abstract：:Cellulitis is a common clinical diagnosis in the outpatient and inpatient setting; studies have demonstrated a surprisingly high misdiagnosis rate: nearly one-third of cases are other conditions (ie, pseudocellulitis). This high rate of misdiagnosis is thought to contribute to nearly $515 million in avoidable health c...

journal_title：Infectious disease clinics of North America

authors： Garcia BM,Cruz-Diaz C,Agnihothri R,Shinkai K

更新日期：2021-03-01 00:00:00

abstract：:Vancomycin and daptomycin are options for the initial treatment of patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. Treatment options for persistent MRSA bacteremia or bacteremia due to vancomycin-intermediate or vancomycin-resistant strains include daptomycin, ceftaroline, and combination ...

journal_title：Infectious disease clinics of North America

authors： Holubar M,Meng L,Alegria W,Deresinski S

更新日期：2020-12-01 00:00:00

abstract：:This article reviews the changing epidemiology of infections associated with injection drug use, perceived barriers to care, features of successful programs for outpatient antimicrobial treatment, models of shared decision making at the time of discharge, and linkage to preventative care after antimicrobial completion...

journal_title：Infectious disease clinics of North America

authors： Hurley H,Sikka M,Jenkins T,Cari EV,Thornton A

更新日期：2020-09-01 00:00:00

abstract：:Tyrosine kinase inhibitors represent the standard of care for several diseases and drug targets in hematologic malignancies. Infectious complications vary by disease status and prior therapy, but overall incidence of infections generally is low. In chronic diseases, such as chronic myeloid leukemia and chronic lymphoc...

journal_title：Infectious disease clinics of North America

authors： Kin A,Schiffer CA

更新日期：2020-06-01 00:00:00

abstract：:Successful antimicrobial stewardship programs rely on engagement with hospital administrators. Antimicrobial stewards should understand the unique pressures and demands of hospital and health system administration and be familiar with key terminology and regulatory requirements. This article provides guidance on strat...

journal_title：Infectious disease clinics of North America

authors： Buckel WR,Kaye KS,Patel PK

更新日期：2020-03-01 00:00:00

abstract：:Viral hepatitis is a major global public health problem affecting hundreds of millions of people and is associated with significant morbidity and mortality. Five major biologically unrelated hepatotropic viruses cause most of the global burden of viral hepatitis. Hepatitis B and hepatitis C are associated with a signi...

journal_title：Infectious disease clinics of North America

authors： Lanini S,Ustianowski A,Pisapia R,Zumla A,Ippolito G

更新日期：2019-12-01 00:00:00

abstract：:Ebola virus disease (EVD) is a deadly zoonotic disease caused by the Ebola virus. There is no specific treatment approved for EVD. Supportive care and management of complications are mainstays of treatment. Effective outbreak control requires a multidisciplinary team effort applying case management, infection preventi...

journal_title：Infectious disease clinics of North America

authors： Nicastri E,Kobinger G,Vairo F,Montaldo C,Mboera LEG,Ansunama R,Zumla A,Ippolito G

更新日期：2019-12-01 00:00:00

abstract：:Cytomegalovirus (CMV) may no longer be the menace that plagues stem cell transplant outcomes, owing to marked improvements in transplantation techniques and methods of prophylaxis. However, it still remains a common and morbid problem for recipients of stem cell transplant and patients with certain hematologic maligna...

journal_title：Infectious disease clinics of North America

authors： Pande A,Dubberke ER

更新日期：2019-06-01 00:00:00

abstract：:Patients with hematologic malignancy or those who undergo hematopoietic stem cell transplantation experience variable degrees of immunosuppression, dependent on underlying disease, therapy received, time since transplant, and complications, such as graft-versus-host disease. Vaccination is an important strategy to mit...

journal_title：Infectious disease clinics of North America

authors： Kamboj M,Shah MK

更新日期：2019-06-01 00:00:00

abstract：:Ultrasound for diagnosis and staging of schistosomiasis and echinococcosis have paved the way over the past several decades for the application of ultrasound in tropical diseases. Until recently, the size and cost of ultrasound systems limited the application in low-resource settings. The increase in portable ultrasou...

journal_title：Infectious disease clinics of North America

authors： Kaminstein D,Heller T,Tamarozzi F

更新日期：2019-03-01 00:00:00

abstract：:Heart transplant remain the definitive therapy for end-stage heart failure but is limited by the availability of suitable donors. Ventricular assist devices (VAD) are designed as mechanical pumps to supplement or replace the function of damaged ventricles and maintain appropriate blood flow in patients with end-stage ...

journal_title：Infectious disease clinics of North America

authors： Teoh TK,Hannan MM

更新日期：2018-12-01 00:00:00

abstract：:Living safely after organ transplantation starts before transplant and continues after transplant. To minimize a solid organ transplant (SOT) recipient's risk for infection and risk for injury, it is important to plan for numerous potential exposures after transplant. These include potential exposure to others with vi...

journal_title：Infectious disease clinics of North America

authors： Blair BM

更新日期：2018-09-01 00:00:00

abstract：:Mold infections carry a substantial clinical and economic burden in solid organ transplant (SOT) recipients with a high overall mortality of near 30%. The most important pathogens include Aspergillus, the Zygomycetes, Fusarium, Scedosporium/Pseudallescheria, and the dematiaceous (dark) molds. Risk factors for the infe...

journal_title：Infectious disease clinics of North America

authors： Lemonovich TL

更新日期：2018-09-01 00:00:00

abstract：:Injection drug use is the most common transmission route for hepatitis C. High rates of infection are observed among individuals on opioid agonist therapy. Although people who inject drugs carry the highest burden, few have initiated treatment. We present a comprehensive review of the evidence on the efficacy of HCV m...

journal_title：Infectious disease clinics of North America

authors： Norton BL,Akiyama MJ,Zamor PJ,Litwin AH

更新日期：2018-06-01 00:00:00

abstract：:Bronchiolitis is a lower respiratory tract illness caused by viral infection in children 2 years of age and younger, frequently associated with wheezing on physical examination. It is a common cause of hospitalization, particularly in patients with risk factors for more serious disease. The diagnosis can be made based...

journal_title：Infectious disease clinics of North America

authors： Kyler KE,McCulloh RJ

更新日期：2018-03-01 00:00:00

abstract：:Norovirus is the leading cause of acute gastroenteritis. In older adults, it is responsible for an estimated 3.7 million illnesses; 320,000 outpatient visits; 69,000 emergency department visits; 39,000 hospitalizations; and 960 deaths annually in the United States. Older adults are particularly at risk for severe outc...

journal_title：Infectious disease clinics of North America

authors： Cardemil CV,Parashar UD,Hall AJ

更新日期：2017-12-01 00:00:00

abstract：:In older adults, pathophysiologic, clinical, and environmental factors all affect the presentation of infections. We explore how age-related changes influence the manifestation and evaluation of infections in this population. Specific topics include immunosenescence, age-related organ-specific physiologic changes, and...

journal_title：Infectious disease clinics of North America

authors： El Chakhtoura NG,Bonomo RA,Jump RLP

更新日期：2017-12-01 00:00:00

abstract：:Herpes zoster (HZ) is the result of reactivation of latent varicella zoster virus (VZV) and occurs most frequently in older adults. Classically, HZ presents as a unilateral, selflimited, dermatomal rash. Postherpetic neuralgia (PHN) is a common sequela, presenting as severe pain that persists after the rash has resolv...

journal_title：Infectious disease clinics of North America

authors： John AR,Canaday DH

更新日期：2017-12-01 00:00:00

abstract：:Antimicrobial stewardship programs aim to monitor, improve, and measure responsible antibiotic use. The intensive care unit (ICU), with its critically ill patients and prevalence of multiple drug-resistant pathogens, presents unique challenges. This article reviews approaches to stewardship with application to the ICU...

journal_title：Infectious disease clinics of North America

authors： Doernberg SB,Chambers HF

更新日期：2017-09-01 00:00:00

abstract：:The combination of molecular pathogen diagnostics and the biomarker procalcitonin (PCT) are changing the use of antimicrobials in patients admitted to critical care units with severe community-acquired pneumonia, possible septic shock, or other clinical syndromes. An elevated serum PCT level is good supportive evidenc...

journal_title：Infectious disease clinics of North America

authors： Gilbert DN

更新日期：2017-09-01 00:00:00

abstract：:Reactive arthritis is classified as a spondyloarthropathy. Current concepts of disease suggest an infectious trigger, followed by inflammatory arthritis. Several mechanisms have been proposed to explain the interaction of host susceptibility and microorganism. Diagnosis relies on a compatible clinical syndrome and mic...

journal_title：Infectious disease clinics of North America

authors： Schmitt SK

更新日期：2017-06-01 00:00:00

abstract：:Antimicrobial resistance is a common iatrogenic complication of both modern life and medical care. Certain multidrug resistant and extensively drug resistant Gram-negative organisms pose the biggest challenges to health care today, predominantly owing to a lack of therapeutic options. Containing the spread of these or...

journal_title：Infectious disease clinics of North America

authors： Adler A,Friedman ND,Marchaim D

更新日期：2016-12-01 00:00:00

abstract：:Catheter-related bloodstream infections (CRBSI) are responsible for significant morbidity, mortality, and excess health care costs. It is increasingly evident that many CRBSI can be prevented with current knowledge and techniques. Preventive measures can be broadly grouped into clinical practice-based interventions an...

journal_title：Infectious disease clinics of North America

authors： Rupp ME,Majorant D

更新日期：2016-12-01 00:00:00

abstract：:When properly used, disinfection and sterilization can ensure the safe use of invasive and noninvasive medical devices. The method of disinfection and sterilization depends on the intended use of the medical device: critical items (contact sterile tissue) must be sterilized before use; semicritical items (contact muco...

journal_title：Infectious disease clinics of North America

authors： Rutala WA,Weber DJ

更新日期：2016-09-01 00:00:00

abstract：:Antimicrobial resistance is a natural evolutionary process, which in the case of Mycobacterium tuberculosis is based on spontaneous chromosomal mutations, meaning that well-designed combination drug regimens provided under supervised therapy will prevent the emergence of drug-resistant strains. Unfortunately, limited ...

journal_title：Infectious disease clinics of North America

authors： Kurz SG,Furin JJ,Bark CM

更新日期：2016-06-01 00:00:00

abstract：:Invasive candidiasis is a collective term that refers to a group of infectious syndromes caused by a variety of species of Candida, 5 of which cause most cases. Candidemia is the most commonly recognized syndrome associated with invasive candidiasis. Certain conditions may influence the likelihood for one species vers...

journal_title：Infectious disease clinics of North America

authors： McCarty TP,Pappas PG

更新日期：2016-03-01 00:00:00

abstract：:The incidence of meningococcal disease is at an historic low in the United States, but prevention remains a priority because of the devastating outcomes and risk for outbreaks. Available vaccines are recommended routinely for persons at increased risk for disease to protect against all major serogroups of Neisseria me...

journal_title：Infectious disease clinics of North America

authors： Cohn A,MacNeil J

更新日期：2015-12-01 00:00:00

abstract：:Erythema migrans (EM) is the most common objective manifestation of Borrelia burgdorferi infection. Systemic symptoms are usually present. Most patients do not recall a preceding tick bite. Despite a characteristic appearance, EM is not pathognomonic for Lyme disease and must be distinguished from other similar appear...

journal_title：Infectious disease clinics of North America

authors： Nadelman RB

更新日期：2015-06-01 00:00:00

abstract：:Emerging tick-borne infections continue to be observed in the United States and elsewhere. Current information on the epidemiology, clinical and laboratory features, and treatment of infections due to Ehrlichia muris-like agent, deer tick virus, Borrelia miyamotoi sensu lato, and Heartland virus was provided and criti...

journal_title：Infectious disease clinics of North America

authors： Wormser GP,Pritt B

更新日期：2015-06-01 00:00:00

abstract：:HIV testing and incidence are stable, but trends for certain populations are concerning. Primary prevention must be reinvigorated and target vulnerable populations. Science and policy have progressed to improve the accuracy, speed, privacy, and affordability of HIV testing. More potent and much better tolerated HIV tr...

journal_title：Infectious disease clinics of North America

authors： Rodriguez CV,Horberg MA

更新日期：2014-09-01 00:00:00

abstract：:Although antimicrobial stewardship has been shown to improve microbiologic susceptibility patterns, decrease drug toxicities, and lower overall drug costs in the inpatient setting, there are few studies assessing programs in the long-term care (LTC) setting. Implementing antimicrobial stewardship programs in LTC setti...

journal_title：Infectious disease clinics of North America

authors： Rhee SM,Stone ND

更新日期：2014-06-01 00:00:00

abstract：:Recurrent urinary tract infections (UTIs) are common, especially in women. Low-dose daily or postcoital antimicrobial prophylaxis is effective for prevention of recurrent UTIs and women can self-diagnose and self-treat a new UTI with antibiotics. The increasing resistance rates of Escherichia coli to antimicrobial age...

journal_title：Infectious disease clinics of North America

authors： Geerlings SE,Beerepoot MA,Prins JM

更新日期：2014-03-01 00:00:00

abstract：:This article summarizes the epidemiologic evidence linking Mycoplasma genitalium to sexually transmitted disease syndromes, including male urethritis, and female cervicitis, pelvic inflammatory disease, infertility, and adverse birth outcomes. It discusses the relationship of this bacterium to human immunodeficiency v...

journal_title：Infectious disease clinics of North America

authors： Manhart LE

更新日期：2013-12-01 00:00:00

abstract：:In healthy adults and children in developed countries, most foodborne and water-borne infections are short-lived and resolve without specific treatment. In developing areas, these infections may produce acute mortality and chronic morbidity caused by developmental impairment. Immune-compromised hosts are at increased ...

journal_title：Infectious disease clinics of North America

authors： Steiner T

更新日期：2013-09-01 00:00:00

abstract：:Renal transplant recipients continue to have progressive kidney dysfunction and renal graft loss has been attributed to emerging opportunistic infections, specifically BK virus (BKV). BKV is postulated to be selected by the new potent immunosuppressive medications and to be an important factor in graft failure. The pr...

journal_title：Infectious disease clinics of North America

authors： Balba GP,Javaid B,Timpone JG Jr

更新日期：2013-06-01 00:00:00

abstract：:HIV-positive patients are now undergoing solid organ transplantation at increasing rates, with successful outcomes. Transplantation in this unique patient population presents new challenges in the postoperative management of both antiretroviral regimens and immunosuppressive regimens. This review highlights the drug-d...

journal_title：Infectious disease clinics of North America

authors： Primeggia J,Timpone JG Jr,Kumar PN

更新日期：2013-06-01 00:00:00

abstract：:Community-acquired pneumonia (CAP) is the leading cause of death from infectious diseases in the United States. The mortality rate due to severe CAP has shown little improvement over the past few years, with a rate as high as 50% mainly in patients admitted to intensive care units. Death and adverse outcomes from CAP ...

journal_title：Infectious disease clinics of North America

authors： Sibila O,Restrepo MI,Anzueto A

更新日期：2013-03-01 00:00:00

abstract：:Genome-wide association studies have identified polymorphisms located near the gene encoding IL28B, which turned out to be the best predictor of response to pegylated interferon plus ribavirin for chronic hepatitis C virus (HCV) genotype 1 infection. This association was extended to spontaneous clearance of HCV, sugge...

journal_title：Infectious disease clinics of North America

authors： Berger CT,Kim AY

更新日期：2012-12-01 00:00:00

abstract：:Mass gatherings have attracted the attention of the medical community because of the increased demand made on existing services and the potential for public health problems resulting from changes in population dynamics and behaviors. Crowding, lack of hygiene, and rapid population movement at mass gatherings can lead ...

journal_title：Infectious disease clinics of North America

authors： Al-Tawfiq JA,Memish ZA

更新日期：2012-09-01 00:00:00

abstract：:Tegumentary leishmaniases are caused by approximately 15 species of protozoa of the genus Leishmania. They prevail in tropical and subtropical areas of the Old and New World but human mobility also makes them a medical problem in nonendemic areas. Clinical manifestations may comprise cutaneous and mucocutaneous forms ...

journal_title：Infectious disease clinics of North America

authors： Goto H,Lauletta Lindoso JA

更新日期：2012-06-01 00:00:00