Arterial wall injury and proteoglycan changes in atherosclerosis.

Abstract:

:The concept of injury as a mechanism leading to atherosclerosis has been fostered by numerous studies of initiating factors and by observation of the response of cardiovascular connective tissue, ie, cellular and extracellular matrix components. Carbohydrate-protein macromolecules of the extracellular matrix are a complex group of biologically important substances that play a crucial role in mesenchymal tissue repair following injury, a process needed to maintain arterial wall integrity. Of particular interest are the proteoglycans that enter into a variety of roles, from that of inhibiting atherosclerosis and helping to maintain fibrillar structures to that of taking part in lipid deposition in the development of atherosclerosis.

journal_name

Arch Pathol Lab Med

authors

Berenson GS,Radhakrishnamurthy B,Srinivasan SR,Vijayagopal P,Dalferes ER Jr

subject

Has Abstract

pub_date

1988-10-01 00:00:00

pages

1002-10

issue

10

eissn

0003-9985

issn

1543-2165

journal_volume

112

pub_type

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