Exacerbation of hepatic cirrhosis may trigger admission for epilepsy and status epilepticus.

abstract：:Optogenetics is a novel technology that combines optics and genetics by optical control of microbial opsins, targeted to living cell membranes. The versatility and the electrophysiologic characteristics of the light-sensitive ion-channels channelrhodopsin-2 (ChR2), halorhodopsin (NpHR), and the light-sensitive proton ...

journal_title：Epilepsia

authors： Mantoan Ritter L,Golshani P,Takahashi K,Dufour S,Valiante T,Kokaia M

更新日期：2014-11-01 00:00:00

abstract：:From the earliest days of neurology, the classification of epileptic seizures into those generalized from the beginning and those with a definable localization in the cortex from the onset has added to knowledge about the function of the nervous system. Further elaboration of the classification of seizures into those ...

journal_title：Epilepsia

authors： Dreifuss FE

更新日期：1990-01-01 00:00:00

abstract：:DBA/2J (DBA) mice are susceptible to audiogenic seizures (AGSs) in an age-dependent manner, susceptibility being maximal at 21 days and absent at 110 days of age. Previous studies have demonstrated that there is a decrease in anion transport and an increase in carbonic anhydrase (CA) activity in brain from DBA mice as...

journal_title：Epilepsia

authors： Engstrom FL,Kemp JW,Chow SY,Woodbury DM

更新日期：1986-03-01 00:00:00

abstract：:Folic acid deficient diet reduces the duration and severity of intravenous megimide seizures in the rat after 6 months of diet. Plasma and serum folate levels are strongly reduced after that period. The difference between Lactobacillus casei and Streptococcus faecalis activity in brain show a slight, but not significa...

journal_title：Epilepsia

authors： Hommes OR,ten Berge EJ,Jansen MJ,Kok JC

更新日期：1977-12-01 00:00:00

abstract：OBJECTIVE:Nonadherence to prescribed dosing regimens is a significant problem in the treatment of pediatric and adult chronic epilepsy, and can result in severe consequences to patient outcomes. In this first-of-kind preclinical study, the impact of nonadherence on seizure control was studied by simulating human patter...

journal_title：Epilepsia

authors： Thomson KE,Modi AC,Glauser TA,Rausch JR,Steve White H

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Little is known about offspring of parents who both have idiopathic generalized epilepsy (IGE). This is of importance for understanding the complex genetic architecture of IGE. METHODS:Families in whom both parents had proven IGE were ascertained through a multiplex families database. Clinical information i...

journal_title：Epilepsia

authors： Marini C,Harvey AS,Pelekanos JT,Berkovic SF

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:Recent evidence suggests a metabolic contribution of cytochrome P450 enzymes (CYPs) to the drug-resistant phenotype in human epilepsy. However, the upstream molecular regulators of CYP in the epileptic brain remain understudied. We therefore investigated the expression and function of pregnane xenobiotic (PXR...

journal_title：Epilepsia

authors： Ghosh C,Hossain M,Solanki J,Najm IM,Marchi N,Janigro D

更新日期：2017-04-01 00:00:00

abstract：:Early treatment of prolonged seizures with benzodiazepines given intravenously by paramedics in the prehospital setting had been shown to be associated with improved outcomes, but the comparative efficacy and safety of an intramuscular (IM) route, which is faster and consistently achievable, was previously unknown. RA...

journal_title：Epilepsia

authors： Silbergleit R,Lowenstein D,Durkalski V,Conwit R,NETT Investigators.

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:To examine the relationship between seizures and excitatory amino acid transporter (EAAT) activity and whether up-regulation of EAAT activity alters epileptogenicity. METHODS:In this study, we exposed rat hippocampal slices to different convulsants before measuring EAAT activity. Rats were exposed to the EAAT ...

journal_title：Epilepsia

authors： Claudio OI,Ferchmin P,Velísek L,Sperber EF,Moshé SL,Ortiz JG

更新日期：2000-01-01 00:00:00

abstract：:Clinical features of seizures occurring in a neurofibromatosis clinic population were examined in a retrospective study. Twenty-two individuals in a population of 359 persons with neurofibromatos 1 (NF1) had had one or more seizures. Age at first seizure ranged from 4 days to > 20 years. Patients were classified into ...

journal_title：Epilepsia

authors： Korf BR,Carrazana E,Holmes GL

更新日期：1993-07-01 00:00:00

abstract：PURPOSE:The study was conducted to determine the familiarity with, knowledge of, misunderstandings, and attitudes toward epilepsy among the Kuwaiti population. METHODS:A pretested questionnaire was used to collect data from a sample of 784 Kuwaiti individuals, selected from five governorates in Kuwait using a multista...

journal_title：Epilepsia

authors： Awad A,Sarkhoo F

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:Optimal choice of antiseizure medication (ASM) depends on seizure type, syndrome, age, gender, comorbidities and co-medications. There are no fixed rules on how to weigh these factors; choices are subjective and experience-driven. We investigated agreement among experts in selecting ASM as monotherapy and use...

journal_title：Epilepsia

authors： Beniczky S,Rampp S,Asadi-Pooya AA,Rubboli G,Perucca E,Sperling MR

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:Considering the complexity of neuronal circuits and their epilepsy-associated alterations, epilepsy models cannot be completely replaced by in vitro experimental approaches. Decisions about ethical approval of in vivo studies require a thorough weighing of the animal's burden and the benefit regarding the exp...

journal_title：Epilepsia

authors： Koska I,van Dijk RM,Seiffert I,Di Liberto V,Möller C,Palme R,Hellweg R,Potschka H

更新日期：2019-10-01 00:00:00

abstract：:A 10-year-old boy developed febrile convulsions at age 2 years, and multiple types of nonfebrile generalized seizures over the ensuing months and years. Gestation, birth, and early development were normal, as were initial EEG and brain imaging studies. By age 5 years, he had developed behavioral difficulties, and the ...

journal_title：Epilepsia

authors： Grant AC,Vazquez B

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:Nonconvulsive status epilepticus (NCSE) is an under-recognized cause of altered mental status. There are hardly any reported data on NCSE in developing countries. MATERIAL AND METHODS:Prospectively 210 consecutive patients with altered mental status admitted to neurological intensive care unit (NICU) of a tert...

journal_title：Epilepsia

authors： Narayanan JT,Murthy JM

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:Patients with suspected mesial temporal lobe (MTL) epilepsy typically undergo inpatient video-electroencephalography (EEG) monitoring with scalp and/or intracranial electrodes for 1 to 2 weeks to localize and lateralize the seizure focus or foci. Chronic ambulatory electrocorticography (ECoG) in patients with...

journal_title：Epilepsia

authors： King-Stephens D,Mirro E,Weber PB,Laxer KD,Van Ness PC,Salanova V,Spencer DC,Heck CN,Goldman A,Jobst B,Shields DC,Bergey GK,Eisenschenk S,Worrell GA,Rossi MA,Gross RE,Cole AJ,Sperling MR,Nair DR,Gwinn RP,Park YD,

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:Previous neuroimaging studies provide growing evidence that patients with juvenile myoclonic epilepsy (JME) have both structural and functional abnormalities of the thalamus and frontal lobe gray matter. However, limited data are available regarding the issue of white matter (WM) involvement, making the microst...

journal_title：Epilepsia

authors： Kim JH,Suh SI,Park SY,Seo WK,Koh I,Koh SB,Seol HY

更新日期：2012-08-01 00:00:00

abstract：PURPOSE:To evaluate the demographic impact of epilepsy a rural area of Africa. METHODS:A cohort study was conducted between 1991 and 2001 in the Mbam Valley (Cameroon) on two groups of subjects (one of persons with epilepsy, and the other of control individuals matched for sex, age, and village of residence). At the e...

journal_title：Epilepsia

authors： Kamgno J,Pion SD,Boussinesq M

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:Genetic testing has become a routine part of the diagnostic workup in children with early onset epilepsies. In the present study, we sought to investigate a cohort of adult patients with epilepsy, to determinate the diagnostic yield and explore the gain of personalized treatment approaches in adult patients. ...

journal_title：Epilepsia

authors： Johannesen KM,Nikanorova N,Marjanovic D,Pavbro A,Larsen LHG,Rubboli G,Møller RS

更新日期：2020-06-01 00:00:00

abstract：:Each antiepileptic drug has a characteristic pharmacokinetic profile, and the unique properties of each must be considered when selecting the optimal agent for a particular patient. Detailed pharmacologic data are obtained during the preapproval evaluation of a drug, particularly in early phase studies in healthy volu...

journal_title：Epilepsia

authors： Faught E

更新日期：2001-01-01 00:00:00

abstract：:Electroencephalography (EEG)-the direct recording of the electrical activity of populations of neurons-is a tremendously important tool for diagnosing, treating, and researching epilepsy. Although standard procedures for recording and analyzing human EEG exist and are broadly accepted, there are no such standards for ...

journal_title：Epilepsia

authors： Moyer JT,Gnatkovsky V,Ono T,Otáhal J,Wagenaar J,Stacey WC,Noebels J,Ikeda A,Staley K,de Curtis M,Litt B,Galanopoulou AS

更新日期：2017-11-01 00:00:00

abstract：:Our understanding of the neural mechanisms of non-rapid eye movement sleep (NREM) is steadily increasing. Given the intriguing activation of paroxysmal activity during NREM sleep in patients with Landau-Kleffner syndrome (LKS), a thorough characterization of commonalities and differences between the neural correlates ...

journal_title：Epilepsia

authors： Mascetti L,Foret A,Bonjean M,Matarazzo L,Dang-Vu T,Maquet P

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:Ictal vomiting represents a rare clinical manifestation during seizures originating from the temporal lobes of the nondominant hemisphere. The precise anatomic structures responsible for generation of ictal vomiting remain to be clarified. Ictal single photon emission computed tomography (SPECT), which allows o...

journal_title：Epilepsia

authors： Baumgartner C,Olbrich A,Lindinger G,Pataraia E,Gröppel G,Bacher J,Aull S,Serles W,Hoffmann M,Leutmezer F,Czech T,Prayer D,Pietrzyk U,Asenbaum S,Podreka I

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVE:Identifying adverse outcomes and examining trends and causes of nonelective admissions among persons with epilepsy would be beneficial to optimize patient care and reduce health services utilization. We examined the association of epilepsy with discharge status, in-hospital mortality, length-of-stay, and char...

journal_title：Epilepsia

authors： Kwon CS,Wong B,Agarwal P,Lin JY,Mazumdar M,Dhamoon M,Jetté N

更新日期：2020-09-01 00:00:00

abstract：:The identification and correction of adverse physiological changes that lead to seizures in children can improve the effectiveness of current therapeutic practices in epilepsy. It is proposed that various circadian rhythms (respiration, hormones, water balance, electrolytes, intracranial pressure, blood pressure), met...

journal_title：Epilepsia

authors： LeWinn EB

更新日期：1980-08-01 00:00:00

abstract：PURPOSE:To evaluate reproductive endocrine function in boys and young men with epilepsy taking an antiepileptic drug in a population-based, controlled study. METHODS:Seventy patients and 70 controls matched for age and pubertal stage participated in this study. Twenty-eight patients were taking carbamazepine (CBZ); fi...

journal_title：Epilepsia

authors： Mikkonen K,Tapanainen P,Pakarinen AJ,Päivänsalo M,Isojärvi JI,Vainionpää LK

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:A questionnaire survey was conducted in Japan to investigate the causes and prevalence of death related to Dravet syndrome. METHODS:A questionnaire was delivered to 246 hospitals at which physicians were treating childhood epilepsy to gain information about the total number of patients with Dravet syndrome and...

journal_title：Epilepsia

authors： Sakauchi M,Oguni H,Kato I,Osawa M,Hirose S,Kaneko S,Takahashi Y,Takayama R,Fujiwara T

更新日期：2011-06-01 00:00:00

abstract：:The effects of 5 alpha-pregnan-3 alpha-ol-20-one (3 alpha-OH-DHP) and phenobarbital (PB) on synaptic excitation and inhibition in rat hippocampal slices in vitro were compared. Stimulations were made orthodromically and antidromically while we recorded extracellularly from the dendritic and the somatic layer of the CA...

journal_title：Epilepsia

authors： Taubøll E,Gjerstad L

更新日期：1993-03-01 00:00:00

abstract：PURPOSE:Benign epilepsy with centrotemporal spikes (BECTS) is associated with mild cognitive deficits, especially language impairment. This study aimed to clarify whether children with BECTS with left- or right-hemispheric, or bilateral focus have specific neuropsychological language deficits when compared to healthy c...

journal_title：Epilepsia

authors： Datta AN,Oser N,Bauder F,Maier O,Martin F,Ramelli GP,Steinlin M,Weber P,Penner IK

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:Blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI), an important research and clinical tool, depends on relatively greater transient increases in (regional cerebral blood flow) rCBF than cerebral metabolic rate for oxygen during neural activity. We investigated whether reduced rest...

journal_title：Epilepsia

authors： Appel S,Duke ES,Martinez AR,Khan OI,Dustin IM,Reeves-Tyer P,Berl MB,Sato S,Gaillard WD,Theodore WH

更新日期：2012-04-01 00:00:00