Transformation of small B-cell lymphoma into large cell CD30⁺, CD4⁺, Epstein-Barr virus-negative lymphoma.

Abstract:

:We report here 2 separate cases in which patients with known low-grade B-cell lymphomas presented with transformed lesions that were CD30⁺, CD4⁺, Epstein-Barr virus negative, and negative or focally weak for a wide range of B-cell, T-cell, and histiocytic/dendritic cell markers. In each case the transformed lymphoma possessed an identical pattern of immunoglobulin heavy chain and/or BCL2 rearrangement to the corresponding original low-grade B-cell lymphoma, confirming their identity as transformed B-cell lymphoma. A review of the relevant literature reveals that, to our knowledge, no transformed B-cell lymphomas with this immunophenotype have been previously reported, which creates the opportunity for potential errors of diagnosis. These cases highlight the importance of correlation with the patient's history and with molecular genetic results in rendering an accurate diagnosis.

journal_name

Arch Pathol Lab Med

authors

Shaver AC,Ma L,Vnencak-Jones C,Schwarting RS,Fasig KJ,Kim AS

doi

10.5858/arpa.2013-0089-CR

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

1101-5

issue

8

eissn

0003-9985

issn

1543-2165

journal_volume

138

pub_type

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