Concomitant Epstein-Barr virus-negative large B-cell lymphoma (Richter syndrome) and Epstein-Barr virus- positive B-cell lymphoproliferation after treatment with fludarabine and cyclophosphamide in a patient with B-cell chronic lymphocytic leukemia.

Abstract:

:We report the case of a patient treated with a combination of fludarabine and cyclophosphamide after suffering from B-cell chronic lymphocytic leukemia for 10 years. Three months after treatment, the patient presented with an unusual association, not previously reported in the literature: Richter syndrome (monotypic Epstein-Barr virus- negative large B-cell lymphoma) with the proliferation of Epstein-Barr virus-positive B cells secreting a polytypic immunoglobulin A. The Epstein-Barr virus-positive lymphoproliferation can be accounted for by the type of immunosuppression induced by the treatment.

journal_name

Arch Pathol Lab Med

authors

Compérat E,Delmer A,Le Tourneau A,Molina TJ,Diebold J,Audouin J

doi

10.1043/1543-2165(2006)130[1227:CEVLBL]2.0.CO;2

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

1227-30

issue

8

eissn

0003-9985

issn

1543-2165

pii

CR4120

journal_volume

130

pub_type

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