abstract：:Cortical auditory evoked potentials (CAEPs) have been successfully used to explore the effects of noise on speech processing at the cortical level in adults and children. The purpose of this study was to determine whether +15 dB signal-to-noise ratios (SNRs), often recommended for optimal speech perception in children...

journal_title：Hearing research

authors： Benítez-Barrera CR,Key AP,Ricketts TA,Tharpe AM

更新日期：2021-01-05 00:00:00

abstract：:The concept of perceptual inferences taking place over multiple timescales simultaneously raises questions about how the brain can balance the demands of remaining sensitive to local rarity while utilising more global longer-term predictability to modulate cortical responses. In the present study auditory evoked poten...

journal_title：Hearing research

authors： Todd J,Frost JD,Yeark M,Paton B

更新日期：2021-01-01 00:00:00

abstract：:Males and females differ in their subcortical evoked responses to sound. For many evoked response measures, the sex difference is driven by a faster developmental decline of auditory processing in males. Using the frequency-following response (FFR), an evoked potential that reflects predominately midbrain processing o...

journal_title：Hearing research

authors： Krizman J,Bonacina S,Kraus N

更新日期：2020-12-01 00:00:00

abstract：:The cerebellum is historically considered to be involved in motor control and motor learning. However, it is also a site of multimodal sensory and sensory-motor integration, implicated in auditory processing. The flocculus and paraflocculus are small lobes of the cerebellum, in humans located in the cerebellopontine a...

journal_title：Hearing research

authors： Mennink LM,van Dijk JMC,van Dijk P

更新日期：2020-12-01 00:00:00

abstract：:Cochlear Implant (CI) sound coding strategies based on simultaneous stimulation lead to an increased loudness percept when compared to sequential stimulation using the same current levels. This is due to loudness summation as a result of channel interactions. Studying the loudness perception evoked by dual-channels co...

journal_title：Hearing research

authors： Langner F,McKay CM,Büchner A,Nogueira W

更新日期：2020-12-01 00:00:00

abstract：:There are multiple etiologies and phenotypes of age-related hearing loss or presbyacusis. In this review we summarize findings from animal and human studies of presbyacusis, including those that provide the theoretical framework for distinct metabolic, sensory, and neural presbyacusis phenotypes. A key finding in quie...

journal_title：Hearing research

authors： Eckert MA,Harris KC,Lang H,Lewis MA,Schmiedt RA,Schulte BA,Steel KP,Vaden KI Jr,Dubno JR

更新日期：2020-10-31 00:00:00

abstract：:Owing to the advances in transgenic animal technology and the advent of the next-generation sequencing era, over 120 genes causing hereditary hearing loss have been identified by now. In parallel, the field of human gene therapy continues to make exciting and rapid progress, culminating in the recent approval of sever...

journal_title：Hearing research

authors： Fakhiri J,Landegger LD,Grimm D

更新日期：2020-10-15 00:00:00

abstract：:Wavelength-swept optical coherence tomography (OCT) was used to scan the structure of cadaveric chinchilla ears in three dimensions with high spatial resolution and measure the sound-induced displacements of the entire OCT-visible lateral surfaces of the ossicles in the lateral-to-medial direction. The simultaneous me...

journal_title：Hearing research

authors： Rosowski JJ,Ramier A,Cheng JT,Yun SH

更新日期：2020-10-01 00:00:00

abstract：:Age-related cochlear synaptopathy (CS) has been shown to occur in rodents with minimal noise exposure, and has been hypothesized to play a crucial role in age-related hearing declines in humans. Because CS affects mainly low-spontaneous rate auditory nerve fibers, differential electrophysiological measures such as the...

journal_title：Hearing research

authors： Carcagno S,Plack CJ

更新日期：2020-10-01 00:00:00

abstract：:One of the key components of fully-implantable hearing devices is the implantable microphone. A crucial parameter when characterizing implantable microphones is the acoustic sensitivity, as it is one of the input parameters for the fitting algorithm and influences the achievable gain. The aim of our study was to inves...

journal_title：Hearing research

authors： D'hondt C,Wouters J,Verhaert N

更新日期：2020-09-15 00:00:00

abstract：:Congenital hearing loss (HL) affects about 1 in every 500 infants. Among those affected more than half are caused by genetic mutations. According to the cellular sites affected by mutations in the cochlea, deafness genes could be classified into three major groups: those affecting the function of hair cells and synaps...

journal_title：Hearing research

authors： Zhang L,Wu X,Lin X

更新日期：2020-09-01 00:00:00

abstract：:Gene therapy using virus vectors to treat hereditary diseases has made remarkable progress in the past decade. There are FDA-approved products for ex-vivo gene therapy for diseases such as immunodeficiencies (e.g., SCID), and in vivo gene therapy for a rare blindness and neuro-muscular disease. Gene therapy for heredi...

journal_title：Hearing research

authors： Maguire CA,Corey DP

更新日期：2020-09-01 00:00:00

abstract：:Proper functioning of the auditory nerve is of critical importance for auditory rehabilitation by cochlear implants. Here we used the Cldn14-/- mouse to study in detail the effects of Claudin 14 loss on auditory synapses and the auditory nerve. Mutations in the tight junction protein Claudin 14 cause autosomal recessi...

journal_title：Hearing research

authors： Claußen M,Schulze J,Nothwang HG

更新日期：2020-06-01 00:00:00

abstract：:Severe damage to the organ of Corti leads to degeneration of the spiral ganglion cells (SGCs) which form the auditory nerve. This degeneration starts at the level of synaptic connection of the peripheral processes (PPs) of SGCs with the cochlear hair cells. It is generally thought that from this point SGC degeneration...

journal_title：Hearing research

authors： Ramekers D,Klis SFL,Versnel H

更新日期：2020-05-01 00:00:00

abstract：:Collin and Lavandier [J. Acoust. Soc. Am. 134, 1146-1159 (2013)] proposed a binaural model predicting speech intelligibility against envelope-modulated noises, evaluated in 24 acoustic conditions, involving similar masker types. The aim of the present study was to test the model robustness modeling 80 additional condi...

journal_title：Hearing research

authors： Vicente T,Lavandier M

更新日期：2020-05-01 00:00:00

abstract：:Phantom electrode (PE) stimulation can extend the lower limit of pitch perception with cochlear implants (CIs) by using simultaneous out-of-phase stimulation of the most apical primary electrode and the adjacent basal compensating electrode. The total electrical field may push the excitation pattern beyond the most ap...

journal_title：Hearing research

authors： Luo X,Garrett C

更新日期：2020-05-01 00:00:00

abstract：:In different animal models, auditory nerve fibers display variation in spontaneous activity and response threshold. Functional and structural differences among inner hair cell ribbon synapses are believed to contribute to this variation. The relative volumes of synaptic proteins at individual synapses might be one suc...

journal_title：Hearing research

authors： Reijntjes DOJ,Köppl C,Pyott SJ

更新日期：2020-05-01 00:00:00

abstract：:The highest spectral ripple density at which the discrimination of ripple glide direction was possible (STRtdir task) was assessed for one-octave wide (narrowband) stimuli with center frequencies of 500, 1000, 2000, and 4000 Hz and for a broadband stimulus. A pink noise lowpass filtered at the lower edge frequency of ...

journal_title：Hearing research

authors： Narne VK,Jain S,Sharma C,Baer T,Moore BCJ

更新日期：2020-04-01 00:00:00

abstract：:Cochlear implant users with ipsilateral residual hearing combine acoustic and electric hearing in one ear, this is called electric-acoustic stimulation (EAS). In EAS users, masking can be shown for electric probes in the presence of acoustic maskers and vice versa. Masking effects in acoustic hearing are generally att...

journal_title：Hearing research

authors： Imsiecke M,Büchner A,Lenarz T,Nogueira W

更新日期：2020-02-01 00:00:00

abstract：:Sensorineural hearing loss is the most common sensory deficit worldwide, yet our understanding of the underlying pathophysiology is limited by the challenges of access to the inner ear in a safe and reliable manner. We present a novel microneedle device for trans-round window membrane liquid biopsy, which utilizes con...

journal_title：Hearing research

authors： Early S,Moon IS,Bommakanti K,Hunter I,Stankovic KM

更新日期：2019-09-15 00:00:00

abstract：:The pupil dilation response is sensitive both to listening effort and the emotional significance of a task. We aimed to assess the influence of evaluative feedback on the pupil dilation response using a speech reception threshold (SRT) task. Besides the pupil dilation response, we acquired subjective ratings and two p...

journal_title：Hearing research

authors： Zekveld AA,van Scheepen JAM,Versfeld NJ,Veerman ECI,Kramer SE

更新日期：2019-09-15 00:00:00

abstract：OBJECTIVE:To objectively measure speech intelligibility of individual subjects from the EEG, based on cortical tracking of different representations of speech: low-level acoustical, higher-level discrete, or a combination. To compare each model's prediction of the speech reception threshold (SRT) for each individual wi...

journal_title：Hearing research

authors： Lesenfants D,Vanthornhout J,Verschueren E,Decruy L,Francart T

更新日期：2019-09-01 00:00:00

abstract：:Emerging evidence suggests that cochlear synaptopathy is a common feature of sensorineural hearing loss, but it is not known to what extent electrophysiological metrics targeting synaptopathy in animals can be applied to people, such as those with impaired audiograms. This study investigates the applicability of subco...

journal_title：Hearing research

authors： Garrett M,Verhulst S

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:Investigation of bone conduction sound propagation by osseous and non-osseous pathways and their interactions based upon the stimulation site and coupling method of the actuator from a bone conduction hearing aid (BCHA). METHODS:Experiments were conducted on five Thiel embalmed whole head cadaver specimens....

journal_title：Hearing research

authors： Dobrev I,Sim JH,Pfiffner F,Huber AM,Röösli C

更新日期：2019-07-01 00:00:00

abstract：:The inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from many bilateral lower auditory nuclei, intrinsic projections within IC, contralateral IC through the commissure of IC and from the auditory cortex (AC). These excitatory and inhibitory inputs from both ascending and descending au...

journal_title：Hearing research

authors： Wang X,Cheng YL,Yang DD,Si WJ,Jen PH,Yang CH,Chen QC

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:The heterogeneity of tinnitus is substantial. Its numerous pathophysiological mechanisms and clinical manifestations have hampered fundamental and treatment research significantly. A decade ago, the Tinnitus Research Initiative introduced the Tinnitus Sample Case History Questionnaire, a case history instrum...

journal_title：Hearing research

authors： Genitsaridi E,Partyka M,Gallus S,Lopez-Escamez JA,Schecklmann M,Mielczarek M,Trpchevska N,Santacruz JL,Schoisswohl S,Riha C,Lourenco M,Biswas R,Liyanage N,Cederroth CR,Perez-Carpena P,Devos J,Fuller T,Edvall NK,Hellbe

更新日期：2019-06-01 00:00:00

abstract：:It is well known that quality of hearing decreases with increasing age due to changes in the peripheral or central auditory pathway. Along with the decrease in the number of neurons the neurotransmitter profile is also affected in the various parts of the auditory system. Particularly, changes in the inhibitory neuron...

journal_title：Hearing research

authors： Pal I,Paltati CRB,Kaur C,Shubhi Saini,Kumar P,Jacob TG,Bhardwaj DN,Roy TS

更新日期：2019-06-01 00:00:00

abstract：:Making small head movements facilitates spatial hearing by resolving front-back confusions, otherwise common in free field sound source localization. The changes in interaural time difference (ITD) in response to head rotation provide a robust front-back cue, but whether interaural level difference (ILD) can be used a...

journal_title：Hearing research

authors： Pöntynen H,Salminen NH

更新日期：2019-06-01 00:00:00

abstract：:The inferior colliculus occupies a central position in ascending and descending auditory pathways. A substantial proportion of its neurons are GABAergic, and these neurons contribute to intracollicular circuits as well as to extrinsic projections to numerous targets. A variety of types of evidence - morphology, physio...

journal_title：Hearing research

authors： Schofield BR,Beebe NL

更新日期：2019-05-01 00:00:00

abstract：:DNA methylation and histone modifications such as methylation, acetylation, and phosphorylation, are two types of epigenetic modifications that alter gene expression. These additions to DNA regulatory elements or to the tails of histones can be inherited or can also occur de novo. Since epigenetic modifications can ha...

journal_title：Hearing research

authors： Walters BJ,Cox BC

更新日期：2019-05-01 00:00:00

abstract：:Cisplatin-induced ototoxicity results in significant, permanent hearing loss in pediatric and adult cancer survivors. Elucidating the mechanisms underlying cisplatin-induced hearing loss as well as the development of therapies to reduce and/or reverse cisplatin ototoxicity have been impeded by suboptimal animal models...

journal_title：Hearing research

authors： Fernandez K,Wafa T,Fitzgerald TS,Cunningham LL

更新日期：2019-04-01 00:00:00

abstract：:In mammals, the cochlear sensory epithelium becomes quiescent early during development. After the first postnatal week, there is no cell replacement or proliferation, and severe damage leads to permanent deafness. Supporting cells' trans-differentiation has been suggested as a way to regenerate cochlear hair cells aft...

journal_title：Hearing research

authors： Silva SA,Maass JC

更新日期：2019-03-01 00:00:00

abstract：:Auditory cortex exhibit a capacity of modulating the functions of subcortical auditory nuclei and even inner ear through descending pathways. The cochlear nucleus (CN), which acts as the gateway from the auditory periphery to the central auditory system, is also subjected to corticofugal modulation. Cortical modulatio...

journal_title：Hearing research

authors： Liu X,Zhang O,Qi J,Chen A,Hu K,Yan J

更新日期：2019-03-01 00:00:00

abstract：:Transient-evoked otoacoustic emissions (TEOAEs) at high frequencies are a non-invasive physiological test of basilar membrane mechanics at the basal end, and have clinical potential to detect risk of hearing loss related to outer-hair-cell dysfunction. Using stimuli with constant incident pressure across frequency, TE...

journal_title：Hearing research

authors： Keefe DH,Feeney MP,Hunter LL,Fitzpatrick DF,Blankenship CM,Garinis AC,Putterman DB,Wróblewski M

更新日期：2019-01-01 00:00:00

abstract：:The understanding of speech in noise relies (at least partially) on spectrotemporal modulation sensitivity. This sensitivity can be measured by spectral ripple tests, which can be administered at different presentation levels. However, it is not known how presentation level affects spectrotemporal modulation threshold...

journal_title：Hearing research

authors： Magits S,Moncada-Torres A,Van Deun L,Wouters J,van Wieringen A,Francart T

更新日期：2019-01-01 00:00:00

abstract：:The Frequency-Following Response (FFR) is a neurophonic auditory evoked potential that reflects the efficient encoding of speech sounds and is disrupted in a range of speech and language disorders. This raises the possibility to use it as a potential biomarker for literacy impairment. However, reference values for com...

journal_title：Hearing research

authors： Ribas-Prats T,Almeida L,Costa-Faidella J,Plana M,Corral MJ,Gómez-Roig MD,Escera C

更新日期：2019-01-01 00:00:00

abstract：:Biomarkers in easy-to-access body fluid compartments, such as blood, are commonly used to assess health of various organ systems in clinical medicine. At present, no such biomarkers are available to inform on the health of the inner ear. Previously, we proposed the outer-hair-cell-specific protein prestin, as a possib...

journal_title：Hearing research

authors： Parham K,Sohal M,Petremann M,Romanet C,Broussy A,Tran Van Ba C,Dyhrfjeld-Johnsen J

更新日期：2019-01-01 00:00:00

abstract：:Using transgenic fluorescent reporter mice in combination with an established tissue clearing method, we detail heretofore optically opaque regions of the spiral lamina and spiral limbus where the auditory peripheral nervous system is located and provide insight into changes in cochlear vascular density with ageing. W...

journal_title：Hearing research

authors： Jiang H,Wang X,Zhang J,Kachelmeier A,Lopez IA,Shi X

更新日期：2019-01-01 00:00:00

abstract：:Interaural time and intensity differences (ITD and IID) are important cues in binaural hearing and allow for sound localization, improving speech understanding in noise and reverberation, and integrating sound sources in the auditory scene. Whereas previous research showed that the upper-frequency limit for ITD detect...

journal_title：Hearing research

authors： Ross B

更新日期：2018-12-01 00:00:00

abstract：:Syndromic hearing loss accounts for approximately 30% of all cases of hearing loss due to genetic causes. Mutation screening in known genes is important because it potentially sheds light on the genetic etiology of hearing loss and helps in genetic counseling of families. In this study, we describe a customized Ion Am...

journal_title：Hearing research

authors： Soares de Lima Y,Chiabai M,Shen J,Córdoba MS,Versiani BR,Benício ROA,Pogue R,Mingroni-Netto RC,Lezirovitz K,Pic-Taylor A,Mazzeu JF,Oliveira SF

更新日期：2018-12-01 00:00:00