Abstract：
CONTEXT:Clear cell chondrosarcoma (CCC) is commonly considered to be a low-grade subtype of chondrosarcoma. However, a few cases of CCC behave as high-grade lesions (with early metastases or multiple/synchronous locations). OBJECTIVE:To investigate morphologic features that can help predict the aggressiveness of these CCCs. DESIGN:To investigate possible hallmarks of this aggressiveness, we are presenting the clinicopathologic features of 6 cases of CCC, 4 of which presented aggressive features and 2 low-grade behavior. The patients were 5 men and 1 woman; their ages ranged from 22 to 47 years. Histologic appearance, ultrastructure, and immunohistochemical expression of metalloproteinase 1 and 2 and their inhibitors were evaluated in all 6 cases. RESULTS:Pain was the most common symptom; the lesions were located in the femur (4), humerus (2), and vertebral body (1), with 1 patient presenting a double/synchronous lesion. Although no major differences were detected using conventional light microscopy, an ultrastructural analysis--at variance with usual cases--showed a lack of superficial microvilli in more than 50% of neoplastic cells in the aggressive cases, therefore suggesting a less differentiated phenotype. In addition, metalloproteinase 2 was more diffusely expressed in the aggressive tumors than in the conventional CCCs, whereas p53 labeling was always negative. CONCLUSIONS:The aggressive behavior of some CCCs may be, at least in part, correlated to a lesser degree of cell differentiation and to the expression of tumor cell proteins, such as metalloproteinase 2, which are able to favor neoplastic spreading.
journal_name
Arch Pathol Lab Medjournal_title
Archives of pathology & laboratory medicineauthors
Corradi D,Bacchini P,Campanini N,Bertoni Fdoi
10.1043/1543-2165(2006)130[1673:ACCCDD]2.0.CO;2subject
Has Abstractpub_date
2006-11-01 00:00:00pages
1673-9issue
11eissn
0003-9985issn
1543-2165pii
OA-5-795journal_volume
130pub_type
杂志文章abstract：:We report here 2 separate cases in which patients with known low-grade B-cell lymphomas presented with transformed lesions that were CD30⁺, CD4⁺, Epstein-Barr virus negative, and negative or focally weak for a wide range of B-cell, T-cell, and histiocytic/dendritic cell markers. In each case the transformed lymphoma p...
journal_title：Archives of pathology & laboratory medicine
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journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1989-11-01 00:00:00
abstract：:Recent advances in molecular genetics and cancer stem cell biology have shed some light on the molecular basis of melanomagenesis. In this review, we will focus on major genetic alterations in the melanoma, particularly pathways involved in cell proliferation, apoptosis, and tumor suppression. The potential role of me...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章,评审
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abstract：:We investigated how route of infection with Treponema pallidum affects cellular responses of various lymphoid tissues. Lymphoid cells from spleens and lymph nodes of rabbits infected intradermally with T pallidum showed enhanced in vitro responses to treponemal antigens when cultured in autologous rabbit serum. Intrav...
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doi：10.1043/0003-9985(2000)124<0894:SCTOUB>2.0.CO;2
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journal_title：Archives of pathology & laboratory medicine
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doi：
更新日期：1990-07-01 00:00:00
abstract：:Human leukocyte antigen typing is currently being done by both serologic and cellular techniques. It is this methodology that forms the basis for organ transplantation, since HLA antigens are the major proteins involved in graft rejection. Matching organ graft donors with recipients at these polymorphic HLA loci clear...
journal_title：Archives of pathology & laboratory medicine
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doi：
更新日期：1988-01-01 00:00:00
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更新日期：1984-10-01 00:00:00
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journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1976-02-01 00:00:00
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journal_title：Archives of pathology & laboratory medicine
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journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1995-04-01 00:00:00
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journal_title：Archives of pathology & laboratory medicine
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-10-01 00:00:00
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journal_title：Archives of pathology & laboratory medicine
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doi：
更新日期：1983-10-01 00:00:00
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journal_title：Archives of pathology & laboratory medicine
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doi：
更新日期：1985-12-01 00:00:00
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journal_title：Archives of pathology & laboratory medicine
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doi：
更新日期：1978-01-01 00:00:00
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journal_title：Archives of pathology & laboratory medicine
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doi：
更新日期：1986-07-01 00:00:00
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更新日期：1983-12-01 00:00:00
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更新日期：1977-07-01 00:00:00
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更新日期：1987-08-01 00:00:00
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journal_title：Archives of pathology & laboratory medicine
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doi：
更新日期：1992-03-01 00:00:00
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journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章,评审
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更新日期：1983-12-01 00:00:00
