Clinical implementation of KRAS testing in metastatic colorectal carcinoma: the pathologist's perspective.

abstract：CONTEXT:-The data in College of American Pathologists cancer protocols have to be presented effectively to health care providers. There is no consensus on the format of those protocols, resulting in various designs among pathologists. Cancer protocols are independently created by site-specific experts, so there is inco...

journal_title：Archives of pathology & laboratory medicine

authors： Strickland-Marmol LB,Muro-Cacho CA,Barnett SD,Banas MR,Foulis PR

更新日期：2016-06-01 00:00:00

abstract：CONTEXT:Clear cell chondrosarcoma (CCC) is commonly considered to be a low-grade subtype of chondrosarcoma. However, a few cases of CCC behave as high-grade lesions (with early metastases or multiple/synchronous locations). OBJECTIVE:To investigate morphologic features that can help predict the aggressiveness of these...

journal_title：Archives of pathology & laboratory medicine

authors： Corradi D,Bacchini P,Campanini N,Bertoni F

更新日期：2006-11-01 00:00:00

abstract：:We report a case of an intraocular inflammatory myofibroblastic tumor nearly filling the vitreous cavity of the eye of a 50-year-old man. The tumor was composed of a mixture of spindle cells and mixed inflammatory elements, including numerous plasma cells. The differential diagnosis included inflammatory pseudotumor a...

journal_title：Archives of pathology & laboratory medicine

authors： O'Malley DP,Poulos C,Czader M,Sanger WG,Orazi A

更新日期：2004-01-01 00:00:00

abstract：:Pathologists' advocacy plays a central role in the establishment of continuously improving patient care quality and patient safety, and in the maintenance and progress of pathology as a profession. Pathology advocacy's primary goal is the betterment of patient safety and quality medical care; however, payment is a nec...

journal_title：Archives of pathology & laboratory medicine

authors： Allen TC

更新日期：2017-07-01 00:00:00

abstract：:Nine pathologists from different institutions reviewed in a double-blind study 16 breast tumors previously indexed as typical medullary carcinoma, atypical medullary carcinoma, or infiltrative ductal carcinoma. A set of 16 slides was circulated two times among the nine pathologists. The diagnoses of typical and atypic...

journal_title：Archives of pathology & laboratory medicine

authors： Rigaud C,Theobald S,Noël P,Badreddine J,Barlier C,Delobelle A,Gentile A,Jacquemier J,Maisongrosse V,Peffault de Latour M

更新日期：1993-10-01 00:00:00

abstract：CONTEXT:- Fine-needle aspiration of thyroid nodules is a reliable diagnostic method to determine the nature of thyroid nodules. Nonetheless, indeterminate cytology diagnoses remain a diagnostic challenge. The development of multiplex molecular techniques and the identification of genetic alterations associated with dif...

journal_title：Archives of pathology & laboratory medicine

authors： Zhang M,Lin O

更新日期：2016-12-01 00:00:00

abstract：:The hemostatic response to vascular damage results in the focal generation of thrombin to produce a fibrin/platelet clot at the site of vascular injury. This regulated hemostatic response derives from the assembly and activity of enzyme complexes that are localized to surfaces presented by the vascular damage. The pro...

journal_title：Archives of pathology & laboratory medicine

authors： Mann KG,Lawson JH

更新日期：1992-12-01 00:00:00

abstract：:Analysis of 1,261 adult subjects, ages 25 to 80 years, showed that there is a positive relationship between the brain weight and the body dimensions. The brain weight, however, increases at a slower rate than the body dimensions. There is indication that only a small portion of the brain varies with variation in the b...

journal_title：Archives of pathology & laboratory medicine

authors： Ho KC,Roessmann U,Straumfjord JV,Monroe G

更新日期：1980-12-01 00:00:00

abstract：CONTEXT:Plasma cell myeloma and chronic lymphocytic leukemia are both common hematologic malignancies, sharing many epidemiologic features. Concomitant detection of the 2 conditions poses special diagnostic challenges for the pathologist. OBJECTIVE:To describe the pathologic findings in cases of concomitant bone marro...

journal_title：Archives of pathology & laboratory medicine

authors： Alley CL,Wang E,Dunphy CH,Gong JZ,Lu CM,Boswell EL,Burchette J,Lagoo AS

更新日期：2013-04-01 00:00:00

abstract：:In a series of 342 bone marrow examinations from 314 patients with human immunodeficiency virus infection, 70 examinations (20%) detected opportunistic mycobacterial or fungal infections. One hundred eleven of the 314 patients had such infections, and, hence, 63% (70/111) were detected by bone marrow examination. Spec...

journal_title：Archives of pathology & laboratory medicine

authors： Nichols L,Florentine B,Lewis W,Sattler F,Rarick MU,Brynes RK

更新日期：1991-11-01 00:00:00

abstract：CONTEXT:Two recent studies have identified a high rate of microsatellite instability (MSI) in pancreatic neuroendocrine tumors (pNETs). Microsatellite instability is rare in small intestinal neuroendocrine tumors (NETs). It is unclear why there is discordance in the frequency of MSI in the 2 studies of pNETs and why th...

journal_title：Archives of pathology & laboratory medicine

authors： Arnason T,Sapp HL,Rayson D,Barnes PJ,Drewniak M,Nassar BA,Huang WY

更新日期：2011-12-01 00:00:00

abstract：CONTEXT:No study has evaluated radiology/pathology correlation of percentage viable tumor (PVT) estimates in ablated hepatocellular carcinoma (HCC) to examine the reliability of radiologic estimates. OBJECTIVE:To determine how well interdisciplinary PVT estimates correlate and identify pathologic factors that influenc...

journal_title：Archives of pathology & laboratory medicine

authors： Hanson JA,Ason R,Weinreb J,Van Dyke A,Mitchell KA

更新日期：2013-03-01 00:00:00

abstract：:We report a case of solitary fibrous tumor involving the spinal nerve root at the L1-L2 level in a 67-year-old man. The patient presented with lumbar pain and weakness in his right lower extremity. Histologically, the tumor was composed of a proliferation of monomorphous spindle cells in an abundant collagenous stroma...

journal_title：Archives of pathology & laboratory medicine

authors： Piana S,Putrino I,Cavazza A,Nigrisoli E

更新日期：2004-03-01 00:00:00

abstract：CONTEXT:Fine-needle aspiration has been the initial step in the workup of thyroid nodular lesions and has successfully reduced the number of unnecessary surgeries and improved preoperative malignancy detection. However, up to one-third of cases fall in the diagnostically "indeterminate group," which poses a patient-man...

journal_title：Archives of pathology & laboratory medicine

authors： Zhang X

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:The term heterotopia, a term derived from Greek, implies "other place." It refers to the finding of normal tissues at foreign sites. Heterotopic gastric tissue rarely involves the large bowel. We report 2 cases of this rare entity. DATA SOURCES:Case reports of 2 patients with sessile polypoid lesion in the r...

journal_title：Archives of pathology & laboratory medicine

authors： Srinivasan R,Loewenstine H,Mayle JE

更新日期：1999-03-01 00:00:00

abstract：CONTEXT:Recent advances in laboratory testing technology have resulted in a rapidly increasing number of test systems targeted for physician office, point-of-care, and home health care settings. With enhanced error detection mechanisms and unitized reagents, these new systems simplify the testing process and the assess...

journal_title：Archives of pathology & laboratory medicine

authors： LaBeau KM,Simon M,Steindel SJ

更新日期：2000-08-01 00:00:00

abstract：CONTEXT:- The Ki-67 index is strongly prognostic and is used as a surrogate marker to distinguish luminal A from luminal B breast cancer types. OBJECTIVE:- To investigate differences in Ki-67 index between core needle biopsy samples and matched surgical samples in breast cancer. DESIGN:- We included patients with inv...

journal_title：Archives of pathology & laboratory medicine

authors： Ahn S,Lee J,Cho MS,Park S,Sung SH

更新日期：2018-03-01 00:00:00

abstract：CONTEXT:Urothelial tumors are rare in young patients. Because of their rarity, the natural history of the disease in young patients remains poorly understood. OBJECTIVE:To understand the pathologic and clinical features of urothelial tumors of the urinary bladder in young patients. DESIGN:We identified 59 young patie...

journal_title：Archives of pathology & laboratory medicine

authors： Stanton ML,Xiao L,Czerniak BA,Guo CC

更新日期：2013-10-01 00:00:00

abstract：:We reviewed the clinicopathologic features of 17 androgenic granulosa cell tumors. The patients, two of whom were pregnant, ranged from 2 to 58 years of age (average age, 22.5 years). Fourteen of the patients were masculinized as evidenced by various combinations of facial acne, temporal recession of hair, clitorimega...

journal_title：Archives of pathology & laboratory medicine

authors： Nakashima N,Young RH,Scully RE

更新日期：1984-10-01 00:00:00

abstract：CONTEXT:Correction factors have been proposed for estimating true potassium concentrations in blood samples with evidence of in vitro hemolysis. OBJECTIVE:We used 2 different models of true (ie, nonsimulated) in vitro hemolysis to evaluate the clinical utility of correction factors for estimating potassium concentrati...

journal_title：Archives of pathology & laboratory medicine

authors： Mansour MM,Azzazy HM,Kazmierczak SC

更新日期：2009-06-01 00:00:00

abstract：:We examined psammoma bodies at the ultrastructural level within meningocytic whorls in nine cases of meningioma. The cells comprising the meningocytic whorls displayed the typical fine structural characteristics of meningothelial cells. The extracellular spaces contained amorphous substances in some whorls and interst...

journal_title：Archives of pathology & laboratory medicine

authors： Kubota T,Hirano A,Sato K,Yamamoto S

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:Contamination of nontumor tissue makes genetic analysis difficult. For this reason, it is important to obtain pure tumor tissue to ensure accurate genetic analysis. OBJECTIVE:To accurately assess the incidence of mutation of tumor suppressor genes (p53: exon 5-8; APC: mutated cluster region; NF-2 gene: all ...

journal_title：Archives of pathology & laboratory medicine

authors： Sugai T,Habano W,Nakamura Si,Uesugi N,Sasou S,Itoh C

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVES:To assess the value of receiver operating characteristic curves (ROCs) as a tool for improvement in the evaluation of cervicovaginal smear results. DESIGN:We reviewed the results of cervicovaginal smear interpretation for 1 year by 10 different cytopathologists working in the same laboratory (total number o...

journal_title：Archives of pathology & laboratory medicine

authors： Renshaw AA,Dean BR,Cibas ES

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:To determine the diagnostic accuracy of an investigational test for human immunodeficiency virus (HIV) envelope antibodies in urine. DESIGN:Matched blood and urine specimens were tested for HIV by two independent laboratories, both of which were blinded to all results at the other site. Duplicate positive en...

journal_title：Archives of pathology & laboratory medicine

authors： Berrios DC,Avins AL,Haynes-Sanstad K,Eversley R,Woods WJ

更新日期：1995-02-01 00:00:00

abstract：:Indirect immunofluorescence antibody testing is a mainstay of retrovirus serodiagnosis in the public health community, affording quick, inexpensive, and clear results with significant advantages over Western blot testing. Limitations regarding training of personnel and availability of reagents will probably continue a...

journal_title：Archives of pathology & laboratory medicine

authors： Ascher MS,Wilber JC

更新日期：1990-03-01 00:00:00

abstract：:Toxoplasmosis of both donor and recipient hearts was diagnosed by means of endomyocardial biopsy specimens after heterotopic cardiac transplantation for dilated cardiomyopathy. Before transplantation, the donor had raised antibody titers to Toxoplasma, and the recipient was negative. When toxoplasmosis was diagnosed o...

journal_title：Archives of pathology & laboratory medicine

authors： Rose AG,Uys CJ,Novitsky D,Cooper DK,Barnard CN

更新日期：1983-07-01 00:00:00

abstract：:A causal role of coronary thrombosis in evolving myocardial infarction is now widely accepted. Patients recovering from an acute heart attack have a higher risk of dying, or suffering another infarction, than an age-matched non-coronary population. Thrombosis plays a major part in this additional mortality and morbidi...

journal_title：Archives of pathology & laboratory medicine

authors： Smith P

更新日期：1993-01-01 00:00:00

abstract：:Petrification of the auricle results in a rigid and immalleable ear. The etiology of such a finding is usually ectopic calcification. The condition has been associated with injurious processes, such as cold injury, and with various endocrinopathies, including Addison disease. In a significant number of cases, ossifica...

journal_title：Archives of pathology & laboratory medicine

authors： High WA,Larson MJ,Hoang MP

更新日期：2004-12-01 00:00:00

abstract：:I report a case of peripheral bronchial carcinoid tumor composed of bundles of large spindle cells, very much resembling cells of smooth muscle or neural tumors. Despite the unusual appearance, argyrophil staining and electron microscopic examination demonstrated small secretory granules of the type found in other per...

journal_title：Archives of pathology & laboratory medicine

authors： Churg A

更新日期：1977-04-01 00:00:00

abstract：:A case of tracheal neurilemoma that was removed by segmental tracheal resection was studied. Only seven other cases of benign neurogenic tracheal tumor (three neurofibromas and four neurilemomas) were found in the literature. Failure to consider this rare tracheal tumor as a cause of respiratory distress has frequentl...

journal_title：Archives of pathology & laboratory medicine

authors： Ma CK,Raju U,Fine G,Lewis JW Jr

更新日期：1981-04-01 00:00:00