Antimicrobial Stewardship Approaches in the Intensive Care Unit.

Abstract:

:Antimicrobial stewardship programs aim to monitor, improve, and measure responsible antibiotic use. The intensive care unit (ICU), with its critically ill patients and prevalence of multiple drug-resistant pathogens, presents unique challenges. This article reviews approaches to stewardship with application to the ICU, including the value of diagnostics, principles of empirical and definitive therapy, and measures of effectiveness. There is good evidence that antimicrobial stewardship results in more appropriate antimicrobial use, shorter therapy durations, and lower resistance rates. Data demonstrating hard clinical outcomes, such as adverse events and mortality, are more limited but encouraging; further studies are needed.

authors

Doernberg SB,Chambers HF

doi

10.1016/j.idc.2017.05.002

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

513-534

issue

3

eissn

0891-5520

issn

1557-9824

pii

S0891-5520(17)30032-6

journal_volume

31

pub_type

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