当前位置： SCI文献检索 > ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE期刊下所有文献 > Evaluation of the BiliChek being used on hyperbilirubinemic newborns undergoing home phototherapy.

Evaluation of the BiliChek being used on hyperbilirubinemic newborns undergoing home phototherapy.

Abstract：

CONTEXT:Newborns are often screened prior to discharge for hyperbilirubinemia. Transcutaneous bilirubin analyzers, such as the BiliChek, are promoted as screening tools, but it is unclear whether they also function well as monitoring devices. Newborns on home phototherapy require frequent determinations of serum bilirubin levels to monitor therapy effects. A transcutaneous bilirubin analyzer would be helpful to limit blood draws and enhance staff efficiency. We evaluated the accuracy of the BiliChek analyzer in this setting. OBJECTIVE:Is the BiliChek sufficiently accurate to monitor the effectiveness of home phototherapy and establish when to terminate therapy? DESIGN:Paired serum bilirubin results and results from the BiliChek were obtained from newborns on home phototherapy during daily home health care visits. RESULTS:The BiliChek demonstrates a negative bias (mean bias, -1.71 mg/dL; 95% confidence interval, -1.89 to -1.52 mg/dL) compared with serum bilirubin values. This bias worsens as the serum bilirubin level rises. If a value of 14 mg/dL or less obtained using the BiliChek had been used as the cutoff for termination of phototherapy, 45% of newborns would have had therapy terminated prematurely. If, knowing the negative bias of the BiliChek, the cutoff for termination of therapy was set at less than or equal to 11 mg/dL, then 29% of newborns would have had therapy terminated prematurely. CONCLUSIONS:The values obtained using the BiliChek, compared to serum bilirubin values, have a negative bias that worsens at the higher bilirubin levels expected in newborns at home on phototherapy. The BiliChek does not provide sufficient accuracy to be utilized to monitor newborns on home phototherapy or to ascertain when to discontinue such therapy.

journal_name

Arch Pathol Lab Med

journal_title

Archives of pathology & laboratory medicine

authors

Reyes CA,Stednitz DR,Hahn C,Mutchie KD,McCullough SR,Kronberg K

doi

10.1043/1543-2165(2008)132[684:EOTBBU]2.0.CO;2

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

684-9

issue

eissn

0003-9985

issn

1543-2165

pii

2007-0262-OAR

journal_volume

132

pub_type

杂志文章

在线工具

Evaluation of the BiliChek being used on hyperbilirubinemic newborns undergoing home phototherapy.