Conjugated hyperbilirubinemia and renal function in bone marrow transplant recipients.

Abstract:

:Although it has long been recognized that hyperbilirubinemia is enhanced in patients with impaired renal function, a clear correlation between the levels of bilirubin and creatinine in serum has never been established. We have studied this relationship in 13 bone marrow transplant recipients who had episodes of combined conjugated hyperbilirubinemia and renal impairment. Most of the patients had graft-vs-host disease and various degrees of hepatic cholestasis as evidenced by histologic examination results and abnormal liver function tests. Serial serum specimens obtained during this period showed a good correlation between the two analytes, with a mean (+/- SD) correlation coefficient of .86 +/- .10. The slopes of the regression lines, represented as bilirubin-creatinine ratios, varied widely (0.2 to 3.6), reflecting the wide variation in the degree of hyperbilirubinemia attributable to renal impairment.

journal_name

Arch Pathol Lab Med

authors

Yasmineh WG,Killeen AA,Filipovich AH

subject

Has Abstract

pub_date

1988-03-01 00:00:00

pages

245-50

issue

3

eissn

0003-9985

issn

1543-2165

journal_volume

112

pub_type

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