflammation and fibrosis and develop hepatocellular carcinoma (H...

journal_title：Archives of pathology & laboratory medicine

authors： Celli R,Saffo S,Kamili S,Wiese N,Hayden T,Taddei T,Jain D

更新日期：2020-08-18 00:00:00

abstract：CONTEXT.—:Endometrial serous carcinoma is an aggressive subtype of endometrial cancer with the highest rate of recurrence and mortality among all histotypes. A recent clinical trial showed prolonged progression-free survival in advanced-stage and recurrent human epidermal growth factor receptor 2 (HER2)-positive endome...

journal_title：Archives of pathology & laboratory medicine

authors： Buza N

更新日期：2020-07-10 00:00:00

abstract：CONTEXT.—:Data regarding the clinical impact of subspecialist pathology review of appendiceal neoplasms are limited. OBJECTIVE.—:To determine whether pathology review by gastrointestinal pathologists at a tertiary-care referral center resulted in significant changes in the diagnosis and clinical management of appendic...

journal_title：Archives of pathology & laboratory medicine

authors： Jedrzkiewicz J,Tateishi Y,Kirsch R,Conner J,Bischof D,McCart A,Riddell R,Pollett A,Taylor EL,Govindarajan A

更新日期：2020-06-01 00:00:00

abstract：CONTEXT.—:With increasing use and efficacy of antiretroviral therapy for human immunodeficiency virus (HIV) infection, deaths from acquired immunodeficiency syndrome (AIDS)-defining conditions have decreased. OBJECTIVE.—:To examine trends in the cause of death of HIV-infected patients who underwent autopsy at a major ...

journal_title：Archives of pathology & laboratory medicine

authors： Nizami S,Morales C,Hu K,Holzman R,Rapkiewicz A

更新日期：2020-05-01 00:00:00

abstract：CONTEXT.—:Automated analyzers have advanced the field of clinical hematology, mandating updated complete blood count (CBC) reference intervals (RIs) to be clinically useful. Contemporary newborn CBC RI publications are mostly retrospective, which some authors have cited as one of their cardinal limitations and recommen...

journal_title：Archives of pathology & laboratory medicine

authors： Ianni B,McDaniel H,Savilo E,Wade C,Micetic B,Johnson S,Gerkin R

更新日期：2020-04-16 00:00:00

abstract：CONTEXT.—:Squamous lesions of the esophagus encompass a spectrum of disorders ranging from reactive changes and benign papilloma to squamous dysplasia and squamous cell carcinoma, which may pose diagnostic challenges especially in superficial biopsies. OBJECTIVE.—:To provide a review on the typical features of squamou...

journal_title：Archives of pathology & laboratory medicine

authors： Savant D,Zhang Q,Yang Z

更新日期：2020-04-09 00:00:00

abstract：:Pseudomyogenic hemangioendothelioma (PMH) is a rare vascular tumor that presents more frequently in young adults and has a male predominance. It is usually located in the superficial or deep soft tissues of the extremities, but concurrent bone involvement can be present. In approximately two-thirds of patients this di...

journal_title：Archives of pathology & laboratory medicine

authors： Caballero GA,Roitman PD

更新日期：2020-04-01 00:00:00

abstract：CONTEXT.—:There is an ongoing perception that the pathology job market is poor, which may be discouraging medical students from pursuing the specialty. Academic pathologists believe that jobs are available but relocation may be necessary. OBJECTIVE.—:To identify trends regarding the geographic relocation of pathologis...

journal_title：Archives of pathology & laboratory medicine

authors： George MR,Johnson KA,Gratzinger DA,Brissette MD,McCloskey CB,Conran RM,Dixon LR,Roberts CA,Rojiani AM,Shyu I,Timmons CF Jr,Hoffman RD

更新日期：2020-04-01 00:00:00

abstract：CONTEXT.—:The approval of pembrolizumab for treatment of patients with microsatellite instability-high (MSI-H) or mismatch repair-deficient (dMMR) advanced cancers has led to increased requests for MSI and/or MMR immunoperoxidase (IPOX) testing. Diagnoses for patients with advanced-stage cancer are frequently made from...

journal_title：Archives of pathology & laboratory medicine

authors： Jacobi EM,Landon G,Broaddus RR,Roy-Chowdhuri S

更新日期：2020-03-30 00:00:00

abstract：CONTEXT.—:Amyloidosis is an uncommon but important entity. A protein-based classification of amyloidosis defines the underlying disease process, directing clinical management and providing prognostic information. However, in routine surgical pathology there often is no attempt to classify amyloid other than staining to...

journal_title：Archives of pathology & laboratory medicine

authors： Giannini G,Nast CC

更新日期：2020-03-01 00:00:00

abstract：CONTEXT.—:Related to the advances in prenatal diagnosis and the emergence of medically challenging situations, there has been an increased interest in conducting a pathologic study of first-trimester abortion products. OBJECTIVE.—:To evaluate measurements across a large group of first-trimester spontaneous abortion sp...

journal_title：Archives of pathology & laboratory medicine

authors： Nogueira R,Sousa S,Braga AC,Azevedo A,Pereira N,Carmo O,Tavares MP,Pinto JC

更新日期：2020-02-01 00:00:00

abstract：CONTEXT.—:Urine drug testing is frequently ordered by health care providers. Immunoassays are widely used for drug testing, yet have potential limitations, including variable cross-reactivity. The last decade has seen worsening of a prescription drug abuse epidemic. OBJECTIVE.—:To use data from a College of American P...

journal_title：Archives of pathology & laboratory medicine

authors： Krasowski MD,McMillin GA,Melanson SEF,Dizon A,Magnani B,Snozek CLH

更新日期：2020-02-01 00:00:00

abstract：CONTEXT.—:The separation of benign from malignant mesothelial proliferations is a difficult morphologic problem. Some mesotheliomas stain for programmed death ligand-1 (PD-L1). OBJECTIVE.—:To determine whether PD-L1 staining can separate mesotheliomas from reactive mesothelial proliferations (RMPs). DESIGN.—:We stain...

journal_title：Archives of pathology & laboratory medicine

authors： Derakhshan F,Ionescu D,Cheung S,Churg A

更新日期：2020-02-01 00:00:00

abstract：:Mucinous tubular and spindle cell carcinomas are rare kidney tumors with generally indolent behavior. As the name suggests, classic histomorphology reveals bland spindle cells, tubules, and mucinous stroma. Uncommon histologic features include mucin-poor stroma, high nuclear grade, cellular pleomorphism, and presence ...

journal_title：Archives of pathology & laboratory medicine

authors： Nathany S,Monappa V

更新日期：2020-01-01 00:00:00

abstract：CONTEXT.—:Ossifying fibromyxoid tumor (OFMT) is a rare, slow-growing mesenchymal neoplasm of uncertain histogenesis with intermediate malignant potential. OBJECTIVE.—:To highlight the most important diagnostic features, including morphologic, immunohistochemical, and molecular findings; to provide comparisons to other...

journal_title：Archives of pathology & laboratory medicine

authors： Carter CS,Patel RM

更新日期：2019-12-01 00:00:00

abstract：CONTEXT.—:Repair is a challenging diagnosis and a significant source of false-positive (FP) interpretations in cervical cytology. No large-scale study of performance of repair in the liquid-based era has been performed. OBJECTIVE.—:To evaluate the performance of repair in the College of American Pathologists Pap Educa...

journal_title：Archives of pathology & laboratory medicine

authors： Staats PN,Souers RJ,Nunez AL,Li Z,Kurtycz DFI,Goodrich K,Witt BL,Davey DD,Booth CN

更新日期：2019-11-22 00:00:00

abstract：:Human papillomavirus (HPV)-related carcinoma with adenoid cystic-like features is a rare, recently recognized entity restricted to the sinonasal tract. By definition, it is associated with high-risk HPV infection, particularly with HPV type 33. In most cases, tumors are composed of dual cell populations, including pre...

journal_title：Archives of pathology & laboratory medicine

authors： Chen CC,Yang SF

更新日期：2019-11-01 00:00:00

abstract：CONTEXT.—:Resection of breast carcinoma with adequate margins reduces the risk of local recurrence and reoperation. Tozuleristide (BLZ-100) is an investigational peptide-fluorophore agent that may aid in intraoperative tumor detection and margin assessment. In this study, fluorescence imaging was conducted ex vivo on g...

journal_title：Archives of pathology & laboratory medicine

authors： Dintzis SM,Hansen S,Harrington KM,Tan LC,Miller DM,Ishak L,Parrish-Novak J,Kittle D,Perry J,Gombotz C,Fortney T,Porenta S,Hales L,Calhoun KE,Anderson BO,Javid SH,Byrd DR

更新日期：2019-09-01 00:00:00

abstract：CONTEXT.—:Nodal metastasis of a primary tumor influences therapy decisions for a variety of cancers. Histologic identification of tumor cells in lymph nodes can be laborious and error-prone, especially for small tumor foci. OBJECTIVE.—:To evaluate the application and clinical implementation of a state-of-the-art deep ...

journal_title：Archives of pathology & laboratory medicine

authors： Liu Y,Kohlberger T,Norouzi M,Dahl GE,Smith JL,Mohtashamian A,Olson N,Peng LH,Hipp JD,Stumpe MC

更新日期：2019-07-01 00:00:00

abstract：:Hepatoid carcinoma of the ovary (HCO) is a rare malignant tumor of uncertain histogenesis that was first described by Ishikura and Scully in the late 1980s. Unlike hepatoid yolk sac tumor (HYST), one of its main differential diagnoses, HCO usually presents in perimenopausal and postmenopausal women without gonadal dys...

journal_title：Archives of pathology & laboratory medicine

authors： Acosta AM,Pins MR

更新日期：2019-07-01 00:00:00

abstract：CONTEXT.—:The management of lobular neoplasia (LN) found on core biopsy is controversial and ranges from obligatory surgical excision to clinical/imaging observation. OBJECTIVE.—:To determine if in cases of core needle biopsy yielding LN, quantification of normal and diseased terminal ductal lobular units (TDLUs) can ...

journal_title：Archives of pathology & laboratory medicine

authors： Holbrook AI,Hanley K,Jeffers C,Kang J,Cohen MA

更新日期：2019-05-01 00:00:00

abstract：:Succinate dehydrogenase (SDH)-deficient renal cell carcinoma is a recently recognized distinct subtype of renal cell carcinoma in the 2016 World Health Organization classification. It is associated with SDH gene germline mutations, which also cause paraganglioma/pheochromocytoma, gastrointestinal stromal tumor, and pi...

journal_title：Archives of pathology & laboratory medicine

authors： Tsai TH,Lee WY

更新日期：2019-05-01 00:00:00

abstract：:Primary malignant deciduoid mesothelioma is a rare subtype of epithelioid mesothelioma that was first described in the peritoneum in young women without a history of asbestos exposure. It was thought to be a distinct clinicopathologic entity with ominous prognosis; recent studies have better characterized this entity....

journal_title：Archives of pathology & laboratory medicine

authors： Regragui M,Guebessi NB

更新日期：2019-04-01 00:00:00

abstract：CONTEXT.—:Intestinal neuronal dysplasia type B (IND B) is a controversial histopathologic phenotype that has been associated with intestinal dysmotility, either as an isolated condition or in conjunction with established pathologic disorders (eg, Hirschsprung disease). Many factors contribute to the debate over the exi...

journal_title：Archives of pathology & laboratory medicine

authors： Kapur RP,Reyes-Mugica M

更新日期：2019-02-01 00:00:00

abstract：CONTEXT.—:The College of American Pathologists guidelines recommend testing additional tumor foci in multifocal invasive breast carcinomas for the biomarkers estrogen receptor (ER), progesterone receptor, and HER2 only if the carcinomas show different morphologies or grades. OBJECTIVE.—:To assess clinical significance...

journal_title：Archives of pathology & laboratory medicine

authors： Navale P,Bleiweiss IJ,Jaffer S,Nayak A

更新日期：2019-02-01 00:00:00

abstract：CONTEXT.—:Mutations within the same signature transduction pathway are redundant and, therefore, most are mutually exclusive. Laboratory errors, however, may introduce unexpected coexisting mutations. OBJECTIVE.—:To validate coexisting mutations within epidermal growth factor receptor (EGFR), mitogen-activated protein...

journal_title：Archives of pathology & laboratory medicine

authors： De Marchi F,Haley L,Fryer H,Ibrahim J,Beierl K,Zheng G,Gocke CD,Eshleman JR,Belchis D,Illei P,Lin MT

更新日期：2019-02-01 00:00:00

abstract：CONTEXT.—:The incidence of anal cancer in the United States is on the rise in high-risk populations. The anal Papanicolaou test (APT) is advocated as a screening tool, in addition to digital rectal examination and high-resolution anoscopy. OBJECTIVE.—:To review our experience and the current literature to create, in c...

journal_title：Archives of pathology & laboratory medicine

authors： Morency EG,Harbert T,Fatima N,Samolcyzk J,Maniar KP,Nayar R

更新日期：2019-01-01 00:00:00

abstract：CONTEXT.—:Distinction of hydatidiform moles from nonmolar specimens and subclassification of hydatidiform moles as complete hydatidiform mole versus partial hydatidiform mole are important for clinical practice and investigational studies. Risk of persistent gestational trophoblastic disease and clinical management dif...

journal_title：Archives of pathology & laboratory medicine

authors： Ronnett BM

更新日期：2018-12-01 00:00:00

abstract：CONTEXT.—:Follicular lymphoma is a common small B-cell lymphoma, likely to be encountered by any practicing pathologist, regardless of specialty. Although the features of typical follicular lymphoma are well known and in most instances easily identifiable, there are lesser-appreciated morphologic appearances that can r...

journal_title：Archives of pathology & laboratory medicine

authors： Choi SM,Betz BL,Perry AM

更新日期：2018-11-01 00:00:00

abstract：:Kikuchi-Fujimoto disease (KFD) is a rare entity characterized by subacute necrotizing lymphadenopathy and frequently associated with fever. Young adults of Asian ancestry are most commonly affected, but it has been reported worldwide. Despite many studies in the literature, the cause of KFD remains uncertain. Histolog...

journal_title：Archives of pathology & laboratory medicine

authors： Perry AM,Choi SM

更新日期：2018-11-01 00:00:00

abstract：CONTEXT.—:Atypical ductal hyperplasia (ADH) is a challenging diagnosis defined by cytologic and architectural features that carries an increased risk of subsequent carcinoma when diagnosed in isolation. In addition, ADH may secondarily involve benign breast lesions, wherein it carries variable clinical significance. O...

journal_title：Archives of pathology & laboratory medicine

authors： East EG,Carter CS,Kleer CG

更新日期：2018-10-01 00:00:00

abstract：CONTEXT:- This review examines challenges and opportunities in preparing laboratories in a startup phase for accreditation by both the College of American Pathologists (CAP) and International Organization for Standardization (ISO) 15189 in an international setting as it relates to our experience at Cleveland Clinic Abu...

journal_title：Archives of pathology & laboratory medicine

authors： AbdelWareth LO,Pallinalakam F,Ibrahim F,Anderson P,Liaqat M,Palmer B,Harris J,Bashir S,Alatoom A,Algora M,Alduaij A,Mirza I

更新日期：2018-09-01 00:00:00

abstract：CONTEXT:- Prostate cancer antigen 3 (PCA3) is a noncoding RNA that is highly overexpressed in prostate cancer (PCa) tissue and excreted in urine in patients with PCa. OBJECTIVE:- To assess the clinical utility of urinary PCA3 in men at risk of PCa. DESIGN:- We retrospectively reviewed a cohort of 271 men (median age,...

journal_title：Archives of pathology & laboratory medicine

authors： Cao L,Lee CH,Ning J,Handy BC,Wagar EA,Meng QH

更新日期：2018-09-01 00:00:00

abstract：:Fibrolamellar carcinoma is a rare primary hepatocellular malignancy arising in noncirrhotic livers of young individuals. Patients commonly present with a large solitary liver mass and nonspecific symptoms. Characteristic histologic features include large polygonal cells with oncocytic cytoplasm and prominent nucleoli ...

journal_title：Archives of pathology & laboratory medicine

authors： Lin CC,Yang HM

更新日期：2018-09-01 00:00:00

abstract：CONTEXT:- Early diagnosis of malignant mesothelioma (MM) is urgently needed because life expectancies and treatment options are limited in advanced stages of the disease. Malignant mesothelioma often presents with recurrent hemorrhagic or inflammatory effusions, which might mask the incipient stages of the disease and ...

journal_title：Archives of pathology & laboratory medicine

authors： Hjerpe A,Abd-Own S,Dobra K

更新日期：2018-08-01 00:00:00

abstract：:Lipoplasty, or liposuction, the surgical process of removing excess fat, is an elective procedure with rising frequency in the United States. Fat embolism syndrome is a clinical diagnosis and is defined as fat in the circulation with an identifiable clinical pattern of signs and symptoms (eg, hypoxemia, respiratory in...

journal_title：Archives of pathology & laboratory medicine

authors： Cantu CA,Pavlisko EN

更新日期：2018-07-01 00:00:00