Succinate Dehydrogenase-Deficient Renal Cell Carcinoma.

abstract：:In an attempt to improve physicians' laboratory practice behavior, the Department of Hospital Laboratories at the University of Massachusetts Medical Center developed a rotation for first year housestaff. Medical interns were chosen for this pilot program because they are the most frequent users of our laboratory faci...

journal_title：Archives of pathology & laboratory medicine

authors： Griffiths EB,Pechet L,Snyder LM

更新日期：1995-05-01 00:00:00

abstract：:Although it has long been recognized that hyperbilirubinemia is enhanced in patients with impaired renal function, a clear correlation between the levels of bilirubin and creatinine in serum has never been established. We have studied this relationship in 13 bone marrow transplant recipients who had episodes of combin...

journal_title：Archives of pathology & laboratory medicine

authors： Yasmineh WG,Killeen AA,Filipovich AH

更新日期：1988-03-01 00:00:00

abstract：CONTEXT.—:Mutations within the same signature transduction pathway are redundant and, therefore, most are mutually exclusive. Laboratory errors, however, may introduce unexpected coexisting mutations. OBJECTIVE.—:To validate coexisting mutations within epidermal growth factor receptor (EGFR), mitogen-activated protein...

journal_title：Archives of pathology & laboratory medicine

authors： De Marchi F,Haley L,Fryer H,Ibrahim J,Beierl K,Zheng G,Gocke CD,Eshleman JR,Belchis D,Illei P,Lin MT

更新日期：2019-02-01 00:00:00

abstract：:Mucinous tubular and spindle cell carcinomas are rare kidney tumors with generally indolent behavior. As the name suggests, classic histomorphology reveals bland spindle cells, tubules, and mucinous stroma. Uncommon histologic features include mucin-poor stroma, high nuclear grade, cellular pleomorphism, and presence ...

journal_title：Archives of pathology & laboratory medicine

authors： Nathany S,Monappa V

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:The pathogenesis of appendicitis remains poorly understood. However, there is increasing evidence of involvement of the enteric nervous system in immune regulation and in inflammatory responses. This study was set up to characterize the status of the enteric nervous system in normal and in inflamed appendixes...

journal_title：Archives of pathology & laboratory medicine

authors： Xiong S,Puri P,Nemeth L,O'Briain DS,Reen DJ

更新日期：2000-10-01 00:00:00

abstract：CONTEXT:Barrett esophagus is a metaplastic, premalignant lesion associated with approximately 0.5% annual incidence of progression to esophageal adenocarcinoma. Diagnosis and screening of Barrett esophagus and Barrett-related dysplasia relies on histologic evaluation of endoscopic mucosal biopsies, a process that is bu...

journal_title：Archives of pathology & laboratory medicine

authors： Voltaggio L,Montgomery EA,Lam-Himlin D

更新日期：2011-10-01 00:00:00

abstract：:Herein, we report a case of cutaneous angiosarcoma in a 35-year-old, morbidly obese woman. The tumor arose in the most dependent portion of the lower abdominal panniculus and showed typical changes of chronic lymphedema. The patient underwent a radical resection of her lower abdominal wall panniculus, which showed a m...

journal_title：Archives of pathology & laboratory medicine

authors： Azam M,Saboorian H,Bieligk S,Smith T,Molberg K

更新日期：2001-04-01 00:00:00

abstract：CONTEXT:Glomerular cysts, defined as Bowman space dilatation greater than 2 to 3 times normal size, are found in disorders of diverse etiology and with a spectrum of clinical manifestations. The term glomerulocystic kidney (GCK) refers to a kidney with greater than 5% cystic glomeruli. Although usually a disease of the...

journal_title：Archives of pathology & laboratory medicine

authors： Lennerz JK,Spence DC,Iskandar SS,Dehner LP,Liapis H

更新日期：2010-04-01 00:00:00

abstract：:In 1986, the College of American Pathologists introduced an interlaboratory proficiency testing program for clinical laboratories that perform flow cytometry. Specimens consisting of fresh human lymphocytes isolated from blood or tissue or neoplastic cells grown in culture were mailed to participants by overnight mail...

journal_title：Archives of pathology & laboratory medicine

authors： Homburger HA,McCarthy R,Deodhar S

更新日期：1989-06-01 00:00:00

abstract：CONTEXT:CpG island hypermethylation is attracting attention because of its importance as a tumor marker and its potential mechanism for the development of human cancers. Extrahepatic cholangiocarcinoma has been poorly investigated with respect to CpG island hypermethylation, and the number of genes known to be methylat...

journal_title：Archives of pathology & laboratory medicine

authors： Kim BH,Cho NY,Choi M,Lee S,Jang JJ,Kang GH

更新日期：2007-06-01 00:00:00

abstract：CONTEXT:Advances in RHD genotyping offer an opportunity to update policies and practices for testing weak D phenotypes and administration of Rh immune globulin to postpartum women. OBJECTIVES:To repeat questions from a 1999 College of American Pathologists proficiency test survey, to evaluate current practices for tes...

journal_title：Archives of pathology & laboratory medicine

authors： Sandler SG,Roseff SD,Domen RE,Shaz B,Gottschall JL

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:To investigate ras gene alteration in human gastric adenocarcinomas and its potential relationship to ras signal transduction mediators. DESIGN:Genomic DNA from 104 gastric tumors were analyzed by sequencing of polymerase chain reaction-amplified products for the presence of ras mutations. All the samples we...

journal_title：Archives of pathology & laboratory medicine

authors： Yoo J,Park SY,Robinson RA,Kang SJ,Ahn WS,Kang CS

更新日期：2002-09-01 00:00:00

abstract：:Questionnaires sent to representative medicolegal jurisdictions in the United States showed that medicolegal necropsies comprise a substantial proportion of the total number of autopsies performed. Qualitative differences between customary hospital autopsies and their forensic counterparts include autopsy bias, the im...

journal_title：Archives of pathology & laboratory medicine

authors： Hirsch CS

更新日期：1984-06-01 00:00:00

abstract：CONTEXT:Although the value of pharmacogenomics to improve patient outcomes has become increasingly clear, adoption in medical practice has been slow, which can be attributed to several factors, including complicated and expensive testing procedures and required equipment, lack of training by private practice physicians...

journal_title：Archives of pathology & laboratory medicine

authors： Spizz G,Chen Z,Li P,McGuire IC,Klimkiewicz P,Zysling D,Yasmin R,Hungerford W,Thomas B,Wilding G,Mouchka G,Young L,Zhou P,Montagna RA

更新日期：2015-06-01 00:00:00

abstract：:The usual gross appearance of a renal oncocytoma is that of a well-circumscribed homogeneous tan-brown tumor with no evidence of necrosis or hemorrhage, but with a central fibrous scar. We describe a case of renal oncocytoma with the unusual gross appearance of a cystic tumor. While cystic change has occasionally been...

journal_title：Archives of pathology & laboratory medicine

authors： Ogden BW,Beckman EN,Rodriguez FH Jr

更新日期：1987-05-01 00:00:00

abstract：:Periosteal osteoblastoma is an extremely rare bone-forming neoplasm located on the surface of cortical bone. Of the fewer than 30 cases of periosteal osteoblastomas found in the literature, 2 have been reported to be located in cranial bone, and these have not been documented in detail with clinical history, radiograp...

journal_title：Archives of pathology & laboratory medicine

authors： Lin YC,Commins DL,Fedenko AN,Pinsky GS

更新日期：2005-06-01 00:00:00

abstract：:Natural killer cell and cytotoxic T-cell lymphomas are frequently difficult to distinguish because they share many common features, and yet it is important to make an accurate diagnosis because their prognoses differ. We report an unusual case of a white man with a CD56-positive T-cell lymphoma in the ileum. The histo...

journal_title：Archives of pathology & laboratory medicine

authors： Frank MC,Bono E,Sun T

更新日期：2005-04-01 00:00:00

abstract：CONTEXT:Sclerosing hemangioma of the lung is well characterized histologically, but the line of differentiation expressed by the tumor cells has been unclear. Despite the implication by its name of a vascular neoplasm, sclerosing hemangioma is considered by most authorities to be an epithelial tumor, possibly related t...

journal_title：Archives of pathology & laboratory medicine

authors： Illei PB,Rosai J,Klimstra DS

更新日期：2001-10-01 00:00:00

abstract：:In cases of obscure gastrointestinal bleeding, when a source for blood loss is not apparent from examination of the colon and upper gastrointestinal tract, the small bowel usually becomes the focus of investigation. A tumor with interesting pathologic features was found in a patient who presented with recurrent episod...

journal_title：Archives of pathology & laboratory medicine

authors： Sass DA,Chopra KB,Finkelstein SD,Schauer PR

更新日期：2004-02-01 00:00:00

abstract：:Recent advances in molecular genetics and cancer stem cell biology have shed some light on the molecular basis of melanomagenesis. In this review, we will focus on major genetic alterations in the melanoma, particularly pathways involved in cell proliferation, apoptosis, and tumor suppression. The potential role of me...

journal_title：Archives of pathology & laboratory medicine

authors： Kong Y,Kumar SM,Xu X

更新日期：2010-12-01 00:00:00

abstract：:We report a case of a malignant peripheral nerve sheath tumor arising in the distal femur of a 28-year-old man who had no stigmata of von Recklinghausen's disease. Roentgenograms and computed tomographic scans of the distal femur showed a single lytic intraosseous lesion with minimal soft tissue extension. Light micro...

journal_title：Archives of pathology & laboratory medicine

authors： Bullock MJ,Bedard YC,Bell RS,Kandel R

更新日期：1995-04-01 00:00:00

abstract：CONTEXT:Most posttransplantation lymphoproliferative disorders (PTLDs) are associated with Epstein-Barr virus (EBV) infection. The EBV latent membrane protein 1 (LMP-1) is important in the transformation of B lymphocytes through its interaction with intracellular tumor necrosis factor receptor-associated factors (TRAFs...

journal_title：Archives of pathology & laboratory medicine

authors： Ramalingam P,Chu WS,Tubbs R,Rybicki L,Pettay J,Hsi ED

更新日期：2003-10-01 00:00:00

abstract：CONTEXT:Hemolyzed specimens delay clinical laboratory results, proliferate unnecessary testing, complicate physician decisions, injure patients indirectly, and increase health care costs. OBJECTIVE:To determine quality improvement practices when hemolysis occurs. DESIGN:We used the College of American Pathologists (C...

journal_title：Archives of pathology & laboratory medicine

authors： Howanitz PJ,Lehman CM,Jones BA,Meier FA,Horowitz GL

更新日期：2015-07-01 00:00:00

abstract：CONTEXT:-Results of the American College of Surgeons Oncology Group Z0011 trial showed that patients with early-stage breast cancer and limited sentinel node metastasis treated with breast conservation and systemic therapy did not benefit from axillary lymph node dissection. Subsequently, most pathology departments hav...

journal_title：Archives of pathology & laboratory medicine

authors： Bishop JA,Sun J,Ajkay N,Sanders MA

更新日期：2016-08-01 00:00:00

abstract：CONTEXT:Nucleophosmin 1 (NPM1) is the most commonly mutated gene in acute myeloid leukemia. Detection of NPM1 mutations is useful for stratifying patients for therapy, predicting prognosis, and assessing for minimal residual disease. Several methods have been developed to rapidly detect NPM1 mutations in genomic DNA an...

journal_title：Archives of pathology & laboratory medicine

authors： Barakat FH,Luthra R,Yin CC,Barkoh BA,Hai S,Jamil W,Bhakta YI,Chen S,Medeiros LJ,Zuo Z

更新日期：2011-08-01 00:00:00

abstract：CONTEXT:c-kit, a proto-oncogene, encodes the transmembrane tyrosine kinase receptor CD117 and is detected by flow cytometry in the majority of cases of acute myeloid leukemia. The prognostic significance of the presence of c-Kit in acute myeloid leukemia is debated. Recently, c-kit inhibitors have been studied as possi...

journal_title：Archives of pathology & laboratory medicine

authors： Chen J,Yanuck RR 3rd,Abbondanzo SL,Chu WS,Aguilera NS

更新日期：2001-11-01 00:00:00

abstract：CONTEXT:Timely and accurate diagnosis of hematologic malignancies is crucial to appropriate clinical management. Acute leukemias are a diverse group of malignancies with a range of clinical presentations, prognoses, and preferred treatment protocols. Historical classification systems relied predominantly on morphologic...

journal_title：Archives of pathology & laboratory medicine

authors： Peters JM,Ansari MQ

更新日期：2011-01-01 00:00:00

abstract：:Ovulation induction protocols for oocyte retrieval have evolved from clomiphene citrate/human menopausal gonadotropins (menotropins) to human menopausal gonadotropins alone and, finally, to a combination of human menopausal gonadotropins and an agonist of gonadotropin-releasing hormone (GnRH-a). The almost abandonment...

journal_title：Archives of pathology & laboratory medicine

authors： Meldrum DR

更新日期：1992-04-01 00:00:00

abstract：CONTEXT:Because of a marked increase in the number of requests for antinuclear antibodies, anti-extractable nuclear antigen antibodies, and anti-double-stranded DNA antibodies for the diagnosis of autoimmune rheumatic disease, guidelines have been proposed for their appropriate use. OBJECTIVE:To evaluate in terms of c...

journal_title：Archives of pathology & laboratory medicine

authors： Tampoia M,Brescia V,Fontana A,Zucano A,Morrone LF,Pansini N

更新日期：2007-01-01 00:00:00

abstract：:Mixed epithelial and stromal tumor of the kidney is a recently recognized distinct neoplasm that should be distinguished from other renal neoplasms. These tumors are relatively rare with a female preponderance. Imaging studies are not diagnostic but reveal a solid or solid and cystic mass in most cases. Histopathologi...

journal_title：Archives of pathology & laboratory medicine

authors： Mohanty SK,Parwani AV

更新日期：2009-09-01 00:00:00