解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:Background:Clinical data on pure-neuritic leprosy (PNL) is limited. Objective:To study the clinical and epidemiological features of PNL in the leprosy post-elimination era. Methods:This was a retrospective analysis of the clinic records of leprosy patients from January 2006 to June 2013. Data regarding age, sex, dise...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2016-12-01 00:00:00
abstract::Adaptive shortening of long flexors is the common secondary impairment which can occur in patients with long standing claw hand, particularly in those who do not undergo any supervised physiotherapy programme.¹ The main purpose of this short report is to describe the current physiotherapeutic means which are commonly ...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2016-12-01 00:00:00
abstract::New cases of leprosy indicate that M. leprae transmission is continuing. In the first half of 2015 we sequentially diagnosed new leprosy patients attending Cebu Skin Clinic, a referral and leprosy treatment centre in Cebu City, Philippines. The great majority of patients were characterised as multibacillary (145 of 14...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2016-06-01 00:00:00
abstract::Leprosy has been labelled as a great imitator since times immemorial. This mainly is because of the wide range of its clinical presentations. In endemic regions it is important to entertain the possibility of leprosy even in atypical presentations so as to avoid misdiagnosis. Here we report three cases of leprosy with...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Chronic planter ulcer, also known as trophic ulcer, shows no tendency towards healing. It is usually seen in sensory deficient foot. The clinical result of a sensory, motor or autonomic loss of a nerve function is frequently the same--ulceration, although the exact cause may vary. The treatment principle inv...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:To estimate the incidence of relapse among leprosy patients released after completing multi-drug therapy (MDT) during 2005-2010 under India's National Leprosy Eradication Programme in South India. METHODS:We conducted a retrospective cohort study of leprosy patients who were released from treatment (RFT) wit...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2015-12-01 00:00:00
abstract::Cutaneous complications of Bacillus Calmette-Guerin (BCG) vaccine, especially in the form of generalised disease, are uncommon and mostly occur in immunocompromised individuals. There is a paucity of data on the cutaneous adverse reactions secondary to BCG immunotherapy in leprosy. We report two unique cases of dissem...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVE:To measure oxidative stress in Type 1 leprosy reaction, and to document the effect of anti-leprosy multidrug therapy (MDT) and anti-reaction drugs on measures of oxidative stress. MATERIALS AND METHODS:A prospective study was carried out at a teaching hospital involving consecutive patients with Type 1 react...
journal_title:Leprosy review
pub_type: 临床试验,杂志文章
doi:
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Many believe that the regular treatment for multibacillary (MB) leprosy cases could be shortened. A shorter treatment allowing uniformity in treatment for all cases renders case classification superfluous and therefore simplifies leprosy control. OBJECTIVE:To evaluate the association between treatment durat...
journal_title:Leprosy review
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2014-12-01 00:00:00
abstract::Lucio's phenomenon (LPh) is considered a necrotizing panvasculitis and a variant of leprosy Type 2 reaction, clinically characterised by necrotic-haemorrhagic lesions on the extremities and trunk. LPh is observed in diffuse lepromatous leprosy (DLL or Lucio-Latapí leprosy). This is a distinct form of lepromatous lepro...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:To study the impact of tendon transfer surgery for ulnar claw hand correction in children with leprosy. SUBJECTS AND METHODS:All the children who underwent reconstructive surgery for ulnar nerve paralysis during the period 2007 to 2012 were included in the study. Unassisted angle, grasp contact, pinch conta...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2014-06-01 00:00:00
abstract:INTRODUCTION:Sensory and/or motor nerve function impairment as a consequence of neuropathy is often assessed using electroneurophysiological tests. However, in low-resource countries where the required equipment is rarely available, manual muscle strength testing (MMST) and monofilament testing (MFT) offer very reliabl...
journal_title:Leprosy review
pub_type: 杂志文章,多中心研究,随机对照试验
doi:
更新日期:2014-03-01 00:00:00
abstract::Brazil has high rates of leprosy case detection, especially in the northern and west-central areas of the country. Effective decentralisation of routine treatment for leprosy has gathered pace since the year 2000 and this has improved access for patients, leading to a peak in new case detection in 2003 and a gradual d...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Multidrug therapy in leprosy has failed to eliminate the problem of persister bacilli. Clearance of bacterial antigens is extremely slow which could predispose to continued nerve damage even after release from treatment. In the present study the immunomodulatory efficacy of BCG vaccine administ...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVES:The COLEP trial in Bangladesh showed a 57% reduction in leprosy incidence among contacts of newly diagnosed patients in the first 2 years after chemoprophylaxis with single dose rifampicin (SDR). We assessed the impact of this intervention after 6 years and identified characteristics of the leprosy index pat...
journal_title:Leprosy review
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2012-09-01 00:00:00
abstract:INTRODUCTION:Many initiatives are undertaken to improve the empowerment of people with disabilities in developing countries. However, an overview of adequate measurement tools to evaluate such activities is not available to date. This systematic literature review aims to describe and assess the available tools to measu...
journal_title:Leprosy review
pub_type: 杂志文章,评审
doi:
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVES:We evaluated the leprosy surveillance system in the Amazon region, Brazil, 2001-2007, using evaluation guidelines from the US Centers for Disease Control and Prevention. RESULTS:We found that the leprosy surveillance system in the Amazon region is simple, presents good data quality and is representative in ...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2012-03-01 00:00:00
abstract::Due to changes in leprosy control programs and the special expertise required for diagnosis, the need for simple rapid diagnostic tests that could be applied in non-expert settings may now be greater than ever before. Since the sequencing of the M. leprae genome, many research groups have investigated the potential of...
journal_title:Leprosy review
pub_type: 杂志文章,评审
doi:
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVES:To study sociodemographic profiles, perceptions about leprosy and health seeking patterns among adult leprosy patients and parents of children with leprosy detected through a prevalence survey conducted earlier, in rural areas of Panvel tehsil in Maharashtra. METHODS:The study was cross-sectional and used m...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:In India, many people affected by leprosy still live in self-established settlements, commonly referred to as leprosy colonies. Aid organisations generally attribute the social segregation of colony members to the stigma attached to leprosy. In this article, I argue that the common approach towards leprosy co...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2011-06-01 00:00:00
abstract:UNLABELLED:Conventional Mouse foot-pad (MFP) assay for screening drug resistance in M. leprae is cumbersome and time-consuming (approximately 6 to 12 months). Molecular targets for different anti-leprosy drugs have been well defined. Molecular tools for rapid detection of drug resistance in M. leprae have been standard...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2011-03-01 00:00:00
abstract:UNLABELLED:This is the second part of a study conducted to evaluate the decentralisation of leprosy control activities in Betim, Minas Gerais, Brazil. OBJECTIVES:To identify factors which hindered or facilitated the decentralisation of leprosy control activities in Betim municipality and to evaluate the quality of car...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:Karigiri was set up initially to be a sanatorium with a difference, and the objective of this review is to study whether this had been achieved. METHODS:A broad search of 43 various publications from Karigiri. RESULTS:Stigma towards leprosy lead to the creation of this sanatorium, and within 20 years of its...
journal_title:Leprosy review
pub_type: 历史文章,杂志文章,评审
doi:
更新日期:2010-06-01 00:00:00
abstract::Delay in diagnosis of leprosy can increase the risk of nerve function impairments and promote the transmission of the infection in a community. In order to understand the factors associated with the delays in diagnosis of leprosy, a questionnaire-based interview was conducted to collect information on the delays among...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:To study the stability and allelic diversity of tandem repeat loci in M. leprae in leprosy patients of Cebu, Philippines, and the suitability of multilocus variable number of tandem repeat (VNTR) analysis (MLVA) typing for detecting transmission. METHODS:Seventy newly diagnosed leprosy patients consulting at...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:Establish a typing system for Mycobacterium leprae based on polymorphic DNA structures known as short tandem repeats (STR). DESIGN:Assess 16 polymorphic STR for sensitivity, specificity and reproducibility in standard assays using reference strains of M. leprae. RESULTS:Primers for 16 STR loci were selected...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Leprosy reactions are a major cause of disability before, during and after anti-bacterial treatment. Prompt diagnosis and correct management of reaction is a crucial matter for improving the quality of leprosy health services. OBJECTIVES:To describe the pattern of leprosy reaction and its management in Chin...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2009-06-01 00:00:00
abstract:INTRODUCTION:Leprosy has been a major public health problem in India for centuries. In India, between 2001 and 2005, the prevalence of leprosy was reduced by 80%. This sharp decline in the prevalence of leprosy alongside the cessation of active surveillance for detection of leprosy cases has raised a sense of alarm in ...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:The immune-mediated events that precipitate erythema nodosum leprosum (ENL) are not well understood. One component may be the complexing of antibody with antigens released from infected macrophages, the activation of complement and the subsequent local inflammation. We assess here the ability of highly-purifi...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVES:An MRI study done in 2000 on 10 leprosy patients with neuropathic feet, without clinical complications such as ulcerations, osteomyelitis or Charcot deformities revealed abnormalities in nine patients, with degradation, interruption of subcutaneous fat and effusion/synovitis, all located in the first metatar...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2008-06-01 00:00:00
abstract::In 2005, Handicap International commissioned a study on the practices of funding for self-employment activities of people with disabilities (PWD), with a special focus on access to microfinance. The overall goal of the study was to produce a framework document highlighting good practices, strategies, tools and operati...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
abstract:INTRODUCTION:Sensory testing in people affected by Hansen's disease is usually performed on palms and soles only. In Israel, both palmar/plantar and dorsal aspects of limbs are routinely tested. OBJECTIVES:The aim of this study was to describe the magnitude of dorsal sensory impairment (SI) in limbs and compare the fr...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2007-12-01 00:00:00
abstract::The objective of the present study was to compare the warm cold perception thresholds (WPT), cold perception thresholds (CPT) and the warm and cold perception interval (WCPI) determined in our previous study with the touch-pressure thresholds, in leprosy-suspected skin lesions ('patch'). Thermal testing was conducted ...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2007-06-01 00:00:00
abstract::The archives of leprosy and its global history are currently evolving in Oxford. A collection of documents and books are housed in the historical library of Sir William Osler under the heading of 'Public Health before and after Osler' and the history of leprosy can be found on http://www.leprosyhistory.org. A striking...
journal_title:Leprosy review
pub_type: 历史文章,杂志文章,评审
doi:
更新日期:2007-03-01 00:00:00
abstract::Leprosy affects the larynx, damaging its mucosa and sensory nerves and loss of sensation may result in aspiration of food and secretions. The laryngeal lesion may be insidious. Post-mortem studies showed bronchopneumonia that could have originated from aspiration. In patients with laryngeal symptoms, dysphagia or aspi...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2007-03-01 00:00:00
abstract::The last half-century has seen tremendous advances in the surgical treatment of neuropathic conditions of the hand. Many of these procedures give clear benefit to patients and have been established by clinical practice and well-formulated assessment. However, much remains to be discovered, especially with respect to w...
journal_title:Leprosy review
pub_type:
doi:
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:To investigate the prevalence and characteristics of depressed patients living in a Japanese leprosarium who have been isolated by national law and are now becoming very elderly. METHODS:We surveyed the prevalence of depressed patients living in the National Tamazenshouen Sanatorium, a major leprosarium in J...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2006-09-01 00:00:00
abstract::Nucleic acid sequences of Mycobacterium leprae were detected using gene probes hybridizing with targeting ribosomal RNA (16S rRNA), ribosomal DNA (16S rDNA) and gene amplification techniques (PCR) in skin lesion of paediatric leprosy patients and the effect of treatment on the by these methods. Eighty paediatric lepro...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2006-06-01 00:00:00
abstract::We identified risk factors associated with increased yearly incidence rates of leprosy in five island populations. Age, sex, household size and Mycobacterium leprae-specific antibodies as well as contact factors were studied. Of 94 index patients (patients diagnosed in 2000), 43 (46%) were classified as multibacillary...
journal_title:Leprosy review
pub_type: 杂志文章
doi:
更新日期:2006-03-01 00:00:00
abstract::The World Health Organisation International Classification of Functioning, Disability and Health defines participation as involvement in a life situation. Participation restrictions are problems experienced in any life situation, for example, in relationships or in employment. Our research explored risk factors for pa...
journal_title:Leprosy review
pub_type: 多中心研究,总体
doi:
更新日期:2005-12-01 00:00:00