Drug-Resistant Tuberculosis: Challenges and Progress.

Abstract:

:Antimicrobial resistance is a natural evolutionary process, which in the case of Mycobacterium tuberculosis is based on spontaneous chromosomal mutations, meaning that well-designed combination drug regimens provided under supervised therapy will prevent the emergence of drug-resistant strains. Unfortunately, limited resources, poverty, and neglect have led to the emergence of drug-resistant tuberculosis throughout the world. The international community has responded with financial and scientific support, leading to new rapid diagnostics, new drugs and regimens in advanced clinical development, and an increasingly sophisticated understanding of resistance mechanisms and their application to all aspects of TB control and treatment.

authors

Kurz SG,Furin JJ,Bark CM

doi

10.1016/j.idc.2016.02.010

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

509-522

issue

2

eissn

0891-5520

issn

1557-9824

pii

S0891-5520(16)30016-2

journal_volume

30

pub_type

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