:Cutaneous complications of Bacillus Calmette-Guerin (BCG) vaccine, especially in the form of generalised disease, are uncommon and mostly occur in immunocompromised individuals. There is a paucity of data on the cutaneous adverse reactions secondary to BCG immunotherapy in leprosy. We report two unique cases of disseminated cutaneous BCG infection following immunotherapy in patients with lepromatous leprosy. To our knowledge, cutaneous BCG infection presenting as widespread lesions after immunotherapy and confirmed by isolation of Mycobacterium bovis by polymerase chain reaction (PCR) has not been described. A high index of suspicion is required when leprosy patients who receive BCG immunotherapy develop new lesions that cannot be classified as either reaction or relapse, and diagnosis may be confirmed on histopathology and PCR.
authorsKhullar G,Narang T,Sharma K,Saikia UN,Dogra S
abstract：UNLABELLED:Human serum paraoxonase (PON1) activity is reduced in standard hemodialysis (SHD) (4 hours, 3 days/week) patients. Home nocturnal hemodialysis (HNHD) (8 hours, 6 days/week), provides a greater dialysis dose resulting in a greater clearance of metabolites. Whether improvements in the metabolic milieu of HNHD ...
abstract：:The understanding of cell function often requires that complex intracellular pathways are considered in quantitative terms. The access to precise measurement of activities in live cells is increasingly provided by the advances in fluorescence lifetime imaging microscopy (FLIM) of Förster (or fluorescence) resonance en...
journal_title：Methods in cell biology
abstract：:We compared muscle strength between Japanese men with and without metabolic syndrome. We used data for 323 Japanese men with metabolic syndrome and 893 Japanese men without the syndrome. Metabolic syndrome was defined by a new criterion in Japan, and the parameters for muscle strength, i.e. grip strength, leg strength...
journal_title：Acta medica Okayama
abstract：:In order to assess short-term exposures to ethylene oxide, formaldehyde and glutaraldehyde in a sterilization process, the authors conducted continuous environmental monitoring of these chemicals in the breathing zone of workers in 2 hospitals. The arithmetic mean of ethylene oxide was 1.2 ppm near unventilated cabine...
journal_title：Acta medica Okayama
abstract：:If people stay healthy, less health care treatments need to be paid. Alternatively, health care treatments are uneconomical and unethical when they only remove signs and symptoms and leave the primary cause neglected and unchanged to cause future harm. Neglected preventable causes continue to cause massive health-rela...
journal_title：Prostaglandins & other lipid mediators
abstract：:On the basis of documentary analysis and interviews with decision makers, this paper discusses the cost accounting methodologies used for price setting of inpatient services in the Hungarian health care system focusing on sector of acute inpatient care, which is financed through the Hungarian adaptation of Diagnosis R...
journal_title：Health care management science
abstract：BACKGROUND:Glaucoma is the leading cause of irreversible blindness in the world and risk factors to developing glaucoma must be determined early to prevent blindness from the disease. AIM:To determine the relationship between vertical cup disc ratio (VCDR) and body mass index (BMI) in a population screened for glaucom...
journal_title：Nigerian journal of clinical practice
abstract：:The aim of this study was to develop a technique to assay for the activity of antioxidants in a finished cosmetic product. This was accomplished by adapting the Randox Assay for Total Antioxidant Status kit so that diluted samples could be evaluated by kinetic as well as end-point determinations. Using this technique,...
journal_title：Journal of cosmetic science
abstract：:Bluetongue (BTV) is a double-stranded RNA virus that induces apoptosis both in mammalian cell cultures and in target tissues. To elucidate the apoptosis pathways in BTV infection, we have examined in detail the apoptosis mechanism by examination of caspases, Bax, cytochrome c, Smac/DIABLO and NF-B signalling pathways....
journal_title：Revista Argentina de microbiologia
abstract：:Ewing sarcoma (ES) is the second most common bone tumor in children and young adults, with dismal outcomes for metastatic and relapsed disease. To better understand the molecular pathogenesis of ES and to identify new prognostic markers, we used molecular inversion probes (MIPs) to evaluate copy number alterations (CN...
abstract：INTRODUCTION:The aim of this case report is to show the results of therapeutical procedures in the facial granuloma. CASE:A 48 year old male patient had multiple facial granulomas persisting for at least 8 years. They were unresponsive to dapsone. The surgical removal of two lesions and the liquid nitrogen cryotherapy...
journal_title：Annales de dermatologie et de venereologie
abstract：OBJECTIVE:Evidence-based medicine is a difficult goal to achieve in rare diseases where randomized controlled trials are lacking. This report provides guidelines that capitalize on both the literature and expertise of the French National Huntington Disease Reference Centre to optimalize pharmacological therapeutic inte...
abstract：PURPOSE OF INVESTIGATION:The aim of this prospective randomized study was to evaluate a red clover based isoflavones supplementation in the treatment of climacteric syndrome and its effects on cardiovascular risk serum profile. MATERIALS AND METHODS:The study included 150 healthy postmenopausal women that were randoml...
journal_title：Clinical and experimental obstetrics & gynecology
abstract：INTRODUCTION:The emergency department (ED) is often the initial site of identification of patients with sepsis. We aimed to determine the characteristics of ED attendances that predict poor hospital outcomes. METHODS:We conducted a retrospective cohort study of adult patients in eight metropolitan EDs in Perth, Wester...
journal_title：Singapore medical journal
abstract：:Agnogenic myeloid metaplasia (AMM) is a clonal hematopoietic stem cell disorder characterized by bone marrow fibrosis, extramedullary hemopoiesis, splenomegaly and a leukoerythroblastic blood picture. Current standard therapies using hydroxyurea, interferon, androgens or corticosteroids have not shown to prolong survi...
journal_title：Asian Pacific journal of allergy and immunology
abstract：:Dr John Rankin (1923-1981) is one of the many distinguished alumni of the former University Department of Materia Medica and Therapeutics, Stobhill Hospital Glasgow. While his varied international career encompassed pulmonary physiology, occupational medicine and public health, he remains best remembered in the United...
journal_title：Scottish medical journal
abstract：:In insects, decreased reproduction is a sublethal consequence of high temperatures, with males being more sensitive to this in many species. In hymenoptera, arrhenotokous parthenogenesis means that female offspring are produced using sperm and are thus diploid, while males are haploid. Consequently, sperm stocks in ma...
journal_title：Journal of thermal biology
abstract：:A very uncommon ocular and mucocutaneous syndrome is reported. Cutaneous manifestations include keratotic plugs occasionally disposed into verrucous plaques (in mountainous chain), lichenoid lesions on face, neck and hand's back, and nail's involvement. Histologically three types of lesions are observed: marked hyperk...
journal_title：Annales de dermatologie et de venereologie
abstract：:The survey covers 1546 people from three towns of Falcón, which present different climatological characteristics. The diagnostic of P.V. was confirmed through microscopic observation. It is demonstrated a notable increase of the frequency of P.V. during and after the puberty. Significative differences were found betwe...
abstract：:Curcumin possesses wide spectrum of biological actions, on that account the current study was aimed to investigate the beneficial effectiveness of curcumin on memory and oxidative stress if any, over synthetic drug donepezil approved for the treatment of memory disorders. Eighteen Albino wistar (male) rats were divide...
journal_title：Pakistan journal of pharmaceutical sciences
abstract：:The authors report a case of leiomyomatosis peritonealis disseminata in a non pregnant woman. The numerous nodules were first considered by the surgeon as a disseminated abdominal carcinoma, fact which often happens in the literature. Diagnosis was changed on frozen section showing histologically benign appearing smoo...
journal_title：Annales de pathologie
abstract：:A 46-year-old woman suffered a meningococcal meningitis followed by a rapidly progressive lumbosacral pluriradicular syndrome. Myelography showed multiple nodules on the lumbar radices. A biopsy showed tissue with numerous Verocay-like bodies, spindle shaped and lymphocytoid cells which was diagnosed as schwannoma. Th...
abstract：:Cefaclor is a well-absorbed oral cephalosporin antibiotic. Peak concentrations in serum are attained within 30-60 minutes. Food intake reduces the rate, but not the extent of absorption. Cefaclor is not metabolized to a significant degree, but it degrades chemically in the body with an approximate half-life of 2 hours...
journal_title：International journal of clinical pharmacology and therapeutics
abstract：:Mutant protein aggregation and misfolding is often correlated with toxicity in neurodegenerative diseases. Aggregate-prone proteins are tagged by ubiquitin that signals them for destruction by the proteasome or autophagy, two key pathways for protein degradation and proteostasis. Here, we review recent studies showing...
journal_title：Trends in biochemical sciences
abstract：BACKGROUND:Haematospermia is an alarming symptom for patients. Reassuringly, most cases are benign in origin and self-limiting. Occasionally, however, an underlying malignancy is responsible and must not be missed by the treating doctor. OBJECTIVE:The aim of this article is to review the causes, diagnosis and manageme...
journal_title：Australian family physician
abstract：:A forty-six-year-old, non smoker, patient presented with an intermittent claudication of the right calf, clinically compatible with a low popliteal artery obliteration. Arteriography showed an irregular intercondylar popliteal artery and oblitered low popliteal and anterior tibial arteries. Surgical posterior access s...
journal_title：Acta chirurgica Belgica
abstract：:A unique pathogenetic process for onion-bulb (Ob) formation is disclosed with disclosed with immunohistochemistry and electron microscopy. Biopsy of a swollen segment of tibial nerve from a 42 year-old white female histologically demonstrated diffuse and angiocentric lymphocytic infiltrate in both endo- and perineuriu...
abstract：:In this study we determined the prevalence of extended-spectrum beta-lactamases (ESBLs) in phylogenetic groups of uropathogenic E. coli (UPEC) isolated from patients in the community. Twenty one UPEC strains with reduced susceptibility to broad-spectrum cephalosporins were collected between January 2009 and July 2010,...
abstract：:Increasing interest has been shown in Brief Interventions for troubled persons, including those with substance abuse problems. Most of the published literature on this topic has focused on adults, and on the efficacy of these interventions. Few of these studies have examined the critical issues of enrollment and engag...
journal_title：Journal of child & adolescent substance abuse
abstract：:The inter-observer variation of the WHO classification of glomerulonephritis (GN) was studied using Kappa statistics. One hundred renal biopsies were selected with almost equal representation of the following types of GN: minimal change nephropathy, membranous GN, focal proliferative GN, diffuse mesangial proliferativ...