abstract：OBJECTIVE:Our objective was to identify whether the whole-brain structural network alterations in patients with temporal lobe epilepsy (TLE) and focal to bilateral tonic-clonic seizures (FBTCS) differ from alterations in patients without FBTCS. METHODS:We dichotomized a cohort of 83 drug-resistant patients with TLE in...

journal_title：Epilepsia

authors： Sinha N,Peternell N,Schroeder GM,de Tisi J,Vos SB,Winston GP,Duncan JS,Wang Y,Taylor PN

更新日期：2021-01-21 00:00:00

abstract：OBJECTIVE:To determine if three different commercially available seizure-detection software packages (Besa 2.0, Encevis 1.7, and Persyst 13) accurately detect seizures with high sensitivity, high specificity, and short detection delay in epilepsy patients undergoing long-term video-electroencephalography (EEG) monitori...

journal_title：Epilepsia

authors： Koren J,Hafner S,Feigl M,Baumgartner C

更新日期：2021-01-19 00:00:00

abstract：OBJECTIVE:Many antiseizure drugs (ASDs) act on voltage-dependent sodium channels, and the molecular basis of these effects is well established. In contrast, how ASDs act on the level of neuronal networks is much less understood. METHODS:In the present study, we determined the effects of eslicarbazepine (S-Lic) on diff...

journal_title：Epilepsia

authors： Schmidt S,Pothmann L,Müller-Komorowska D,Opitz T,Soares da Silva P,Beck H

更新日期：2021-01-16 00:00:00

abstract：OBJECTIVE:A large number of studies have highlighted the important role of the gut microbiota in the pathophysiology of neurological disorders, suggesting that its manipulation might serve as a treatment strategy. We hypothesized that the gut microbiota participates in absence seizure development and maintenance in the...

journal_title：Epilepsia

authors： Citraro R,Lembo F,De Caro C,Tallarico M,Coretti L,Iannone LF,Leo A,Palumbo D,Cuomo M,Buommino E,Nesci V,Marascio N,Iannone M,Quirino A,Russo R,Calignano A,Constanti A,Russo E,De Sarro G

更新日期：2021-01-11 00:00:00

abstract：OBJECTIVE:To assess seizure and cognitive outcomes and their predictors in children (<16 years at surgery) and adults undergoing temporal lobe epilepsy (TLE) surgery in eight Italian centers. METHODS:This is a retrospective multicenter study. We performed a descriptive analysis and subsequently carried out multivariab...

journal_title：Epilepsia

authors： Barba C,Cossu M,Guerrini R,Di Gennaro G,Villani F,De Palma L,Grisotto L,Consales A,Battaglia D,Zamponi N,d'Orio P,Revay M,Rizzi M,Casciato S,Esposito V,Quarato PP,Di Giacomo R,Didato G,Pastori C,Pavia GC,Pellacani

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:Optimal choice of antiseizure medication (ASM) depends on seizure type, syndrome, age, gender, comorbidities and co-medications. There are no fixed rules on how to weigh these factors; choices are subjective and experience-driven. We investigated agreement among experts in selecting ASM as monotherapy and use...

journal_title：Epilepsia

authors： Beniczky S,Rampp S,Asadi-Pooya AA,Rubboli G,Perucca E,Sperling MR

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:Common data elements (CDEs) are standardized questions and answer choices that allow aggregation, analysis, and comparison of observations from multiple sources. Clinical CDEs are foundational for learning health care systems, a data-driven approach to health care focused on continuous improvement of outcomes...

journal_title：Epilepsia

authors： Grinspan ZM,Patel AD,Shellhaas RA,Berg AT,Axeen ET,Bolton J,Clarke DF,Coryell J,Gaillard WD,Goodkin HP,Koh S,Kukla A,Mbwana JS,Morgan LA,Singhal NS,Storey MM,Yozawitz EG,Abend NS,Fitzgerald MP,Fridinger SE,Helbig

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:Electroencephalographic seizures (ESs) are common in encephalopathic critically ill children, but identification requires extensive resources for continuous electroencephalographic monitoring (CEEG). In a previous study, we developed a clinical prediction rule using three clinical variables (age, acute enceph...

journal_title：Epilepsia

authors： Fung FW,Parikh DS,Jacobwitz M,Vala L,Donnelly M,Wang Z,Xiao R,Topjian AA,Abend NS

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:Ablation surgery has become the first line of treatment for hypothalamic hamartomas (HHs). For effective treatment, optimum targeting of ablation is mandatory. The present study aimed to evaluate the correspondence between the electrophysiological features of HHs and morphological targeting by semimicrorecord...

journal_title：Epilepsia

authors： Shirozu H,Masuda H,Kameyama S

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:The posterior cingulate cortex (PCC)/precuneus is a key hub of the default mode network, whose function is known to be altered in epilepsy. Glutamate and γ-aminobutyric acid (GABA) are the main excitatory and inhibitory neurotransmitters in the central nervous system, respectively. Glutathione (GSH) is the mo...

journal_title：Epilepsia

authors： Gonen OM,Moffat BA,Desmond PM,Lui E,Kwan P,O'Brien TJ

更新日期：2020-12-01 00:00:00

abstract：:Reliably detecting focal seizures without secondary generalization during daily life activities, chronically, using convenient portable or wearable devices, would offer patients with active epilepsy a number of potential benefits, such as providing more reliable seizure count to optimize treatment and seizure forecast...

journal_title：Epilepsia

authors： Ryvlin P,Cammoun L,Hubbard I,Ravey F,Beniczky S,Atienza D

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:Diazepam buccal film (DBF) is in development for treatment of patients experiencing bouts of increased seizure activity. We assessed safety, tolerability, and usability of self- or caregiver-administered DBF in the outpatient setting. METHODS:Patients aged 2-65 years needing treatment with a rescue benzodiaz...

journal_title：Epilepsia

authors： Seinfeld S,Gelfand MA,Heller AH,Buan C,Slatko G

更新日期：2020-11-01 00:00:00

abstract：:The occurrence of seizures at specific times of the day has been consistently observed for centuries in individuals with epilepsy. Electrophysiological recordings provide evidence that seizures have a higher probability of occurring at a given time during the night and day cycle in individuals with epilepsy here refer...

journal_title：Epilepsia

authors： Bernard C

更新日期：2020-10-16 00:00:00

abstract：OBJECTIVE:Despite national guidelines supporting surgical referral in drug-resistant epilepsy, it is hypothesized that surgery is underutilized. We investigated the volumes of lobectomy/amygdalohippocampectomy surgeries over time and examined differences in outcomes between (1) high-volume (HV), middle-volume (MV), and...

journal_title：Epilepsia

authors： Kwon CS,Blank L,Mu L,Jetté N

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:Development of novel therapies for temporal lobe epilepsy is hindered by a lack of models suitable for drug screening. While testing the hypothesis that "inhibiting inhibitory neurons" was sufficient to induce seizures, it was discovered that a mild electrical kindling protocol of VGAT-Cre mice led to spontan...

journal_title：Epilepsia

authors： Straub J,Gawda A,Ravichandran P,McGrew B,Nylund E,Kang J,Burke C,Vitko I,Scott M,Williamson J,Joshi S,Kapur J,Perez-Reyes E

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:Treatments for convulsive status epilepticus (SE) have a wide range of effectiveness. The estimated effectiveness of non-intravenous benzodiazepines (non-IV BZDs) ranges from approximately 70% to 90% and the estimated effectiveness of non-benzodiazepine antiseizure medications (non-BZD ASMs) ranges from appro...

journal_title：Epilepsia

authors： Sánchez Fernández I,Gaínza-Lein M,Barcia Aguilar C,Amengual-Gual M,Loddenkemper T

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:Initial identification of new investigational drugs for the treatment of epilepsy is commonly conducted in well-established mouse acute and chronic seizure models: for example, maximal electroshock (MES), 6 Hz, and corneal kindling. Comparison of the median effective dose (ED50) of approved antiseizure drugs ...

journal_title：Epilepsia

authors： Koneval Z,Knox KM,Memon A,Zierath DK,White HS,Barker-Haliski M

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:Stress is a known trigger for seizures in patients with epilepsy (PWE). However, the association between stress and seizures has not been thoroughly investigated. In December 2019, an outbreak of coronavirus disease (COVID-19) occurred in Wuhan, Hubei province, China, causing tremendous collateral stress. Thi...

journal_title：Epilepsia

authors： Huang S,Wu C,Jia Y,Li G,Zhu Z,Lu K,Yang Y,Wang F,Zhu S

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:Identifying adverse outcomes and examining trends and causes of nonelective admissions among persons with epilepsy would be beneficial to optimize patient care and reduce health services utilization. We examined the association of epilepsy with discharge status, in-hospital mortality, length-of-stay, and char...

journal_title：Epilepsia

authors： Kwon CS,Wong B,Agarwal P,Lin JY,Mazumdar M,Dhamoon M,Jetté N

更新日期：2020-09-01 00:00:00

abstract：:In January 2019, a new plant-derived purified cannabidiol preparation, approved by the US Food and Drug Administration, became commercially available for patients ≥2 years old with Lennox-Gastaut syndrome or Dravet syndrome. Among our patients who were prescribed the new cannabidiol formulation, we observed several ca...

journal_title：Epilepsia

authors： McNamara NA,Dang LT,Sturza J,Ziobro JM,Fedak Romanowski EM,Smith GC,Joshi SM,Leber SM,Carlson M,Robertson P,Shellhaas RA

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:Voltage-gated potassium channels of the KCNQ (Kv7) family are targeted by a variety of activator compounds with therapeutic potential for treatment of epilepsy. Exploration of this drug class has revealed a variety of effective compounds with diverse mechanisms. In this study, we aimed to clarify functional c...

journal_title：Epilepsia

authors： Kanyo R,Wang CK,Locskai LF,Li J,Allison WT,Kurata HT

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:Drebrins are crucial for synaptic function and dendritic spine development, remodeling, and maintenance. In temporal lobe epilepsy (TLE) patients, a significant hippocampal synaptic reorganization occurs, and synaptic reorganization has been associated with hippocampal hyperexcitability. This study aimed to e...

journal_title：Epilepsia

authors： Dombroski TCD,Peixoto-Santos JE,Maciel K,Baqui MMA,Velasco TR,Sakamoto AC,Assirati JA,Carlotti CG,Machado HR,Sousa GK,Hanamura K,Leite JP,Costa da Costa J,Palmini AL,Paglioli E,Neder L,Spreafico R,Shirao T,Garbelli R

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:To define the association between late-onset epilepsy (LOE) and 25-year change in cognitive performance. METHODS:The Atherosclerosis Risk in Communities (ARIC) study is a multicenter longitudinal cohort study with participants from four U.S. communities. From linked Medicare claims, we identified cases of LO...

journal_title：Epilepsia

authors： Johnson EL,Krauss GL,Walker KA,Brandt J,Kucharska-Newton A,Mosley TH Jr,Yasar S,Gottesman RF

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:To identify the timelines of magnetic resonance imaging (MRI) abnormalities and their relationships with the clinical outcomes of patients with new-onset refractory status epilepticus (NORSE). METHODS:This retrospective observational study enrolled patients with NORSE who were admitted from March 2008 to Jul...

journal_title：Epilepsia

authors： Kim HJ,Lee SA,Kim HW,Kim SJ,Jeon SB,Koo YS

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:Magnetic resonance imaging (MRI)-guided laser interstitial thermal therapy (MRg-LITT) is an alternative to open epilepsy surgery. We assess safety and effectiveness of MRg-LITT for extratemporal lobe epilepsy (ETLE) in patients who are considered less favorable for open resection. METHODS:We retrospectively ...

journal_title：Epilepsia

authors： Gupta K,Cabaniss B,Kheder A,Gedela S,Koch P,Hewitt KC,Alwaki A,Rich C,Ramesha S,Hu R,Drane DL,Gross RE,Willie JT

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:Movement-based wearable sensors are used for detection of convulsive seizures. The identification of the absence of motion following a seizure, known as post-ictal immobility (PI), may represent a potential additional application of wearables. PI has been associated with potentially life-threatening complicat...

journal_title：Epilepsia

authors： Bruno E,Böttcher S,Biondi A,Epitashvili N,Manyakov NV,Lees S,Schulze-Bonhage A,Richardson MP,RADAR-CNS Consortium.

更新日期：2020-07-01 00:00:00

abstract：:Fibroblast growth-factor homologous factor (FHF1) gene variants have recently been associated with developmental and epileptic encephalopathy (DEE). FHF1 encodes a cytosolic protein that modulates neuronal sodium channel gating. We aim to refine the electroclinical phenotypic spectrum of patients with pathogenic FHF1 ...

journal_title：Epilepsia

authors： Trivisano M,Ferretti A,Bebin E,Huh L,Lesca G,Siekierska A,Takeguchi R,Carneiro M,De Palma L,Guella I,Haginoya K,Shi RM,Kikuchi A,Kobayashi T,Jung J,Lagae L,Milh M,Mathieu ML,Minassian BA,Novelli A,Pietrafusa N,T

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:Epilepsy is a nervous system abnormality that may be caused by unknown exposures during fetal development. Studies have shown neuroprotective effects of early exposure to vitamin D in other neurological disorders, and seasonal variation in birth of children with epilepsy. We aimed to investigate if neonatal 2...

journal_title：Epilepsia

authors： Specht IO,Thorsteinsdottir F,Walker KC,Olsen J,Heitmann BL

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:Corpus callosotomy is an effective palliative treatment for drug-resistant Lennox-Gastaut syndrome (LGS). Laser interstitial thermal therapy has been increasingly used in the treatment of epilepsy. Here, we assess the safety and effectiveness of minimally invasive stereotactic laser anterior corpus callosotom...

journal_title：Epilepsia

authors： Tao JX,Satzer D,Issa NP,Collins J,Wu S,Rose S,Henry J,Santos de Lima F,Nordli D,Warnke PC

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:Genetic testing has become a routine part of the diagnostic workup in children with early onset epilepsies. In the present study, we sought to investigate a cohort of adult patients with epilepsy, to determinate the diagnostic yield and explore the gain of personalized treatment approaches in adult patients. ...

journal_title：Epilepsia

authors： Johannesen KM,Nikanorova N,Marjanovic D,Pavbro A,Larsen LHG,Rubboli G,Møller RS

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:To define the phenotypic spectrum of phosphatidylinositol glycan class A protein (PIGA)-related congenital disorder of glycosylation (PIGA-CDG) and evaluate genotype-phenotype correlations. METHODS:Our cohort encompasses 40 affected males with a pathogenic PIGA variant. We performed a detailed phenotypic ass...

journal_title：Epilepsia

authors： Bayat A,Knaus A,Pendziwiat M,Afenjar A,Barakat TS,Bosch F,Callewaert B,Calvas P,Ceulemans B,Chassaing N,Depienne C,Endziniene M,Ferreira CR,Moura de Souza CF,Freihuber C,Ganesan S,Gataullina S,Guerrini R,Guerrot AM,

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:To assess pharmacokinetics and safety of diazepam nasal spray (NRL-1; VALTOCO®) in pediatric and adult patients with epilepsy in seizure and nonseizure states. METHODS:A single dose of diazepam nasal spray (5, 10, 15, or 20 mg based on weight) was administered during each of two conditions (ictal/peri-ictal ...

journal_title：Epilepsia

authors： Hogan RE,Tarquinio D,Sperling MR,Klein P,Miller I,Segal EB,Rabinowicz AL,Carrazana E

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:Genetic variants in STXBP1, which encodes the conserved exocytosis protein Munc18-1, are associated with a variety of infantile epilepsy syndromes. We aimed to develop an in vivo Caenorhabditis elegans model that could be used to test the pathogenicity of such variants in a cost-effective manner. METHODS:The...

journal_title：Epilepsia

authors： Zhu B,Mak JCH,Morris AP,Marson AG,Barclay JW,Sills GJ,Morgan A

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:In patients with temporal lobe epilepsy (TLE) with a nonlesional and nonepileptogenic hippocampus (HC), in order to preserve functionally intact brain tissue, the HC is not resected. However, some patients experience postoperative memory decline, possibly due to disruption of the extrahippocampal memory netwo...

journal_title：Epilepsia

authors： Wagner K,Gau K,Metternich B,Geiger MJ,Wendling AS,Kadish NE,Reuner G,Mayer H,Mader I,Beck J,Zentner J,Urbach H,Schulze-Bonhage A,Kaller CP,Foit NA

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:Through international collaboration, we evaluated the phenotypic aspects of a multiethnic cohort of KCNT1-related epilepsy and explored genotype-phenotype correlations associated with frequently encountered variants. METHODS:A cross-sectional analysis of children harboring pathogenic or likely pathogenic KCN...

journal_title：Epilepsia

authors： Borlot F,Abushama A,Morrison-Levy N,Jain P,Puthenveettil Vinayan K,Abukhalid M,Aldhalaan HM,Almuzaini HS,Gulati S,Hershkovitz T,Konanki R,Lingappa L,Luat AF,Shafi S,Tabarki B,Thomas M,Yoganathan S,Alfadhel M,Arya R,

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:The "adenosine hypothesis of SUDEP" (sudden unexpected death in epilepsy) predicts that a seizure-induced adenosine surge combined with impaired metabolic clearance can foster lethal apnea or cardiac arrest. Changes in adenosine receptor density and adenosine kinase (ADK) occur in surgical epilepsy patients. ...

journal_title：Epilepsia

authors： Patodia S,Paradiso B,Garcia M,Ellis M,Diehl B,Thom M,Devinsky O

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:To determine whether acute exacerbations of cirrhotic liver disease are associated with higher odds of readmission for epilepsy or status epilepticus. METHODS:The New York State Inpatient Database is a statewide dataset containing data on 97% of hospitalizations for New York State. In this retrospective, cas...

journal_title：Epilepsia

authors： Gursky JM,Rossi KC,Jetté N,Dhamoon MS

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:To determine predictors of focal to bilateral tonic-clonic seizures (FBTCS) during video-electroencephalography (EEG) monitoring (VEM). METHODS:All adult patients undergoing presurgical VEM from 2014 to 2015 in the department of epileptology were eligible (N = 229). Those with refractory focal epilepsy and e...

journal_title：Epilepsia

authors： Pensel MC,Schnuerch M,Elger CE,Surges R

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:To profile European trends in pediatric epilepsy surgery (<16 years of age) between 2008 and 2015. METHODS:We collected information on volumes and types of surgery, pathology, and seizure outcome from 20 recognized epilepsy surgery reference centers in 10 European countries. RESULTS:We analyzed retrospectiv...

journal_title：Epilepsia

authors： Barba C,Cross JH,Braun K,Cossu M,Klotz KA,De Masi S,Perez Jiménez MA,Gaily E,Specchio N,Cabral P,Toulouse J,Dimova P,Battaglia D,Freri E,Consales A,Cesaroni E,Tarta-Arsene O,Gil-Nagel A,Mindruta I,Di Gennaro G,Giu

更新日期：2020-02-01 00:00:00

abstract：:The mechanism(s) for sudden death in epilepsy (SUDEP) remain(s) unknown, but seizure spread to brainstem areas serving autonomic and respiratory function is critical. In a rat model, we established a mechanism for SUDEP that involves seizure-induced laryngospasm and obstructive apnea lasting until respiratory arrest. ...

journal_title：Epilepsia

authors： Irizarry R,Sukato D,Kollmar R,Schild S,Silverman J,Sundaram K,Stephenson S,Stewart M

更新日期：2020-02-01 00:00:00