Toxoplasmosis of donor and recipient hearts after heterotopic cardiac transplantation.

Abstract:

:Toxoplasmosis of both donor and recipient hearts was diagnosed by means of endomyocardial biopsy specimens after heterotopic cardiac transplantation for dilated cardiomyopathy. Before transplantation, the donor had raised antibody titers to Toxoplasma, and the recipient was negative. When toxoplasmosis was diagnosed on the basis of endomyocardial biopsy specimen, the recipient had a greatly elevated antibody titer of 1:1,027. This suggests that the infection could have been transferred with the donor heart. The mononuclear cell response elicited by disrupted toxoplasmic cysts interferes with the diagnosis of rejection in graft biopsy specimens. Electron microscopy is valuable in confirming a light microscopic diagnosis of toxoplasmosis. Drug therapy eradicated the toxoplasmosis, but the patient died later of tuberculous meningitis.

journal_name

Arch Pathol Lab Med

authors

Rose AG,Uys CJ,Novitsky D,Cooper DK,Barnard CN

subject

Has Abstract

pub_date

1983-07-01 00:00:00

pages

368-73

issue

7

eissn

0003-9985

issn

1543-2165

journal_volume

107

pub_type

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