The effect of presentation level on spectrotemporal modulation detection.

abstract：:The stimulus level and frequency dependence of the quadratic difference tone (QDT) measured as an otoacoustic emission in the ear canal has been investigated in the guinea pig and compared with simultaneously measured cubic difference tone (CDT) and with the round window electrical response. Acoustic QDT level tended ...

journal_title：Hearing research

authors： Brown AM

更新日期：1993-11-01 00:00:00

abstract：:A simple model for the acoustic enhancement of electrically evoked otoacoustic emissions (EEOEs) is presented in this paper. The model is based on the assumption that the enhancement is a result of the local interaction between the electrical current spreading in the scala media and the basilar membrane (BM) response ...

journal_title：Hearing research

authors： Xue S,Mountain DC,Hubbard AE

更新日期：1995-11-01 00:00:00

abstract：:Sodium salicylate (SS) can penetrate the blood-brain barrier to target neurons in the central auditory system. Understanding how SS alters functional behaviors of different types of central auditory neurons will provide insights into the neural mechanisms of SS-induced tinnitus. Here, we report the differential effect...

journal_title：Hearing research

authors： Su YY,Luo B,Wang HT,Chen L

更新日期：2009-07-01 00:00:00

abstract：:Drugs of the salicylate family (aspirin-like drugs) are reversibly ototoxic. Electrophysiologic and ultrastructural evidence suggests an impairment of the sensory hair cells of the cochlea following salicylate treatment. In addition, since these drugs can cause vasoconstriction, the ototoxicity of salicylates may also...

journal_title：Hearing research

authors： Didier A,Miller JM,Nuttall AL

更新日期：1993-09-01 00:00:00

abstract：:Laser Doppler vibrometry was used to measure the sound-induced tympanic membrane (TM) velocity, assessed near the umbo, in 56 normal hearing human subjects at nine sound frequencies. A second series of measurements was made in 47 subjects with sensorineural hearing loss (SNHL). Each set of measurements has features in...

journal_title：Hearing research

authors： Whittemore KR Jr,Merchant SN,Poon BB,Rosowski JJ

更新日期：2004-01-01 00:00:00

abstract：:The purpose of this study was to investigate the protective effects of U74389F (Upjohn Co. Kalamazoo, MI), a 21-aminosteroid/lipid peroxidation inhibitor, and a member of the lazaroid drug class, on temporary threshold shifts in animals exposed to prolonged noise stimulation. Animals treated with U74389F and exposed t...

journal_title：Hearing research

authors： Quirk WS,Shivapuja BG,Schwimmer CL,Seidman MD

更新日期：1994-04-01 00:00:00

abstract：:Both outer hair cells (OHCs) and inner hair cells (IHCs) survive and mature in 3 days old rat organ of Corti explants cultured for 1 month in a minimal essential medium. In contrast, under the same culture conditions, only IHCs survive in explants from adult guinea pig organ of Corti while many of the OHCs are lost wi...

journal_title：Hearing research

authors： Malgrange B,Rigo JM,Coucke P,Thiry M,Hans G,Nguyen L,van de Water TR,Moonen G,Lefebvre PP

更新日期：2002-08-01 00:00:00

abstract：:Salicylate is a well-known substance to produce reversible tinnitus in animals and humans as well. It has been shown that systemic application of salicylate changes the neuronal spontaneous activity in several parts of the auditory pathway. The effects observed in central auditory structures in vivo could be based upo...

journal_title：Hearing research

authors： Basta D,Goetze R,Ernst A

更新日期：2008-06-01 00:00:00

abstract：:A technique was devised in order to study the fast electromechanical length changes of outer hair cells at low stimulus levels. Solitary outer hair cells were drawn into a glass microchamber. Length changes were evoked by the application of transcellular potentials and were detected with a photodiode. The method is no...

journal_title：Hearing research

authors： Evans BN,Hallworth R,Dallos P

更新日期：1991-04-01 00:00:00

abstract：:The avian auditory papilla provides an interesting object on which to study efferent influences, because whereas a significant population of hair cells in birds is not afferently innervated, all hair cells are efferently innervated (Fischer, 1992, 1994a, b). Previous studies in mammals using contralateral sound to sti...

journal_title：Hearing research

authors： Manley GA,Taschenberger G,Oeckinghaus H

更新日期：1999-12-01 00:00:00

abstract：:The present study aimed to investigate whether gap-prepulse inhibition (GPI) deficit in patients with tinnitus occurred in the N1-P2 complex of the cortical auditory evoked potential. Auditory late responses to the intense sound of the GPI paradigm were obtained from 16 patients with tinnitus and 18 age- and hearing l...

journal_title：Hearing research

authors： Ku Y,Ahn JW,Kwon C,Kim DY,Suh MW,Park MK,Lee JH,Oh SH,Kim HC

更新日期：2017-05-01 00:00:00

abstract：:We have estimated the transfer curve relating instantaneous sound pressure in the ear canal to instantaneous receptor current through the outer hair cells (OHCs) in the basal turn of the guinea pig cochlea using the cochlear microphonic (CM) elicited by continuous 200 Hz tones. The transfer curve is well approximated ...

journal_title：Hearing research

authors： Patuzzi R,Moleirinho A

更新日期：1998-11-01 00:00:00

abstract：:A field potential could be recorded in the deep layers of the superior colliculus (SCd) in the guinea pig following presentation of pure tone bursts at frequencies between 1 and 22 kHz, bursts of white noise, and clicks presented in the free field. The potentials evoked by these stimuli at different intensities had tw...

journal_title：Hearing research

authors： Carlile S,Pettigrew AG

更新日期：1987-12-01 00:00:00

abstract：:Hearing aids are a relatively non-invasive means of reducing the negative effects of hearing loss on an individual who does not require a cochlear implant. Music amplified through hearing aids has some interesting characteristics but high fidelity is not typically one of them. This poses a serious problem for the inve...

journal_title：Hearing research

authors： Chasin M,Hockley NS

更新日期：2014-02-01 00:00:00

abstract：:Acetylcholine (ACh) is the dominant transmitter released from inner ear efferent neurons. In frog vestibular organs, these efferent neurons synapse exclusively with type II hair cells. Hair cells isolated from the frog saccule hyperpolarize following the application of 50 microM ACh, thereby demonstrating the presence...

journal_title：Hearing research

authors： Holt JC,Pantoja AM,Athas GB,Guth PS

更新日期：2000-08-01 00:00:00

abstract：:The human auditory system is comprised of specialized but interacting anatomic and functional pathways encoding object, spatial, and temporal information. We review how learning-induced plasticity manifests along these pathways and to what extent there are common mechanisms subserving such plasticity. A first series o...

journal_title：Hearing research

authors： Spierer L,De Lucia M,Bernasconi F,Grivel J,Bourquin NM,Clarke S,Murray MM

更新日期：2011-01-01 00:00:00

abstract：:In a wide variety of mammals, the rim of the tympanic membrane (annulus fibrosus) has an array of contractile elements, either smooth muscle [Henson and Henson, J. Assoc. Res. Otolaryngol. 1 (2000) 25-32] or myofibroblasts [Kuijpers et al., Hear. Res. 128 (1999) 80-88]. These elements are anchored peripherally to the ...

journal_title：Hearing research

authors： Yang X,Henson OW Jr

更新日期：2002-02-01 00:00:00

abstract：:A hyperpolarization-activated current (termed I[h]) is believed to provide a pacemaker depolarization in sinoatrial node cells and in some central and peripheral neurons. In the present study, we examined if such an inward cation current exists in primary auditory neurons using the whole-cell patch-clamp technique. A ...

journal_title：Hearing research

authors： Chen C

更新日期：1997-08-01 00:00:00

abstract：:Several studies have demonstrated that treatment with intracochlear chronic electrical stimulation (CES) protects spiral ganglion cells (SGCs) from degeneration in deafened animals. Other studies could not confirm this effect of CES. The present study examined whether CES in a mode as presented in cochlear implant use...

journal_title：Hearing research

authors： Agterberg MJ,Versnel H,de Groot JC,van den Broek M,Klis SF

更新日期：2010-10-01 00:00:00

abstract：:Interaural time and intensity differences (ITD and IID) are important cues in binaural hearing and allow for sound localization, improving speech understanding in noise and reverberation, and integrating sound sources in the auditory scene. Whereas previous research showed that the upper-frequency limit for ITD detect...

journal_title：Hearing research

authors： Ross B

更新日期：2018-12-01 00:00:00

abstract：:The IgG1 mouse monoclonal antibody (MAb) KHRI-3, binds to an antigen of 65-68 kDa expressed on inner ear supporting cells in guinea pigs. We previously showed [Nair et al. (1995) Monoclonal antibody induced hearing loss. Hear. Res. 83, 101-113] that mice carrying the KHRI-3 hybridoma develop high frequency hearing los...

journal_title：Hearing research

authors： Nair TS,Prieskorn DM,Miller JM,Mori A,Gray J,Carey TE

更新日期：1997-05-01 00:00:00

abstract：:The cochlear frequency map is believed to depend on the progressive decrease in partition stiffness from base to apex. Measurements on cochleae from human cadavers by von Békésy (1960) suggested that the elasticity of the partition increases by a factor of 100 from the stapes to the helicotrema. However, conventional ...

journal_title：Hearing research

authors： Naidu RC,Mountain DC

更新日期：1998-10-01 00:00:00

abstract：:The effects of endogenous and exogenous Ca(2+) buffers on Ca(2+) current kinetics have been investigated by patch clamp in hair cells mechanically isolated from frog semicircular canals. This preparation displays at least three different Ca(2+) channel types: transient currents flow through a drug-resistant channel ("...

journal_title：Hearing research

authors： Martini M,Rispoli G,Farinelli F,Fesce R,Rossi ML

更新日期：2004-09-01 00:00:00

abstract：:Measurements of the responses to tones and clicks were made from single primary auditory fibres of the caiman. The distribution of the amplitude and phase of the fundamental component of the response rate modulation over the best frequencies of the fibres is comparable to that reported in the cat, despite the fact tha...

journal_title：Hearing research

authors： Smolders JW,Klinke R

更新日期：1986-01-01 00:00:00

abstract：:Synaptic bodies (SBs) associated with rings of synaptic vesicles and well-defined, pre- and post-synaptic membrane structures are indicators of maturity in most hair cell-afferent nerve junctions. The role of the SBs remains elusive despite several experiments showing that they may be involved in storage of neurotrans...

journal_title：Hearing research

authors： Guth P,Norris C,Fermin CD,Pantoja M

更新日期：1993-04-01 00:00:00

abstract：:Proper functioning of the auditory nerve is of critical importance for auditory rehabilitation by cochlear implants. Here we used the Cldn14-/- mouse to study in detail the effects of Claudin 14 loss on auditory synapses and the auditory nerve. Mutations in the tight junction protein Claudin 14 cause autosomal recessi...

journal_title：Hearing research

authors： Claußen M,Schulze J,Nothwang HG

更新日期：2020-06-01 00:00:00

abstract：:Ototoxicity is a dose-limiting side effect of chemotherapeutic treatment with cisplatin. In a series of experiments on neonatal rat cochlear organotypic cultures, the extent of damage induced by a broad range of cisplatin treatment concentrations was examined. Paradoxically, it was found that hair cell loss was greate...

journal_title：Hearing research

authors： Ding D,He J,Allman BL,Yu D,Jiang H,Seigel GM,Salvi RJ

更新日期：2011-12-01 00:00:00

abstract：:The latency, the rise time and the influence of the acoustic reflex on sound transmission were investigated in the adult rat during ketamin anesthesia. This was done by recordings of the cochlear microphonics (CM) and electromyographic (EMG) recordings of the reflex responses of the tensor tympani muscle. The acoustic...

journal_title：Hearing research

authors： van den Berge H,Kingma H,Kluge C,Marres EH

更新日期：1990-10-01 00:00:00

abstract：:Hypoxia/ischemia is a major pathogenetic factor in the development of hearing loss. An important transcription factor involved in the signaling and adaptation to hypoxia/ischemia is the hypoxia-inducible factor-1 (HIF-1). To study HIF-1 expression we used an in vitro hypoxia model of explant and dissociated cultures o...

journal_title：Hearing research

authors： Gross J,Rheinländer C,Fuchs J,Mazurek B,Machulik A,Andreeva N,Kietzmann T

更新日期：2003-09-01 00:00:00

abstract：:Thresholds to sinusoidal and biphasic pulsatile electrical stimuli were measured in two patients with electrodes positioned on the cochlear nucleus. The threshold functions differ from those observed in patients with scala tympani electrodes, primarily at low sinusoidal frequencies and long pulse widths. This differen...

journal_title：Hearing research

authors： Shannon RV

更新日期：1989-06-15 00:00:00