Diffuse large B-cell lymphoma of the prostate.

Abstract:

:In this article, we review prostatic lymphomas and discuss the differential diagnosis of high-grade malignant neoplasms of the prostate. We illustrate this with a case of a 46-year-old man seen with lower urinary tract obstruction who had diffuse involvement by a high-grade malignancy on prostate biopsy. Morphologic evaluation and immunohistochemistry were consistent with diffuse large B-cell lymphoma of the prostate. Workup with positron emission tomography-computed tomography demonstrated intensely hypermetabolic lymph nodes in the mediastinum, as well as widespread osseous involvement and involvement of the pancreatic tail, prostate, and urinary bladder, suggesting secondary prostatic involvement by a nodal lymphoma. Lymphomas of the prostate are uncommon in surgical pathology practice and usually represent secondary involvement from leukemia/lymphoma at a more typical site. Chronic lymphocytic leukemia/small lymphocytic lymphoma is the most common subtype.

journal_name

Arch Pathol Lab Med

authors

Warrick JI,Owens SR,Tomlins SA

doi

10.5858/arpa.2014-0276-CC

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

1286-9

issue

10

eissn

0003-9985

issn

1543-2165

journal_volume

138

pub_type

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