Intestinal Neuronal Dysplasia Type B: An Updated Review of a Problematic Diagnosis.

Abstract:

CONTEXT.—:Intestinal neuronal dysplasia type B (IND B) is a controversial histopathologic phenotype that has been associated with intestinal dysmotility, either as an isolated condition or in conjunction with established pathologic disorders (eg, Hirschsprung disease). Many factors contribute to the debate over the existence and/or clinical significance of IND B, including a large body of published data based on inconsistent diagnostic criteria and methods, which have fostered many unwarranted conclusions that lack sufficient scientific basis. OBJECTIVE.—:To critically analyze existing published data regarding IND B to provide supporting evidence-based diagnostic practice and to stimulate necessary and scientifically sound research. DATA SOURCES.—:This update focuses on published literature related to the pathology of IND B because without a reliable pathologic diagnosis, studies of epidemiology, pathogenesis, natural history, management, and outcome are all suspect. Problems with existing data are identified explicitly with suggestions as to how future investigations should be designed and evaluated to better understand this entity. CONCLUSIONS.—:Inconsistencies in diagnostic criteria and methods used to define IND B justifiably encumber the universal acceptance of IND B as a neuropathologic etiology for intestinal dysmotility. IND B will remain a controversial diagnosis until rigorous, well-controlled scientific studies are conducted to establish reproducible and reliable diagnostic criteria that reliably translate from one laboratory to another.

journal_name

Arch Pathol Lab Med

authors

Kapur RP,Reyes-Mugica M

doi

10.5858/arpa.2017-0524-RA

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

235-243

issue

2

eissn

0003-9985

issn

1543-2165

journal_volume

143

pub_type

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