Multicentric metachronous pulmonary and intravagal paraganglioma: a case report with immunohistochemical findings.

Abstract:

:An unprecedented presentation of multicentric paraganglioma in a 48-year-old man is described. One of the paragangliomas, originally diagnosed as a carcinoid tumor, presented as a lung mass and was removed. Four years later, an intravagal paraganglioma was discovered. The lung and intravagal tumors had identical morphologic and immunoreactive characteristics. Both tumors consisted of chief cells (type 1) and sustentacular cells (type 2). The chief cells were immunoreactive with neuroendocrine markers (synaptophysin and chromogranin), but nonreactive with epithelial markers (CAM 5.2, high- and low-molecular-weight keratins, epithelial membrane antigen, and carcinoembryonic antigen). The sustentacular cells were positive for S100 protein. Although pulmonary carcinoids may mimic paragangliomas and occasionally contain sustentacular cells, the diagnosis was rejected because the tumor cells did not demonstrate reactivity with epithelial markers.

journal_name

Arch Pathol Lab Med

authors

Medalie NS,Mendelsohn MG,Esposito M

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

1137-40

issue

12

eissn

0003-9985

issn

1543-2165

journal_volume

120

pub_type

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