Seizures induce obstructive apnea in DBA/2J audiogenic seizure-prone mice: Lifesaving impact of tracheal implants.

Abstract:

:The mechanism(s) for sudden death in epilepsy (SUDEP) remain(s) unknown, but seizure spread to brainstem areas serving autonomic and respiratory function is critical. In a rat model, we established a mechanism for SUDEP that involves seizure-induced laryngospasm and obstructive apnea lasting until respiratory arrest. We hypothesized that DBA/2J mice, which display lethal audiogenic seizures, would be protected from death by implanting a tracheal T-tube as a surrogate airway. In a 2 × 2 design, mice were implanted with either open or closed tracheal T-tubes and treated with either low-dose ketamine/xylazine to moderate thoracic spasm during the tonic seizure phase or no drug. Animals receiving both treatments had the highest survival rate, followed by animals receiving the open tube without ketamine/xylazine. The odds ratio for survival was >20 higher with an open T-tube (odds ratio = 24.14). The impact of open tracheal tubes indicates that the mechanism of death in DBA/2J mice involves seizure-induced upper airway obstruction until respiratory arrest. These results, our rat work, and our demonstration of inspiratory effort-based electromyographic signals and electrocardiographic abnormalities in rats and humans suggest that seizure-induced laryngospasm and obstructive apnea directly link seizure activity to respiratory arrest in these sudden death examples.

journal_name

Epilepsia

journal_title

Epilepsia

authors

Irizarry R,Sukato D,Kollmar R,Schild S,Silverman J,Sundaram K,Stephenson S,Stewart M

doi

10.1111/epi.16431

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

e13-e16

issue

2

eissn

0013-9580

issn

1528-1167

journal_volume

61

pub_type

杂志文章
  • Trends in pediatric epilepsy surgery in Europe between 2008 and 2015: Country-, center-, and age-specific variation.

    abstract:OBJECTIVE:To profile European trends in pediatric epilepsy surgery (<16 years of age) between 2008 and 2015. METHODS:We collected information on volumes and types of surgery, pathology, and seizure outcome from 20 recognized epilepsy surgery reference centers in 10 European countries. RESULTS:We analyzed retrospectiv...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.16414

    authors: Barba C,Cross JH,Braun K,Cossu M,Klotz KA,De Masi S,Perez Jiménez MA,Gaily E,Specchio N,Cabral P,Toulouse J,Dimova P,Battaglia D,Freri E,Consales A,Cesaroni E,Tarta-Arsene O,Gil-Nagel A,Mindruta I,Di Gennaro G,Giu

    更新日期:2020-02-01 00:00:00

  • Prevalence, classification, and severity of epilepsy in children in western Norway.

    abstract:PURPOSE:To determine prevalence of active epilepsy in school children in a defined area and assess the usefulness of International League Against Epilepsy classification of seizures and epileptic syndromes, with special emphasis on frequency, additional handicaps, and therapeutic problems of severe cases. METHODS:The ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.2000.tb00246.x

    authors: Waaler PE,Blom BH,Skeidsvoll H,Mykletun A

    更新日期:2000-07-01 00:00:00

  • The effects of antimicrobial and antiepileptic treatment on the outcome of epilepsy associated with central nervous system (CNS) infections.

    abstract::The course and outcome of epilepsy following central nervous system (CNS) infections has been poorly characterized. Likewise, the impact of antimicrobial treatment as well as other preventative and therapeutic interventions on the development of epilepsy following neurological infectious disorders has been insufficien...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2008.01755.x

    authors: Singh G,Prabhakar S

    更新日期:2008-08-01 00:00:00

  • Epilepsy in the elderly.

    abstract::The elderly are the most rapidly growing segment of the population and the incidence of epilepsy is higher in the elderly than in any other age group. They have been subdivided into the "young old," 65-74 years, "middle old" 75-84 years, and the "old old," 85 years or older. But further subdivisions are needed: person...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2006.00664.x

    authors: Leppik IE

    更新日期:2006-01-01 00:00:00

  • Changes in regional cerebral blood flow beyond the temporal lobe in unilateral temporal lobe epilepsy.

    abstract:PURPOSE:Single photon emission computed tomography (SPECT) is widely used to evaluate functional abnormalities during the epileptic event. Changes in regional cerebral blood flow (rCBF) are well defined in patients with temporal lobe epilepsy (TLE) undergoing surgical resection. Nonetheless, the interpretation of ictal...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1997.tb01484.x

    authors: Rabinowicz AL,Salas E,Beserra F,Leiguarda RC,Vazquez SE

    更新日期:1997-09-01 00:00:00

  • Spectrum of clinical and histopathologic responses to intracranial electrodes: from multifocal aseptic meningitis to multifocal hypersensitivity-type meningovasculitis.

    abstract:PURPOSE:We sought to characterize and compare the histopathologic and clinical changes elicited by subdural and depth electrodes in subjects undergoing epilepsy surgery evaluation. METHODS:A retrospective review of clinical records, imaging and histopathologic studies of epilepsy surgery cases requiring subdural strip...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1046/j.1528-1157.2001.042007895.x

    authors: Stephan CL,Kepes JJ,SantaCruz K,Wilkinson SB,Fegley B,Osorio I

    更新日期:2001-07-01 00:00:00

  • Regional expression of multidrug resistance genes in genetically epilepsy-prone rat brain after a single audiogenic seizure.

    abstract:PURPOSE:The multidrug resistance (mdr) gene family encodes the drug transport macromolecule P-glycoprotein (P-gp), which contributes to the functionality of the blood-brain barrier. Recent evidence suggests that P-gp-mediated drug extrusion may play a facilitatory role in refractory epilepsy. We investigated the region...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1046/j.1528-1157.2002.156702.x

    authors: Kwan P,Sills GJ,Butler E,Gant TW,Meldrum BS,Brodie MJ

    更新日期:2002-11-01 00:00:00

  • Effect of magnesium on epileptic foci.

    abstract::Parenteral magnesium sulfate has been used to control acute convulsions of diverse etiologies and is currently a mainstay in controlling eclamptic convulsions. However, the site of this anticonvulsant action has remained controversial and not well studied in experimental epileptic models. Therefore we determined the e...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1978.tb05015.x

    authors: Borges LF,Gücer G

    更新日期:1978-02-01 00:00:00

  • Adverse effects of valproate on bone: defining a model to investigate the pathophysiology.

    abstract:PURPOSE:Bone disease and fractures are common with chronic antiepileptic drug (AED) therapy, but the underlying mechanisms are poorly understood. This study aimed to characterize adverse bone effects of valproate and to identify mouse strains either resistant or sensitive to these effects. METHODS:Seven mouse strains ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2009.02516.x

    authors: Senn SM,Kantor S,Poulton IJ,Morris MJ,Sims NA,O'Brien TJ,Wark JD

    更新日期:2010-06-01 00:00:00

  • Differential effects of acute and repeated electrically and chemically induced seizures on [3H]Nimodipine and [125I]omega-conotoxin GVIA binding in rat brain.

    abstract::[3H]Nimodipine and high-affinity [125I]omega-conotoxin GVIA (CgTX) binding were investigated in membranes from rat cerebral cortex, cerebellum, and hippocampus after electrically and chemically induced seizures. Animals were decapitated 30 min after a single electroconvulsive shock (ECS) or lidocaine-induced seizure a...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1989.tb05330.x

    authors: Gleiter CH,Cain CJ,Weiss SR,Post RM,Marangos PJ

    更新日期:1989-07-01 00:00:00

  • Bidirectional relation between schizophrenia and epilepsy: a population-based retrospective cohort study.

    abstract:PURPOSE:Schizophrenia and epilepsy may share a mutual susceptibility. This study examined the bidirectional relation between the two disorders. METHODS:We used claims data obtained from the Taiwan National Health Insurance database to conduct retrospective cohort analyses. Analysis 1 compared 5,195 patients with incid...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2011.03268.x

    authors: Chang YT,Chen PC,Tsai IJ,Sung FC,Chin ZN,Kuo HT,Tsai CH,Chou IC

    更新日期:2011-11-01 00:00:00

  • Characteristic distribution of interictal brain electrical activity in idiopathic generalized epilepsy.

    abstract:PURPOSE:To demonstrate the anatomic localization of the cortical sources of the interictal EEG activity in human idiopathic generalized epilepsy (IGE). METHODS:Multiple cortical and hippocampal sources of the interictal spontaneous EEG activity were investigated by low-resolution electromagnetic tomography in 15 untre...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2007.01030.x

    authors: Clemens B,Bessenyei M,Piros P,Tóth M,Seress L,Kondákor I

    更新日期:2007-05-01 00:00:00

  • Eye-closure-triggered paroxysmal activity and cognitive impairment: a case report.

    abstract:PURPOSE:To study the neuropsychological status of an epileptic patient presenting with epileptic activity triggered by eye closure in a 14-year follow-up period. METHODS:The patient was studied at 12 and 26 years of age; during this period he underwent periodical clinical evaluations and EEG investigations; brain magn...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2006.00708.x

    authors: Termine C,Rubboli G,Veggiotti P

    更新日期:2006-01-01 00:00:00

  • Effects of taurine on kindled amygdaloid seizures in rats, cats, and photosensitive baboons.

    abstract::Acute administration of taurine produced a transient loss of susceptibility to photically induced seizures in photosensitive baboons, but failed to affect kindled amygdaloid convulsions in baboons, rats, and cats. In addition, it was totally ineffective in changing the course of spontaneous status epilepticus in kindl...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1975.tb06052.x

    authors: Wada JA,Osawa T,Wake A,Corcoran ME

    更新日期:1975-06-01 00:00:00

  • The medical treatment of epilepsy in the elderly: A systematic review and meta-analysis.

    abstract:OBJECTIVE:To evaluate the efficacy and tolerability of antiepileptic drugs (AEDs) in elderly individuals with epilepsy. METHODS:We searched four electronic databases as well as bibliographies and conference abstracts. Published and unpublished, randomized, or quasirandomized trials reporting the use of AEDs in people ...

    journal_title:Epilepsia

    pub_type: 杂志文章,meta分析

    doi:10.1111/epi.16068

    authors: Lezaic N,Gore G,Josephson CB,Wiebe S,Jetté N,Keezer MR

    更新日期:2019-07-01 00:00:00

  • Biting behavior, aggression, and seizures.

    abstract:PURPOSE:To describe the semiologic features of aggressive behaviors observed in human epileptic seizures with particular reference to the act of biting a conspecific. METHODS:We analyzed the biting behavior (BB) and other aggressive gestures occurring in a group of 11 patients retrospectively selected from >1,000 pati...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2005.58404.x

    authors: Tassinari CA,Tassi L,Calandra-Buonaura G,Stanzani-Maserati M,Fini N,Pizza F,Sartori I,Michelucci R,Lo Russo G,Meletti S

    更新日期:2005-05-01 00:00:00

  • Proton spectroscopic imaging shows abnormalities in glial and neuronal cell pools in frontal lobe epilepsy.

    abstract:PURPOSE:Proton magnetic resonance spectroscopic imaging (1H MRSI) can lateralize the epileptogenic frontal lobe by detecting metabolic ratio abnormalities in frontal lobe epilepsy (FLE). We used 1H MRS to lateralize and localize the epileptogenic focus, and we also sought to characterize further the metabolic abnormali...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1046/j.1528-1157.2001.15301.x

    authors: Lundbom N,Gaily E,Vuori K,Paetau R,Liukkonen E,Rajapakse JC,Valanne L,Häkkinen AM,Granström ML

    更新日期:2001-12-01 00:00:00

  • Screening for major depression in epilepsy with common self-report depression inventories.

    abstract:PURPOSE:Major depression is a common psychiatric comorbidity in chronic epilepsy that is frequently unrecognized and untreated. A variety of self-report mood inventories are available, but their validity as well as ability to detect major depression in epilepsy remains uncertain. The purpose of this study was to determ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2005.49704.x

    authors: Jones JE,Hermann BP,Woodard JL,Barry JJ,Gilliam F,Kanner AM,Meador KJ

    更新日期:2005-05-01 00:00:00

  • Help-seeking patterns for children with epilepsy in rural India: implications for service delivery.

    abstract:PURPOSE:Most people in the world with epilepsy are untreated with antiepileptic drugs (AEDs). In some developing countries, this is because treatment facilities are unavailable or difficult to access. It has even been suggested that indigenous health systems threaten the prospect of the global control of epilepsy with ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1046/j.1528-1157.2002.47601.x

    authors: Pal DK,Das T,Sengupta S,Chaudhury G

    更新日期:2002-08-01 00:00:00

  • Is the cell death in mesial temporal sclerosis apoptotic?

    abstract:PURPOSE:Mesial temporal sclerosis (MTS) is characterized by neuronal loss in the hippocampus. Studies on experimental models and patients with intractable epilepsy suggest that apoptosis may be involved in neuronal death induced by recurrent seizures. METHODS:We searched evidence for apoptotic cell death in temporal l...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1046/j.1528-1157.2003.37402.x

    authors: Uysal H,Cevik IU,Soylemezoglu F,Elibol B,Ozdemir YG,Evrenkaya T,Saygi S,Dalkara T

    更新日期:2003-06-01 00:00:00

  • Ex vivo characterization of neuroinflammatory and neuroreceptor changes during epileptogenesis using candidate positron emission tomography biomarkers.

    abstract:OBJECTIVE:Identification of patients at risk of developing epilepsy before the first spontaneous seizure may promote the development of preventive treatment providing opportunity to stop or slow down the disease. METHODS:As development of novel radiotracers and on-site setup of existing radiotracers is highly time-con...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.16353

    authors: Bascuñana P,Gendron T,Sander K,Jahreis I,Polyak A,Ross TL,Bankstahl M,Arstad E,Bankstahl JP

    更新日期:2019-11-01 00:00:00

  • Toward evidence-based severity assessment in rat models with repeated seizures: II. Chemical post-status epilepticus model.

    abstract:OBJECTIVE:Considering the complexity of neuronal circuits and their epilepsy-associated alterations, epilepsy models cannot be completely replaced by in vitro experimental approaches. Decisions about ethical approval of in vivo studies require a thorough weighing of the animal's burden and the benefit regarding the exp...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.16330

    authors: Koska I,van Dijk RM,Seiffert I,Di Liberto V,Möller C,Palme R,Hellweg R,Potschka H

    更新日期:2019-10-01 00:00:00

  • Double-blind, placebo-controlled trial of topiramate as add-on therapy in patients with refractory partial seizures.

    abstract::In a double-blind, randomized, parallel-group trial, we compared topiramate (TPM) with placebo as add-on therapy in patients with refractory partial epilepsy. TPM was titrated either to the target dosage of 800 mg/ day [400 mg twice daily (b.i.d)] or to the maximal tolerated dose if lower. Twenty-eight (28) patients w...

    journal_title:Epilepsia

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1528-1157.1996.tb00606.x

    authors: Ben-Menachem E,Henriksen O,Dam M,Mikkelsen M,Schmidt D,Reid S,Reife R,Kramer L,Pledger G,Karim R

    更新日期:1996-06-01 00:00:00

  • Late-onset periodic asystolia during vagus nerve stimulation.

    abstract::Cardiac changes may occasionally occur during vagus nerve stimulation (VNS) used in epileptic patients. As they can be potentially life-threatening, it is important to detect them, and this is why an intraoperative test is performed during the implantation. Few cases of asystole during this test have been described. O...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2008.01918.x

    authors: Iriarte J,Urrestarazu E,Alegre M,Macías A,Gómez A,Amaro P,Artieda J,Viteri C

    更新日期:2009-04-01 00:00:00

  • A comparison of two methods for estimating the health care costs of epilepsy.

    abstract:PURPOSE:Previous studies have estimated medical care costs of epilepsy by applying unit costs to estimated utilization or by summing costs for (a) ambulatory care and hospitalizations coded as epilepsy and (b) procedures and drugs specifically associated with the diagnosis or treatment of epilepsy. These methods may un...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.2000.tb00288.x

    authors: Frost FJ,Hurley JS,Petersen HV,Gunter MJ,Gause D

    更新日期:2000-08-01 00:00:00

  • The effects of oxcarbazepine, levetiracetam, and lamotrigine on semen quality, sexual function, and sex hormones in male adults with epilepsy.

    abstract:OBJECTIVE:To investigate the effects of antiepileptic drugs (AEDs; oxcarbazepine [OXC], levetiracetam [LEV], and lamotrigine [LTG]) on semen quality, sexual function, and sex hormones in male adults with epilepsy. METHODS:Individual treatment with OXC, LEV, or LTG was randomly assigned to 38 newly diagnosed male adult...

    journal_title:Epilepsia

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/epi.14450

    authors: Wu D,Chen L,Ji F,Si Y,Sun H

    更新日期:2018-07-01 00:00:00

  • Effects of lamotrigine compared with levetiracetam on anger, hostility, and total mood in patients with partial epilepsy.

    abstract:PURPOSE:To assess anger/hostility during treatment with lamotrigine adjunctive therapy versus levetiracetam adjunctive therapy in patients with partial seizures. METHODS:This randomized, double-blind, parallel-group study in adults with partial seizures included an 8-week escalation phase, during which adjunctive lamo...

    journal_title:Epilepsia

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1528-1167.2008.01792.x

    authors: Labiner DM,Ettinger AB,Fakhoury TA,Chung SS,Shneker B,Tatum Iv WO,Mitchell Miller J,Vuong A,Hammer AE,Messenheimer JA

    更新日期:2009-03-01 00:00:00

  • Seizure-associated Takotsubo cardiomyopathy.

    abstract::Takotsubo cardiomyopathy is characterized by chest pain, dyspnea, electrocardiographic changes resembling an acute coronary syndrome, and transient wall-motion abnormalities without identifiable coronary culprit lesion explaining the wall-motion abnormality. Takotsubo cardiomyopathy occurs frequently after emotional o...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1528-1167.2011.03185.x

    authors: Stöllberger C,Wegner C,Finsterer J

    更新日期:2011-11-01 00:00:00

  • Gabapentin as add-on therapy in children with refractory partial seizures: a 12-week, multicentre, double-blind, placebo-controlled study. Gabapentin Paediatric Study Group.

    abstract:PURPOSE:To evaluate the efficacy and safety of gabapentin (Neurontin; GBP) as add-on therapy for refractory partial seizures in paediatric patients aged 3-12 years. METHODS:After a 6-week baseline period, 247 patients (54 centres) entered a 12-week double-blind phase and were randomized to receive either GBP (t.i.d., ...

    journal_title:Epilepsia

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1528-1157.1999.tb00833.x

    authors: Appleton R,Fichtner K,LaMoreaux L,Alexander J,Halsall G,Murray G,Garofalo E

    更新日期:1999-08-01 00:00:00

  • Seizure expression, behavior, and brain morphology differences in colonies of Genetic Absence Epilepsy Rats from Strasbourg.

    abstract:OBJECTIVE:Originally derived from a Wistar rat strain, a proportion of which displayed spontaneous absence-type seizures, Genetic Absence Epilepsy Rats from Strasbourg (GAERS) represent the most widely utilized animal model of genetic generalized epilepsy. Here we compare the seizure, behavioral, and brain morphometric...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.12840

    authors: Powell KL,Tang H,Ng C,Guillemain I,Dieuset G,Dezsi G,Çarçak N,Onat F,Martin B,O'Brien TJ,Depaulis A,Jones NC

    更新日期:2014-12-01 00:00:00