解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Atherosclerotic plaques impair vascular function and can lead to arterial obstruction and tissue ischaemia. Rupture of an atherosclerotic plaque within a coronary artery can result in an acute myocardial infarction, which is responsible for significant morbidity and mortality worldwide. Prompt reperfusion can salvage ...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-020-00829-5
更新日期:2020-11-30 00:00:00
abstract::Ex vivo multicellular preparations are essential tools to study tissue physiology. Among them, the recent methodological and technological developments in living myocardial slices (LMS) are attracting increasing interest by the cardiac research field. Despite this, this research model remains poorly perceived and util...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-020-00822-y
更新日期:2020-09-10 00:00:00
abstract::Sympathetic neural remodeling, which involves the inflammatory response, plays an important role in ventricular arrhythmias (VAs) after myocardial infarction (MI). Adrenergic receptors on macrophages potentially modulate the inflammatory response. We hypothesized that the increased level of catecholamines activates ma...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-020-0813-3
更新日期:2020-08-07 00:00:00
abstract::The concentration of fibroblast growth factor 23 (FGF23) rises progressively in renal failure (RF). High FGF23 concentrations have been consistently associated with adverse cardiovascular outcomes or death, in chronic kidney disease (CKD), heart failure or liver cirrhosis. We identified the mechanisms whereby high con...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-020-0810-6
更新日期:2020-07-22 00:00:00
abstract::Cardiac disease is associated with deleterious emission of mitochondrial reactive oxygen species (mito-ROS), as well as enhanced oxidation and activity of the sarcoplasmic reticulum (SR) Ca2+ release channel, the ryanodine receptor (RyR2). The transfer of Ca2+ from the SR via RyR2 to mitochondria is thought to play a ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-020-0797-z
更新日期:2020-05-22 00:00:00
abstract::From January 2020, coronavirus disease (COVID-19) originated in China has spread around the world. The disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The presence of myocarditis, cardiac arrest, and acute heart failure in COVID-19 patients suggests the existence of a relationshi...
journal_title:Basic research in cardiology
pub_type: 社论
doi:10.1007/s00395-020-0791-5
更新日期:2020-04-09 00:00:00
abstract::Mesenchymal stromal cells (MSCs) exhibit antiapoptotic and proangiogenic functions in models of myocardial infarction which may be mediated by secreted small extracellular vesicles (sEVs). However, MSCs have frequently been harvested from aged or diseased patients, while the isolated sEVs often contain high levels of ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-020-0785-3
更新日期:2020-03-07 00:00:00
abstract::Myocardial ischemia-reperfusion (I/R) injury leads to intensive sympathetic nervous system (SNS) activation and inflammatory reactions. Whether renal sympathetic denervation (RDN) could be a new therapeutic strategy to modulate I/R inflammation and reduce infarct size after myocardial I/R injury needs to be explored. ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-020-0776-4
更新日期:2020-01-13 00:00:00
abstract::DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a novel inducer to promote mitochondrial apoptosis and suppress tumor growth in a variety of cells although its role in cardiovascular diseases remains obscure. This study was designed to examine the role of DNA-PKcs in cardiac ischemia reperfusion (IR) inju...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-019-0773-7
更新日期:2020-01-09 00:00:00
abstract::The success of therapies targeting myocardial reperfusion injury is limited, while the cardioprotective impact of mitigating ischemia-related damage remains less explored. We have recently shown in a pig model that the intravenous administration of a modified atorvastatin preparation during ischemia attenuates the ris...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-019-0760-z
更新日期:2019-11-28 00:00:00
abstract::Cardioprotection aims at infarct size reduction and improvement of clinical outcome from myocardial infarction. The translation of cardioprotection from preclinical and promising proof-of-concept studies to clinical benefit for patients has been largely disappointing. Almost all of these studies which did not translat...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-019-0756-8
更新日期:2019-10-15 00:00:00
abstract::Carotid baroreceptor stimulation (CBS) has been shown to improve cardiac dysfunction and pathological structure remodelling. This study aimed to investigate the effects of CBS on the ventricular electrophysiological properties in canines with chronic heart failure (CHF). Thirty-eight beagles were randomized into contr...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-019-0750-1
更新日期:2019-09-09 00:00:00
abstract::We compared the effects of linagliptin (Lina, a DPP4 inhibitor) and GLP-1 receptor activation by exenatide followed by exendin-4 in an infusion pump (EX) on infarct size (IS), post-infarction activation of the inflammasome and remodeling in wild-type (WT) and db/db diabetic mice. Mice underwent 30 min ischemia followe...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-019-0743-0
更新日期:2019-08-06 00:00:00
abstract::Sprouty1 (Spry1) is a negative modulator of receptor tyrosine kinase signaling, but its role in cardiomyocyte survival has not been elucidated. The aim of this study was to investigate the potential role of cardiomyocyte Spry1 in cardiac ischemia-reperfusion (I/R) injury. Infarct areas of mouse hearts showed an increa...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-018-0713-y
更新日期:2019-01-11 00:00:00
abstract::Patients with insulin resistance and type 2 diabetes have poor cardiac outcomes following myocardial infarction (MI). The mitochondrial uncoupling protein 3 (UCP3) is down-regulated in the heart with insulin resistance. We hypothesized that decreased UCP3 levels contribute to poor cardiac recovery following ischemia/r...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-018-0707-9
更新日期:2018-10-29 00:00:00
abstract::The authors have retracted this article [1] because of modifications in the control lanes of Figs. 2a and 8a of the COX1 blot obtained for 18-week-old rats (rotation, horizontal flipping and re-use of the control lanes for the 35-week-old rats blot). In light of the concerns raised, the conclusions drawn in this artic...
journal_title:Basic research in cardiology
pub_type: 杂志文章,撤回出版物
doi:10.1007/s00395-018-0680-3
更新日期:2018-04-18 00:00:00
abstract::The molecular mechanisms through which ghrelin exerts its cardioprotective effects during cardiac remodeling post-myocardial infarction (MI) are poorly understood. The aim of this study was to investigate whether the cardioprotection mechanisms are mediated by modulation of JAK/STAT signaling and what triggers this mo...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-018-0671-4
更新日期:2018-02-01 00:00:00
abstract::This study was designed to identify mechanisms responsible for coronary vasodilation in response to progressive decreases in hematocrit. Isovolemic hemodilution was produced in open-chest, anesthetized swine via concurrent removal of 500 ml of arterial blood and the addition of 500 ml of 37 °C saline or synthetic plas...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-017-0654-x
更新日期:2017-09-30 00:00:00
abstract::Cardiac physiology and hypertrophy are regulated by the phosphorylation status of many proteins, which is partly controlled by a poorly defined type 2A protein phosphatase-alpha4 intracellular signalling axis. Quantitative PCR analysis revealed that mRNA levels of the type 2A catalytic subunits were differentially exp...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-017-0625-2
更新日期:2017-07-01 00:00:00
abstract::The mitochondrial electrochemical gradient (Δp), which comprises the pH gradient (ΔpH) and the membrane potential (ΔΨ), is crucial in controlling energy transduction. During myocardial ischemia and reperfusion (IR), mitochondrial dysfunction mediates superoxide (·O2-) and H2O2 overproduction leading to oxidative injur...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-017-0626-1
更新日期:2017-07-01 00:00:00
abstract::Ischemic heart disease is the main cause of death worldwide and is accelerated by increased levels of low-density lipoprotein cholesterol (LDL-C). Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a potent circulating regulator of LDL-C through its ability to induce degradation of the LDL receptor (LDLR) in the...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-017-0619-0
更新日期:2017-05-01 00:00:00
abstract::Autologous bone marrow mononuclear cell (BM-MNC) therapy for patients with ST-segment elevation myocardial infarction (STEMI) has produced inconsistent results, possibly due to BM-MNC product heterogeneity. Patient-specific cardiovascular risk factors (CRFs) may contribute to variations in BM-MNC composition. We sough...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-016-0592-z
更新日期:2017-01-01 00:00:00
abstract::Recent attention has focused on the concept that mitochondrial dynamics-that is, the balance between mitochondrial fusion and fission (fragmentation)-may play a pivotal role in determining cell fate in the setting of myocardial ischemia-reperfusion injury. In this regard, there is an emerging consensus that: (1) ische...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-016-0578-x
更新日期:2016-09-01 00:00:00
abstract::Coronary artery disease (CAD), also known as ischemic heart disease (IHD), is the leading cause of mortality in the western world, with developing countries showing a similar trend. With the increased understanding of the role of the immune system and inflammation in coronary artery disease, it was shown that macropha...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-016-0554-5
更新日期:2016-07-01 00:00:00
abstract::Nitroglycerin (GTN) and other organic nitrates are widely used vasodilators. Their side effects are development of nitrate tolerance and endothelial dysfunction. Given the potential of GTN to induce nitro-oxidative stress, we investigated the interaction between nitro-oxidative DNA damage and vascular dysfunction in e...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-016-0571-4
更新日期:2016-07-01 00:00:00
abstract::Transgenic and gene knockout rodent models are primordial to study pathophysiological processes in cardiovascular research. Over time, cardiac MRI has become a gold standard for in vivo evaluation of such models. Technical advances have led to the development of magnets with increasingly high field strength, allowing ...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-016-0565-2
更新日期:2016-07-01 00:00:00
abstract::Sirtuin 3 (Sirt3) is an NAD(+)-dependent mitochondrial deacetylase associated with superoxide dismutase 2 (SOD2)-mediated protection from oxidative stress. We have reported accelerated weight gain and impaired metabolic flexibility in atherosclerotic Sirt3 (-/-) mice. Oxidative stress is a hallmark of endothelial dysf...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-016-0552-7
更新日期:2016-05-01 00:00:00
abstract::Since the discovery of a novel mechanism of cell death that differs from traditional necrosis, i.e., apoptosis, there have been numerous studies concluding that increased apoptosis augments myocardial infarction and heart failure and that limiting apoptosis protects the heart. Importantly, the vast majority of cells i...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-016-0549-2
更新日期:2016-05-01 00:00:00
abstract::Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia with a strong genetic component. Molecular pathways involving the homeodomain transcription factor Shox2 control the development and function of the cardiac conduction system in mouse and zebrafish. Here we report the analysis of human SHOX2 as a potent...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-016-0557-2
更新日期:2016-05-01 00:00:00
abstract::N,N-dimethylsphingosine (DMS) has been documented to be in vitro protective against myocardial ischemia-reperfusion injury (IRI) and can recruit CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs), which may participate in the cardioprotection. We hypothesized that when in vivo applied after a myocardial ischemia, DMS ma...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-016-0548-3
更新日期:2016-05-01 00:00:00
abstract::SIRT6, a member of the NAD(+)-dependent class III deacetylase sirtuin family, has been revealed to play important roles in promoting cellular resistance against oxidative stress. The formation of reactive oxygen species (ROS) and oxidative stress are the crucial mechanisms underlying cellular damage and dysfunction in...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-016-0531-z
更新日期:2016-03-01 00:00:00
abstract::The cardiac hormone atrial natriuretic peptide (ANP) regulates systemic and pulmonary arterial blood pressure by activation of its cyclic GMP-producing guanylyl cyclase-A (GC-A) receptor. In the lung, these hypotensive effects were mainly attributed to smooth muscle-mediated vasodilatation. It is unknown whether pulmo...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-016-0541-x
更新日期:2016-03-01 00:00:00
abstract::Intermittent, normobaric hypoxia confers robust cardioprotection against ischemia-induced myocardial infarction and lethal ventricular arrhythmias. δ-Opioid receptor (DOR) signaling and reactive oxygen species (ROS) have been implicated in cardioprotective phenomena, but their roles in intermittent hypoxia are unknown...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-016-0538-5
更新日期:2016-03-01 00:00:00
abstract::Long QT syndrome is a potentially life-threatening disease characterized by delayed repolarization of cardiomyocytes, QT interval prolongation in the electrocardiogram, and a high risk for sudden cardiac death caused by ventricular arrhythmia. The genetic type 3 of this syndrome (LQT3) is caused by gain-of-function mu...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-016-0530-0
更新日期:2016-03-01 00:00:00
abstract::Cardiomyopathy is one of the most common causes of chronic heart failure worldwide. Mutations in the gene encoding nexilin (NEXN) occur in patients with both hypertrophic and dilated cardiomyopathy (DCM); however, little is known about the pathophysiological mechanisms and relevance of NEXN to these disorders. Here, w...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-015-0522-5
更新日期:2016-01-01 00:00:00
abstract::It is commonly thought that the optimal method for intracoronary administration of cells is to stop coronary flow during cell infusion, in order to prolong cell/vascular wall contact, enhance adhesion, and promote extravasation of cells into the interstitial space. However, occlusion of a coronary artery with a balloo...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-015-0503-8
更新日期:2015-09-01 00:00:00
abstract::Over the past decade, hydrogen sulfide has emerged as an important cardioprotective molecule with potential for clinical applications. Although several pathways have been proposed to mediate the beneficial effects of H2S, the NO/cGMP axis has attracted significant attention. Recent evidence has suggested that cGMP-dep...
journal_title:Basic research in cardiology
pub_type: 社论
doi:10.1007/s00395-015-0510-9
更新日期:2015-09-01 00:00:00
abstract::Recent reports indicate that elevating DNA glycosylase/AP lyase repair enzyme activity offers marked cytoprotection in cultured cells and a variety of injury models. In this study, we measured the effect of EndoIII, a fusion protein construct that traffics Endonuclease III, a DNA glycosylase/AP lyase, to the mitochond...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-014-0459-0
更新日期:2015-03-01 00:00:00
abstract::Short repeated cycles of peripheral ischemia/reperfusion (I/R) can protect distant organs from subsequent prolonged I/R injury; a phenomenon known as remote ischemic preconditioning (RIPC). A RIPC-mediated release of humoral factors might play a key role in this protection and vascular endothelial cells are potential ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-015-0474-9
更新日期:2015-03-01 00:00:00
abstract::Recent studies demonstrated that NADPH oxidase 2 (NOX2) expression in myocardium after ischemia-reperfusion (IR) is significantly upregulated. However, the underlying mechanisms remain unknown. This study aims to determine if nuclear cardiac myosin light chain 2 (MYL2), a well-known regulatory subunit of myosin, funct...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-015-0494-5
更新日期:2015-01-01 00:00:00