Abstract：
:Most mesenchymal tumors of the gastrointestinal tract are now referred to as gastrointestinal stromal tumors (GISTs). The tumors differ from ordinary leiomyomas and schwannomas in several respects: the GISTs typically express c-kit protein (CD117) and CD34, 30% to 50% of them are (often focally) positive for alpha-smooth muscle actin, and all are negative for desmin and S100 protein. Recently, mutations in the exon 11 of the c-kit gene have been identified and confirmed as a molecular genetic marker for the subset of GISTs. In this report, we describe a mesenchymal tumor removed from the pelvic cavity of a 52-year-old woman, who is alive without disease 36 months after the surgery. The 5-cm tumor was densely attached to the external aspect of the urinary bladder but was attached to small intestine by only filmy adhesions. The tumor grossly resembled a leiomyoma and was histologically composed of sheets of spindle cells with a dense collagenous background. The mitotic activity was low, less then 1 per 50 high-power fields. Immunohistochemically, the tumor cells were negative for alpha-smooth muscle actin and desmin and positive for CD117 and CD34. Molecular genetic analysis of the exon 11 of the c-kit gene revealed a point mutation in the region commonly mutated in GISTs. This mutation substituted T for A in the codon 557, leading to the change of amino acid sequence (tryptophan for arginine) of the KIT protein. This case illustrates that tumors phenotypically and genotypically similar to GISTs may present in sites other than the tubular gastrointestinal tract.
journal_name
Arch Pathol Lab Medjournal_title
Archives of pathology & laboratory medicineauthors
Lasota J,Carlson JA,Miettinen Mdoi
10.1043/0003-9985(2000)124<0894:SCTOUB>2.0.CO;2subject
Has Abstractpub_date
2000-06-01 00:00:00pages
894-7issue
6eissn
0003-9985issn
1543-2165journal_volume
124pub_type
杂志文章abstract：:Examination of the bone marrow poses several unique challenges to the pathologist: it is a semisolid organ without helpful gross correlation, it exists in a dynamic state with the peripheral blood and other organs of the lymphohemopoietic system, and the diagnosis of diseases affecting bone marrow often depends heavil...
journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章,评审
doi：10.1043/1543-2165(2008)132[587:RVNBMP]2.0.CO;2
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abstract：:In 4% formaldehyde-fixed, paraffin-embedded tissues, PAS negativity for mycobacteria in the literature has been axiomatic. However, recent observations of disseminated human mycobacteriosis have shown that intracellular (phagocytosed) organisms stained strongly positive with the routine PAS technique. This staining wa...
journal_title：Archives of pathology & laboratory medicine
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doi：
更新日期：1984-05-01 00:00:00
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journal_title：Archives of pathology & laboratory medicine
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journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：10.1043/0003-9985(2002)126<0738:NKLTCL>2.0.CO;2
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journal_title：Archives of pathology & laboratory medicine
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doi：
更新日期：1981-11-01 00:00:00
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journal_title：Archives of pathology & laboratory medicine
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更新日期：1986-07-01 00:00:00
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pub_type： 杂志文章
doi：10.5858/arpa.2020-0037-OA
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journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章,评审
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journal_title：Archives of pathology & laboratory medicine
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doi：10.1043/1543-2165-133.8.1203
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更新日期：1982-07-01 00:00:00
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journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：10.5858/arpa.2012-0126-OA
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pub_type： 杂志文章,评审
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journal_title：Archives of pathology & laboratory medicine
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journal_title：Archives of pathology & laboratory medicine
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doi：10.5858/arpa.2019-0250-OA
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journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章,评审
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journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1984-08-01 00:00:00
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journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：10.1043/1543-2165(2006)130[465:MCOHCU]2.0.CO;2
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journal_title：Archives of pathology & laboratory medicine
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doi：10.5858/arpa.2011-0147-OA
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journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
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journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章,多中心研究
doi：
更新日期：1993-10-01 00:00:00
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journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章,评审
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journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章,评审
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journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1988-05-01 00:00:00
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journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1986-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1043/1543-2165(2004)128<621:CMOSAR>2.0.CO;2
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journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
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更新日期：2005-04-01 00:00:00
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journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1977-06-01 00:00:00
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journal_title：Archives of pathology & laboratory medicine
pub_type： 杂志文章
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更新日期：2006-12-01 00:00:00
