Fibrolamellar Carcinoma: A Concise Review.

Abstract:

:Fibrolamellar carcinoma is a rare primary hepatocellular malignancy arising in noncirrhotic livers of young individuals. Patients commonly present with a large solitary liver mass and nonspecific symptoms. Characteristic histologic features include large polygonal cells with oncocytic cytoplasm and prominent nucleoli separated into trabeculae and cords by dense parallel bands of collagen. Important differential diagnoses include classical hepatocellular carcinoma and intrahepatic cholangiocarcinoma, which may be distinguished by a judicious panel of immunohistochemical studies, including cytokeratin 7, CD68, and hepatocyte paraffin 1 (HepPar-1). In addition, fibrolamellar carcinomas are characterized by activation of protein kinase A. Prognosis of fibrolamellar carcinoma is similar to classical hepatocellular carcinoma occurring in the absence of liver cirrhosis and is strongly correlated with tumor resectability. Other treatment options include liver transplant, chemotherapy, and hepatic artery embolization. In this article, we review the clinical features, gross and microscopic pathology, molecular genetics, differential diagnosis, treatment, and prognosis of this rare and interesting tumor.

journal_name

Arch Pathol Lab Med

authors

Lin CC,Yang HM

doi

10.5858/arpa.2017-0083-RS

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

1141-1145

issue

9

eissn

0003-9985

issn

1543-2165

journal_volume

142

pub_type

杂志文章,评审
  • Measurements in First-Trimester Abortion Products: A Pathologic Study.

    abstract:CONTEXT.—:Related to the advances in prenatal diagnosis and the emergence of medically challenging situations, there has been an increased interest in conducting a pathologic study of first-trimester abortion products. OBJECTIVE.—:To evaluate measurements across a large group of first-trimester spontaneous abortion sp...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2018-0181-OA

    authors: Nogueira R,Sousa S,Braga AC,Azevedo A,Pereira N,Carmo O,Tavares MP,Pinto JC

    更新日期:2020-02-01 00:00:00

  • Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group.

    abstract:CONTEXT:- Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose. OBJECTIVE:- To provide updated, practical guidelines for the pathologic diagnosis of MM. DATA SOURCES:- Pathologists involved in the International Mesothelioma Interest Group and others with an interest and expertise in the ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,实务指引

    doi:10.5858/arpa.2017-0124-RA

    authors: Husain AN,Colby TV,Ordóñez NG,Allen TC,Attanoos RL,Beasley MB,Butnor KJ,Chirieac LR,Churg AM,Dacic S,Galateau-Sallé F,Gibbs A,Gown AM,Krausz T,Litzky LA,Marchevsky A,Nicholson AG,Roggli VL,Sharma AK,Travis WD,Walt

    更新日期:2018-01-01 00:00:00

  • Malignant Mesothelioma and Its Non-Asbestos Causes.

    abstract:CONTEXT:- Although many mesotheliomas are related to asbestos exposure, not all are, and there is increasing information on other causes of mesothelioma. OBJECTIVE:- To provide a review of non-asbestos causes for malignant mesothelioma. DATA SOURCES:- Review of relevant published literature via PubMed and other searc...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.5858/arpa.2017-0365-RA

    authors: Attanoos RL,Churg A,Galateau-Salle F,Gibbs AR,Roggli VL

    更新日期:2018-06-01 00:00:00

  • Vascular transformation of lymph node sinuses. A process displaying a spectrum of histologic features.

    abstract::Nonneoplastic vascular lesions in lymph nodes have been infrequently reported. These lesions are believed to be rare and display histologic features ranging from minimal changes associated with vasodilation to vascular proliferative lesions resembling Kaposi's sarcoma. The spectrum of histologic features observed in t...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Ostrowski ML,Siddiqui T,Barnes RE,Howton MJ

    更新日期:1990-07-01 00:00:00

  • Placental mesenchymal dysplasia.

    abstract::Placental mesenchymal dysplasia is a rare placental lesion characterized by stem villous cystic dilation and vesicle formation, placentomegaly, and vascular abnormalities. It can be associated with growth restriction, stillbirth, Beckwith-Wiedemann syndrome, and some chromosomal abnormalities, and needs to be distingu...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.5858/arpa.2013-0399-RS

    authors: Pawoo N,Heller DS

    更新日期:2014-09-01 00:00:00

  • The impact of template format on the completeness of surgical pathology reports.

    abstract:CONTEXT:The College of American Pathologists Cancer Case Summaries templates provide a method for including all necessary pathology information in surgical pathology reports with cancer. How effective these templates are at ensuring a complete report, as measured by a separate outside tumor registry, is not known. OBJ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2012-0733-OA

    authors: Renshaw SA,Mena-Allauca M,Touriz M,Renshaw A,Gould EW

    更新日期:2014-01-01 00:00:00

  • Invasive secretory (juvenile) carcinoma arising in ectopic breast tissue of the axilla.

    abstract::Mammary carcinoma arising in ectopic breast tissue is an uncommon occurrence. Most reported cases have involved ductal carcinoma, but other types, such as medullary, papillary, and lobular carcinomas, have been described. For pathologists, the diagnosis of mammary carcinoma arising in ectopic breast tissue can be diff...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/0003-9985(2001)125<1372:ISJCAI>2.0.CO;2

    authors: Shin SJ,Sheikh FS,Allenby PA,Rosen PP

    更新日期:2001-10-01 00:00:00

  • Effect of therapeutic digoxin antibodies on digoxin assays.

    abstract::The introduction of therapeutic digoxin antibodies in the treatment of digoxin toxicity has resulted in spurious results in the many assays of cardioglycoside in serum of patients receiving this therapy. An evaluation of currently used assay methods was incorporated into a pilot Ligand Assay Survey Program of the Coll...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Hansell JR

    更新日期:1989-11-01 00:00:00

  • The confidential unit exclusion and allogeneic blood donation. Results from supplementary questions to the Donor Center and Viral Markers surveys of the College of American Pathologists.

    abstract:OBJECTIVE:The confidential unit exclusion (CUE) is a mechanism for allogeneic blood donors to confidentially indicate whether they feel their blood is safe for transfusion to others. The purpose of this national survey was to determine the extent of use of the CUE procedure and its related policies. DESIGN:Supplementa...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Domen RE

    更新日期:1995-11-01 00:00:00

  • Use of Thromboelastography (TEG) for Detection of New Oral Anticoagulants.

    abstract:CONTEXT:The clinical introduction of new oral anticoagulants (NOACs) has stimulated the development of tests to quantify the effects of these drugs and manage complications associated with their use. Until recently, the only treatment choices for the prevention of venous thromboembolism in orthopedic surgical patients,...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2014-0170-OA

    authors: Dias JD,Norem K,Doorneweerd DD,Thurer RL,Popovsky MA,Omert LA

    更新日期:2015-05-01 00:00:00

  • Primary leiomyosarcoma of the pancreas: a case report and review of literature.

    abstract::Primary leiomyosarcoma of the pancreas is a rare tumor for which only 21 reports appear in the world literature. We describe an additional case of pancreatic leiomyosarcoma in a 76-year-old man, who complained of persistent high fever. Histologic examination revealed a pleomorphic spindle cell tumor. Reactivity for mu...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1043/0003-9985(2001)125<0152:PLOTP>2.0.CO;2

    authors: Nesi G,Pantalone D,Ragionieri I,Amorosi A

    更新日期:2001-01-01 00:00:00

  • Groove pancreatitis: a brief review of a diagnostic challenge.

    abstract::Groove pancreatitis is an uncommon, yet well-described, type of focal chronic pancreatitis, affecting "the groove"-the area between the head of the pancreas, the duodenum, and the common bile duct. Men aged 40 to 50 years are most commonly affected, with a history of alcohol abuse frequently disclosed. Clinical manife...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.5858/arpa.2013-0597-RS

    authors: DeSouza K,Nodit L

    更新日期:2015-03-01 00:00:00

  • Proximal tubulopathies associated with monoclonal light chains: the spectrum of clinicopathologic manifestations and molecular pathogenesis.

    abstract:CONTEXT:Lesions associated with monoclonal light and heavy chains display a variety of glomerular, tubular interstitial, and vascular manifestations. While some of the entities are well recognized, including light and heavy chain deposition diseases, AL (light chain) and AH (heavy chain) amyloidosis, and light chain ("...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,多中心研究

    doi:10.5858/arpa.2013-0493-OA

    authors: Herrera GA

    更新日期:2014-10-01 00:00:00

  • Unintended reporting of misleading Hb A(1c) values when using assays incapable of detecting hemoglobin variants.

    abstract:CONTEXT:It is recommended that hemoglobin (Hb) A1c (Hb A1c) not be used to assess average glycemia in patients who have altered red blood cell life span. OBJECTIVE:To investigate the frequency of reporting an Hb A1c value for Hb variant samples that do not include Hb A. DESIGN:Hb A1c samples (n = 500) were procured a...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2012-0714-OA

    authors: Rhea JM,Koch D,Ritchie J,Singh HV,Young AN,Burgess T,Molinaro RJ

    更新日期:2013-12-01 00:00:00

  • Opportunistic cancers in patients with immunodeficiency syndromes.

    abstract::Patients with inherited or acquired immunodeficiency disorders are vulnerable to a broad spectrum of opportunistic infectious diseases, but a narrow spectrum of malignancies. These malignancies--B-cell lymphomas, Kaposi's sarcomas, and squamous cell carcinomas--are likely due to failure of immune surveillance to recog...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Purtilo DT

    更新日期:1987-12-01 00:00:00

  • Human lymphocyte antigen molecular typing: how to identify the 1250+ alleles out there.

    abstract::The human lymphocyte antigen (HLA) typing community was one of the early groups to adopt molecular testing. This action was borne out of the need to identify the many alleles of the highly polymorphic HLA system. Early paradigms used restriction fragment length polymorphism regimes, but the polymerase chain reaction m...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1043/0003-9985(2002)126<0281:HLAMT>2.0.CO;2

    authors: Gerlach JA

    更新日期:2002-03-01 00:00:00

  • Angioimmunoblastic T-cell lymphoma with cutaneous involvement: a case report with subtle histologic changes and clonal T-cell proliferation.

    abstract::Angioimmunoblastic T-cell lymphoma is a nodal peripheral T-cell lymphoma that rarely involves the skin. We describe a 62-year-old Taiwanese man who developed a second relapse of angioimmunoblastic T-cell lymphoma with generalized erythroderma and numerous plaquelike and nodular lesions. Biopsy of the erythematous skin...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/1543-2165(2004)1282.0.CO;2

    authors: Huang CT,Chuang SS

    更新日期:2004-10-01 00:00:00

  • Accuracy of Burkitt lymphoma diagnosis in constrained pathology settings: importance to epidemiology.

    abstract:CONTEXT:Burkitt lymphoma (BL) is endemic in Uganda and because of the high incidence, diagnosis is often presumed during clinical care and epidemiologic studies. OBJECTIVES:To assess the accuracy of the clinical and the local pathology diagnosis of BL as assessed by an outside pathology review diagnosis and to underst...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/2009-0443-EP.1

    authors: Ogwang MD,Zhao W,Ayers LW,Mbulaiteye SM

    更新日期:2011-04-01 00:00:00

  • Evolution of liver disease in morbid obesity after small-intestinal bypass and its restoration. A case report.

    abstract::We studied a woman who underwent a jejunoileal bypass for the treatment of morbid obesity and in whom severe jaundice and hepatic failure developed six months later; these developments prompted restoration of the normal continuity of the small bowel. Four serial wedge biopsy specimens of the liver were taken during a ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Allam C,Bala'a M,Shamma'a M

    更新日期:1983-04-01 00:00:00

  • Adenoid cystic carcinoma of the ovary.

    abstract::We describe a case of ovarian adenoid cystic carcinoma (ACC) of the left ovary in a 23-year-old woman. The tumor had the typical cribriform pattern of ACC, lacked any component of surface epithelial carcinoma, and showed myoepithelial differentiation. The features of salivary gland-type tumor seen in this case are unu...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/0003-9985(2000)124<1529:ACCOTO>2.0.CO;2

    authors: Zámecník M,Michal M,Curík R

    更新日期:2000-10-01 00:00:00

  • Mucinous carcinomas of the gallbladder: clinicopathologic analysis of 15 cases identified in 606 carcinomas.

    abstract:CONTEXT:There are virtually no data in the literature regarding the incidence, patterns, and clinicopathologic characteristics of mucinous carcinomas (MCs) of the gallbladder (GB). OBJECTIVE:To determine the incidence of mucinous differentiation in invasive GB carcinomas and the clinicopathologic characteristics of th...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2011-0447-OA

    authors: Dursun N,Escalona OT,Roa JC,Basturk O,Bagci P,Cakir A,Cheng J,Sarmiento J,Losada H,Kong SY,Ducato L,Goodman M,Adsay NV

    更新日期:2012-11-01 00:00:00

  • The impact of new DNA diagnostic technology on the management of cancer patients. Survey of diagnostic techniques.

    abstract::Revolutionary advances in technology have enhanced our understanding of the genetic changes that occur in cancer cells. This article summarizes some of the basic features of these techniques and describes their application to the identification of specific types of genetic alterations in cells. The emphasis is on thei...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Rowley JD,Aster JC,Sklar J

    更新日期:1993-11-01 00:00:00

  • Malignant lymphoma with primary presentation in the spleen. A study of 20 patients.

    abstract::We describe 20 adult patients with malignant lymphoma with primary presentation in the spleen. The most common presenting symptoms were fever, malaise, and weight loss. Physical examination revealed prominent splenomegaly without palpable lymphadenopathy. Small lymphocytic lymphoma was the most frequent histologic typ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Spier CM,Kjeldsberg CR,Eyre HJ,Behm FG

    更新日期:1985-12-01 00:00:00

  • Teratoid hepatoblastoma with abundant neuroendocrine and squamous differentiation with extensive parenchymal metastasis.

    abstract::Teratoid hepatoblastoma is a rare histologic subtype accounting for 4% to 10% of all hepatoblastomas and is characterized by the presence of divergent differentiation, including squamous, mucinous, melanocytic, cartilaginous, osseous, skeletal muscle, and neural elements. It is postulated that the teratoid elements mi...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2012-0212-CR

    authors: Rabah R

    更新日期:2012-08-01 00:00:00

  • Serous Tubal Intraepithelial Carcinoma or Not? Metastases to Fallopian Tube Mucosa Can Masquerade as In Situ Lesions.

    abstract:CONTEXT:- Nonuterine high-grade serous carcinomas (HGSCs) are believed to arise most often from precursors in the fallopian tube referred to as serous tubal intraepithelial carcinomas (STICs). A designation of tubal origin has been suggested for all cases of nonuterine HGSC if a STIC is identified. OBJECTIVE:- To high...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.5858/arpa.2017-0231-RA

    authors: Singh R,Cho KR

    更新日期:2017-10-01 00:00:00

  • An in-depth look at Leydig cell tumor of the testis.

    abstract::Leydig cell tumor (LCT) is a rare tumor of the male testicular interstitium. This article provides an overview of the major pathologic manifestations of LCT of the testis; patient characteristics; clinical, radiologic, and laboratory features; prognosis; and management. LCTs of the testis are frequently hormonally act...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1043/1543-2165(2007)131[311:AILALC]2.0.CO;2

    authors: Al-Agha OM,Axiotis CA

    更新日期:2007-02-01 00:00:00

  • Small Glandular Proliferations of the Breast With Absent or Attenuated Myoepithelial Reactivity by Immunohistochemistry: A Review Focusing on the Differential Diagnosis and Interpretative Pitfalls.

    abstract:CONTEXT:-Small glandular proliferations of the breast encompass a variety of benign, atypical, and malignant lesions that show some overlapping morphologic features. Myoepithelial stains are frequently used in the workup of these lesions in order to rule out or establish a diagnosis of invasive carcinoma. Some benign l...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.5858/arpa.2015-0289-SA

    authors: Ginter PS,Shin SJ,D'Alfonso TM

    更新日期:2016-07-01 00:00:00

  • Umbilical artery catheterization complicated by multiple mycotic aortic aneurysms.

    abstract::A premature infant had three pseudoaneurysms of the thoracic and abdominal aorta secondary to umbilical artery catheterization and sepsis. The infant had septicemia as the direct result of bacterial contamination of an umbilical artery catheter with Staphylococcus aureus. The thoracic pseudoaneurysm caused massive hem...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Rabin E,Vye MV,Farrell EE

    更新日期:1986-05-01 00:00:00

  • Diffuse neuroendocrine differentiation in a morphologically composite mammary infiltrating ductal carcinoma: a case report and review of the literature.

    abstract::Neuroendocrine differentiation has been reported in both in situ and infiltrating breast cancers. The prognostic significance of neuroendocrine differentiation in mammary carcinoma is unclear. We report a case of infiltrating ductal carcinoma in which there was a morphologically conventional-appearing infiltrating duc...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1043/0003-9985(2003)1272.0.CO;2

    authors: David O,Bhattacharjee M

    更新日期:2003-03-01 00:00:00

  • Allelic loss of 3 different tumor suppressor gene loci in benign and malignant endothelial tumors of the head and neck.

    abstract:CONTEXT:Angiosarcomas are rare malignancies that commonly arise in the head and neck. No definitive precursor lesion or etiological link between hemangiomas and angiosarcoma has been postulated. Evidence at the cell culture level suggests that loss of heterozygosity of 13q might be involved in tumorigenesis of endothel...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/1543-2165(2006)130[1184:ALODTS]2.0.CO;2

    authors: Domfeh AB,Fichera M,Hunt JL

    更新日期:2006-08-01 00:00:00