Intraocular inflammatory myofibroblastic tumor with ALK overexpression.

Abstract:

:We report a case of an intraocular inflammatory myofibroblastic tumor nearly filling the vitreous cavity of the eye of a 50-year-old man. The tumor was composed of a mixture of spindle cells and mixed inflammatory elements, including numerous plasma cells. The differential diagnosis included inflammatory pseudotumor and neoplastic mimics of this condition. Further investigation with immunohistochemistry revealed the mass to be composed of myofibroblasts, positive for smooth muscle actin stains and with weak anaplastic lymphoma kinase (ALK) expression in some tumor cells. Evaluation by fluorescence in situ hybridization revealed the tumor cells to have multiple copies of chromosome 2 and ALK but no rearrangement of the ALK gene. The authors propose that multiple copies of the ALK gene may be involved in inflammatory myofibroblastic tumor tumorigenesis, in addition to ALK gene rearrangements.

journal_name

Arch Pathol Lab Med

authors

O'Malley DP,Poulos C,Czader M,Sanger WG,Orazi A

doi

10.1043/1543-2165(2004)1282.0.CO;2

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

e5-7

issue

1

eissn

0003-9985

issn

1543-2165

pii

CR3086

journal_volume

128

pub_type

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