Selective staining of pancreatic beta-cell granules. Evolution and present status.

abstract：:A 14-year-old adolescent girl presented with severe congestive heart failure, progressive throughout 3 months. A precordial thrill, machinery-like murmur, and right bundle branch block were noted. Death occurred despite digitalis and diuretic therapy and removal of pleural and ascitic fluid. The autopsy revealed 2 mul...

journal_title：Archives of pathology & laboratory medicine

authors： Lucey BP,Thomas CB,Hutchins GM

更新日期：2005-09-01 00:00:00

abstract：CONTEXT:Clear cell chondrosarcoma (CCC) is commonly considered to be a low-grade subtype of chondrosarcoma. However, a few cases of CCC behave as high-grade lesions (with early metastases or multiple/synchronous locations). OBJECTIVE:To investigate morphologic features that can help predict the aggressiveness of these...

journal_title：Archives of pathology & laboratory medicine

authors： Corradi D,Bacchini P,Campanini N,Bertoni F

更新日期：2006-11-01 00:00:00

abstract：:We report a large cell neuroendocrine carcinoma arising in the ampulla of Vater. The patient, a 74-year-old woman, presented with a 3-cm ulcerated mass located in the ampullary region. She died of disease 8 months after surgery. Microscopically, the tumor was extensively necrotic. It was composed of islands and trabec...

journal_title：Archives of pathology & laboratory medicine

authors： Cavazza A,Gallo M,Valcavi R,De Marco L,Gardini G

更新日期：2003-02-01 00:00:00

abstract：:Pathologic study of a rare 11-deoxycorticosterone-producing adrenocortical tumor causing primary aldosteronismlike signs and symptoms, revealed several characteristic features as follows: (1) fairly large size with histologic features corresponding to those of benign zone glomerulosa-type aldosteronoma, (2) lack of sp...

journal_title：Archives of pathology & laboratory medicine

authors： Aiba M,Iri H,Suzuki H,Kageyama K,Kawai T,Abe O,Murai M,Tazaki H,Saruta T

更新日期：1985-04-01 00:00:00

abstract：CONTEXT:Fine-needle aspiration has become an accepted and cost-effective procedure for rapid diagnosis of thyroid lesions. The routine use of fine-needle aspiration has reduced the rate of unnecessary surgery for thyroid nodules. OBJECTIVES:To determine the accuracy of fine-needle aspiration biopsy diagnosis and to di...

journal_title：Archives of pathology & laboratory medicine

authors： Amrikachi M,Ramzy I,Rubenfeld S,Wheeler TM

更新日期：2001-04-01 00:00:00

abstract：:The fluorescent dye thioflavin T stains intensely the deposits in dense deposit disease and can be used for identification purposes. Comparison of thioflavin T staining with electron microscopy was carried out in 25 patients and showed excellent congruity. Thioflavin T is much easier to use, but is less specific than ...

journal_title：Archives of pathology & laboratory medicine

authors： Churg J,Duffy JL,Bernstein J

更新日期：1979-02-01 00:00:00

abstract：:Spindle cell tumors arising in the lymph nodes are very rare. We report the light microscopic, histochemical, immunohistochemical, and ultrastructural findings of an unusual solitary spindle cell tumor in a peripheral lymph node of a 45-year-old woman. Microscopically, the tumor was characterized by interlacing fascic...

journal_title：Archives of pathology & laboratory medicine

authors： Lee JY,Abell E,Shevechik GJ

更新日期：1989-05-01 00:00:00

abstract：CONTEXT:The College of American Pathologists periodically surveys laboratories to determine changes in cytopathology practices. We report the results of a 2011 gynecologic cytology survey. OBJECTIVE:To provide a cross-sectional survey of gynecologic cytology practices in 2010. DESIGN:In 2011, a survey was sent to 160...

journal_title：Archives of pathology & laboratory medicine

authors： Crothers BA,Darragh TM,Tambouret RH,Nayar R,Barkan GA,Zhao C,Booth CN,Padmanabhan V,Tabatabai ZL,Souers RJ,Thomas N,Wilbur DC,Moriarty AT

更新日期：2016-01-01 00:00:00

abstract：:We report a case of endometrial metaplasia of the endocervix, which was associated with tubal and squamous metaplasias. The similarity to normal endometrial glands and its benign nature should be recognized, and over-diagnosis of endocervical glandular dysplasia should be avoided. ...

journal_title：Archives of pathology & laboratory medicine

authors： Yeh IT,Bronner M,LiVolsi VA

更新日期：1993-07-01 00:00:00

abstract：:Ergotamine has been associated with numerous vascular complications but only rarely with fibrosing disorders or valvular heart disease. Two patients are described in whom severe valvular dysfunction developed during ergotamine therapy for migraine headache. The surgically excised mitral and aortic valves were involved...

journal_title：Archives of pathology & laboratory medicine

authors： Hauck AJ,Edwards WD,Danielson GK,Mullany CJ,Bresnahan DR

更新日期：1990-01-01 00:00:00

abstract：:We reviewed the clinicopathologic features of 17 androgenic granulosa cell tumors. The patients, two of whom were pregnant, ranged from 2 to 58 years of age (average age, 22.5 years). Fourteen of the patients were masculinized as evidenced by various combinations of facial acne, temporal recession of hair, clitorimega...

journal_title：Archives of pathology & laboratory medicine

authors： Nakashima N,Young RH,Scully RE

更新日期：1984-10-01 00:00:00

abstract：CONTEXT:KRAS mutations can be detected in approximately 30% to 40% of all patients with colorectal cancer. Several recent studies have shown that patients with KRAS mutations in codons 12 or 13 in metastatic tumors do not benefit from anti-epidermal growth factor receptor therapy with cetuximab or panitumumab. OBJECTI...

journal_title：Archives of pathology & laboratory medicine

authors： Monzon FA,Ogino S,Hammond ME,Halling KC,Bloom KJ,Nikiforova MN

更新日期：2009-10-01 00:00:00

abstract：:We report the case of a patient treated with a combination of fludarabine and cyclophosphamide after suffering from B-cell chronic lymphocytic leukemia for 10 years. Three months after treatment, the patient presented with an unusual association, not previously reported in the literature: Richter syndrome (monotypic E...

journal_title：Archives of pathology & laboratory medicine

authors： Compérat E,Delmer A,Le Tourneau A,Molina TJ,Diebold J,Audouin J

更新日期：2006-08-01 00:00:00

abstract：CONTEXT:-Multiple sources have identified challenges that training programs face in preparing graduates for the "real world" practice of pathology, and many training programs have sought to decrease the gap between skills acquired during training and those required in practice. However, there exists the possibility tha...

journal_title：Archives of pathology & laboratory medicine

authors： Post MD,Johnson K,Brissette MD,Conran RM,Domen RE,Hoffman RD,McCloskey CB,Raciti PM,Roberts CA,Rojiani AM,Tucker JA,Powell SZ

更新日期：2017-02-01 00:00:00

abstract：CONTEXT:Dysregulation of mediators of apoptosis is associated with carcinogenesis. For biliary duct cancers, p53 gene mutation is an important contributor to carcinogenesis. Mutations in the p53 gene affect transcription of the Fas gene, resulting in lack of Fas expression on cell membrane. It has been previously shown...

journal_title：Archives of pathology & laboratory medicine

authors： Jhala NC,Vickers SM,Argani P,McDonald JM

更新日期：2005-04-01 00:00:00

abstract：CONTEXT:Cytologic examination of the respiratory tract has been a useful diagnostic tool when evaluating neoplastic lesions of the respiratory tract. However, we have limited experience in the application of this technique in the management of nonneoplastic occupational and environmental diseases of the lung and pleura...

journal_title：Archives of pathology & laboratory medicine

authors： Laucirica R,Ostrowski ML

更新日期：2007-11-01 00:00:00

abstract：:In an attempt to improve physicians' laboratory practice behavior, the Department of Hospital Laboratories at the University of Massachusetts Medical Center developed a rotation for first year housestaff. Medical interns were chosen for this pilot program because they are the most frequent users of our laboratory faci...

journal_title：Archives of pathology & laboratory medicine

authors： Griffiths EB,Pechet L,Snyder LM

更新日期：1995-05-01 00:00:00

abstract：:This study was performed to evaluate the correlation between HER-2/neu gene expression and DNA ploidy patterns. Forty-five cases of breast-cancer were analyzed. Immunohistochemical staining of HER-2/neu protein on frozen sections was used to detect the HER-2/neu protein, and the Feulgen DNA staining method was used to...

journal_title：Archives of pathology & laboratory medicine

authors： Bacus SS,Bacus JW,Slamon DJ,Press MF

更新日期：1990-02-01 00:00:00

abstract：CONTEXT:Laboratory data are essential to the medical care of fetuses, infants, children, and adolescents. However, the performance and interpretation of laboratory tests on specimens from these patients, which may constitute a significant component of the workload in general hospitals and integrated health care systems...

journal_title：Archives of pathology & laboratory medicine

authors： Pysher TJ,Bach PR,Geaghan SM,Hamilton MS,Laposata M,Lockitch G,Brugnara C,Coffin CM,Pasquali M,Rinaldo P,Roberts WL,Rutledge JC,Ashwood ER,Blaylock RC,Campos JM,Goldsmith B,Jones PM,Lim M,Meikle AW,Perkins SL,Perr

更新日期：2006-07-01 00:00:00

abstract：CONTEXT:In the normal course of activity, pathologists create and archive immense data sets of scientifically valuable information. Researchers need pathology-based data sets, annotated with clinical information and linked to archived tissues, to discover and validate new diagnostic tests and therapies. Pathology recor...

journal_title：Archives of pathology & laboratory medicine

authors： Berman JJ

更新日期：2003-06-01 00:00:00

abstract：:The salivary glands, despite their relatively simple morphology, give rise to more than 30 histologically distinct benign and malignant tumors. Salivary gland neoplasms comprise less than 2% of all tumors in humans and 3% of all head and neck tumors. They arise in the parotid gland in 80% of cases, and approximately 8...

journal_title：Archives of pathology & laboratory medicine

authors： Schneider M,Rizzardi C

更新日期：2008-02-01 00:00:00

abstract：CONTEXT.—:The approval of pembrolizumab for treatment of patients with microsatellite instability-high (MSI-H) or mismatch repair-deficient (dMMR) advanced cancers has led to increased requests for MSI and/or MMR immunoperoxidase (IPOX) testing. Diagnoses for patients with advanced-stage cancer are frequently made from...

journal_title：Archives of pathology & laboratory medicine

authors： Jacobi EM,Landon G,Broaddus RR,Roy-Chowdhuri S

更新日期：2020-03-30 00:00:00

abstract：:The use of digoxin-specific fragments, antigen-binding (Fab) for antidotal therapy of severe digitalis intoxication is rapidly becoming a treatment of choice. Furthermore, studies with this mode of drug-specific therapy using Fab specific for desipramine and for phencyclidine suggest that this treatment may be applica...

journal_title：Archives of pathology & laboratory medicine

authors： Hursting MJ,Raisys VA,Opheim KE

更新日期：1987-08-01 00:00:00

abstract：:We report a case of "uncombable hair syndrome" that occurred in a boy who had no other abnormalities. The diagnosis was clinically suspected and confirmed by examination of the scalp hair, which was treated with a bath of gold. Scanning electron microscopy was used for examination. The main defect of the hair was a lo...

journal_title：Archives of pathology & laboratory medicine

authors： Zegpi M,Roa I

更新日期：1987-08-01 00:00:00

abstract：CONTEXT:Advances in RHD genotyping offer an opportunity to update policies and practices for testing weak D phenotypes and administration of Rh immune globulin to postpartum women. OBJECTIVES:To repeat questions from a 1999 College of American Pathologists proficiency test survey, to evaluate current practices for tes...

journal_title：Archives of pathology & laboratory medicine

authors： Sandler SG,Roseff SD,Domen RE,Shaz B,Gottschall JL

更新日期：2014-05-01 00:00:00

abstract：:Intravenously (IV) injected Evans blue dye consistently accumulates at particular areas in aortas of normal swine. Theses areas are also where IV injected tracer cholesterol accumulates. We studied the ultrastructural characteristics of blue vs nonblue areas in the abdominal aortas of both control and atherosclerotic ...

journal_title：Archives of pathology & laboratory medicine

authors： Imai H,Scott RF,Thomas WA

更新日期：1982-04-01 00:00:00

abstract：:Twenty-eight weanling swine were divided into two groups and fed a basal ration of corn and soybean meal or one containing a high fat and cholesterol supplement. One subgroup of each received 220,000 IU of vitamin D3 per kilogram. Grossly normal areas of the distal abdominal aorta were used for quantitative comparison...

journal_title：Archives of pathology & laboratory medicine

authors： Kamio A,Kummerow FA,Imai H

更新日期：1977-07-01 00:00:00

abstract：:This study was undertaken to assess the specificity of split renal basement membranes in hereditary nephritis (HN). Thirteen specimens from eight patients with HN were mixed in a random fashion with specimens from control patients with either idiopathic nephrotic syndrome or various forms of glomerulonephritis and wit...

journal_title：Archives of pathology & laboratory medicine

authors： Kohaut EC,Singer DB,Nevels BK,Hill LL

更新日期：1976-09-01 00:00:00

abstract：:Myocyte injury in acute cardiac transplant rejection was studied ultrastructurally in 45 patients. Mild myocyte injury consisted of increased glycogen granules and mitochondria, and condensation and streaming of myofilaments. More severe cell injury was characterized by clumping of Z-band material at the periphery of ...

journal_title：Archives of pathology & laboratory medicine

authors： Myles JL,Ratliff NB,McMahon JT,Golding LR,Hobbs RE,Rincon G,Sterba RW,Stewart R

更新日期：1987-10-01 00:00:00

abstract：CONTEXT:Platelet-derived microparticles (PDMPs) probably function in hemostasis, thrombosis, inflammation, and transfusion-related immunomodulation. OBJECTIVE:To compare PDMP levels of leukocyte-filtered and unfiltered whole blood during storage. DESIGN:Ten whole blood donations were collected and processed. Half of ...

journal_title：Archives of pathology & laboratory medicine

authors： Sugawara A,Nollet KE,Yajima K,Saito S,Ohto H

更新日期：2010-05-01 00:00:00