abstract：BACKGROUND:Atopic dermatitis (AD) is characterized by impaired skin barrier function and immune system dysfunction. The expression and role of Yes-associated protein (YAP) in AD are unclear. OBJECTIVE:To characterize the role of the YAP in T cell imbalance and epidermal keratinocyte dysfunction in the pathogenesis of ...

journal_title：Journal of dermatological science

authors： Jia J,Mo X,Yan F,Liu J,Ye S,Zhang Y,Lin Y,Li H,Chen D

更新日期：2020-12-18 00:00:00

abstract：BACKGROUND:Ultraviolet (UV) irradiation is the main contributing factor for skin aging. UV irradiation induces epigenetic changes in skin. It increases the activity of histone acetylases (HATs) but decreases that of histone deacetylases (HDACs). OBJECTIVE:We aimed to investigate alterations in all classes of HDACs and...

journal_title：Journal of dermatological science

authors： Lee Y,Shin MH,Kim MK,Park CH,Shin HS,Lee DH,Chung JH

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND:Lichen sclerosus (LS) is an acquired inflammatory mucocutaneous disease affecting the anogenital area, characterized histologically by hyalinosis and thickened vessel walls in the dermis. The presence of serum autoantibodies against extracellular matrix protein 1 (ECM1) in LS patients may suggest its involve...

journal_title：Journal of dermatological science

authors： Utsunomiya N,Utsunomiya A,Chino T,Hasegawa M,Oyama N

更新日期：2020-11-01 00:00:00

abstract：:Bullous pemphigoid (BP) is a common autoimmune blistering skin disease that mainly affects elderly patients. Although BP risk is strongly influenced by age, genetic factors are also important determinants of this disease. Many genomic regions, especially in the HLA-II region, have been found to influence BP susceptibi...

journal_title：Journal of dermatological science

authors： Zhang J,Wang G

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Human Apurinic/Apyrimidinic Endonuclease 1 (APE1/REF-1/HAP1) is a multifunction protein involved in the progression of cancer. But the role of APE1 in cutaneous squamous cell carcinoma (cSCC) is unclear. OBJECTIVE:This study is aimed to investigate the basic modulatory mechanism of APE1 in cSCC development ...

journal_title：Journal of dermatological science

authors： Deng X,Zhen P,Niu X,Dai Y,Wang Y,Zhou M

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Antimicrobial peptide derived from insulin-like growth factor binding protein-5 (AMP-IBP5) is a potent antimicrobial agent that possesses various immunomodulatory activities. The parent protein of AMP-IBP5, IGFBP-5, has been shown to exert its effects via an insulin-like growth factor-1 receptor-independent ...

journal_title：Journal of dermatological science

authors： Chieosilapatham P,Yue H,Ikeda S,Ogawa H,Niyonsaba F

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Extramammary Paget's disease (EMPD) is a rare skin cancer that frequently occurs in the anogenital region in the elderly. Prognosis in patients with metastatic EMPD is poor as EMPD treatment has advanced little in recent years, primarily because no EMPD cell line has been established. OBJECTIVE:We aimed to ...

journal_title：Journal of dermatological science

authors： Arita T,Kondo J,Kaneko Y,Tsutsumi M,Kanemaru M,Matsui M,Arakawa Y,Katoh N,Inoue M,Asai J

更新日期：2020-09-01 00:00:00

abstract：:Psoriasis is an immune-mediated disease associated with skin and joint inflammation that affects large proportions of populations worldwide. It is a heritable disease: individuals' genetic backgrounds modulate their susceptibility. In genetics, multiple human leukocyte antigen (HLA) genes are most strongly associated ...

journal_title：Journal of dermatological science

authors： Ogawa K,Okada Y

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Various cutaneous manifestations have been observed in patients with COVID-19 infection. However, overall similarities in the clinical presentation of these dermatological manifestations have not yet been summarized. OBJECTIVE:This review aims to provide an overview of various cutaneous manifestations in pa...

journal_title：Journal of dermatological science

authors： Sachdeva M,Gianotti R,Shah M,Bradanini L,Tosi D,Veraldi S,Ziv M,Leshem E,Dodiuk-Gad RP

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Sarcoidosis is a systemic granulomatous disease characterized by the combination of Th1 and Th17 responses. Recently, several arguments have suggested a potential involvement of B cells as well as T cells in the pathogenesis of sarcoidosis. Follicular helper CD4+ T (TFH) cells are specialized in interacting ...

journal_title：Journal of dermatological science

authors： Ly NTM,Ueda-Hayakawa I,Nguyen CTH,Okamoto H

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Psoriasis is a chronic inflammatory disease characterized by demarcated, raised, and scaling skin lesions. It often serves as a model for immune-mediated disorders. Gene expression profiling of affected skin has allowed insights into psoriasis pathogenesis. However, the mechanisms leading to specific mRNA ex...

journal_title：Journal of dermatological science

authors： Delić D,Wolk K,Schmid R,Gabrielyan O,Christou D,Rieber K,Rolser M,Jakob I,Wiech F,Griesser M,Wohnhaas C,Kokolakis G,Witte-Händel E,Baum P,Sabat R

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:NIPAL4, encoding the NIPA-like domain containing 4 protein (NIPAL4), is one of the causative genes of autosomal recessive congenital ichthyosis (ARCI). The physiological role of NIPAL4 and the pathogenetic mechanisms of ARCI caused by NIPAL4 mutations remain unclear. OBJECTIVE:To clarify the changes of cera...

journal_title：Journal of dermatological science

authors： Murase Y,Takeichi T,Kawamoto A,Tanahashi K,Okuno Y,Takama H,Shimizu E,Ishikawa J,Ogi T,Akiyama M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The process of repair after skin injury is precisely regulated by a variety of mediators such as cytokines and chemokines. Recent reports demonstrated that cytoplasmic DNA-sensor cyclic GMP-AMP synthase (cGAS) activates the stimulator of interferon genes (STING) via production of cyclic GMP-AMP (cGAMP) and s...

journal_title：Journal of dermatological science

authors： Mizutani Y,Kanbe A,Ito H,Seishima M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Reactive oxygen species (ROS)-induced mitochondrial damage aggravates oxidative stress and activates mitochondrial apoptosis pathway to mediate melanocyte death. However, the repair mechanisms underlying damaged mitochondria of melanocytes remain unclear. Accumulative evidence has revealed that the aryl hydr...

journal_title：Journal of dermatological science

authors： Wang X,Li S,Liu L,Jian Z,Cui T,Yang Y,Guo S,Yi X,Wang G,Li C,Gao T,Li K

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:We sometimes encounter difficulties in assessing the severity of pediatric atopic dermatitis (AD) using currently available biomarkers such as thymus and activation-regulated chemokine (TARC) due to the higher baseline values in non-AD children. Recent case control studies have indicated the usefulness of sq...

journal_title：Journal of dermatological science

authors： Takeuchi S,Furusyo N,Ono J,Azuma Y,Takemura M,Esaki H,Yamamura K,Mitamura Y,Tsuji G,Kiyomatsu-Oda M,Hayashi J,Izuhara K,Furue M

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Zinc deficiency is believed to be a predisposing factor for the development and intractable healing of pressure ulcers (PUs); however, the mechanisms of this association have not been elucidated. OBJECTIVE:Objective was to elucidate the mechanisms of the formation of severe and prolonged PUs under the zinc ...

journal_title：Journal of dermatological science

authors： Nakamura H,Sekiguchi A,Ogawa Y,Kawamura T,Akai R,Iwawaki T,Makiguchi T,Yokoo S,Ishikawa O,Motegi SI

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Netherton syndrome (NS) is a rare but severe type of ichthyosis characterized by atopy, allergies, and potentially lethal skin overdesquamation associated with highly elevated proteolytic activities in LEKTI-deficient epidermis. NS symptoms are recapitulated in Spink5-/- mouse where the gene encoding Lekti h...

journal_title：Journal of dermatological science

authors： Zingkou E,Pampalakis G,Charla E,Nauroy P,Kiritsi D,Sotiropoulou G

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Ultraviolet B (UVB) radiation is a major cause of skin photodamage, including the damage associated with photodermatoses, aging, and cancer. Although many studies have shown that red light has photoprotective effects on skin, the mechanisms underlying these effects are still poorly understood. OBJECTIVE:The...

journal_title：Journal of dermatological science

authors： Kim HS,Kim YJ,Kim SJ,Kang DS,Lee TR,Shin DW,Kim HJ,Seo YR

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Transforming growth factor beta 1 (TGFβ) is known to be a regulator of autoimmunity. Loss of TGFβ leads to severe multi-organ autoimmunity in mice. In skin, role of TGFβ in suppressing autoimmunity is unclear. OBJECTIVE:Determine whether Keratinocyte (KC)-derived TGFβ is required for skin immune homeostasis...

journal_title：Journal of dermatological science

authors： Yang Y,Zenke Y,Hirai T,Kaplan DH

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Congenital ichthyoses (CIs) adversely affect quality of life (QOL) in patients. However, the effects of CIs on patient QOL have not been studied sufficiently. OBJECTIVE:To investigate the association between disease severity and QOL in patients with harlequin ichthyosis (HI) and ichthyosis: syndromic forms ...

journal_title：Journal of dermatological science

authors： Murase C,Takeichi T,Shibata A,Nakatochi M,Kinoshita F,Kubo A,Nakajima K,Ishii N,Amano H,Masuda K,Kawakami H,Kanekura T,Washio K,Asano M,Teramura K,Akasaka E,Tohyama M,Hatano Y,Ochiai T,Moriwaki S,Sato T,Ishida-Y

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) is an inflammatory skin disease with an associated barrier dysfunction and Staphylococcus aureus infection. The mainstay steroid and calcineurin inhibitor therapy shows some adverse effects. 2,4-Dimethoxy-6-methylbenzene-1,3-diol (DMD) is a benzenoid isolated from Antrodia camphorata. ...

journal_title：Journal of dermatological science

authors： Yang SC,Huang TH,Chiu CH,Chou WL,Alalaiwe A,Yeh YC,Su KW,Fang JY

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Due to their immunosuppressive therapy, organtransplant recipients (OTRs) exhibit a high incidence for the development of cutaneous squamous cell carcinoma (cSCC). Randomized studies of kidney-transplanted patients indicate a significant lower susceptibility for cSCC among patients receiving the mTOR-inhibit...

journal_title：Journal of dermatological science

authors： Schaper-Gerhardt K,Walter A,Schmitz-Rode C,Satzger I,Gutzmer R

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Psoriasis is a systemic inflammatory disease with dramatic responses to TNF-α inhibitors. TNF-α is mainly produced by macrophages. However, how macrophage polarization contributes to psoriasis remains unknown. OBJECTIVE:We aimed to investigate the molecular mechanisms of macrophage polarization in psoriasis...

journal_title：Journal of dermatological science

authors： Lin SH,Chuang HY,Ho JC,Lee CH,Hsiao CC

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:The CC chemokine ligand 18 (CCL18) has a higher expression in some tumors, while the CCL18 level can be a marker of tumor progression and prognosis. We previously reported that the expression of CCL18 gene was dramatically up-regulated in cutaneous malignant melanoma (CMM) and its expression levels were corr...

journal_title：Journal of dermatological science

authors： Song H,Tao Y,Ni N,Zhou X,Xiong J,Zeng X,Xu X,Qi J,Sun J

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Scleroderma is caused by aberrant transforming growth factor-ß signaling. The degradation of extracellular matrix proteins is regulated by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Ultraviolet (UV) radiation has been a therapy for scleroderma. 6-Formylindolo[3,2-b]...

journal_title：Journal of dermatological science

authors： Murai M,Yamamura K,Hashimoto-Hachiya A,Tsuji G,Furue M,Mitoma C

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) is a highly pruritic, chronic inflammatory skin disease associated with hyperreactivity to environmental triggers. Among those, outdoor air pollutants such as particulate matter (PM) have been reported to aggravate pre-existing AD. However, underlying mechanisms of air pollution-induce...

journal_title：Journal of dermatological science

authors： Han RT,Kim HY,Ryu H,Jang W,Cha SH,Kim HY,Lee J,Back SK,Kim HJ,Na HS

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Currently available topical treatments for actinic keratosis (AK) are associated with substantial side-effects. OBJECTIVES:To evaluate the efficacy and safety of topical SR-T100 gel in treating AK. METHODS:A multicenter, randomized, double-blinded phase III trial was conducted. Patients with at least two c...

journal_title：Journal of dermatological science

authors： Yang CC,Wong TW,Lee CH,Hong CH,Chang CH,Lai FJ,Lin SH,Chi CC,Lin TK,Yen H,Wu CH,Sheu HM,Lan CE

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Rutin, due to its polyphenolic structure, has antioxidant properties and can be used as a cytoprotective compound against UV-induced effects on skin cells. OBJECTIVE:The aim of this study was to examine the effect of rutin on proteomic profile in human skin fibroblasts irradiated with UV dose that induces a...

journal_title：Journal of dermatological science

authors： Gęgotek A,Domingues P,Skrzydlewska E

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Atopic dermatitis is a common skin disease characterized by a Th2 cell-dominant inflammatory infiltrate, elevated serum IgE levels and impaired epidermal barrier function. It is associated to abnormal epidermal lamellar body secretion, producing alteration in lipid composition and extracellular lamellar memb...

journal_title：Journal of dermatological science

authors： Moner V,Fernández E,Calpena AC,Garcia-Herrera A,Cócera M,López O

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Both lymph nodes (LNs) and lymphatic channels from primary sites to regional LNs are critical for initiation of adaptive immunity. However, as LNs are common metastatic sites in skin cancers, LN biopsies or dissections are frequently performed. In addition, reconstructive skin flaps after tumor resection may...

journal_title：Journal of dermatological science

authors： Nakamura Y,Fujisawa Y,Okiyama N,Watanabe R,Tanaka R,Ishitsuka Y,Tahara H,Fujimoto M

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Cutaneous T cell lymphoma (CTCL) comprises a heterogeneous group of skin-homing T cell tumors. The small guanosine triphosphate effector p21-activated kinase 1 (PAK1) plays an important role in many fundamental cellular functions, including cell motility, proliferation, and apoptosis. The expression of PAK1 ...

journal_title：Journal of dermatological science

authors： Wang Y,Gu X,Li W,Zhang Q,Zhang C

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Resolvin D1 (RvD1), a pro-resolution lipid mediator derived from docosahexaenoic acid (DHA), has been described to promote several kinds of inflammatory resolution. However, the effects and anti-inflammatory mechanisms of RvD1 on psoriasis have not been previously reported. OBJECTIVE:The present study aimed...

journal_title：Journal of dermatological science

authors： Xu J,Duan X,Hu F,Poorun D,Liu X,Wang X,Zhang S,Gan L,He M,Zhu K,Ming Z,Chen H

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) is recently increasing among populations, but the underlying mechanisms remain controversial. Interactions between the gut microbiota and mucosal immunity are considered to be a crucial etiology. Fructooligosaccharide (FOS), prebiotics have been reported as activators of the gut microb...

journal_title：Journal of dermatological science

authors： Kim HJ,Lee SH,Go HN,Ahn JR,Kim HJ,Hong SJ

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:In vivo application of confocal Raman spectroscopy (CRS) allows non-invasive depth measurement of the skin. Thereby obtained knowledge of the skin composition is essential to reliably assess the actual skin state. Besides other components, the skin cholesterol concentration is of interest; however, little is...

journal_title：Journal of dermatological science

authors： Binder L,SheikhRezaei S,Baierl A,Gruber L,Wolzt M,Valenta C

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) is a chronic inflammatory skin disease that often cannot be completely controlled by modern medicine. Since multiple factors are intricately involved in the pathogenesis of AD, wide-ranging research is required for further advancement of AD treatment. Epidermal keratinocytes are the fo...

journal_title：Journal of dermatological science

authors： Kumagai A,Kubo T,Kawata K,Kamekura R,Yamashita K,Jitsukawa S,Nagaya T,Sumikawa Y,Himi T,Yamashita T,Ichimiya S

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Comprehensive data regarding the epidemiology of chronic urticaria (CU) in general populations are scant. OBJECTIVES:To investigate the prevalence, incidence, and comorbidities of CU in general population. METHODS:The data were sourced from the National Health Insurance Research Database (NHIRD) for 2009-2...

journal_title：Journal of dermatological science

authors： Chu CY,Cho YT,Jiang JH,Lin EI,Tang CH

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:As interest in skin beauty increases, the development of new skin whitening agents has attracted substantial attention; however, the action mechanism of the agents developed so far remains largely unknown. Tranexamic acid (TXA) is commonly being used to reduce melanin synthesis in patients with melasma and a...

journal_title：Journal of dermatological science

authors： Cho YH,Park JE,Lim DS,Lee JS

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:In addition to their microbicidal properties, host defense peptides (HDPs) display various immunomodulatory functions, including keratinocyte production of cytokines/chemokines, proliferation, migration and wound healing. Recently, a novel HDP named AMP-IBP5 (antimicrobial peptide derived from insulin-like g...

journal_title：Journal of dermatological science

authors： Chieosilapatham P,Niyonsaba F,Kiatsurayanon C,Okumura K,Ikeda S,Ogawa H

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Autophagy is a highly conserved cellular catabolic pathway for degradation and recycling of intracellular components in response to nutrient starvation or environmental stress. Endoplasmic reticulum (ER) homeostasis can be disturbed by physiological and pathological influences, resulting in accumulation of m...

journal_title：Journal of dermatological science

authors： Chang SH,Huang SW,Wang ST,Chung KC,Hsieh CW,Kao JK,Chen YJ,Wu CY,Shieh JJ

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Retinoic acid (RA) enhances skin-lightening capabilities of hydroquinone (HQ), at least in part, by facilitating desquamation which leads to increase penetration of HQ. The desquamation also affects skin irritation levels. The mechanism of RA-induced desquamation, however, has not been completely explored an...

journal_title：Journal of dermatological science

authors： Cheong KA,Lee TR,Lee AY

更新日期：2017-08-01 00:00:00