Abstract:
:We report a case of an intraocular inflammatory myofibroblastic tumor nearly filling the vitreous cavity of the eye of a 50-year-old man. The tumor was composed of a mixture of spindle cells and mixed inflammatory elements, including numerous plasma cells. The differential diagnosis included inflammatory pseudotumor and neoplastic mimics of this condition. Further investigation with immunohistochemistry revealed the mass to be composed of myofibroblasts, positive for smooth muscle actin stains and with weak anaplastic lymphoma kinase (ALK) expression in some tumor cells. Evaluation by fluorescence in situ hybridization revealed the tumor cells to have multiple copies of chromosome 2 and ALK but no rearrangement of the ALK gene. The authors propose that multiple copies of the ALK gene may be involved in inflammatory myofibroblastic tumor tumorigenesis, in addition to ALK gene rearrangements.
journal_name
Arch Pathol Lab Medjournal_title
Archives of pathology & laboratory medicineauthors
O'Malley DP,Poulos C,Czader M,Sanger WG,Orazi Adoi
10.1043/1543-2165(2004)128subject
Has Abstractpub_date
2004-01-01 00:00:00pages
e5-7issue
1eissn
0003-9985issn
1543-2165pii
CR3086journal_volume
128pub_type
杂志文章abstract::The demands for information retrieval, processing, and synthesis placed on all providers of health care have increased dramatically in the last several decades. Although systems have been developed to capture charge-related data in support of cost reimbursement, there has been a conspicuous lack of attention paid to i...
journal_title:Archives of pathology & laboratory medicine
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