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Effects of kestose on gut mucosal immunity in an atopic dermatitis mouse model.

Abstract：

BACKGROUND:Atopic dermatitis (AD) is recently increasing among populations, but the underlying mechanisms remain controversial. Interactions between the gut microbiota and mucosal immunity are considered to be a crucial etiology. Fructooligosaccharide (FOS), prebiotics have been reported as activators of the gut microbiota. OBJECTIVE:The aim of this study was to investigate the effects of kestose, the smallest FOS and FOS on atopic dermatitis in mice. METHODS:An AD mouse model was developed by (ovalbumin) epidermal sensitization using BALB/c mice. Kestose (1%, 5%, and 10%) or FOS (5%, positive control) was orally administered throughout the study. RESULTS:In comparison with the values observed for the control AD mice, transepidermal water loss (TEWL), clinical score, and skin inflammation on histopathology were significantly decreased by the oral administration of kestose. Total IgE, thymic stromal lymphopoietin (TSLP) in skin, and IL-4 were also suppressed by this administration. In addition, the population of CD4+Foxp3+ cells in mesenteric lymph nodes (MLNs) and acetate concentrations in feces were significantly increased by kestose treatment. CONCLUSIONS:These findings suggest that kestose activates the gut immune system to induce the tolerance against allergic skin inflammations in AD.

journal_name

J Dermatol Sci

journal_title

Journal of dermatological science

authors

Kim HJ,Lee SH,Go HN,Ahn JR,Kim HJ,Hong SJ

doi

10.1016/j.jdermsci.2017.10.006

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

27-32

issue

1

eissn

0923-1811

issn

1873-569X

pii

S0923-1811(17)30125-1

journal_volume

89

pub_type

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